Title:
INTERLEUKIN 2 RECEPTOR GAMMA GENE TARGETING VECTOR, PRODUCTION OF IMMUNE CELL-DEFICIENT TRANSGENIC CLONED MINI PIG HAVING VECTOR INTRODUCED THEREIN, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/072761
Kind Code:
A1
Abstract:
The present invention relates to an interleukin 2 receptor gamma gene targeting vector, a production of an immune cell-deficient transgenic cloned mini pig having the vector introduced therein, a preparation method therefor and a use thereof.
Inventors:
KIM JIN-HOI (KR)
KWON DEUG-NAM (KR)
LEE KI-HO (US)
RANDALL S PRATHER (US)
KWON DEUG-NAM (KR)
LEE KI-HO (US)
RANDALL S PRATHER (US)
Application Number:
PCT/KR2014/010897
Publication Date:
May 21, 2015
Filing Date:
November 13, 2014
Export Citation:
Assignee:
UNIV KONKUK IND COOP CORP (KR)
International Classes:
A01K67/027; C12N5/10; C12N15/85
Domestic Patent References:
| WO2012116274A2 | 2012-08-30 |
Foreign References:
| KR20040074108A | 2004-08-21 |
Other References:
WATANABE M. ET AL.: "Generation of Interleukin-2 Receptor Gamma Gene Knockout Pigs from Somatic Cells Genetically Modified by Zinc Finger Nuclease-Encoding mRNA", PLOS ONE., vol. 8, no. 10, 9 October 2013 (2013-10-09), pages E76478, XP055342371
KIM H. ET AL.: "Magnetic separation and antibiotics select ion enable enrichment of cells with ZFN/TALEN-induced mutations", PLOS ONE., vol. 8, no. 2, 18 February 2013 (2013-02-18), pages E56476, XP055342373
JUN SONG ET AL.: "Generation of RAG 1-and 2-deficient rabbits by embryo microinjection of TALENs", CELL RESEARCH, vol. 23, 9 July 2013 (2013-07-09), pages 1059 - 1062, XP055342375
BUCKLEY, RH., ANNUAL REVIEW OF IMMUNOLOGY, vol. 22, 2004, pages 625 - 655
WHYTE, J.J.; PRATHER, RS., MOLECULAR REPRODUCTION AND DEVELOPMENT, vol. 78, 2011, pages 879 - 891
CAO, X. ET AL., IMMUNITY, vol. 2, 1995, pages 223 - 238
SUZUKI, S. ET AL., CELL STEM CELL, vol. 10, 2012, pages 753 - 758
See also references of EP 3069606A4
KIM H. ET AL.: "Magnetic separation and antibiotics select ion enable enrichment of cells with ZFN/TALEN-induced mutations", PLOS ONE., vol. 8, no. 2, 18 February 2013 (2013-02-18), pages E56476, XP055342373
JUN SONG ET AL.: "Generation of RAG 1-and 2-deficient rabbits by embryo microinjection of TALENs", CELL RESEARCH, vol. 23, 9 July 2013 (2013-07-09), pages 1059 - 1062, XP055342375
BUCKLEY, RH., ANNUAL REVIEW OF IMMUNOLOGY, vol. 22, 2004, pages 625 - 655
WHYTE, J.J.; PRATHER, RS., MOLECULAR REPRODUCTION AND DEVELOPMENT, vol. 78, 2011, pages 879 - 891
CAO, X. ET AL., IMMUNITY, vol. 2, 1995, pages 223 - 238
SUZUKI, S. ET AL., CELL STEM CELL, vol. 10, 2012, pages 753 - 758
See also references of EP 3069606A4
Attorney, Agent or Firm:
Hanyang Patent Firm (KR)
한양특허법인 (KR)
한양특허법인 (KR)
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