Title:
INTERMEDIATE USEFUL FOR SYNTHESIS OF SGLT INHIBITOR AND METHOD FOR PREPARING SGLT INHIBITOR USING SAME
Document Type and Number:
WIPO Patent Application WO/2021/172955
Kind Code:
A1
Abstract:
The present invention provides an intermediate useful for the synthesis of an SGLT inhibitor and a method for preparing an SGLT inhibitor using same. According to the present invention, by developing a compound of chemical formula 5 corresponding to a novel intermediate, the difficulty of purification with existing processes can be solved, the quality of related substances can be matched with only one purification step, and the quality control problem in each step can be solved by performing several steps in situ. The method for synthesizing a compound of chemical formula 1 by using a compound of chemical formula 5, according to the present invention, enables purification in the step of synthesizing a compound of chemical formula 5, thereby solving the problems of existing synthesis processes, in which the quality of related substances was difficult to control step by step due to a continuous process, and minimizing the amount of related substances in a final product. In addition, as the number of purification steps increases, the process can be simplified because purification is not necessarily performed two or more times in one step like in the prior art, thereby maximizing the production yield of a diphenylmethane derivative according to chemical formula 1.
Inventors:
YOON YOUN JUNG (KR)
YOON HEE KYOON (KR)
YOON HEE KYOON (KR)
Application Number:
PCT/KR2021/002507
Publication Date:
September 02, 2021
Filing Date:
February 26, 2021
Export Citation:
Assignee:
DAE WOONG PHARMA (KR)
International Classes:
C07D307/82; A61K31/343; C07H1/02; C07H17/04
Domestic Patent References:
| WO2016098016A1 | 2016-06-23 |
Foreign References:
| KR20140114304A | 2014-09-26 | |||
| CN108530408A | 2018-09-14 | |||
| KR20140022086A | 2014-02-21 | |||
| KR20170142904A | 2017-12-28 |
Other References:
METIL DATTATRAY S., SONAWANE SWAPNIL P., PACHORE SHARAD S., MOHAMMAD AASEEF, DAHANUKAR VILAS H., MCCORMACK PETER J., REDDY CH. VEN: "Synthesis and Optimization of Canagliflozin by Employing Quality by Design (QbD) Principles", ORGANIC PROCESS RESEARCH & DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 22, no. 1, 19 January 2018 (2018-01-19), US, pages 27 - 39, XP055841368, ISSN: 1083-6160, DOI: 10.1021/acs.oprd.7b00281
See also references of EP 4112612A4
See also references of EP 4112612A4
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
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