Title:
ISOLATED NUCLEIC ACID MOLECULES WHICH ENCODE SCP PROTEINS, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2000023625
Kind Code:
A3
Abstract:
The invention involves the recognition of a previously unidentified protein family which belongs to the human SCP family. The members of the family, such as SCP-2 and rat SCP-3 homolog, are markers for cell transformation. Also disclosed is the analysis of SCP proteins association with nuclear bodies. Diagnostic and therapeutic uses of these proteins and related molecules are taught.
Inventors:
TURECI OZLEM
SAHIN UGUR
PFREUNDSCHUH MICHAEL
SAHIN UGUR
PFREUNDSCHUH MICHAEL
Application Number:
PCT/US1999/025069
Publication Date:
October 19, 2000
Filing Date:
October 22, 1999
Export Citation:
Assignee:
LUDWIG INST CANCER RES (US)
International Classes:
C07K14/47; C07K16/18; C12Q1/68; G01N33/68; A61K38/00; (IPC1-7): C12Q1/68; C07K14/47; C07K16/18; A61K38/17; G01N33/50; A61K48/00; A61K39/00
Domestic Patent References:
| WO1997038125A1 | 1997-10-16 | |||
| WO1999004040A1 | 1999-01-28 |
Other References:
MEUWISSEN R L J ET AL: "HUMAN SYNAPTONEMAL COMPLEX PROTEIN 1 (SCP1): ISOLATION AND CHARACTERIZATION OF THE CDNA AND CHROMOSOMAL LOCALIZATION OF THE GENE", GENOMICS,US,ACADEMIC PRESS, SAN DIEGO, vol. 39, 1997, pages 377 - 384, XP002913763, ISSN: 0888-7543
OFFENBERG HILDO H ET AL: "SCP2: A major protein component of the axial elements of synaptonemal complexes of the rat.", NUCLEIC ACIDS RESEARCH, vol. 26, no. 11, 1 June 1998 (1998-06-01), pages 2572 - 2579, XP002135252, ISSN: 0305-1048
TURECI O ET AL: "Identification of a meiosis-specific protein as a member of the class of cancer/testis antigens", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,US,NATIONAL ACADEMY OF SCIENCE. WASHINGTON, vol. 95, no. 9, 28 April 1998 (1998-04-28), pages 5211 - 5216, XP002913764, ISSN: 0027-8424
DOBSON MELANIE J ET AL: "Synaptonemal complex proteins: Occurrence, epitope mapping and chromosome disjunction.", JOURNAL OF CELL SCIENCE 1994, vol. 107, no. 10, 1994, pages 2749 - 2760, XP002135250, ISSN: 0021-9533
DATABASE EMBL 25 May 1997 (1997-05-25), HILLIER L ET AL.: "WashU-Merck EST Project 1997", XP002135254
TAKAHASHI S. ET AL.: "Identification of two highly homologous presynaptic proteins distinctly localized at the dendritic and somatic synapses.", FEBS LETT 1995 JUL 24;368(3):455-60, XP000915992
DATABASE GENBANK 25 May 1997 (1997-05-25), HILLIER, L.: "WashU-Merck EST Project 1997", XP002140998
MESSINA MARINELLA ET AL: "A family of dispersed DNA elements that contain GAA repeats in Toxoplasma gondii.", MOLECULAR AND BIOCHEMICAL PARASITOLOGY 1996, vol. 81, no. 2, 1996, pages 247 - 252, XP002135251, ISSN: 0166-6851
DATABASE EMBL 16 June 1995 (1995-06-16), HILLIER L.: "The WashU-Merck EST Project", XP002141000
DATABASE EMBL 9 July 1998 (1998-07-09), STUHLMUELLER B ET AL.: "Differentially expressed genes in activated monocytes from patients with rheumatoid arthritis", XP002141001
DATABASE EMBL 15 July 1998 (1998-07-15), STUHLMUELLER B ET AL.: "Differentially expressed genes in activated monocytes from patients with rheumatoid arthritis", XP002141002
DATABASE GENBANK 10 November 1992 (1992-11-10), CNRS.: "The Arabidopsis thaliana transcribed genome: the GDR cDNA program", XP002141003
LAMMERS JH. ET AL.: "The gene encoding a major component of the lateral elements of synaptonemal complexes of the rat is related to X-linked lymphocyte-regulated genes.", MOL CELL BIOL 1994 FEB;14(2):1137-46, XP000916016
TURECI OZLEM ET AL: "Analysis of ectopic expression and functional role of meiosis specific gene products in cancer cells.", ANNUAL CONGRESS OF THE GERMAN AND AUSTRIAN SOCIETIES OF HEMATOLOGY AND ONCOLOGY;FRANKFURT, GERMANY; OCTOBER 25-28, 1998, vol. 77, no. SUPPL. 2, 1998, Annals of Hematology 1998, pages S14, XP002135253, ISSN: 0939-5555
DATABASE EMBL 22 October 1998 (1998-10-22), STRAUSBERG, R: "National Cancer Institute, Cancer Genome Anatomy Project (CGAP), Tumor", XP002141004
OFFENBERG HILDO H ET AL: "SCP2: A major protein component of the axial elements of synaptonemal complexes of the rat.", NUCLEIC ACIDS RESEARCH, vol. 26, no. 11, 1 June 1998 (1998-06-01), pages 2572 - 2579, XP002135252, ISSN: 0305-1048
TURECI O ET AL: "Identification of a meiosis-specific protein as a member of the class of cancer/testis antigens", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,US,NATIONAL ACADEMY OF SCIENCE. WASHINGTON, vol. 95, no. 9, 28 April 1998 (1998-04-28), pages 5211 - 5216, XP002913764, ISSN: 0027-8424
DOBSON MELANIE J ET AL: "Synaptonemal complex proteins: Occurrence, epitope mapping and chromosome disjunction.", JOURNAL OF CELL SCIENCE 1994, vol. 107, no. 10, 1994, pages 2749 - 2760, XP002135250, ISSN: 0021-9533
DATABASE EMBL 25 May 1997 (1997-05-25), HILLIER L ET AL.: "WashU-Merck EST Project 1997", XP002135254
TAKAHASHI S. ET AL.: "Identification of two highly homologous presynaptic proteins distinctly localized at the dendritic and somatic synapses.", FEBS LETT 1995 JUL 24;368(3):455-60, XP000915992
DATABASE GENBANK 25 May 1997 (1997-05-25), HILLIER, L.: "WashU-Merck EST Project 1997", XP002140998
MESSINA MARINELLA ET AL: "A family of dispersed DNA elements that contain GAA repeats in Toxoplasma gondii.", MOLECULAR AND BIOCHEMICAL PARASITOLOGY 1996, vol. 81, no. 2, 1996, pages 247 - 252, XP002135251, ISSN: 0166-6851
DATABASE EMBL 16 June 1995 (1995-06-16), HILLIER L.: "The WashU-Merck EST Project", XP002141000
DATABASE EMBL 9 July 1998 (1998-07-09), STUHLMUELLER B ET AL.: "Differentially expressed genes in activated monocytes from patients with rheumatoid arthritis", XP002141001
DATABASE EMBL 15 July 1998 (1998-07-15), STUHLMUELLER B ET AL.: "Differentially expressed genes in activated monocytes from patients with rheumatoid arthritis", XP002141002
DATABASE GENBANK 10 November 1992 (1992-11-10), CNRS.: "The Arabidopsis thaliana transcribed genome: the GDR cDNA program", XP002141003
LAMMERS JH. ET AL.: "The gene encoding a major component of the lateral elements of synaptonemal complexes of the rat is related to X-linked lymphocyte-regulated genes.", MOL CELL BIOL 1994 FEB;14(2):1137-46, XP000916016
TURECI OZLEM ET AL: "Analysis of ectopic expression and functional role of meiosis specific gene products in cancer cells.", ANNUAL CONGRESS OF THE GERMAN AND AUSTRIAN SOCIETIES OF HEMATOLOGY AND ONCOLOGY;FRANKFURT, GERMANY; OCTOBER 25-28, 1998, vol. 77, no. SUPPL. 2, 1998, Annals of Hematology 1998, pages S14, XP002135253, ISSN: 0939-5555
DATABASE EMBL 22 October 1998 (1998-10-22), STRAUSBERG, R: "National Cancer Institute, Cancer Genome Anatomy Project (CGAP), Tumor", XP002141004
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