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Title:
IONIZABLE LIPID COMPOUND FOR NUCLEIC ACID DELIVERY AND LNP COMPOSITION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/279836
Kind Code:
A1
Abstract:
Provided are an ionizable lipid compound of formula I for nucleic acid delivery and an LNP composition thereof, which can efficiently and stably deliver a biologically active substance to a target cell or an organ. The mRNA LNP prepared by using the lipid compound as a cationic lipid has better stability and transfection efficiency, and can cause a higher specific antibody response in an experimental animal body.

Inventors:
HAO JING (CN)
WANG QINGBIN (CN)
YAN SHENGYONG (CN)
WANG HAOMENG (CN)
YAN ZHIHONG (CN)
LIU JIAN (CN)
YU XUEFENG (CN)
QIU DONGXU (CN)
LIN MEINA (CN)
GUO JUN (CN)
XIONG YANLI (CN)
ZHU TAO (CN)
ZHAO XUAN (CN)
Application Number:
PCT/CN2022/091881
Publication Date:
January 12, 2023
Filing Date:
May 10, 2022
Export Citation:
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Assignee:
JENKEM TECH CO LTD TIANJIN (CN)
CANSINO SHANGHAI BIOLOGICAL RES CO LTD (CN)
International Classes:
C07C219/06; A61K9/50; A61K31/713; A61K47/18; A61P31/00; A61P35/00; C07C215/14; C07C229/12; C07C233/36; C07C255/24
Domestic Patent References:
WO2021055835A12021-03-25
WO2009122220A12009-10-08
WO2017049245A22017-03-23
WO2021055849A12021-03-25
WO2020252589A12020-12-24
WO2021000041A12021-01-07
WO2021095876A12021-05-20
Foreign References:
CN114149337A2022-03-08
US20210087135A12021-03-25
JP2005015377A2005-01-20
CN110352071A2019-10-18
CN111356444A2020-06-30
US20170210697A12017-07-27
EP3315125A12018-05-02
CN110352071A2019-10-18
CN1882693A2006-12-20
US20200197510A12020-06-25
Attorney, Agent or Firm:
BEIJING LINKTEC IP LAW FIRM (SPECIAL GENERAL PARTNERSHIP) (CN)
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