SYNTHESIS OF 3,6-DIALKYL-5,6-DIHYDRO-4-HYDROXY-PYRAN-2-ONE

Title:

SYNTHESIS OF 3,6-DIALKYL-5,6-DIHYDRO-4-HYDROXY-PYRAN-2-ONE

Document Type and Number:

WIPO Patent Application WO2001057014

Kind Code:

A3

Abstract:

The present invention relates to a novel process for producing a delta -lactone of the formula (I) using an acyl halide of the formula (1) wherein R<1>, R<2>, R<3> and X are described herein, as well as novel intermediates. In particular, the present invention relates to a process for enantioselectively producing the (R)- delta -lactone.

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Inventors:

FLEMING MICHAEL PAUL
HAN YEUN-KWEI
HODGES LEWIS M
JOHNSTON DAVID A
MICHELI ROGER P
PUENTENER KURT
ROBERTS CHRISTOPHER R
SCALONE MICHELANGELO
SCHWINDT MARK A
TOPPING ROBERT J

Application Number:

PCT/EP2001/000866

Publication Date:

April 18, 2002

Filing Date:

January 26, 2001

Export Citation:

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Assignee:

HOFFMANN LA ROCHE (CH)

International Classes:

C07B61/00; C07C67/30; C07C67/31; C07D305/12; C07D309/32; C07F3/02; (IPC1-7): C07D309/32; C07F3/02

Foreign References:

US5420305A

1995-05-30

Other References:

POMMIER A ET AL: "AN SYMMETRIC SYNTHESIS OF(-)-TETRAHYDROLIPSTATIN", SYNTHESIS,DE,GEORG THIEME VERLAG. STUTTGART, 1 December 1994 (1994-12-01), pages 1294 - 1300, XP002064051, ISSN: 0039-7881

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