Title:
IRON OXIDE NANOCOMPOSITE, MAGNETIC RESONANCE IMAGING T2 CONTRAST MEDIUM COMPRISING SAME, AND METHOD FOR MANUFACTURING SAME
Document Type and Number:
WIPO Patent Application WO/2013/151283
Kind Code:
A1
Abstract:
The present invention relates to an iron oxide nanocomposite, a magnetic resonance imaging T2 contrast medium comprising same, and a method for manufacturing same. More specifically, the present invention relates to the iron oxide nanocomposite having a structure in which a ferromagnetic iron oxide nanoparticles, which are covered with a surfactant, is capped with a polyethylene glycol-phospholipid, the magnetic resonance imaging T2 contrast medium comprising same, and the method for manufacturing the iron oxide nanocomposite and the magnetic resonsnce imaging T2 contrast medium comprising same.
Inventors:
HYEON TAEGHWAN (KR)
LEE NOHYUN (KR)
CHOI SEUNGHONG (KR)
LEE NOHYUN (KR)
CHOI SEUNGHONG (KR)
Application Number:
PCT/KR2013/002666
Publication Date:
October 10, 2013
Filing Date:
April 01, 2013
Export Citation:
Assignee:
SNU R&DB FOUNDATION (KR)
International Classes:
A61K49/06; A61K9/14; A61K9/16
Foreign References:
| KR20110068323A | 2011-06-22 | |||
| KR20110080781A | 2011-07-13 | |||
| KR20090125211A | 2009-12-03 |
Other References:
LEE, N. ET AL.: "Magnetosome-like ferrimagnetic iron oxide nanocubes for highly sesitive MRI of single cells and transplanted pancreatic islets", PNAS, vol. 108, no. 7, 2011, pages 2662 - 2667, XP055157611
KIM, D. ET AL.: "Synthesis of uniform ferrimagnetic magnetite nanocubes", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 131, 2009, pages 454 - 455, XP002617592
TONG, S. ET AL.: "Coating optimization of superparamagnetic iron oxide nanoparticles for high T2 relaxivity", NANO LETTERS, vol. 10, 2010, pages 4607 - 4613, XP055157613
Y.-W. JUN; J.-H. LEE; J. CHEON, ANGEW. CHEM., vol. 120, 2008, pages 5200
ANGEW. CHEM. INT. ED., vol. 47, 2008, pages 5122
H. B. NA; C. SONG; T. HYEON, ADV. MATER., vol. 21, 2009, pages 2133
J. XIE; G. LIU; H. S. EDEN; H. AI; X. CHEN, ACC. CHEM. RES., vol. 44, 2011, pages 883
M. SRINIVAS; E. H. J. G. AARNTZEN; J. W. M. BULTE; W. J. OYEN; A. HEERSCHAP; J. M. DE VRIES; C. G. FIGDOR, ADV. DRUG. DELIV. REV., vol. 62, 2010, pages 1080
N. LEE; T. HYEON, CHEM. SOC. REV., 2012
P. BOURRINET; H. H. BENGELE; B. BONNEMAIN; A. DENCAUSSE; J.-M. IDEE; P. M. JACOBS; J. M. LEWIS, INVEST. RADIOL., vol. 41, 2006, pages 313
T. K. JAIN; M. K. REDDY; M. A. MORALES; D. L. LESLIE-PELECKY; V. LABHASETWAR, MOL. PHARM., vol. 5, 2008, pages 316
Y.-W. JUN; Y.-M. HUH; J.-S. CHOI; J.-H. LEE; H.-T. SONG; S. KIM; S. YOON; K.-S. KIM; J.-S. SHIN; J.-S. SUH, J. AM. CHEM. SOC., vol. 127, 2005, pages 5732
R. A. BROOKS; F. MOINY; P. GILLIS, MAGN. RESON. MED., vol. 45, 2001, pages 1014
R. A. BROOKS, MAGN. RESON. MED., vol. 47, 2002, pages 388
D. KIM; N. LEE; M. PARK; B. H. KIM; K. AN; T. HYEON, J. AM. CHEM. SOC., vol. 131, 2009, pages 454
N. LEE ET AL., PROC. NATL. ACAD. SCI. USA, vol. 108, 2011, pages 2662
P. MOROZ; C. METCALF; B. N. GRAY, BIOMETALS, vol. 16, 2003, pages 455
T.-J. YOON; H. LEE; H. SHAO; S. A. HILDERBRAND; R. WEISSLEDER, ADV. MATER., vol. 23, 2011, pages 4793
J.-H. LEE; Y.-W. JUN; S.-I. YEON; J.-S. SHIN; J. CHEON, ANGEW CHEM., vol. 118, 2006, pages 8340
ANGEW CHEM. INT. ED., vol. 45, 2006, pages 8160
J. E. LEE ET AL., J. AM. CHEM. SOC., vol. 132, 2010, pages 552
KIM, D. ET AL.: "Synthesis of uniform ferrimagnetic magnetite nanocubes", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 131, 2009, pages 454 - 455, XP002617592
TONG, S. ET AL.: "Coating optimization of superparamagnetic iron oxide nanoparticles for high T2 relaxivity", NANO LETTERS, vol. 10, 2010, pages 4607 - 4613, XP055157613
Y.-W. JUN; J.-H. LEE; J. CHEON, ANGEW. CHEM., vol. 120, 2008, pages 5200
ANGEW. CHEM. INT. ED., vol. 47, 2008, pages 5122
H. B. NA; C. SONG; T. HYEON, ADV. MATER., vol. 21, 2009, pages 2133
J. XIE; G. LIU; H. S. EDEN; H. AI; X. CHEN, ACC. CHEM. RES., vol. 44, 2011, pages 883
M. SRINIVAS; E. H. J. G. AARNTZEN; J. W. M. BULTE; W. J. OYEN; A. HEERSCHAP; J. M. DE VRIES; C. G. FIGDOR, ADV. DRUG. DELIV. REV., vol. 62, 2010, pages 1080
N. LEE; T. HYEON, CHEM. SOC. REV., 2012
P. BOURRINET; H. H. BENGELE; B. BONNEMAIN; A. DENCAUSSE; J.-M. IDEE; P. M. JACOBS; J. M. LEWIS, INVEST. RADIOL., vol. 41, 2006, pages 313
T. K. JAIN; M. K. REDDY; M. A. MORALES; D. L. LESLIE-PELECKY; V. LABHASETWAR, MOL. PHARM., vol. 5, 2008, pages 316
Y.-W. JUN; Y.-M. HUH; J.-S. CHOI; J.-H. LEE; H.-T. SONG; S. KIM; S. YOON; K.-S. KIM; J.-S. SHIN; J.-S. SUH, J. AM. CHEM. SOC., vol. 127, 2005, pages 5732
R. A. BROOKS; F. MOINY; P. GILLIS, MAGN. RESON. MED., vol. 45, 2001, pages 1014
R. A. BROOKS, MAGN. RESON. MED., vol. 47, 2002, pages 388
D. KIM; N. LEE; M. PARK; B. H. KIM; K. AN; T. HYEON, J. AM. CHEM. SOC., vol. 131, 2009, pages 454
N. LEE ET AL., PROC. NATL. ACAD. SCI. USA, vol. 108, 2011, pages 2662
P. MOROZ; C. METCALF; B. N. GRAY, BIOMETALS, vol. 16, 2003, pages 455
T.-J. YOON; H. LEE; H. SHAO; S. A. HILDERBRAND; R. WEISSLEDER, ADV. MATER., vol. 23, 2011, pages 4793
J.-H. LEE; Y.-W. JUN; S.-I. YEON; J.-S. SHIN; J. CHEON, ANGEW CHEM., vol. 118, 2006, pages 8340
ANGEW CHEM. INT. ED., vol. 45, 2006, pages 8160
J. E. LEE ET AL., J. AM. CHEM. SOC., vol. 132, 2010, pages 552
Attorney, Agent or Firm:
SEO, Kuen Bok et al. (KR)
서근복 (KR)
서근복 (KR)
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