Title:
JUVENILE MYELOMONOCYTIC LEUKEMIA THERAPEUTIC AGENT
Document Type and Number:
WIPO Patent Application WO/2019/039390
Kind Code:
A1
Abstract:
The problem addressed by the present invention is to provide a new molecularly-targeted therapeutic agent for juvenile myelomonocytic leukemia and the use thereof. Provided is a juvenile myelomonocytic leukemia therapeutic agent containing an ALK tyrosine kinase inhibitor or a JAK2 tyrosine kinase inhibitor. Also disclosed is a new fusion gene that regulates juvenile myelomonocytic leukemia.
More Like This:
Inventors:
MURAMATSU HIDEKI (JP)
OKUNO YUSUKE (JP)
MURAKAMI NORIHIRO (JP)
OKUNO YUSUKE (JP)
MURAKAMI NORIHIRO (JP)
Application Number:
PCT/JP2018/030471
Publication Date:
February 28, 2019
Filing Date:
August 17, 2018
Export Citation:
Assignee:
UNIV NAGOYA NAT UNIV CORP (JP)
International Classes:
A61K45/00; A61K31/4545; A61K31/506; A61K31/519; A61K31/5377; A61P35/02; A61P43/00; C12N15/60; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/68
Foreign References:
| JP2017502994A | 2017-01-26 |
Other References:
TENRI MED BULL., vol. 18, no. 2, 2015, pages 80 - 85, ISSN: 1344-1817
HAYASHI A ET AL., CRIZOTINIB TREATMENT FOR PEDIATRIC ACUTE MYELOBLASTIC LEUKEMIA WITH RANBP2-ALK FUSION GENE, vol. 56, no. 9, 2015, pages 1694, ISSN: 0485-1439
MAESAKO Y ET AL., MAJOR CYTOGENETIC RESPONSE AT 3 MONTHS OF CRIZOTINIB TREATMENT IN RANBP-ALK ACUTE MYELOID LEUKEMIA, vol. 55, no. 9, pages 1551, ISSN: 0485-1439
CAYE A ET AL.: "Juvenile myelomonocytic leukemia displays mutations in components of the RAS pathway and the PRC2 network", NAT GENET., vol. 47, no. 11, 2015, pages 1334 - 1340, XP055577900, ISSN: 1061-4036
SALETTA ET AL.: "Molecular profiling of childhood cancer : Biomarkers and novel therapies", BBA CLINICAL, vol. 1, 2014, pages 59 - 77, XP055501424, ISSN: 2214-6474
HAYASHI A ET AL., CRIZOTINIB TREATMENT FOR PEDIATRIC ACUTE MYELOBLASTIC LEUKEMIA WITH RANBP2-ALK FUSION GENE, vol. 56, no. 9, 2015, pages 1694, ISSN: 0485-1439
MAESAKO Y ET AL., MAJOR CYTOGENETIC RESPONSE AT 3 MONTHS OF CRIZOTINIB TREATMENT IN RANBP-ALK ACUTE MYELOID LEUKEMIA, vol. 55, no. 9, pages 1551, ISSN: 0485-1439
CAYE A ET AL.: "Juvenile myelomonocytic leukemia displays mutations in components of the RAS pathway and the PRC2 network", NAT GENET., vol. 47, no. 11, 2015, pages 1334 - 1340, XP055577900, ISSN: 1061-4036
SALETTA ET AL.: "Molecular profiling of childhood cancer : Biomarkers and novel therapies", BBA CLINICAL, vol. 1, 2014, pages 59 - 77, XP055501424, ISSN: 2214-6474
Attorney, Agent or Firm:
HAGINO Mikiharu (JP)
Download PDF:
Previous Patent: SEAT BELT DEVICE
Next Patent: POLYMER THIN FILM, FILM-FORM LAMINATE, AND METHOD FOR PRODUCING POLYMER THIN FILM
Next Patent: POLYMER THIN FILM, FILM-FORM LAMINATE, AND METHOD FOR PRODUCING POLYMER THIN FILM