Title:
ITGB2-MEDIATED DRUG DELIVERY SYSTEM
Document Type and Number:
WIPO Patent Application WO/2023/204330
Kind Code:
A1
Abstract:
The present invention relates to a drug delivery system that specifically binds to ITGB2 on M2 tumor-associated macrophages, and, according to the present invention, the complex of a drug delivery vehicle comprising a targeting agent that specifically binds to ITGB2 on M2 tumor-associated macrophages and a drug bound to the vehicle can selectively (or specifically) act on the M2 tumor-associated macrophages, thereby reducing side effects of the drug and increasing the efficacy thereof, and can be useful as a drug delivery vehicle for apoptosis-inducing agents, anticancer agents, contrast agents, and the like.
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Inventors:
BAE HYUN SU (KR)
HAN IK HWAN (KR)
KANG MOONKYU (KR)
LEE HEEKYUNG (KR)
CHOI JEONGYOON (KR)
HAN IK HWAN (KR)
KANG MOONKYU (KR)
LEE HEEKYUNG (KR)
CHOI JEONGYOON (KR)
Application Number:
PCT/KR2022/005783
Publication Date:
October 26, 2023
Filing Date:
April 22, 2022
Export Citation:
Assignee:
TWINPIGBIOLAB INC (KR)
International Classes:
A61K47/64; A61P35/00; C12Q1/6886; G01N33/574; G01N33/68
Domestic Patent References:
| WO2012005800A1 | 2012-01-12 |
Foreign References:
| US20190309073A1 | 2019-10-10 | |||
| KR20010034708A | 2001-04-25 |
Other References:
XU HOUSHI; ZHANG ANKE; HAN XIAYING; LI YANNING; ZHANG ZEYU; SONG LIYING; WANG WEI; LOU MEIQING: "ITGB2 as a prognostic indicator and a predictive marker for immunotherapy in gliomas", CANCER IMMUNOLOGY IMMUNOTHERAPY, SPRINGER, BERLIN/HEIDELBERG, vol. 71, no. 3, 27 July 2021 (2021-07-27), Berlin/Heidelberg , pages 645 - 660, XP037694336, ISSN: 0340-7004, DOI: 10.1007/s00262-021-03022-2
XIAO KAI, ZHAO SHUSHAN, YUAN JIAN, PAN YIMIN, SONG YA, TANG LANHUA: "Construction of Molecular Subtypes and Related Prognostic and Immune Response Models Based on M2 Macrophages in Glioblastoma", INTERNATIONAL JOURNAL OF GENERAL MEDICINE, vol. Volume 15, pages 913 - 926, XP093101490, DOI: 10.2147/IJGM.S343152
WEI JIE, HUANG XUN-JUN, HUANG YAN, XIONG MING-YUE, YAO XIANG-YOU, HUANG ZHI-NING, LI SI-NIAN, ZHOU WEI-JIE, FANG DA-LANG, DENG DON: "Key immune-related gene ITGB2 as a prognostic signature for acute myeloid leukemia", ANNALS OF TRANSLATIONAL MEDICINE, AME PUBLISHING COMPANY, US, vol. 9, no. 17, 1 September 2021 (2021-09-01), US , pages 1386 - 1386, XP093101492, ISSN: 2305-5839, DOI: 10.21037/atm-21-3641
XIAO KAI, ZHAO SHUSHAN, YUAN JIAN, PAN YIMIN, SONG YA, TANG LANHUA: "Construction of Molecular Subtypes and Related Prognostic and Immune Response Models Based on M2 Macrophages in Glioblastoma", INTERNATIONAL JOURNAL OF GENERAL MEDICINE, vol. Volume 15, pages 913 - 926, XP093101490, DOI: 10.2147/IJGM.S343152
WEI JIE, HUANG XUN-JUN, HUANG YAN, XIONG MING-YUE, YAO XIANG-YOU, HUANG ZHI-NING, LI SI-NIAN, ZHOU WEI-JIE, FANG DA-LANG, DENG DON: "Key immune-related gene ITGB2 as a prognostic signature for acute myeloid leukemia", ANNALS OF TRANSLATIONAL MEDICINE, AME PUBLISHING COMPANY, US, vol. 9, no. 17, 1 September 2021 (2021-09-01), US , pages 1386 - 1386, XP093101492, ISSN: 2305-5839, DOI: 10.21037/atm-21-3641
Attorney, Agent or Firm:
WIE, Byoung-Gap (KR)
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