Title:
KARL FISCHER TITRATOR AND KARL FISCHER TITRATION METHOD
Document Type and Number:
WIPO Patent Application WO/2012/111306
Kind Code:
A1
Abstract:
The invention renders a back titration and titer determination possible by means of a coulometric back titration. A titration flask is provided with electrolytic electrodes, and iodine is caused to be present in a solution filled into the titration flask. A coulometric back titration is performed to generate iodine ions from the iodine at the working electrode of the electrolytic electrodes. When the solution is a dehydrated solvent which contains a Karl Fischer reagent for use in volumetric titration methods, the titer can be determined by the coulometric back titration. Alternatively, when the solution is a liquid which has resulted from a coulometric titration in a coulometric titration method and in which iodine remains as a result of the titration, then the amount of the water contained in the sample is determined from the quantity of electricity used for the coulometric titration and from the quantity of electricity to be used for the coulometric back titration. Alternatively, when the solution is a liquid which has resulted from the addition of a Karl Fischer reagent in a volumetric titration method and in which iodine remains as a result of the reagent addition, then the amount of the water contained in the sample introduced into the titration flask is determined from the addition amount of the Karl Fischer reagent and from quantity of electricity to be used for the coulometric back titration.
Inventors:
KUROSE IKUMI
ISHIKURA MASAAKI
ISHIKURA MASAAKI
Application Number:
PCT/JP2012/000946
Publication Date:
August 23, 2012
Filing Date:
February 14, 2012
Export Citation:
Assignee:
KYOTO ELECTRONICS MFG (JP)
KUROSE IKUMI
ISHIKURA MASAAKI
KUROSE IKUMI
ISHIKURA MASAAKI
International Classes:
G01N27/44
Foreign References:
| JPS5524652A | 1980-02-21 | |||
| JP2000356621A | 2000-12-26 | |||
| JPH06308113A | 1994-11-04 | |||
| JPH01260362A | 1989-10-17 | |||
| JPH06308113A | 1994-11-04 | |||
| JP2007278919A | 2007-10-25 |
Other References:
HIROMASA KATO ET AL.: "Determination of Water in Pharmaceuticals by Back-Titration of the Karl Fischer Volumetric Titration", STUDY OF MEDICAL SUPPLIES, vol. 30, no. 6, 20 June 1999 (1999-06-20), pages 285 - 288
See also references of EP 2677310A4
See also references of EP 2677310A4
Attorney, Agent or Firm:
FUKUI, TOYOAKI (JP)
Fukui Toyoake (JP)
Fukui Toyoake (JP)
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Claims: