Title:
KAL1 PROTEIN CONTROLLING CELL CYCLE OF HEMATOPOIETIC STEM CELL, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/178514
Kind Code:
A1
Abstract:
The present invention relates to a KAl1 protein controlling the cell cycle of a hematopoietic stem cell and a use thereof, and more specifically, a composition comprising a KAl1(CD82) polypeptide or a gene encoding the same for controlling the cell cycle of a hematopoietic stem cell, or a pharmaceutical composition for preventing or treating blood tumors. In the present invention, KAl1(CD82) is expressed only in a hematopoietic stem cell (LT-HSC) which is the uppermost stem cell in the hierarchy of the hematopoietic stem cell, can obtain an LT-HSC with high purity using the KAl1, and thus can inhibit various side effects of hematopoietic stem cell transplantation by transplanting only an LT-HSC with high purity. In addition, KAl1 importantly acts on the quiescence of an LT-HSC, and has resistance against cell damage due to various stresses (5-FU, irradiation) by maintaining the quiescence of the LT-HSC. Thus, it is expected that the cell can be used for making a cell bank and can be used as a blood tumor cell therapy product through cell transplantation.
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Inventors:
KIM HYO-SOO (KR)
HUR JIN (KR)
CHOI JAE IL (KR)
KANG JIN-A (KR)
NHAM PNIEL (KR)
HUR JIN (KR)
CHOI JAE IL (KR)
KANG JIN-A (KR)
NHAM PNIEL (KR)
Application Number:
PCT/KR2016/004707
Publication Date:
November 10, 2016
Filing Date:
May 04, 2016
Export Citation:
Assignee:
SEOUL NAT UNIV R & DB FOUND (KR)
International Classes:
A61K38/17; A61K35/28; C07K14/705; C12N5/0789
Foreign References:
| JPH11504803A | 1999-05-11 |
Other References:
BANDYOPADHYAY ET AL.: "Interaction of KAI1 on Tumor cells with DARC on Vascular Endothelium leads to Metastasis Suppression", NATURE MEDICINE, vol. 12, no. 8, 2006, pages 933 - 938, XP003012828
TSAI ET AL.: "Dissecting the Diverse Functions of the Metastasis Suppressor CDBVKMI", FEBS LETTERS, vol. 585, no. 20, 2011, pages 3166 - 3173, XP028314401
KOO ET AL.: "Differential Expression of the Metastasis Suppressor KAIl in Decidual Cells and Trophoblast Giant Cells at the Feto-maternal Interface", BMB REPORTS, vol. 46, no. 10, 2013, pages 507 - 512, XP055327019
LAROCHELLE ET AL.: "Bone Marrow Homing and Engraftment of Human Hematopoietic Stem and Progenitor Cells is mediated by a Polarized Membrane Domain", BLOOD, vol. 119, no. 8, 2012, pages 1848 - 1855, XP055327036
DATABASE NCBI [O] 15 July 2006 (2006-07-15), XP055327247, Database accession no. AAH00726.1
DATABASE NCBI 15 February 2015 (2015-02-15), Database accession no. NP 031682.1
HUR ET AL.: "CD 82/KAI1 maintains the Dormancy of Long-term Hematopoietic Stem Cells through Interaction with DARC-expressing Macrophages", CELL STEM CELL, vol. 18, 17 March 2016 (2016-03-17), pages 508 - 521, XP029496783
See also references of EP 3292869A4
TSAI ET AL.: "Dissecting the Diverse Functions of the Metastasis Suppressor CDBVKMI", FEBS LETTERS, vol. 585, no. 20, 2011, pages 3166 - 3173, XP028314401
KOO ET AL.: "Differential Expression of the Metastasis Suppressor KAIl in Decidual Cells and Trophoblast Giant Cells at the Feto-maternal Interface", BMB REPORTS, vol. 46, no. 10, 2013, pages 507 - 512, XP055327019
LAROCHELLE ET AL.: "Bone Marrow Homing and Engraftment of Human Hematopoietic Stem and Progenitor Cells is mediated by a Polarized Membrane Domain", BLOOD, vol. 119, no. 8, 2012, pages 1848 - 1855, XP055327036
DATABASE NCBI [O] 15 July 2006 (2006-07-15), XP055327247, Database accession no. AAH00726.1
DATABASE NCBI 15 February 2015 (2015-02-15), Database accession no. NP 031682.1
HUR ET AL.: "CD 82/KAI1 maintains the Dormancy of Long-term Hematopoietic Stem Cells through Interaction with DARC-expressing Macrophages", CELL STEM CELL, vol. 18, 17 March 2016 (2016-03-17), pages 508 - 521, XP029496783
See also references of EP 3292869A4
Attorney, Agent or Firm:
LEE, MYOUNG-JIN (KR)
이명진 (KR)
이명진 (KR)
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