IONICALLY CROSSLINKED HYDROGELS WITH ADJUSTABLE GELATION TIME

Title:

IONICALLY CROSSLINKED HYDROGELS WITH ADJUSTABLE GELATION TIME

Document Type and Number:

WIPO Patent Application WO2001040370

Kind Code:

A3

Abstract:

Biocompatible hydrogels, for: scaffoldings for tissue engineering; cell encapsulation matrices; injectable bulking materials for cosmetic and functional restorations; controlled release matrices; gene delivery vehicles; immunoprotection matrices; immobilization materials; food additives; medical gels; conductive electrode gels; lubricious coatings; film forming creams; membranes; superabsorbents; hydrophilic coatings; and wound dressings. The hydrogels include: at least one water-soluble polymer/copolymer; and at least one slow and/or fast dissolving and/or releasing divalent and/or multivalent cation-containing compound. At least one of the monomers is an acid, and/or contains an acid group or a derivative thereof. Such monomer reacts with the cations to form a three-dimensional ionically crosslinked hydrogel composition. A method for preparing such a composition comprises the step of controlling a rate of gel formation by varying at least one of: solubility of the cation containing compounds; cation concentration; mixture of cation containing compounds; polymer concentration; gelation temperature.

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Inventors:

MA PETER X (US)

Application Number:

PCT/US2000/031635

Publication Date:

September 26, 2002

Filing Date:

November 17, 2000

Export Citation:

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Assignee:

UNIV MICHIGAN (US)
MA PETER X (US)

International Classes:

A61K9/00; A61K47/32; A61K47/36; A61L27/52; C08J3/075; C08L5/04; C08L5/06; C08L5/08; C08L5/10; (IPC1-7): C08L5/04; C08L5/06; C08L5/08; C08L5/10; C08L33/02

Domestic Patent References:

WO1998002488A1

1998-01-22

Foreign References:

US5089606A	1992-02-18
EP0537999A2	1993-04-21
US4603054A	1986-07-29
US4268533A	1981-05-19
US4053627A	1977-10-11
US4228056A	1980-10-14
US5273750A	1993-12-28

Other References:

DRAGET K I ET AL: "HOMOGENEOUS ALGINATE GELS: A TECHNICAL APPROACH", CARBOHYDRATE POLYMERS,APPLIED SCIENCE PUBLISHERS, LTD. BARKING,GB, vol. 14, no. 2, 1990, pages 159 - 178, XP000161126, ISSN: 0144-8617

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