Title:
IONIZABLE LIPID FOR NUCLEIC ACID DELIVERY AND COMPOSITION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/246218
Kind Code:
A1
Abstract:
Provided are an ionizable lipid for nucleic acid delivery and a composition thereof, which belong to the field of pharmaceutical chemistry. Provided are a compound represented by formula I and use of the compound as a nucleic acid delivery carrier. When used as a delivery carrier of a nucleic acid drug, the compound shows stronger delivery efficiency and higher safety than traditional materials.
Inventors:
SONG XIANGRONG (CN)
WEI XIAWEI (CN)
WEI YUQUAN (CN)
WEI XIAWEI (CN)
WEI YUQUAN (CN)
Application Number:
PCT/CN2023/084750
Publication Date:
December 28, 2023
Filing Date:
June 15, 2023
Export Citation:
Assignee:
WESTGENE BIOPHARMA CO LTD (CN)
International Classes:
C07D295/185; A61K31/7088; A61K31/713; A61K47/22; A61P31/00; A61P35/00; A61P37/00
Domestic Patent References:
| WO2017112865A1 | 2017-06-29 | |||
| WO2021142280A1 | 2021-07-15 | |||
| WO2021026358A1 | 2021-02-11 | |||
| WO2021022173A1 | 2021-02-04 | |||
| WO2019226650A1 | 2019-11-28 |
Foreign References:
| US20210198200A1 | 2021-07-01 | |||
| CN113939282A | 2022-01-14 | |||
| CN113164561A | 2021-07-23 | |||
| CN114391008A | 2022-04-22 | |||
| CN114044741A | 2022-02-15 |
Other References:
DATABASE Registry 16 March 1985 (1985-03-16), ANONYMOUS: "1,4-Piperazinedicarboxylic acid, 1,4-bis[4-(diethylamino)butyl] ester (CA INDEX NAME)", XP093121428, retrieved from STNext Database accession no. 95286-94-5
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