Title:
KIT FOR DIAGNOSING ALZHEIMER'S DISEASE AND PHARMACEUTICAL COMPOSITION FOR TREATING ALZHEIMER'S DISEASE
Document Type and Number:
WIPO Patent Application WO/2024/053519
Kind Code:
A1
Abstract:
Disclosed are a kit for diagnosing Alzheimer's disease and a pharmaceutical composition for treating Alzheimer's disease that use EDIL3 or a nucleic acid that encodes EDIL3 as an indicator or a target.
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Inventors:
WATANABE HIROTAKA (JP)
OKANO HIDEYUKI (JP)
TAKAHASHI KENTARO (JP)
OKANO HIDEYUKI (JP)
TAKAHASHI KENTARO (JP)
Application Number:
PCT/JP2023/031575
Publication Date:
March 14, 2024
Filing Date:
August 30, 2023
Export Citation:
Assignee:
EISAI R&D MAN CO LTD (JP)
UNIV KEIO (JP)
UNIV KEIO (JP)
International Classes:
C12Q1/6876; A61K39/395; A61K45/00; A61K48/00; A61P25/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/11; C12N15/13; G01N33/50; G01N33/53
Other References:
RAMANAN V K; RISACHER S L; NHO K; KIM S; SWAMINATHAN S; SHEN L; FOROUD T M; HAKONARSON H; HUENTELMAN M J; AISEN P S; PETERSEN R C;: "APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study", MOLECULAR PSYCHIATRY, NATURE PUBLISHING GROUP UK, LONDON, vol. 19, no. 3, 19 February 2013 (2013-02-19), London, pages 351 - 357, XP037789716, ISSN: 1359-4184, DOI: 10.1038/mp.2013.19
GRUBMAN ALEXANDRA; CHEW GABRIEL; OUYANG JOHN F.; SUN GUIZHI; CHOO XIN YI; MCLEAN CATRIONA; SIMMONS REBECCA K.; BUCKBERRY SAM; VARG: "A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation", NATURE NEUROSCIENCE, NATURE PUBLISHING GROUP US, NEW YORK, vol. 22, no. 12, 25 November 2019 (2019-11-25), New York, pages 2087 - 2097, XP036929835, ISSN: 1097-6256, DOI: 10.1038/s41593-019-0539-4
GRUBMAN ALEXANDRA; CHEW GABRIEL; OUYANG JOHN F.; SUN GUIZHI; CHOO XIN YI; MCLEAN CATRIONA; SIMMONS REBECCA K.; BUCKBERRY SAM; VARG: "A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation", NATURE NEUROSCIENCE, NATURE PUBLISHING GROUP US, NEW YORK, vol. 22, no. 12, 25 November 2019 (2019-11-25), New York, pages 2087 - 2097, XP036929835, ISSN: 1097-6256, DOI: 10.1038/s41593-019-0539-4
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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