INTERNAL 1,15-LACTONES OF FLUPROSTENOL AND RELATED PROSTAGLANDIN F>2 alpha < ANALOGS AND THEIR USE IN THE TREATMENT OF GLAUCOMA AND INTRAOCULAR HYPERTENSION

Title:

INTERNAL 1,15-LACTONES OF FLUPROSTENOL AND RELATED PROSTAGLANDIN F>2 alpha < ANALOGS AND THEIR USE IN THE TREATMENT OF GLAUCOMA AND INTRAOCULAR HYPERTENSION

Document Type and Number:

WIPO Patent Application WO2001057015

Kind Code:

A9

Abstract:

Novel derivatives of prostaglandin compounds of the F-series (PGF), specifically macrocyclic internal 1,15-lactones of fluprostenol and related PGF analogs, such as cloprostenol or latanoprost. The novel analogs can be formulated into ophthalmic solutions and topically applied for the treatment of the increased intraocular pressure caused by glaucoma and the reduction of ocular hypertension.

Inventors:

MAXEY KIRK M (US)
STANTON MICHELLE L (US)

Application Number:

PCT/US2001/003559

Publication Date:

October 17, 2002

Filing Date:

February 01, 2001

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Assignee:

CAYMAN CHEMICAL CO INC (US)
MAXEY KIRK M (US)
STANTON MICHELLE L (US)

International Classes:

A61K9/08; A61K31/365; A61P27/02; A61P27/06; A61P43/00; C07C405/00; C07D267/00; C07D313/00; C07D321/00; C07D327/02; (IPC1-7): C07D313/00; A61K31/365; A61P27/06

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