Title:
RECOMBINATION ACTIVATING GENE 2 GENE TARGETING VECTOR, PRODUCTION OF SCID-LIKE MINIATURE PIGS BY TALEN-MEDIATED GENE TARGETING AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/072760
Kind Code:
A1
Abstract:
There are provided to a Rag-2 (Recombination activating gene 2) gene targeting vector, a method for producing SCID-like miniature pigs introduced with the vector, and a use thereof.
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Inventors:
KIM JIN-HOI (KR)
KWON DEUG-NAM (KR)
RANDALL S PRATHER (US)
LEE KI-HO (US)
KWON DEUG-NAM (KR)
RANDALL S PRATHER (US)
LEE KI-HO (US)
Application Number:
PCT/KR2014/010896
Publication Date:
May 21, 2015
Filing Date:
November 13, 2014
Export Citation:
Assignee:
UNIV KONKUK IND COOP CORP (KR)
International Classes:
A01K67/027; C12N15/12; C12N15/85
Foreign References:
| US20120222143A1 | 2012-08-30 | |||
| KR20040074108A | 2004-08-21 |
Other References:
WATANABE M. ET AL., PLOS ONE., vol. 9, no. 10, 9 October 2013 (2013-10-09), pages E76478, XP055342371
JUN SONG ET AL.: "Generation of RAG 1- and 2-deficient rabbits by embryo microinjection of TALENs", CELL RESEARCH, vol. 23, 9 July 2013 (2013-07-09), pages 1059 - 1062, XP055342375
KIM H. ET AL.: "Magnetic separation and antibiotics selection enable enrichment of cells with ZFN/TALEN-induced mutations", PLOS ONE., vol. 8, no. 2, 18 February 2013 (2013-02-18), pages E56476, XP055342373
BUCKLEY, R.H., ANNUAL REVIEW OF IMMUNOLOGY, vol. 22, 2004, pages 625 - 655
WHYTE, J.J.; PRATHER, R.S., MOLECULAR REPRODUCTION AND DEVELOPMENT, vol. 78, 2011, pages 879 - 891
VILLA, A.; SANTAGATA, S.; BOZZI, F.; IMBERTI, L.; NOTARANGELO, L.D., JOURNAL OF CLINICAL IMMUNOLOGYL, vol. 9, 1999, pages 87 - 97
SHINKAI, Y. ET AL., CELL, vol. 68, 1992, pages 855 - 867
WATANABEE ET AL., PLOS ONE, vol. 9, no. 10, 2013, pages e76478
SONG ET AL., CELL RESEARCH, vol. 1059-106, 2013
See also references of EP 3068217A4
JUN SONG ET AL.: "Generation of RAG 1- and 2-deficient rabbits by embryo microinjection of TALENs", CELL RESEARCH, vol. 23, 9 July 2013 (2013-07-09), pages 1059 - 1062, XP055342375
KIM H. ET AL.: "Magnetic separation and antibiotics selection enable enrichment of cells with ZFN/TALEN-induced mutations", PLOS ONE., vol. 8, no. 2, 18 February 2013 (2013-02-18), pages E56476, XP055342373
BUCKLEY, R.H., ANNUAL REVIEW OF IMMUNOLOGY, vol. 22, 2004, pages 625 - 655
WHYTE, J.J.; PRATHER, R.S., MOLECULAR REPRODUCTION AND DEVELOPMENT, vol. 78, 2011, pages 879 - 891
VILLA, A.; SANTAGATA, S.; BOZZI, F.; IMBERTI, L.; NOTARANGELO, L.D., JOURNAL OF CLINICAL IMMUNOLOGYL, vol. 9, 1999, pages 87 - 97
SHINKAI, Y. ET AL., CELL, vol. 68, 1992, pages 855 - 867
WATANABEE ET AL., PLOS ONE, vol. 9, no. 10, 2013, pages e76478
SONG ET AL., CELL RESEARCH, vol. 1059-106, 2013
See also references of EP 3068217A4
Attorney, Agent or Firm:
HANYANG PATENT FIRM (Gangnam-gu, Seoul 135-854, KR)
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