| JP4395632 | Mismatched endonucleases and usage |
| WO/2024/059516 | METHODS FOR GENERATING CDNA LIBRARY FROM RNA |
| WO/2011/026194 | NUCLEIC ACID EXTRACTION |
KIM YOUN-JUNG (KR)
SONG MI-KYUNG (KR)
JEON HEE-KYUNG (KR)
RYU JAE-CHUN (KR)
KIM YOUN-JUNG (KR)
SONG MI-KYUNG (KR)
JEON HEE-KYUNG (KR)
| [CLAIMS] [Claim l] A kit for identification of exposure to phenanthrene containing oligonucleotide comprising total length or a part of a gene selected from the group consisting of the genes below or its complementary oligonucleotide: GeneBank accession No: NM_004420 (DUSP8 , Dual specificity phosphatase 8), GeneBank accession No: L11329(DUSP2, Dual specificity phosphatase 2), GeneBank accession No: BC094766 (PKNl , Protein kinase Nl), GeneBank accession No: AY247738 (TRIB3 , Tribbles homolog 3(Drosophila) ) , GeneBank accession No: AK129595 (GADD45B, Growth arrest and DNA-damage-inducible, beta), GeneBank accession No: AB208849 ( SHCl , SHC (Src homology 2 domain containing) transforming protein 1), GeneBank accession No: X02812 (TGFBl, Transforming growth factor, beta l(Camurati- Engelmann disease) ) , GeneBank accession No: NM_198951 (TGM2 , Transglutaminase 2(C polypeptide, protein-glutamine-gamma- glutamyltransferase) ) , GeneBank accession No: NM_147780 (CTSB, Cathepsin B), GeneBank accession No: NM_078467 (CDKNlA, Cyclin-dependent kinase inhibitor lA(p21, Cipl)), GeneBank accession No: NM_033027 (AXUDl , AXINl up- regulated 1), GeneBank accession No: NM_032797 (AMID, Apoptosis-inducing factor (AIF) -like mitochondrion- associated inducer of death), GeneBank accession No: NM_021960 (MCLl, Myeloid cell leukemia sequence 1(BCL2- related)), GeneBank accession No: NM_016639 (TNFRSF12A, Tumor necrosis factor receptor superfamily, member 12A) , GeneBank accession No: NM_016222 (DDX41 , DEAD( Asp-Glu-Ala- Asp) box polypeptide 41), GeneBank accession No: NM_013246(CLC, Cardiotrophin-like cytokine factor 1), GeneBank accession No: NM_004401 (DFFA, DNA fragmentation factor, 45kDa, alpha polypeptide), GeneBank accession No: NM_004281(BAG3, BCL2-associated athanogene 3), GeneBank accession No: NM_003897 ( IER3 , Immediate early response 3), GeneBank accession No: NM_003806 (HRK, Harakiri, BCL2 interacting protein (contains only BH3 domain)), GeneBank accession No: NM_003639 ( IKBKG, Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma), GeneBank accession No: NM_003311 (PHLDA2 , Pleckstrin homology-like domain, family A, member 2), GeneBank accession No: NM_002737 (PRKCA, Protein kinase C, alpha), GeneBank accession No: NM_002648 (PIMl , Pim-1 oncogene), GeneBank accession No: NM_002507 (NGFR, Nerve growth factor receptor (TNFR superfamily, member 16)), GeneBank accession No: NM_002305 (LGALSl, Lectin, galactoside-binding, soluble, l(galectin I)), GeneBank accession No: NM_001013398 ( IGFBP3 , Insulin-like growth factor binding protein 3), GeneBank accession No: BX640923 (MDM4 , Mdm4 , transformed 3T3 cell double minute 4, p53 binding protein ( mouse )), GeneBank accession No: BX537586 ( STK17A, Serine/threonine kinase 17a( apoptosis-inducing) ) , GeneBank accession No: BG284742(P8, P8 protein (candidate of metastasis I)), GeneBank accession No: BE903247 (PDCD6IP, Programmed cell death 6 interacting protein), GeneBank accession No: BC027949(P2RXl, Purinergic receptor P2X, ligand-gated ion channel, 1), GeneBank accession No: BC006365 (PSEN2 , Presenilin 2 (Alzheimer disease 4)), GeneBank accession No: AY869712 (PPP1R13L, Protein phosphatase 1, regulatory ( inhibitor ) subunit 13 like), GeneBank accession No: AY028896 (CARDlO, Caspase recruitment domain family, member 10), GeneBank accession No: AK122614 (PPARD, Peroxisome proliferative activated receptor, delta), GeneBank accession No: AK092872 (ERCC2 , Excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)), GeneBank accession No: AK092808 (RRAGC, Ras-related GTP binding C), GeneBank accession No: AJ001898 (GDNF, Glial cell derived neurotrophic factor), GeneBank accession No: AF220656 (PHLDAl, Pleckstrin homology-like domain, family A, member 1), GeneBank accession No: AF055634 (UNC5C, Unc-5 homolog C(C. elegans)), GeneBank accession No: AB209485 (VEGF, Vascular endothelial growth factor), GeneBank accession No: AB096256 (UNC5B, Unc-5 homolog B(C. elegans)), GeneBank accession No: AB007960 (SH3GLB1 , SH3- domain GRB2-like endophilin Bl), GeneBank accession No: X06374 (PDGFA, Platelet-derived growth factor alpha polypeptide), GeneBank accession No: S62138 (DDIT3 , DNA- damage-inducible transcript 3), GeneBank accession No: NM_078487(CDKN2B, Cyclin-dependent kinase inhibitor 2B(pl5, inhibits CDK4 ) ) , GeneBank accession No: NM_012127 (CIZl , CDKNlA interacting zinc finger protein 1), GeneBank accession No: NM_005883 ( APC2 , Adenomatosis polyposis coli 2), GeneBank accession No: NM_004196 (CDKLl , Cyclin- dependent kinase-like 1 (CDC2-related kinase)), GeneBank accession No: NM_003236 (TGFA, Transforming growth factor, alpha), GeneBank accession No: NM_001261 (CDK9 , Cyclin- dependent kinase 9 (CDC2-related kinase)), GeneBank accession No: NM_001007271 (DUSP13 , Dual specificity phosphatase 13), GeneBank accession No: CR749511 (PARC, P53- associated parkin-like cytoplasmic protein), GeneBank accession No: CR623038 ( ID2 , Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein), GeneBank accession No: CR618371 (EGFR, Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)), GeneBank accession No: BF965144 ( IFITMl , Interferon induced transmembrane protein 1(9-27)), GeneBank accession No: AK127679 (DUSPl , Dual specificity phosphatase 1), GeneBank accession No: AK096276 (CCND3 , Cyclin D3 ) , GeneBank accession No: AB209586 (MAPK13 , Mitogen-activated protein kinase 13), GeneBank accession No: AB209465 (PCTKl , PCTAIRE protein kinase 1), GeneBank accession No: Z19588(SKIL, SKI-like), GeneBank accession No: NM_020429 (SMURFl, SMAD specific E3 ubiquitin protein ligase 1), GeneBank accession No: NM_014767 ( SPOCK2 , Sparc/osteonectin, cwcv and kazal-like domains proteoglycan( testican) 2), GeneBank accession No: NM_005979(S100Al3, SlOO calcium binding protein A13), GeneBank accession No: NM_005187 (CBFA2T3, Core-binding factor, runt domain, alpha subunit 2; translocated to, 3), GeneBank accession No: NM_004364 (CEBPA, CCAAT/enhancer binding protein ( C/EBP ), alpha), GeneBank accession No: NM_001769(CD9, CD9 antigen(p24 ) ) , GeneBank accession No: NM_001718 (BMP6, Bone morphogenetic protein 6), GeneBank accession No: NM_000641 ( ILlI , Interleukin 11), GeneBank accession No: BX647459 ( SERPINE2 , Serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 2), GeneBank accession No: BQ066037 (RPS19 , Ribosomal protein S19), GeneBank accession No: BE791300 (EDFl , Endothelial differentiation-related factor 1), GeneBank accession No: BC038504 ( SNFlLK, SNFl-like kinase), GeneBank accession No: AL832287 ( ZAP70 , Zeta-chain(TCR) associated protein kinase 7OkDa), GeneBank accession No: AK125742 (PCGFl, Polycomb group ring finger 1), GeneBank accession No: AK124709 (NDRGl , N-myc downstream regulated gene 1), GeneBank accession No: AB011157 (PTDSR, Phosphatidylserine receptor), GeneBank accession No: NM_013255 (MKLNl, Muskelin 1, intracellular mediator containing kelch motifs), GeneBank accession No: NM_006572(GNA13, Guanine nucleotide binding protein(G protein), alpha 13), GeneBank accession No: NM_002211 ( ITGBl , Integrin, beta 1 ( fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2 , MSK12)), GeneBank accession No: CR601067 (PLAUR, Plasminogen activator, urokinase receptor), GeneBank accession No: BC050456 (THBS4, Thrombospondin 4), GeneBank accession No: AK027389 (CXCL16 , Chemokine (C-X-C motif) ligand 16), GeneBank accession No: AJ132099 (VNNl , Vanin 1), GeneBank accession No: XM_371354 (FLJ10157 , Hypothetical protein FLJ10157), GeneBank accession No: XM_208313(TPM3, Similar to tropomyosin 4), GeneBank accession No: XM_208270 ( ACR, Acrosin-like protease), GeneBank accession No: NM_203353 (PDLIM7 , PDZ and LIM domain 7(enigma)), GeneBank accession No: NM_201382 (PLECl , Plectin 1, intermediate filament binding protein 50OkDa), GeneBank accession No: NM_182961 (SYNEl , Spectrin repeat containing, nuclear envelope 1), GeneBank accession No: NM_181826 (NF2 , Neurofibromin 2 (bilateral acoustic neuroma)), GeneBank accession No: NM_172069 (PLEKHH2 , Pleckstrin homology domain containing, family H(with MyTH4 domain) member 2), GeneBank accession No: NM_022648 (TNS, Tensin 1), GeneBank accession No: NM_017556 (FBLP-I, Filamin binding LIM protein 1), GeneBank accession No: NM_016081 (KIAA0992 , Palladin, cytoskeletal associated protein), GeneBank accession No: NM_006617 (NES, Nestin), GeneBank accession No: NM_006262 (PRPH, Peripherin), GeneBank accession No: NM_005100(AKAP12, A kinase (PRKA) anchor protein ( gravin) 12), GeneBank accession No: NM_004368 (CNN2 , Calponin 2), GeneBank accession No: NM_003388 (CYLN2 , Cytoplasmic linker 2), GeneBank accession No: NM_003370 (VASP, Vasodilator- stimulated phosphoprotein) , GeneBank accession No: NM_003128 (SPTBNl, Spectrin, beta, non-erythrocytic 1), GeneBank accession No: NM_002705 (PPL, Periplakin), GeneBank accession No: NM_002475 (MLClSA, Myosin light chain 1 slow a), GeneBank accession No: NM_002018 (FLII, Flightless I homolog(Drosophila) ) , GeneBank accession No: NM_001465 ( FYB, FYN binding protein(FYB-120/130 ) ) , GeneBank accession No: NM_001069(TUBB2, Tubulin, beta 2A), GeneBank accession No: CR625172 (MGC8685, Tubulin, beta 2B), GeneBank accession No: CR616919(KRT18, Keratin 18), GeneBank accession No: CR606241 (ACTGl, Actin, gamma 1), GeneBank accession No: CB240572 (MYHIl, Myosin, heavy polypeptide 11, smooth muscle), GeneBank accession No: BX648253 (PTPN3 , Protein tyrosine phosphatase, non-receptor type 3), GeneBank accession No: BX648190 (WDRl , WD repeat domain 1), GeneBank accession No: BX641076 (ACTNl , Actinin, alpha 1), GeneBank accession No: BX537978 (EPB41L1 , Erythrocyte membrane protein band 4.1-like 1), GeneBank accession No: BG121847 (NUDC, Nuclear distribution gene C homolog(A. nidulans)), GeneBank accession No: BC068013 (MYOlC, Myosin IC), GeneBank accession No: BC065499 (MAST2 , Microtubule associated serine/threonine kinase 2), GeneBank accession No: BC051890 (TUBG2 , Tubulin, gamma 2), GeneBank accession No: BC041874 (MAP1LC3B, Microtubule-associated protein 1 light chain 3 beta), GeneBank accession No: BC012597 (ACTAl , Actin, alpha 1, skeletal muscle), GeneBank accession No: AY484427(KIF17, Kinesin family member 17), GeneBank accession No: AK130546 (STOML2 , Stomatin(EPB72 ) -like 2), GeneBank accession No: AK124711 (CORO2B, Coronin, actin binding protein, 2B), GeneBank accession No: AK123974 (MYL5 , Myosin, light polypeptide 5, regulatory), GeneBank accession No: AK092792 (LOC389833 , Similar to hypothetical protein MGC27019), GeneBank accession No: AK026518 (MYOHDl , Myosin head domain containing 1), GeneBank accession No: AK024500 (NICAL, Microtubule associated monoxygenase, calponin and LIM domain containing 1), GeneBank accession No: AF085886(FLJ46675, Ribosomal protein L29 pseudogene 2), GeneBank accession No: AB209997 (MY09B, Myosin IXB), GeneBank accession No: Y12692 (WNTlI , Wingless-type MMTV integration site family, member 11), GeneBank accession No: Y11307 (CYR61, Cysteine-rich, angiogenic inducer, 61), GeneBank accession No: X17033 ( ITGA2 , Integrin, alpha 2(CD49B, alpha 2 subunit of VLA-2 receptor)), GeneBank accession No: U41763 (CLTCLl , Clathrin, heavy polypeptide- like 1), GeneBank accession No: NM_153609 (TMPRSS6 , Transmembrane protease, serine 6), GeneBank accession No: NM_031483(ITCH, Itchy homolog E3 ubiquitin protein ligase (mouse )), GeneBank accession No: NM_024342 (GRLFl , Glucocorticoid receptor DNA binding factor 1 ) , GeneBank accession No: NM_017555 (EGLN2 , EgI nine homolog 2(C. elegans)), GeneBank accession No: NM_016569 (TBX3 , T-box 3 (ulnar mammary syndrome)), GeneBank accession No: NM_004148(NINJl, Ninjurin 1), GeneBank accession No: NM_003377 (VEGFB, Vascular endothelial growth factor B), GeneBank accession No: NM_001983 (ERCCl , Excision repair cross-complementing rodent repair deficiency, complementation group 1( includes overlapping antisense sequence)), GeneBank accession No: NM_001552 ( IGFBP4 , Insulin-like growth factor binding protein 4), GeneBank accession No: NM_001430 (EPASl , Endothelial PAS domain protein 1), GeneBank accession No: NM_001300 (KLF6 , Kruppel- like factor 6), GeneBank accession No: NM__001012661 ( SLC3A2 , Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2), GeneBank accession No: NM_000596( IGFBPl, Insulin-like growth factor binding protein 1), GeneBank accession No: NM_000474 (TWISTl , Twist homolog 1 ( acrocephalosyndactyly 3; Saethre-Chotzen syndrome ) (Drosophila) ), GeneBank accession No: BX649103 (ChGn, Chondroitin betal,4 N- acetylgalactosaminyltransferase ), GeneBank accession No: BM913048 (TIMPl, TIMP metallopeptidase inhibitor 1), GeneBank accession No: BM904612 ( S100A6 , SlOO calcium binding protein A6 (calcyclin) ) , GeneBank accession No: BM556279(EMP3, Epithelial membrane protein 3), GeneBank accession No: BC015041 (VATl , Family with sequence similarity 82, member C), GeneBank accession No: AY258066(OKL38, Pregnancy-induced growth inhibitor), GeneBank accession No: AK126729 (NDRG4 , NDRG family member 4), GeneBank accession No: AK090459 (NFE2L1 , Nuclear factor (erythroid-derived 2) -like 1), GeneBank accession No: AK074163(ROBO4, Roundabout homolog 4, magic roundabout (Drosophila) ), GeneBank accession No: AK024680(FLJ21027 fis, CDNA: FLJ21027 fis, clone CAE07110), GeneBank accession No: AF176422 (HEYl , Hairy/enhancer-of- split related with YRPW motif 1), GeneBank accession No: AF003837 (JAGl, Jagged l(Alagille syndrome)), GeneBank accession No: AB209322 ( SEMA3B, Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, ( semaphorin) 3B), GeneBank accession No: AB011150 (NRXNl , Neurexin 1), GeneBank accession No: NM_201589 (MAFA, V-maf musculoaponeurotic fibrosarcoma oncogene homolog A(avian)), GeneBank accession No: NM_052999 (CKLFSFl , CKLF-like MARVEL transmembrane domain containing 1), GeneBank accession No: NM_006644 (HSPHl, Heat shock 105kDa/110kDa protein 1), GeneBank accession No: NM_005438 (FOSLl, FOS-like antigen 1), GeneBank accession No: NM_004996 (ABCCl , ATP-binding cassette, sub-family C(CFTR/MRP), member 1), GeneBank accession No: NM_002658 (PLAU, Plasminogen activator, urokinase), GeneBank accession No: NM_001353 (AKRlCl , Aldo- keto reductase family 1, member Cl (dihydrodiol dehydrogenase 1; 20-alpha( 3-alpha) -hydroxysteroid dehydrogenase)), GeneBank accession No: H18681 (C20orf 139 , Sulfiredoxin 1 homolog(S. cerevisiae ) ) , GeneBank accession No: DR004094 (HAMP, Hepcidin antimicrobial peptide), GeneBank accession No: BC082272 (KCNMB3 , Potassium large conductance calcium-activated channel, subfamily M beta member 3), GeneBank accession No: BC040494 (DNAJB2 , DnaJ(Hsp40) homolog, subfamily B, member 2), GeneBank accession No: BC018064 ( ATF6 , Activating transcription factor 6), GeneBank accession No: BC006523 ( SGK2 , Serum/glucocorticoid regulated kinase 2), GeneBank accession No: AK090482 (CXCL12 , Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor I)), GeneBank accession No: AF219946 (TULP4 , Tubby like protein 4), GeneBank accession No: AB209112 ( SLC2A8 , Solute carrier family 2 ,( facilitated glucose transporter) member 8), GeneBank accession No: NM_005242 (F2RL1 , Coagulation factor II (thrombin) receptor-like 1), GeneBank accession No: NM_001002029(C4A, Complement component 4B, telomeric), GeneBank accession No: NM_000539 (RHO, Rhodopsin( opsin 2, rod pigment ) (retinitis pigmentosa 4, autosomal dominant)), GeneBank accession No: BX649164 (PAI , serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), GeneBank accession No: BM918324 (LY96 , Lymphocyte antigen 96), GeneBank accession No: AB209647(NCF2, Neutrophil cytosolic factor 2(65kDa, chronic granulomatous disease, autosomal 2)), GeneBank accession No: NM_152221 (CSNKlE, Casein kinase 1, epsilon), GeneBank accession No: NM_017999 (RNF31 , Ring finger protein 31), GeneBank accession No: NM_016819 (OGGl , 8-oxoguanine DNA glycosylase) , GeneBank accession No: NM_016816 (OASl , 2 ',5'- oligoadenylate synthetase 1, 40/46kDa), GeneBank accession No: NM_012235 (SCAP, SREBP cleavage-activating protein), GeneBank accession No: NM_006384 (CIBl , Calcium and integrin binding 1 (calmyrin) ) , GeneBank accession No: NM_001779 (CD58, CD58 antigen, ( lymphocyte function-associated antigen 3)), GeneBank accession No: CB055213 ( ICOSLG, Inducible T-cell co-stimulator ligand), GeneBank accession No: BX641029 (MASPl, Mannan-binding lectin serine peptidase 1(C4/C2 activating component of Ra-reactive factor)), GeneBank accession No: BQ053419 (BATF, Basic leucine zipper transcription factor, ATF-like), GeneBank accession No: BC039299 (STIPl, Stress-induced-phosphoprotein 1 ( Hsp70/Hsp90-organizing protein)), GeneBank accession No: AY055760(DAF, Decay accelerating factor for complement (CD55 , Cromer blood group system)), GeneBank accession No: AK130188 (FGR, Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog), GeneBank accession No: AK095326 (MUS81 , MUS81 endonuclease homolog(yeast ) ) , GeneBank accession No: NM__017670 (OTUBl, OTU domain, ubiquitin aldehyde binding 1), GeneBank accession No: NM_003004 ( SECTMl , Secreted and transmembrane 1), GeneBank accession No: NM_002309 (LIF, Hypothetical protein MGC20647), GeneBank accession No: NM_001421(ELF4, E74-like factor 4(ets domain transcription factor)), GeneBank accession No: NM_000418 ( IL4R, lnterleukin 4 receptor), GeneBank accession No: BI909222 (FCERlG, Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide), GeneBank accession No: BF569086(NK4, lnterleukin 32), GeneBank accession No: BC014470 (AZGPl, Alpha-2-glycoprotein 1, zinc), GeneBank accession No: BC020744 (AKR1C4 , Aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol) dehydrogenase 4), GeneBank accession No: BQ939577 (AKR1C3 , Aldo-keto reductase family 1, member C3( 3-alpha hydroxysteroid dehydrogenase, type H)), GeneBank accession No: NM_000499 (CYPlAl , Cytochrome P450, family 1, subfamily A, polypeptide 1), GeneBank accession No: NM_030622 (CYP2S1 , Cytochrome P450, family 2, subfamily S, polypeptide 1), GeneBank accession No: NM_184041 (ALDOA, Aldolase A, fructose-bisphosphate) , GeneBank accession No: NM_024307 (MGC4171 , Hypothetical protein LOC283901), GeneBank accession No: NM_005336 ( HDLBP, High density lipoprotein binding protein( vigilin) ) , GeneBank accession No: NM_002627 (PFKP, Phosphofructokinase, platelet), GeneBank accession No: BX648281 (LDLR, Low density lipoprotein receptor ( familial hypercholesterolemia) ) , GeneBank accession No: BC069201(FLJ22761, Hexokinase domain containing 1), GeneBank accession No: BC030207 (NR0B2 , Nuclear receptor subfamily 0, group B, member 2), GeneBank accession No: AL833069(KIAA1434, Hypothetical protein KIAA1434), GeneBank accession No: AK124656 (EN02 , Enolase 2 (gamma, neuronal)), GeneBank accession No: AK094474 (RHOC, Ras homolog gene family, member C), GeneBank accession No: AK093461 ( ISYNAl , Myo-inositol 1-phosphate synthase Al), GeneBank accession No: AB053232(GAL3ST3, Galactose-3-O-sulfotransferase 3), GeneBank accession No: AB045292 (TMEM8, Transmembrane protein 8 ( five membrane-spanning domains)), GeneBank accession No: NM_004753 (DHRS3 , Dehydrogenase/reductase ( SDR family) member 3), GeneBank accession No: NM_002900 (RBP3 , Retinol binding protein 3, interstitial), GeneBank accession No: NM_001995 (ACSLl , Acyl-CoA synthetase long- chain family member 1), GeneBank accession No: NM_000018 (ACADVL , Acyl-Coenzyme A dehydrogenase, very long chain), GeneBank accession No: BC094756 (CRA, Myotubularin related protein 11), GeneBank accession No: BC050553 (NTE, Neuropathy target esterase), GeneBank accession No: BCO3311O(HSD17B1, Hydroxysteroid( 17-beta ) dehydrogenase 1), GeneBank accession No: AY268890 (TPPl , Tripeptidyl peptidase I), GeneBank accession No: AK172798 (CPTlA, Carnitine palmitoyltransferase lA(liver)), GeneBank accession No: AK096809(CYP4F8, Cytochrome P450, family 4, subfamily F, polypeptide 8), GeneBank accession No: AK000600 ( SIAT7D, ST6 ( alpha-N-acetyl-neuraminyl-2 , 3-beta- galactosyl-1 , 3 ) -N- acetylgalactosaminide alpha-2 , 6-sialyltransferase 4), GeneBank accession No: AB002454 (CYP4F3 , Cytochrome P450, family 4, subfamily F, polypeptide 3), GeneBank accession No: Z29093 (DDRl, Discoidin domain receptor family, member 1), GeneBank accession No: Z25424 (MKNK2 , MAP kinase interacting serine/threonine kinase 2), GeneBank accession No: XM_291277(DKFZp76lP0423, Hypothetical protein DKFZp76lP0423) , GeneBank accession No: XM_038150 (MAST3 , Microtubule associated serine/threonine kinase 3), GeneBank accession No: U88357 (ERBB3 , V-erb-b2 erythroblastic leukemia viral oncogene homolog 3(avian)), GeneBank accession No: NM_025195 (TRIBl , Tribbles homolog l(Drosophila) ) , GeneBank accession No: NM_020639 (RIPK4 , Receptor-interacting serine-threonine kinase 4 ) , GeneBank accession No: NM_014172 (PHPTl , Phosphohistidine phosphatase 1), GeneBank accession No: NM_006254 (PRKCD, Protein kinase C, delta), GeneBank accession No: NM_005415 (SLC20A1 , Solute carrier family 20 (phosphate transporter), member 1), GeneBank accession No: NM_005026 (PIK3CD, Phosphoinositide- 3-kinase, catalytic, delta polypeptide), GeneBank accession No: NM_004431(EPHA2, EPH receptor A2 ) , GeneBank accession No: NM_004419(DUSP5, Dual specificity phosphatase 5), GeneBank accession No: NM_004327 (BCR, Breakpoint cluster region), GeneBank accession No: NM_004231 (ATP6V1F, ATPase, H+ transporting, lysosomal 14kDa, Vl subunit F), GeneBank accession No: NM_004090 (DUSP3 , Dual specificity phosphatase 3 (vaccinia virus phosphatase VHl-related) ) , GeneBank accession No: NM_002843 (PTPRJ, Protein tyrosine phosphatase, receptor type, J), GeneBank accession No: NM_002496 (NDUFS8 , NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH- coenzyme Q reductase)), GeneBank accession No: NM_001001852(PIM3, Pim-3 oncogene), GeneBank accession No: L76191 ( IRAKI, Interleukin-1 receptor-associated kinase 1), GeneBank accession No: D15049 (PTPRH, Protein tyrosine phosphatase, receptor type, H), GeneBank accession No: BC065207(ATP6V0D2, ATPase, H+ transporting, lysosomal 38kDa, VO subunit d isoform 2), GeneBank accession No: BC035578(STK24, Serine/threonine kinase 24(STE20 homolog, yeast)), GeneBank accession No: BC028724 (DUSP18, Dual specificity phosphatase 18), GeneBank accession No: AL117482(ULK3, Unc-51-like kinase 3(C. elegans)), GeneBank accession No: AK126879 (PCTK3 , PCTAIRE protein kinase 3), GeneBank accession No: AB209416 ( ILK, Integrin-linked kinase-2), GeneBank accession No: NM_000782 (CYP24A1 , Cytochrome P450, family 24, subfamily A, polypeptide 1), GeneBank accession No: CR597101 ( ZFP36 , Zinc finger protein 36, C3H type, homolog( mouse) ), GeneBank accession No: CR936799(FHL2, Four and a half LIM domains 2), GeneBank accession No: M24898 (NRlDl , Nuclear receptor subfamily 1, group D, member 1), GeneBank accession No: AF132818 (KLF5 , Kruppel-like factor 5 ( intestinal )), GeneBank accession No: AK055337(ZNF213, Zinc finger protein 213), GeneBank accession No: BC008834 (PHFl , PHD finger protein 1), GeneBank accession No: AK126918 (GLIS2 , GLIS family zinc finger 2), GeneBank accession No: BC042692 (CTL2 , Solute carrier family 44, member 2), GeneBank accession No: NM_002224(ITPR3, Inositol 1 , 4 , 5-triphosphate receptor, type 3), GeneBank accession No: AK095363 (AQP3 , Aquaporin 3), GeneBank accession No: NM_174953 (ATP2A3 , ATPase, Ca++ transporting, ubiquitous), GeneBank accession No: BC042390 (VTIlB, Vesicle transport through interaction with t-SNAREs homolog lB(yeast)), GeneBank accession No: NM_016113 (TRPV2 , Transient receptor potential cation channel, subfamily V, member 2), GeneBank accession No: BM926478 (RBPl, Retinol binding protein 1, cellular), GeneBank accession No: NM_000069 (CACNAlS, Calcium channel, voltage-dependent, L type, alpha IS subunit), GeneBank accession No: AK002107 (RAB3B, RAB3B, member RAS oncogene family), GeneBank accession No: NM_013321 (SNX8, Sorting nexin 8), GeneBank accession No: AK125026 ( SLC6A12 , Solute carrier family 6 (neurotransmitter transporter, betaine/GABA) , member 12), GeneBank accession No: NM_005843(STAM2, Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2), GeneBank accession No: AK092512(SLC16A5, Solute carrier family 16 (monocarboxylic acid transporters), member 5), GeneBank accession No: U49248(ABCC2, ATP-binding cassette, sub-family C(CFTR/MRP), member 2), GeneBank accession No: AK172792 ( SCNNlA, Sodium channel, nonvoltage-gated 1 alpha), GeneBank accession No: BC044656(CASC3, Cancer susceptibility candidate 3), GeneBank accession No: NM_203403 (C9orf 150 , Chromosome 9 open reading frame 150), GeneBank accession No: NM_080388(S100A16, SlOO calcium binding protein A16), GeneBank accession No: NM_031286 ( SH3BGRL3 , SH3 domain binding glutamic acid-rich protein like 3), GeneBank accession No: NM_022153 (PP2135 , Chromosome 10 open reading frame 54), GeneBank accession No: NM_004864 (GDF15 , Growth differentiation factor 15), GeneBank accession No: NM_003330 (TXNRDl, Thioredoxin reductase 1), GeneBank accession No: NM_001013632 (LOC343521 , Similar to hypothetical protein 4833401D15), GeneBank accession No: BX537968(LOC51149, Hypothetical LOC51149), GeneBank accession No: BU945318 (MT2A, Hypothetical gene supported by X97260; BC070289), GeneBank accession No: BQ683841 ( SlOOAIl , SlOO calcium binding protein All (calgizzarin) ) , GeneBank accession No: BQ276852 (TMSBlO , Thymosin, beta 10), GeneBank accession No: AK126182 (KIAA1949 , KIAA1949), GeneBank accession No: AK124751 (CAPN2 , Calpain 2,(m/ll) large subunit), GeneBank accession No: AK095079 (RGC32 , Response gene to complement 32), GeneBank accession No: AB075871(FLJ42654, Golgi transport 1 homolog A(S. cerevisiae) ) , GeneBank accession No: AK125150 (MAPK8 , Mitogen-activated protein kinase 8), GeneBank accession No: NM_002758 (MAP2K6 , Mitogen-activated protein kinase kinase 6), GeneBank accession No: NM_004612 (TGFBRl , Transforming growth factor, beta receptor I(activin A receptor type II- like kinase, 53kDa)), GeneBank accession No: NM_145686(MAP4K4, Mitogen-activated protein kinase kinase kinase kinase 4), GeneBank accession No: XM_042066 (MAP3K1 , Mitogen-activated protein kinase kinase kinase 1 ) , GeneBank accession No: AB011123 (TNIK, TRAF2 and NCK interacting kinase), GeneBank accession No: AB209031(C5, Complement component 5), GeneBank accession No: NM_022740 (HIPK2 , Homeodomain interacting protein kinase 2 ) , GeneBank accession No: NM_148957 (TNFRSF19 , Tumor necrosis factor receptor superfamily, member 19), GeneBank accession No: AB208909(ITGB2, Integrin, beta 2(antigen CDl8(p95), lymphocyte function-associated antigen 1; macrophage antigen l(mac-l) beta subunit)), GeneBank accession No: AB209211 (TIAl, TIAl cytotoxic granule-associated RNA binding protein), GeneBank accession No: AB209613 (DNASE1L3 , Deoxyribonuclease I-like 3), GeneBank accession No: AK122825 (HMGBl, High-mobility group box 1), GeneBank accession No: AK127326 (PHF17 , PHD finger protein 17), GeneBank accession No: AK223503 (CASPl , Caspase 1, apoptosis-related cysteine peptidase ( interleukin 1, beta, convertase) ) , GeneBank accession No: BC013326 (GAS2 , Growth arrest-specific 2), GeneBank accession No: BC047698 ( IL7 , Interleukin 7), GeneBank accession No: D79987 (ESPLl , Extra spindle poles like 1(S. cerevisiae) ) , GeneBank accession No: NM_000893 (KNGl, Kininogen 1), GeneBank accession No: NM_001012271(BIRC5, Effector cell peptidase receptor 1), GeneBank accession No: NM_004938 (DAPKl , Death-associated protein kinase 1), GeneBank accession No: NM_005879 (TRIP, TRAF interacting protein), GeneBank accession No: NM_014739 (BCLAFl, BCL2-associated transcription factor 1), GeneBank accession No: NM_018947 (CYCS, Cytochrome c, somatic), GeneBank accession No: AB033337 (MPHOSPHl , M-phase phosphoprotein 1), GeneBank accession No: AB209179 (PLKl , Polo-like kinase 1 (Drosophila) ) , GeneBank accession No: AB209337(CDC7, CDC7 cell division cycle 7(S. cerevisiae ) ) , GeneBank accession No: AF053305 (BUBl , BUBl budding uninhibited by benzimidazoles 1 homolog( yeast ) ) , GeneBank accession No: AF053306 (BUBlB, BUBl budding uninhibited by benzimidazoles 1 homolog beta(yeast ) ) , GeneBank accession No: AF345347(SPAG5, Sperm associated antigen 5), GeneBank accession No: AK092638 (CCNG2 , Cyclin G2 ) , GeneBank accession No: AK222819 (NUSAPl , Nucleolar and spindle associated protein 1), GeneBank accession No: AL833191 ( SMC2L1 , SMC2 structural maintenance of chromosomes 2-like l(yeast)), GeneBank accession No: AY257469 (CIT, Citron(rho-interacting, serine/threonine kinase 21)), GeneBank accession No: AY367065 (ASPM, Asp( abnormal spindle) -like, microcephaly associated(Drosophila) ) , GeneBank accession No: BCOIlOOO (CDCA5 , Cell division cycle associated 5), GeneBank accession No: BC032677 (UBE2C, Ubiquitin-conjugating enzyme E2C), GeneBank accession No: BC043502 (NEK2 , NIMA(never in mitosis gene a)-related kinase 2), GeneBank accession No: BU675073 (PTTGl , Pituitary tumor- transforming 1), GeneBank accession No: BX647885(STMN1, Stathmin 1/oncoprotein 18), GeneBank accession No: CR592757 (BRRNl, Barren homolog 1 (Drosophila) ), GeneBank accession No: CR597075 (MAPRE2 , Microtubule-associated protein, RP/EB family, member 2), GeneBank accession No: CR604810(CCNA2, Cyclin A2 ) , GeneBank accession No: CR933728(CDC2, Cell division cycle 2 , Gl to S and G2 to M), GeneBank accession No: NM_000919 (PAM, Peptidylglycine alpha-amidating monooxygenase) , GeneBank accession No: NM_001790(CDC25C, Cell division cycle 25C), GeneBank accession No: NM__001798 (CDK2 , Cyclin-dependent kinase 2), GeneBank accession No: NM_001813 (CENPE, Centromere protein E, 312kDa), GeneBank accession No: NM_003318 (TTK, TTK protein kinase), GeneBank accession No: NM_003981 (PRCl , Protein regulator of cytokinesis 1), GeneBank accession No: NM_004523 (KIFlI, Kinesin family member 11), GeneBank accession No: NM_004701 (CCNB2 , Cyclin B2 ) , GeneBank accession No: NM_005983 ( SKP2 , S-phase kinase-associated protein 2(p45)), GeneBank accession No: NM_006101 (KNTC2 , Kinetochore associated 2), GeneBank accession No: NM_006845(KIF2C, Kinesin family member 2C), GeneBank accession No: NM_007375 ( TARDBP , TAR DNA binding protein), GeneBank accession No: NM_012112 (TPX2 , TPX2 , microtubule- associated, homolog(Xenopus laevis)), GeneBank accession No: NM_014750(DLG7, Discs, large homolog 7 (Drosophila) ) , GeneBank accession No: NM_015097 (CLASP2 , Cytoplasmic linker associated protein 2), GeneBank accession No: NM_016343(CENPF, Centromere protein F, 350/400ka(mitosin) ) , GeneBank accession No: NM_016426 (GTSEl , G-2 and S-phase expressed 1), GeneBank accession No: NM_018492 (PBK, PDZ binding kinase), GeneBank accession No: NM_018685 (ANLN, Anillin, actin binding protein ( scraps homolog, Drosophila) ) , GeneBank accession No: NM_020242 (KNSL7 , Kinesin family member 15), GeneBank accession No: NM_031966 (CCNBl , Cyclin Bl), GeneBank accession No: NM_138555 (KIF23 , Kinesin family member 23), GeneBank accession No: U65410 (MAD2L1 , MAD2 mitotic arrest deficient-like l(yeast)), GeneBank accession No: AB020656 (CYLD, Cylindromatosis (turban tumor syndrome)), GeneBank accession No: AF033122 ( SESNl , Sestrin 1), GeneBank accession No: AK074377 (UHRFl , Chromosome 19 open reading frame 31), GeneBank accession No: AK091170 (CDKN2C, Cyclin- dependent kinase inhibitor 2C(pl8, inhibits CDK4 ) ) , GeneBank accession No: AK094323 (NFYC, Nuclear transcription factor Y, gamma), GeneBank accession No: AY366508 (LOH11CR2A, Loss of heterozygosity, 11, chromosomal region 2, gene A), GeneBank accession No: BC033086 (TCF19 , Transcription factor 19(SCl)), GeneBank accession No: BC040303 (PTP4A1 , Protein tyrosine phosphatase type IVA, member 1), GeneBank accession No: BC040991 (TFDP2 , Transcription factor Dp-2(E2F dimerization partner 2)), GeneBank accession No: BC092412(SGOL2, Shugoshin-like 2(S. pombe ) ) , GeneBank accession No: BQ278454 (CKSlB, CDC28 protein kinase regulatory subunit IB), GeneBank accession No: BX649128(SESN3, Sestrin 3), GeneBank accession No: CD049340(AURKB, Aurora kinase B), GeneBank accession No: M89914(NFl, Neurofibromin 1 (neurofibromatosis , von Recklinghausen disease, Watson disease)), GeneBank accession No: NM_001005414 ( ZWINT, ZWlO interactor antisense), GeneBank accession No: NM_001008491 ( Sep 2, Septin 2), GeneBank accession No: NM_001274 (CHEKl , CHKl checkpoint homolog(S. pombe ) ) , GeneBank accession No: NM_002105(H2AFX, H2A histone family, member X), GeneBank accession No: NM_002388 (MCM3 , MCM3 minichromosome maintenance deficient 3(S. cerevisiae) ) , GeneBank accession No: NM_OO2417(MKI67, Antigen identified by monoclonal antibody Ki-67), GeneBank accession No: NM_002875 (RAD51 , RAD51 homolog(RecA homolog, E. CoIi)(S. cerevisiae)), GeneBank accession No: NM_003884 (PCAF, P300/CBP-associated factor), GeneBank accession No: NM_004526 (MCM2 , MCM2 minichromosome maintenance deficient 2, mitotin(S. cerevisiae)), GeneBank accession No: NM_004847 (AIFl , Allograft inflammatory factor 1), GeneBank accession No: NM_005915 (MCM6 , MCM6 minichromosome maintenance deficient 6(MIS5 homolog, S. pombe) (S. cerevisiae)), GeneBank accession No: NM_012090 (MACFl , Microtubule-actin crosslinking factor 1), GeneBank accession No: NM_012415(RAD54B, RAD54 homolog B(S. cerevisiae)), GeneBank accession No: NM_014264 (PLK4 , Polo-like kinase 4(Drosophila) ) , GeneBank accession No: NM_015714 (G0S2 , GO/Glswitch 2), GeneBank accession No: NM_024680 (FLJ23311 , E2F transcription factor 8), GeneBank accession No: XM_034274 (MYBLl, V-myb myeloblastosis viral oncogene homolog( avian) -like 1), GeneBank accession No: AKOO172O(FLJ1O858, Nei endonuclease Vlll-like 3(E. coli)), GeneBank accession No: AY032677 (POLQ, Polymerase (DNA directed), theta), GeneBank accession No: BC034480 (BLM, Bloom syndrome), GeneBank accession No: BC073161 (RAD51C, RAD51 homolog C(S. cerevisiae) ) , GeneBank accession No: CR600021(HMGB2, High-mobility group box 2), GeneBank accession No: CR625391 (RAD51AP1 , RAD51 associated protein 1), GeneBank accession No: CR936783 (FLJ40869 , Hypothetical protein LOC284952), GeneBank accession No: DQ140356(KIAA1596, Fanconi anemia, complementation group M), GeneBank accession No: NM_001067 (T0P2A, Topoisomerase (DNA) II alpha 17OkDa), GeneBank accession No: NM_001618 (PARPl , Poly ( ADP-ribose) polymerase family, member 1), GeneBank accession No: NM_003362 (UNG, Uracil-DNA glycosylase) , GeneBank accession No: NM_006904 (PRKDC, Protein kinase, DNA-activated, catalytic polypeptide), GeneBank accession No: NM_130398 (EXOl, Exonuclease 1), GeneBank accession No: AB020807 (TLR6, Toll-like receptor 6), GeneBank accession No: AB032980(DCDC2, Doublecortin domain containing 2), GeneBank accession No: AB209866 (TFPI, Tissue factor pathway inhibitor ( lipoprotein-associated coagulation inhibitor)), GeneBank accession No: AK057015 (HSPA4 , Heat shock 7OkDa protein 4), GeneBank accession No: AK095515 ( IFITl , Interferon-induced protein with tetratricopeptide repeats 1), GeneBank accession No: AK122686(IF, I factor (complement) ), GeneBank accession No: AK123010 (RRM2 , Ribonucleotide reductase M2 polypeptide), GeneBank accession No: BC035582 (TRIM22 , Tripartite motif-containing 22), GeneBank accession No: BX537894 (LOC493869 , Similar to RIKEN cDNA 2310016C16), GeneBank accession No: M14338 (PROSl , Protein S(alpha)), GeneBank accession No: NM_000821 (GGCX, Gamma-glutamyl carboxylase), GeneBank accession No: NM_000963 (PTGS2 , Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase ) ) , GeneBank accession No: NM_001001547 (CD36 , CD36 antigen (collagen type I receptor, thrombospondin receptor)), GeneBank accession No: NM_001512(GSTA4, Glutathione S-transferase A4 ) , GeneBank accession No: NM_001629 ( ALOX5AP, Arachidonate 5- lipoxygenase-activating protein), GeneBank accession No: NM_001752(CAT, Catalase), GeneBank accession No: NM_001837(CCR3, Chemokine(C-C motif) receptor 3), GeneBank accession No: NM_001979 (EPHX2 , Epoxide hydrolase 2, cytoplasmic), GeneBank accession No: NM_001994 ( F13B, Coagulation factor XIII, B polypeptide), GeneBank accession No: NM_002182( ILlRAP, Interleukin 1 receptor accessory protein), GeneBank accession No: NM__006120 (HLA-DMA, Major histocompatibility complex, class II, DM alpha), GeneBank accession No: NM_173216 ( SIATl , ST6 beta-galactosamide alpha-2 , 6-sialyltranferase 1), GeneBank accession No: NM_202002 (FOXMl, Forkhead box Ml), GeneBank accession No: AB163917 (LRAP, Leukocyte-derived arginine aminopeptidase ) , GeneBank accession No: BC027881 ( AFP, Alpha-fetoprotein) , GeneBank accession No: NM_015915 ( SPG3A, Spastic paraplegia 3A(autosomal dominant)), GeneBank accession No: NM_000671(ADH5, Alcohol dehydrogenase 5 (class III), chi polypeptide), GeneBank accession No: J05428 (UGT2B7 , UDP glucuronosyltransferase 2 family, polypeptide B7), GeneBank accession No: NM_000672 (ADH6 , Alcohol dehydrogenase 6 (class V)), GeneBank accession No: M15943(ADH4, Alcohol dehydrogenase 4 (class II), pi polypeptide), GeneBank accession No: AK223395 (FBPl , Fructose-1 , 6-bisphosphatase 1), GeneBank accession No: NM_000151 (G6PC, Glucose-6- phosphatase, catalytic ( glycogen storage disease type I, von Gierke disease)), GeneBank accession No: XM_113962 (KIAA0650 , Structural maintenance of chromosomes flexible hinge domain containing 1), GeneBank accession No: AB020644 ( ACSL6 , Acyl- CoA synthetase long-chain family member 6), GeneBank accession No: AB209907 (PLDl , Phospholipase Dl, phophatidylcholine-specific ) , GeneBank accession No: AF285167 (ABCAl, ATP-binding cassette, sub-family A(ABCl), member 1), GeneBank accession No: AF297872 (TRERFl, Transcriptional regulating factor 1), GeneBank accession No: AF3O3134(ALDH8A1, Aldehyde dehydrogenase 8 family, member Al), GeneBank accession No: AF339053 (PLA2G12B, Phospholipase A2 , group XIIB), GeneBank accession No: AK096018 (HADHSC, L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain), GeneBank accession No: AK124635 (PCSK9 , Proprotein convertase subtilisin/kexin type 9), GeneBank accession No: AK127346 ( SIAT9 , ST3 beta-galactoside alpha- 2 , 3-sialyltransferase 5), GeneBank accession No: AL359559 (AGPS, Alkylglycerone phosphate synthase), GeneBank accession No: AY691170 (PLCL3 , Phospholipase C-like 3), GeneBank accession No: BG567934 (APOM, Apolipoprotein M), GeneBank accession No: BX538214 (Cδorf 167 , Chromosome 6 open reading frame 167), GeneBank accession No: BX640945 (FADS2 , Fatty acid desaturase 2), GeneBank accession No: BX648473(PIGK, Phosphatidylinositol glycan, class K), GeneBank accession No: BX648557 (HSD17B2 , Hydroxysteroid( 17- beta) dehydrogenase 2), GeneBank accession No: CR749601 (ETNKl, Death-associated protein kinase 3), GeneBank accession No: NM_000859 (HMGCR, 3-hydroxy-3- methylglutaryl-Coenzyme A reductase), GeneBank accession No: NM_001443(FABPl, Fatty acid binding protein 1, liver), GeneBank accession No: NM_002130 (HMGCSl , 3-hydroxy-3- methylglutaryl-Coenzyme A synthase l(soluble)), GeneBank accession No: NM_003725 ( RODH , Hydroxysteroid( 17-beta) dehydrogenase 6), GeneBank accession No: NM_004845 (PCYTlB, Phosphate cytidylyltransferase 1, choline, beta), GeneBank accession No: NM_014762 (DHCR24 , 24-dehydrocholesterol reductase), GeneBank accession No: NM_020139 (DHRS6 , Dehydrogenase/reductase ( SDR family) member 6), GeneBank accession No: NM_020918 (GPAM, Glycerol-3-phosphate acyltransferase, mitochondrial), GeneBank accession No: NM_032523(OSBPL6, Oxysterol binding protein-like 6), GeneBank accession No: NM_033505 ( SELI , Selenoprotein I), GeneBank accession No: Z28339 (AKRlDl , Aldo-keto reductase family 1, member Dl (delta 4-3-ketosteroid-5-beta- reductase)), GeneBank accession No: AK024899 (ENPP3 , Ectonucleotide pyrophosphatase/phosphodiesterase 3), GeneBank accession No: AK025546 (PTPN4 , Protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte )), GeneBank accession No: AK124910 (ENPP2 , Ectonucleotide pyrophosphatase/phosphodiesterase 2 ( autotaxin) ) , GeneBank accession No: BC035116 (FLJ35059 fis, CDNA FLJ30761 fis, clone FEBRA2000538 ) , GeneBank accession No: BC050565 (PASK, PAS domain containing serine/threonine kinase), GeneBank accession No: L13436(NPR2, Natriuretic peptide receptor B/guanylate cyclase B(atrionatriuretic peptide receptor B)), GeneBank accession No: NM_001005862 (ERBB2 , V-erb-b2 erythroblastic leukemia viral oncogene homolog 2 , neuro/glioblastoma derived oncogene homolog( avian) ), GeneBank accession No: NM_005012 (RORl , Receptor tyrosine kinase-like orphan receptor 1), GeneBank accession No: NM_006035(CDC42BPB, CDC42 binding protein kinase beta(DMPK- like)), GeneBank accession No: NM_014791 (MELK, Maternal embryonic leucine zipper kinase), GeneBank accession No: NM_023028(FGFR2, Fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer yndrome, Jackson-Weiss syndrome)), GeneBank accession No: NM_080836 ( STK35 , Serine/threonine kinase 35), GeneBank accession No: AF419331 (FUSIPl , FUS interacting protein(serine/arginine-rich) 1), GeneBank accession No: AK091927(SFRS3, Splicing factor, arginine/serine-rich 3), GeneBank accession No: BC010266 (HNRNPAl , Heterogeneous nuclear ribonucleoprotein Al), GeneBank accession No: BC012360(CTAGE5, CTAGE family, member 5), GeneBank accession No: BC036046 (PLRGl , Pleiotropic regulator 1(PRLl homolog, Arabidopsis ) ) , GeneBank accession No: BC065384 (PCFIl, PCFIl, cleavage and polyadenylation factor subunit, homolog(S. cerevisiae ) ) , GeneBank accession No: BX537360(CPSF5, Nudix(nucleoside diphosphate linked moiety X) -type motif 21), GeneBank accession No: BX537494 (HNRPA2B1 , Heterogeneous nuclear ribonucleoprotein A2/B1), GeneBank accession No: BX647784 (HNRPR, Heterogeneous nuclear ribonucleoprotein R), GeneBank accession No: CA455267 (PPIH, Peptidyl prolyl isomerase H(cyclophilin H)), GeneBank accession No: CR596214 (HNRPAO , Heterogeneous nuclear ribonucleoprotein AO), GeneBank accession No: NM_001326(CSTF3, Hypothetical protein LOC283267), GeneBank accession No: NM_004640 (BATl , HLA-B associated transcript 1), GeneBank accession No: NM_005463 (HNRPDL, Heterogeneous nuclear ribonucleoprotein D-like), GeneBank accession No: NM_006924 (SFRSl, Splicing factor, arginine/serine-rich 1( splicing factor 2, alternate splicing factor)), GeneBank accession No: NM_012426 ( SF3B3 , Splicing factor 3b, subunit 3, 13OkDa), GeneBank accession No: NM_018048 (FLJ10292 , Mago-nashi homolog), GeneBank accession No: NM_030919(C20orfl29, Chromosome 20 open reading frame 129), GeneBank accession No: NM_031370 (HNRPD, Heterogeneous nuclear ribonucleoprotein D(AU-rich element RNA binding protein 1, 37kDa) ) , GeneBank accession No: NM_138933 ( ACF, Apobec-1 complementation factor), GeneBank accession No: AB193259 ( ACE2 , Angiotensin I converting enzyme (peptidyl- dipeptidase A) 2), GeneBank accession No: BX648769 (EWSRl , Ewing sarcoma breakpoint region 1), GeneBank accession No: AB023154 (DTX4, Deltex 4 homolog ( Drosophila )), GeneBank accession No: AL543755 ( VAV3 , Vav 3 oncogene), GeneBank accession No: M75106(CPB2, Carboxypeptidase B2 (plasma, carboxypeptidase U) ), GeneBank accession No: NM_021045(ZNF248, Zinc finger protein 248), GeneBank accession No: AB209194 (B4GALT6 , UDP-GaI :betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6), GeneBank accession No: AF279145 (ANTXRl , Anthrax toxin receptor 1), GeneBank accession No: NM_025074 (FRASl , Fraser syndrome 1), GeneBank accession No: AK025790 (KIF20A, Kinesin family member 20A), GeneBank accession No: NM_006152 (LRMP, Lymphoid-restricted membrane protein), GeneBank accession No: NM_000340(SLC2A2, Solute carrier family 2 ( facilitated glucose transporter), member 2), GeneBank accession No: AF071592(KIF4A, Kinesin family member 4A), GeneBank accession No: NM_013277 (RACGAPl , Rac GTPase activating protein 1), GeneBank accession No: AY043484 ( SCNlA, Sodium channel, voltage-gated, type I, alpha), GeneBank accession No: AY791349(KIF18A, Kinesin family member 18A), GeneBank accession No: NM_018018 ( SLC38A4 , Solute carrier family 38, member 4), GeneBank accession No: AK094603 (FLJ37284 fis, unnamed protein product; Homo sapiens cDNA FLJ37284 fis, clone BRAMY2013590. ) , GeneBank accession No: NM_021069(ARGBP2, Sorbin and SH3 domain containing 2), GeneBank accession No: NM_001005747 (CACNB4 , Calcium channel, voltage-dependent, beta 4 subunit), GeneBank accession No: AJ496568(SLC25A12, Solute carrier family 25 (mitochondrial carrier, Aralar), member 12), GeneBank accession No: NM_030641 ( AP0L6 , Apolipoprotein L, 6), GeneBank accession No: NM_173512(FLJ39822, Hypothetical protein FLJ39822), GeneBank accession No: NM_000037 (ANKl , Ankyrin 1, erythrocytic), GeneBank accession No: NM_001011554 ( SLC13A3 , Solute carrier family 13 ( sodium-dependent dicarboxylate transporter), member 3), GeneBank accession No: AB091343(C10orf3, Centrosomal protein 55kDa), GeneBank accession No: AK000643 ( ASB9 , Ankyrin repeat and SOCS box- containing 9), GeneBank accession No: AK055221 (FBXO5 , F-box protein 5), GeneBank accession No: AK075271 ( SPTLC2L, Serine palmitoyltransferase, long chain base subunit 2- like ( aminotransferase 2)), GeneBank accession No: AK122685 (GLUDl, Glutamate dehydrogenase 1), GeneBank accession No: AK127098 (FLJ10706 , Chromosome 1 open reading frame 112), GeneBank accession No: AL133031 (MLRl , Transcription factor MLRl), GeneBank accession No: AY007723(MAL2, MaI, T-cell differentiation protein 2), GeneBank accession No: BC022255 (Spc25 , Spindle pole body component 25 homolog(S. cerevisiae) ) , GeneBank accession No: BC041882 (ATF7IP2 , Activating transcription factor 7 interacting protein 2), GeneBank accession No: BC052951 (LMNBl, Lamin Bl), GeneBank accession No: BC098313(FLJ20641, Hypothetical protein FLJ20641), GeneBank accession No: NM_001809 (CENPA, Centromere protein A, 17kDa), GeneBank accession No: NM_145061 (C13orf3 , Chromosome 13 open reading frame 3), GeneBank accession No: XM_372695(LOC390859, PREDICTED: Homo sapiens similar to Chain A, Crystal Structure Of The R463a Mutant Of Human Glutamate Dehydrogenase(LOC390859 ) , mRNA) . [Claim 2] The kit according to claim 1, wherein the below genes are up-regulated by exposure to phenanthrene : GeneBank accession No: NM_004420 (DUSP8 , Dual specificity phosphatase 8), GeneBank accession No: L11329(DUSP2, Dual specificity phosphatase 2), GeneBank accession No: BC094766 (PKNl , Protein kinase Nl), GeneBank accession No: AY247738 (TRIB3 , Tribbles homolog 3(Drosophila) ) , GeneBank accession No: AK129595 (GADD45B, Growth arrest and DNA-damage-inducible, beta), GeneBank accession No: AB208849 ( SHCl , SHC(SrC homology 2 domain containing) transforming protein 1), GeneBank accession No: X02812 (TGFBl , Transforming growth factor, beta l(Camurati- Engelmann disease) ), GeneBank accession No: NM_198951 (TGM2 , Transglutaminase 2(C polypeptide, protein-glutamine-gamma- glutamyltransferase) ), GeneBank accession No: NM_147780 (CTSB, Cathepsin B), GeneBank accession No: NM_078467 (CDKNlA, Cyclin-dependent kinase inhibitor lA(p21, Cipl)), GeneBank accession No: NM_033027 (AXUDl , AXINl up- regulated 1), GeneBank accession No: NM_032797 ( AMID, Apoptosis-inducing factor (AIF) -like mitochondrion- associated inducer of death), GeneBank accession No: NM_021960 (MCLl, Myeloid cell leukemia sequence 1(BCL2- related)), GeneBank accession No: NM_016639 (TNFRSF12A, Tumor necrosis factor receptor superfamily, member 12A) , GeneBank accession No: NM_016222 (DDX41 , DEAD( Asp-Glu-Ala- Asp) box polypeptide 41), GeneBank accession No: NM_013246(CLC, Cardiotrophin-like cytokine factor 1), GeneBank accession No: NM_004401 (DFFA, DNA fragmentation factor, 45kDa, alpha polypeptide), GeneBank accession No: NM_004281(BAG3, BCL2-associated athanogene 3), GeneBank accession No: NM_003897 ( IER3 , Immediate early response 3), GeneBank accession No: NM_003806 (HRK, Harakiri, BCL2 interacting protein (contains only BH3 domain)), GeneBank accession No: NM_003639 ( IKBKG, Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma), GeneBank accession No: NM_003311 (PHLDA2 , Pleckstrin homology-like domain, family A, member 2), GeneBank accession No: NM_002737 (PRKCA, Protein kinase C, alpha), GeneBank accession No: NM_002648 (PIMl , Pim-1 oncogene), GeneBank accession No: NM_002507 (NGFR, Nerve growth factor receptor (TNFR superfamily, member 16)), GeneBank accession No: NM_002305 (LGALSl, Lectin, galactoside-binding, soluble, l(galectin I)), GeneBank accession No: NM_001013398 ( IGFBP3 , Insulin-like growth factor binding protein 3), GeneBank accession No: BX640923 (MDM4 , Mdm4 , transformed 3T3 cell double minute 4, p53 binding protein (mouse )), GeneBank accession No: BX537586 ( STK17A, Serine/threonine kinase 17a ( apoptosis-inducing) ) , GeneBank accession No: BG284742(P8, P8 protein (candidate of metastasis I)), GeneBank accession No: BE903247 (PDCD6IP, Programmed cell death 6 interacting protein), GeneBank accession No: BC027949(P2RXl, Purinergic receptor P2X, ligand-gated ion channel, 1), GeneBank accession No: BC006365 (PSEN2 , Presenilin 2 (Alzheimer disease 4)), GeneBank accession No: AY869712(PPP1R13L, Protein phosphatase 1, regulatory (inhibitor) subunit 13 like), GeneBank accession No: AY028896(CARD10, Caspase recruitment domain family, member 10), GeneBank accession No: AK122614 (PPARD, Peroxisome proliferative activated receptor, delta), GeneBank accession No: AK092872 (ERCC2 , Excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)), GeneBank accession No: AK092808 (RRAGC, Ras-related GTP binding C), GeneBank accession No: AJ001898 (GDNF, Glial cell derived neurotrophic factor), GeneBank accession No: AF220656 (PHLDAl, Pleckstrin homology-like domain, family A, member 1), GeneBank accession No: AF055634 (UNC5C, Unc-5 homolog C(C. elegans)), GeneBank accession No: AB209485 (VEGF, Vascular endothelial growth factor), GeneBank accession No: AB096256 (UNC5B, Unc-5 homolog B(C. elegans)), GeneBank accession No: AB007960 ( SH3GLB1 , SH3- domain GRB2-like endophilin Bl), GeneBank accession No: X06374 (PDGFA, Platelet-derived growth factor alpha polypeptide), GeneBank accession No: S62138 (DDIT3 , DNA- damage-inducible transcript 3), GeneBank accession No: NM_078487(CDKN2B, Cyclin-dependent kinase inhibitor 2B(pl5, inhibits CDK4 ) ) , GeneBank accession No: NM_012127 (CIZl , CDKNlA interacting zinc finger protein 1), GeneBank accession No: NM_005883 ( APC2 , Adenomatosis polyposis coli 2), GeneBank accession No: NM_004196 (CDKLl , Cyclin- dependent kinase-like 1 (CDC2-related kinase)), GeneBank accession No: NM_003236 (TGFA, Transforming growth factor, alpha), GeneBank accession No: NM_001261 (CDK9 , Cyclin- dependent kinase 9 (CDC2-related kinase)), GeneBank accession No: NM_001007271 (DUSP13 , Dual specificity phosphatase 13), GeneBank accession No: CR749511 (PARC, P53- associated parkin-like cytoplasmic protein), GeneBank accession No: CR623038 ( ID2 , Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein), GeneBank accession No: CR618371 (EGFR, Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)), GeneBank accession No: BF965144 ( IFITMl , Interferon induced transmembrane protein 1(9-27)), GeneBank accession No: AK127679 (DUSPl , Dual specificity phosphatase 1), GeneBank accession No: AK096276 (CCND3 , Cyclin D3 ) , GeneBank accession No: AB209586 (MAPK13 , Mitogen-activated protein kinase 13), GeneBank accession No: AB209465 (PCTKl , PCTAIRE protein kinase 1), GeneBank accession No: Z19588(SKIL, SKI-like), GeneBank accession No: NM_020429 (SMURFl, SMAD specific E3 ubiquitin protein ligase 1), GeneBank accession No: NM_014767 ( SPOCK2 , Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2), GeneBank accession No: NM_005979(Sl00A13, SlOO calcium binding protein A13), GeneBank accession No: NM_005187 (CBFA2T3 , Core-binding factor, runt domain, alpha subunit 2; translocated to, 3), GeneBank accession No: NM_004364 (CEBPA, CCAAT/enhancer binding protein(C/EBP) , alpha), GeneBank accession No: NM_001769(CD9, CD9 antigen(p24 ) ) , GeneBank accession No: NM_001718 (BMP6 , Bone morphogenetic protein 6), GeneBank accession No: NM_000641 ( ILIl , Interleukin 11), GeneBank accession No: BX647459 (SERPINE2 , Serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 2), GeneBank accession No: BQ066037 (RPS19 , Ribosomal protein S19), GeneBank accession No: BE791300 (EDFl , Endothelial differentiation-related factor 1), GeneBank accession No: BC038504 ( SNFlLK, SNFl-like kinase), GeneBank accession No: AL832287 ( ZAP70 , Zeta-chain(TCR) associated protein kinase 7OkDa), GeneBank accession No: AK125742 (PCGFl, Polycomb group ring finger 1), GeneBank accession No: AK124709 (NDRGl , N-myc downstream regulated gene 1), GeneBank accession No: AB011157 (PTDSR, Phosphatidylserine receptor), GeneBank accession No: NM_013255 (MKLNl, Muskelin 1, intracellular mediator containing kelch motifs), GeneBank accession No: NM_006572(GNA13, Guanine nucleotide binding protein(G protein), alpha 13), GeneBank accession No: NM_002211 ( ITGBl , Integrin, beta 1 ( fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2 , MSK12 ) ) , GeneBank accession No: CR601067 (PLAUR, Plasminogen activator, urokinase receptor), GeneBank accession No: BC050456 (THBS4 , Thrombospondin 4), GeneBank accession No: AK027389 (CXCL16, Chemokine (C-X-C motif) ligand 16), GeneBank accession No: AJ132099 (VNNl , Vanin 1), GeneBank accession No: XM_371354 (FLJ10157 , Hypothetical protein FLJ10157), GeneBank accession No: XM_208313(TPM3, Similar to tropomyosin 4), GeneBank accession No: XM_208270 (ACR, Acrosin-like protease), GeneBank accession No: NM_203353 (PDLIM7 , PDZ and LIM domain 7(enigma)), GeneBank accession No: NM_201382 (PLECl , Plectin 1, intermediate filament binding protein 50OkDa), GeneBank accession No: NM_182961 ( SYNEl , Spectrin repeat containing, nuclear envelope 1), GeneBank accession No: NM_181826 (NF2 , Neurofibromin 2 (bilateral acoustic neuroma)), GeneBank accession No: NM_172069 (PLEKHH2 , Pleckstrin homology domain containing, family H (with MyTH4 domain) member 2), GeneBank accession No: NM_022648 (TNS , Tensin 1), GeneBank accession No: NM_017556 (FBLP-I, Filamin binding LIM protein 1), GeneBank accession No: NM_016081 (KIAA0992 , Palladin, cytoskeletal associated protein), GeneBank accession No: NM_006617(NES, Nestin), GeneBank accession No: NM_006262 (PRPH, Peripherin), GeneBank accession No: NM_005100 (AKAP 12, A kinase (PRKA) anchor protein ( gravin) 12), GeneBank accession No: NM_004368 (CNN2 , Calponin 2), GeneBank accession No: NM_003388 (CYLN2 , Cytoplasmic linker 2), GeneBank accession No: NM_003370 (VASP, Vasodilator- stimulated phosphoprotein) , GeneBank accession No: NM_003128 (SPTBNl, Spectrin, beta, non-erythrocytic 1), GeneBank accession No: NM_002705 (PPL, Periplakin), GeneBank accession No: NM_002475 (MLClSA, Myosin light chain 1 slow a), GeneBank accession No: NM_002018 (FLII , Flightless I homolog(Drosophila) ) , GeneBank accession No: NM_001465 (FYB, FYN binding protein(FYB-120/130 ) ) , GeneBank accession No: NM_001069(TUBB2, Tubulin, beta 2A), GeneBank accession No: CR625172(MGC8685, Tubulin, beta 2B), GeneBank accession No: CR616919(KRT18, Keratin 18), GeneBank accession No: CR606241 (ACTGl , Actin, gamma 1), GeneBank accession No: CB240572 (MYHlI, Myosin, heavy polypeptide 11, smooth muscle), GeneBank accession No: BX648253 (PTPN3 , Protein tyrosine phosphatase, non-receptor type 3), GeneBank accession No: BX648190 (WDRl , WD repeat domain 1), GeneBank accession No: BX641076 (ACTNl , Actinin, alpha 1), GeneBank accession No: BX537978 (EPB41L1 , Erythrocyte membrane protein band 4.1-like 1), GeneBank accession No: BG121847 (NUDC, Nuclear distribution gene C homolog(A. nidulans)), GeneBank accession No: BC068013 (MYOlC, Myosin IC), GeneBank accession No: BC065499 (MAST2 , Microtubule associated serine/threonine kinase 2), GeneBank accession No: BC051890(TUBG2 , Tubulin, gamma 2), GeneBank accession No: BCO41874(MAP1LC3B, Microtubule-associated protein 1 light chain 3 beta), GeneBank accession No: BC012597 (ACTAl , Actin, alpha 1, skeletal muscle), GeneBank accession No: AY484427(KIF17, Kinesin family member 17), GeneBank accession No: AK130546 (ST0ML2 , Stomatin(EPB72 ) -like 2), GeneBank accession No: AK124711 (C0R02B, Coronin, actin binding protein, 2B), GeneBank accession No: AK123974 (MYL5 , Myosin, light polypeptide 5, regulatory), GeneBank accession No: AK092792 (LOC389833, Similar to hypothetical protein MGC27019), GeneBank accession No: AK026518 (MYOHDl , Myosin head domain containing 1), GeneBank accession No: AK024500 (NICAL, Microtubule associated monoxygenase, calponin and LIM domain containing 1), GeneBank accession No: AF085886(FLJ46675, Ribosomal protein L29 pseudogene 2), GeneBank accession No: AB209997 (MY09B, Myosin IXB), GeneBank accession No: Y12692 (WNTIl , Wingless-type MMTV integration site family, member 11), GeneBank accession No: Y11307 (CYR61 , Cysteine-rich, angiogenic inducer, 61), GeneBank accession No: X17033 ( ITGA2 , Integrin, alpha 2(CD49B, alpha 2 subunit of VLA-2 receptor)), GeneBank accession No: U41763 (CLTCLl , Clathrin, heavy polypeptide- like 1), GeneBank accession No: NM_153609 (TMPRSS6 , Transmembrane protease, serine 6), GeneBank accession No: NM_031483(ITCH, Itchy homolog E3 ubiquitin protein ligase (mouse) ) , GeneBank accession No: NM_024342 (GRLFl , Glucocorticoid receptor DNA binding factor 1 ) , GeneBank accession No: NM_017555 (EGLN2 , EgI nine homolog 2(C. elegans)), GeneBank accession No: NM_016569 (TBX3 , T-box 3 (ulnar mammary syndrome)), GeneBank accession No: NM_004148 (NINJl, Ninjurin 1), GeneBank accession No: NM_003377 (VEGFB, Vascular endothelial growth factor B), GeneBank accession No: NM_001983 (ERCCl , Excision repair cross-complementing rodent repair deficiency, complementation group 1( includes overlapping antisense sequence)), GeneBank accession No: NM_001552 ( IGFBP4 , Insulin-like growth factor binding protein 4), GeneBank accession No: NM_001430 (EPASl , Endothelial PAS domain protein 1), GeneBank accession No: NM_001300 (KLF6 , Kruppel- like factor 6), GeneBank accession No: NM_001012661 ( SLC3A2 , Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2), GeneBank accession No: NM_000596( IGFBPl, Insulin-like growth factor binding protein 1), GeneBank accession No: NM_000474 (TWISTl , Twist homolog 1 ( acrocephalosyndactyly 3; Saethre-Chotzen syndrome ) (Drosophila) ), GeneBank accession No: BX649103 (ChGn, Chondroitin betal,4 N- acetylgalactosaminyltransferase ), GeneBank accession No: BM913048 (TIMPl, TIMP metallopeptidase inhibitor 1), GeneBank accession No: BM904612 ( S100A6 , SlOO calcium binding protein A6 (calcyclin) ) , GeneBank accession No: BM556279 (EMP3 , Epithelial membrane protein 3), GeneBank accession No: BC015041 (VATl , Family with sequence similarity 82, member C), GeneBank accession No: AY258066 (OKL38, Pregnancy-induced growth inhibitor), GeneBank accession No: AK126729 (NDRG4 , NDRG family member 4), GeneBank accession No: AK090459 (NFE2L1 , Nuclear factor (erythroid-derived 2) -like 1), GeneBank accession No: AK074163 (R0B04 , Roundabout homolog 4, magic roundabout (Drosophila) ), GeneBank accession No: AK024680(FLJ21027 fis, CDNA: FLJ21027 fis, clone CAE07110), GeneBank accession No: AF176422 (HEYl , Hairy/enhancer-of- split related with YRPW motif 1), GeneBank accession No: AF003837 (JAGl, Jagged l(Alagille syndrome)), GeneBank accession No: AB209322 ( SEMA3B, Sema domain, immunoglobulin domain(Ig), short basic domain, secreted, ( semaphorin ) 3B), GeneBank accession No: AB011150 (NRXNl , Neurexin 1), GeneBank accession No: NM_201589 (MAFA, V-maf musculoaponeurotic fibrosarcoma oncogene homolog A(avian)), GeneBank accession No: NM_052999 (CKLFSFl , CKLF-like MARVEL transmembrane domain containing 1), GeneBank accession No: NM_006644 (HSPHl, Heat shock 105kDa/110kDa protein 1), GeneBank accession No: NM_005438 (FOSLl , FOS-like antigen 1), GeneBank accession No: NM_004996 (ABCCl , ATP-binding cassette, sub-family C(CFTR/MRP), member 1), GeneBank accession No: NM_002658 (PLAU, Plasminogen activator, urokinase), GeneBank accession No: NM_001353 (AKRlCl , Aldo- keto reductase family 1, member Cl (dihydrodiol dehydrogenase 1; 20-alpha( 3-alpha) -hydroxysteroid dehydrogenase)), GeneBank accession No: H18681 (C20orf 139 , Sulfiredoxin 1 homolog(S. cerevisiae) ) , GeneBank accession No: DR004094 (HAMP, Hepcidin antimicrobial peptide), GeneBank accession No: BC082272 (KCNMB3 , Potassium large conductance calcium-activated channel, subfamily M beta member 3), GeneBank accession No: BC040494 ( DNAJB2 , DnaJ(Hsp40) homolog, subfamily B, member 2), GeneBank accession No: BC018064 (ATF6 , Activating transcription factor 6), GeneBank accession No: BC006523 ( SGK2 , Serum/glucocorticoid regulated kinase 2), GeneBank accession No: AK090482 (CXCL12 , Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor I)), GeneBank accession No: AF219946 (TULP4 , Tubby like protein 4), GeneBank accession No: AB209112 (SLC2A8, Solute carrier family 2 ,( facilitated glucose transporter) member 8), GeneBank accession No: NM_005242 (F2RL1 , Coagulation factor II (thrombin) receptor-like 1), GeneBank accession No: NM_001002029 (C4A, Complement component 4B, telomeric), GeneBank accession No: NM_000539 (RHO, Rhodopsin( opsin 2, rod pigment )( retinitis pigmentosa 4, autosomal dominant)), GeneBank accession No: BX649164 (PAI , serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), GeneBank accession No: BM918324 (LY96 , Lymphocyte antigen 96), GeneBank accession No: AB209647(NCF2, Neutrophil cytosolic factor 2(65kDa, chronic granulomatous disease, autosomal 2)), GeneBank accession No: NM_152221 (CSNKlE, Casein kinase 1, epsilon), GeneBank accession No: NM_017999 (RNF31 , Ring finger protein 31), GeneBank accession No: NM_016819 (OGGl , 8-oxoguanine DNA glycosylase) , GeneBank accession No: NM_016816 (OASl , 2 ',5'- oligoadenylate synthetase 1, 40/46kDa), GeneBank accession No: NM_012235 (SCAP, SREBP cleavage-activating protein), GeneBank accession No: NM_006384 (CIBl, Calcium and integrin binding 1 (calmyrin) ) , GeneBank accession No: NM_001779 (CD58 , CD58 antigen, ( lymphocyte function-associated antigen 3)), GeneBank accession No: CB055213 ( ICOSLG, Inducible T-cell co-stimulator ligand) , GeneBank accession No: BX641029 (MASPl, Mannan-binding lectin serine peptidase 1(C4/C2 activating component of Ra-reactive factor)), GeneBank accession No: BQ053419 (BATF, Basic leucine zipper transcription factor, ATF-like), GeneBank accession No: BC039299 (STIPl, Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein)), GeneBank accession No: AY055760(DAF, Decay accelerating factor for complement (CD55 , Cromer blood group system)), GeneBank accession No: AK130188 (FGR, Gardner-Rasheed feline sarcoma viral(v-fgr) oncogene homolog), GeneBank accession No: AK095326 (MUS81 , MUS81 endonuclease homolog(yeast ) ) , GeneBank accession No: NM_017670 (OTUBl, OTU domain, ubiquitin aldehyde binding 1), GeneBank accession No: NM_003004 ( SECTMl , Secreted and transmembrane 1), GeneBank accession No: NM_002309 (LIF, Hypothetical protein MGC20647), GeneBank accession No: NM_001421(ELF4, E74-like factor 4(ets domain transcription factor)), GeneBank accession No: NM_000418 ( IL4R, Interleukin 4 receptor), GeneBank accession No: BI909222 (FCERlG, Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide), GeneBank accession No: BF569086(NK4, Interleukin 32), GeneBank accession No: BC014470 (AZGPl, Alpha-2-glycoprotein 1, zinc), GeneBank accession No: BC020744 ( AKR1C4 , Aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol ), dehydrogenase 4), GeneBank accession No: BQ939577 ( AKR1C3 , Aldo-keto reductase family 1, member C3( 3-alpha hydroxysteroid dehydrogenase, type H)), GeneBank accession No: NM_000499 (CYPlAl , Cytochrome P450, family 1, subfamily A, polypeptide 1), GeneBank accession No: NM_030622 (CYP2S1 , Cytochrome P450, family 2, subfamily S, polypeptide 1), GeneBank accession No: NM_184041 (ALDOA, Aldolase A, fructose-bisphosphate ) , GeneBank accession No: NM_024307 (MGC4171 , Hypothetical protein LOC283901), GeneBank accession No: NM_005336 (HDLBP, High density lipoprotein binding protein( vigilin) ) , GeneBank accession No: NM_002627 (PFKP, Phosphofructokinase, platelet), GeneBank accession No: BX648281 (LDLR, Low density lipoprotein receptor ( familial hypercholesterolemia)), GeneBank accession No: BC069201(FLJ22761, Hexokinase domain containing 1), GeneBank accession No: BC030207 (NR0B2 , Nuclear receptor subfamily 0, group B, member 2), GeneBank accession No: AL833O69(KIAA1434, Hypothetical protein KIAA1434), GeneBank accession No: AK124656 (ENO2 , Enolase 2(gamma, neuronal)), GeneBank accession No: AK094474 (RHOC, Ras homolog gene family, member C), GeneBank accession No: AK093461 ( ISYNAl , Myo-inositol 1-phosphate synthase Al), GeneBank accession No: AB053232(GAL3ST3, Galactose-3-O-sulfotransferase 3), GeneBank accession No: AB045292 (TMEM8 , Transmembrane protein 8(five membrane-spanning domains)), GeneBank accession No: NM_004753 (DHRS3 , Dehydrogenase/reductase ( SDR family) member 3), GeneBank accession No: NM_002900 (RBP3 , Retinol binding protein 3, interstitial), GeneBank accession No: NM_001995 (ACSLl , Acyl-CoA synthetase long- chain family member 1), GeneBank accession No: NM_000018 ( ACADVL , Acyl-Coenzyme A dehydrogenase, very long chain), GeneBank accession No: BC094756 (CRA, Myotubularin related protein 11), GeneBank accession No: BC050553 (NTE, Neuropathy target esterase), GeneBank accession No: BC033110(HSD17Bl, Hydroxysteroid( 17-beta ) dehydrogenase 1), GeneBank accession No: AY268890 (TPPl , Tripeptidyl peptidase I), GeneBank accession No: AK172798 (CPTlA, Carnitine palmitoyltransferase lA(liver)), GeneBank accession No: AK096809(CYP4F8, Cytochrome P450, family 4, subfamily F, polypeptide 8), GeneBank accession No: AK000600 ( SIAT7D, ST6 ( alpha-N-acetyl-neuraminyl-2 , 3-beta- galactosyl-1 , 3 ) -N- acetylgalactosaminide alpha-2 , 6-sialyltransferase 4), GeneBank accession No: AB002454 (CYP4F3 , Cytochrome P450, family 4, subfamily F, polypeptide 3), GeneBank accession No: Z29093 (DDRl, Discoidin domain receptor family, member 1), GeneBank accession No: Z25424 (MKNK2 , MAP kinase interacting serine/threonine kinase 2), GeneBank accession No: XM_291277(DKFZp761P0423, Hypothetical protein DKFZp761P0423) , GeneBank accession No: XM_038150 (MAST3 , Microtubule associated serine/threonine kinase 3), GeneBank accession No: U88357 (ERBB3 , V-erb-b2 erythroblastic leukemia viral oncogene homolog 3(avian)), GeneBank accession No: NM_025195 (TRIBl , Tribbles homolog l(Drosophila) ) , GeneBank accession No: NM__020639 (RIPK4 , Receptor-interacting serine-threonine kinase 4 ) , GeneBank accession No: NM_014172 (PHPTl , Phosphohistidine phosphatase 1), GeneBank accession No: NM_006254 (PRKCD, Protein kinase C, delta), GeneBank accession No: NM_005415 (SLC20A1 , Solute carrier family 20 (phosphate transporter), member 1), GeneBank accession No: NM_005026 (PIK3CD, Phosphoinositide- 3-kinase, catalytic, delta polypeptide), GeneBank accession No: NM_004431(EPHA2, EPH receptor A2 ) , GeneBank accession No: NM_004419(DUSP5, Dual specificity phosphatase 5), GeneBank accession No: NM_004327 (BCR, Breakpoint cluster region), GeneBank accession No: NM_004231 (ATP6V1F, ATPase, H+ transporting, lysosomal 14kDa, Vl subunit F), GeneBank accession No: NM_004090 (DUSP3 , Dual specificity phosphatase 3 (vaccinia virus phosphatase VHl-related) ) , GeneBank accession No: NM_002843 (PTPRJ, Protein tyrosine phosphatase, receptor type, J), GeneBank accession No: NM_002496 (NDUFS8 , NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH- coenzyme Q reductase)), GeneBank accession No: NM_001001852 (PIM3, Pim-3 oncogene), GeneBank accession No: L76191 ( IRAKI , Interleukin-1 receptor-associated kinase 1), GeneBank accession No: D15049 (PTPRH, Protein tyrosine phosphatase, receptor type, H), GeneBank accession No: BC065207(ATP6V0D2, ATPase, H+ transporting, lysosomal 38kDa, VO subunit d isoform 2), GeneBank accession No: BC035578(STK24, Serine/threonine kinase 24(STE20 homolog, yeast)), GeneBank accession No: BC028724 (DUSP18 , Dual specificity phosphatase 18), GeneBank accession No: AL117482(ULK3, Unc-51-like kinase 3(C. elegans)), GeneBank accession No: AK126879 (PCTK3 , PCTAIRE protein kinase 3), GeneBank accession No: AB209416 ( ILK, Integrin-linked kinase-2), GeneBank accession No: NM_000782 (CYP24A1 , Cytochrome P450, family 24, subfamily A, polypeptide 1), GeneBank accession No: CR597101 ( ZFP36 , Zinc finger protein 36, C3H type, homolog( mouse) ), GeneBank accession No: CR936799(FHL2, Four and a half LIM domains 2), GeneBank accession No: M24898 (NRlDl , Nuclear receptor subfamily 1, group D, member 1), GeneBank accession No: AF132818 (KLF5 , Kruppel-like factor 5 ( intestinal )), GeneBank accession No: AK055337(ZNF213, Zinc finger protein 213), GeneBank accession No: BC008834 (PHFl , PHD finger protein 1), GeneBank accession No: AK126918 (GLIS2 , GLIS family zinc finger 2), GeneBank accession No: BC042692 (CTL2 , Solute carrier family 44, member 2), GeneBank accession No: NM_002224 (ITPR3, Inositol 1 , 4 , 5-triphosphate receptor, type 3), GeneBank accession No: AK095363 (AQP3 , Aquaporin 3), GeneBank accession No: NM_174953 (ATP2A3 , ATPase, Ca++ transporting, ubiquitous), GeneBank accession No: BC042390 (VTIlB, Vesicle transport through interaction with t-SNAREs homolog lB(yeast)), GeneBank accession No: NM_016113(TRPV2, Transient receptor potential cation channel, subfamily V, member 2), GeneBank accession No: BM926478(RBP1, Retinol binding protein 1, cellular), GeneBank accession No: NM_000069 (CACNAlS, Calcium channel, voltage-dependent, L type, alpha IS subunit), GeneBank accession No: AK002107 (RAB3B, RAB3B, member RAS oncogene family), GeneBank accession No: NM_013321 (SNX8 , Sorting nexin 8), GeneBank accession No: AK125026 (SLC6A12 , Solute carrier family 6 (neurotransmitter transporter, betaine/GABA) , member 12), GeneBank accession No: NM_005843(STAM2, Signal transducing adaptor molecule ( SH3 domain and ITAM motif) 2), GeneBank accession No: AK092512 (SLC16A5, Solute carrier family 16 (monocarboxylic acid transporters), member 5), GeneBank accession No: U49248(ABCC2, ATP-binding cassette, sub-family C(CFTR/MRP), member 2), GeneBank accession No: AK172792 ( SCNNlA, Sodium channel, nonvoltage-gated 1 alpha), GeneBank accession No: BC044656(CASC3, Cancer susceptibility candidate 3), GeneBank accession No: NM_203403 (C9orf 150 , Chromosome 9 open reading frame 150), GeneBank accession No: NM_080388(S100Al6, SlOO calcium binding protein A16), GeneBank accession No: NM_031286 ( SH3BGRL3 , SH3 domain binding glutamic acid-rich protein like 3), GeneBank accession No: NM_022153 (PP2135, Chromosome 10 open reading frame 54), GeneBank accession No: NM_004864 (GDF15 , Growth differentiation factor 15), GeneBank accession No: NM_003330 (TXNRDl, Thioredoxin reductase 1), GeneBank accession No: NM_001013632 (LOC343521 , Similar to hypothetical protein 4833401D15), GeneBank accession No: BX537968(LOC51149, Hypothetical LOC51149), GeneBank accession No: BU945318 (MT2A, Hypothetical gene supported by X97260; BC070289), GeneBank accession No: BQ683841 ( SlOOAlI , SlOO calcium binding protein All (calgizzarin) ) , GeneBank accession No: BQ276852 (TMSBlO , Thymosin, beta 10), GeneBank accession No: AK126182 (KIAA1949 , KIAA1949), GeneBank accession No: AK124751 (CAPN2 , Calpain 2,(m/II) large subunit), GeneBank accession No: AK095079 (RGC32 , Response gene to complement 32), GeneBank accession No: AB075871(FLJ42654, Golgi transport 1 homolog A(S. cerevisiae) ) . [Claim 3] The kit according to claim 1, wherein the below genes are down-regulated by exposure to phenanthrene : GeneBank accession No: AK12515O(MAPK8, Mitogen- activated protein kinase 8), GeneBank accession No: NM_002758 (MAP2K6 , Mitogen-activated protein kinase kinase 6), GeneBank accession No: NM_004612 (TGFBRl , Transforming growth factor, beta receptor I(activin A receptor type II- like kinase, 53kDa)), GeneBank accession No: NM_145686 (MAP4K4 , Mitogen-activated protein kinase kinase kinase kinase 4), GeneBank accession No: XM_042066 (MAP3K1 , Mitogen-activated protein kinase kinase kinase 1 ) , GeneBank accession No: AB011123 (TNIK, TRAF2 and NCK interacting kinase), GeneBank accession No: AB209031(C5, Complement component 5), GeneBank accession No: NM_022740 (HIPK2 , Homeodomain interacting protein kinase 2 ) , GeneBank accession No: NM_148957 (TNFRSF19 , Tumor necrosis factor receptor superfamily, member 19), GeneBank accession No: AB208909(ITGB2, Integrin, beta 2(antigen CD18(p95), lymphocyte function-associated antigen 1; macrophage antigen l(mac-l) beta subunit)), GeneBank accession No: AB209211 (TIAl, TIAl cytotoxic granule-associated RNA binding protein), GeneBank accession No: AB209613 (DNASE1L3 , Deoxyribonuclease I-like 3), GeneBank accession No: AK122825 (HMGBl, High-mobility group box 1), GeneBank accession No: AK127326 (PHF17 , PHD finger protein 17), GeneBank accession No: AK223503 (CASPl , Caspase 1, apoptosis-related cysteine peptidase ( interleukin 1, beta, convertase ) ) , GeneBank accession No: BC013326 (GAS2 , Growth arrest-specific 2), GeneBank accession No: BC047698 ( IL7 , Interleukin 7), GeneBank accession No: D79987 (ESPLl , Extra spindle poles like 1(S. cerevisiae) ) , GeneBank accession No: NM_000893 (KNGl, Kininogen 1), GeneBank accession No: NM_001012271(BIRC5, Effector cell peptidase receptor 1), GeneBank accession No: NM_004938 (DAPKl , Death-associated protein kinase 1), GeneBank accession No: NM_005879 (TRIP, TRAF interacting protein), GeneBank accession No: NM_014739 (BCLAFl, BCL2-associated transcription factor 1), GeneBank accession No: NM_018947 (CYCS, Cytochrome c, somatic), GeneBank accession No: AB033337 (MPHOSPHl , M-phase phosphoprotein 1), GeneBank accession No: AB209179 (PLKl , Polo-like kinase 1 (Drosophila) ) , GeneBank accession No: AB209337(CDC7, CDC7 cell division cycle 7(S. cerevisiae ) ) , GeneBank accession No: AF053305 (BUBl , BUBl budding uninhibited by benzimidazoles 1 homolog ( yeast )), GeneBank accession No: AF053306 (BUBlB, BUBl budding uninhibited by benzimidazoles 1 homolog beta(yeast ) ) , GeneBank accession No: AF345347 (SPAG5, Sperm associated antigen 5), GeneBank accession No: AK092638 (CCNG2 , Cyclin G2 ) , GeneBank accession No: AK222819 (NUSAPl , Nucleolar and spindle associated protein 1), GeneBank accession No: AL833191 (SMC2L1, SMC2 structural maintenance of chromosomes 2-like l(yeast)), GeneBank accession No: AY257469 (CIT, Citron (rho-interacting, serine/threonine kinase 21)), GeneBank accession No: AY367065 (ASPM, Asp( abnormal spindle) -like, microcephaly associated(Drosophila) ) , GeneBank accession No: BCOIlOOO (CDCA5 , Cell division cycle associated 5), GeneBank accession No: BC032677 (UBE2C, Ubiquitin-conjugating enzyme E2C), GeneBank accession No: BC043502(NEK2, NIMA(never in mitosis gene a)-related kinase 2), GeneBank accession No: BU675073 (PTTGl , Pituitary tumor- transforming 1), GeneBank accession No: BX647885 ( STMNl , Stathmin 1/oncoprotein 18), GeneBank accession No: CR592757 (BRRNl, Barren homolog 1 (Drosophila) ) , GeneBank accession No: CR597075 (MAPRE2 , Microtubule-associated protein, RP/EB family, member 2), GeneBank accession No: CR604810(CCNA2, Cyclin A2 ) , GeneBank accession No: CR933728(CDC2, Cell division cycle 2, Gl to S and G2 to M), GeneBank accession No: NM_000919 (PAM, Peptidylglycine alpha-amidating monooxygenase) , GeneBank accession No: NM_001790(CDC25C, Cell division cycle 25C), GeneBank accession No: NM_001798 (CDK2 , Cyclin-dependent kinase 2), GeneBank accession No: NM_001813 (CENPE , Centromere protein E, 312kDa), GeneBank accession No: NM_003318 (TTK, TTK protein kinase), GeneBank accession No: NM_003981 (PRCl , Protein regulator of cytokinesis 1), GeneBank accession No: NM_004523 (KIFIl, Kinesin family member 11), GeneBank accession No: NM_004701 (CCNB2 , Cyclin B2 ) , GeneBank accession No: NM_005983 ( SKP2 , S-phase kinase-associated protein 2(p45)), GeneBank accession No: NM_006101 (KNTC2 , Kinetochore associated 2), GeneBank accession No: NM_006845(KIF2C, Kinesin family member 2C), GeneBank accession No: NM_007375 ( TARDBP , TAR DNA binding protein), GeneBank accession No: NM_012112 (TPX2 , TPX2 , microtubule- associated, homolog(Xenopus laevis)), GeneBank accession No: NM_014750(DLG7, Discs, large homolog 7 ( Drosophila ) ) , GeneBank accession No: NM_015097 (CLASP2 , Cytoplasmic linker associated protein 2), GeneBank accession No: NM_016343 (CENPF, Centromere protein F, 350/400ka(mitosin) ) , GeneBank accession No: NM_016426 (GTSEl , G-2 and S-phase expressed 1), GeneBank accession No: NM_018492 (PBK, PDZ binding kinase), GeneBank accession No: NM_018685 (ANLN, Anillin, actin binding protein ( scraps homolog, Drosophila)), GeneBank accession No: NM_020242 (KNSL7 , Kinesin family member 15), GeneBank accession No: NM_031966 (CCNBl , Cyclin Bl), GeneBank accession No: NM__138555 (KIF23 , Kinesin family member 23), GeneBank accession No: U65410 (MAD2L1 , MAD2 mitotic arrest deficient-like l(yeast)), GeneBank accession No: AB020656 (CYLD, Cylindromatosis (turban tumor syndrome)), GeneBank accession No: AF033122 ( SESNl , Sestrin 1), GeneBank accession No: AK074377 (UHRFl , Chromosome 19 open reading frame 31), GeneBank accession No: AK091170 (CDKN2C, Cyclin- dependent kinase inhibitor 2C(pl8, inhibits CDK4 ) ) , GeneBank accession No: AK094323 (NFYC, Nuclear transcription factor Y, gamma), GeneBank accession No: AY366508 (LOH11CR2A, Loss of heterozygosity, 11, chromosomal region 2, gene A), GeneBank accession No: BC033086 (TCF19 , Transcription factor 19(SCl)), GeneBank accession No: BC040303 (PTP4A1 , Protein tyrosine phosphatase type IVA, member 1), GeneBank accession No: BC040991 (TFDP2 , Transcription factor Dp-2(E2F dimerization partner 2)), GeneBank accession No: BC092412(SGOL2, Shugoshin-like 2(S. pombe ) ) , GeneBank accession No: BQ278454 (CKSlB, CDC28 protein kinase regulatory subunit IB), GeneBank accession No: BX649128(SESN3, Sestrin 3), GeneBank accession No: CD049340 (AURKB, Aurora kinase B), GeneBank accession No: M89914(NFl, Neurofibromin 1 (neurofibromatosis , von Recklinghausen disease, Watson disease)), GeneBank accession No: NM_001005414 ( ZWINT, ZWlO interactor antisense), GeneBank accession No: NM_001008491 ( Sep 2, Septin 2), GeneBank accession No: NM_001274 (CHEKl , CHKl checkpoint homolog(S. pombe)), GeneBank accession No: NM_002105(H2AFX, H2A histone family, member X), GeneBank accession No: NM_002388 (MCM3, MCM3 minichromosome maintenance deficient 3(S. cerevisiae) ) , GeneBank accession No: NM_002417(MKI67, Antigen identified by monoclonal antibody Ki-67), GeneBank accession No: NM_002875 (RAD51 , RAD51 homolog(RecA homolog, E. coli)(S. cerevisiae)), GeneBank accession No: NM_003884 (PCAF, P300/CBP-associated factor), GeneBank accession No: NM_004526 (MCM2 , MCM2 minichromosome maintenance deficient 2, mitotin(S. cerevisiae)), GeneBank accession No: NM_004847 (AIFl , Allograft inflammatory factor 1), GeneBank accession No: NM_005915 (MCM6 , MCM6 minichromosome maintenance deficient 6(MIS5 homolog, S. pombe)(S. cerevisiae) ) , GeneBank accession No: NM_012090 (MACFl , Microtubule-actin crosslinking factor 1), GeneBank accession No: NM_012415(RAD54B, RAD54 homolog B(S. cerevisiae)), GeneBank accession No: NM_014264 (PLK4 , Polo-like kinase 4(Drosophila) ) , GeneBank accession No: NM_015714 (G0S2 , GO/Glswitch 2), GeneBank accession No: NM_024680 (FLJ23311 , E2F transcription factor 8), GeneBank accession No: XM_034274 (MYBLl, V-myb myeloblastosis viral oncogene homolog ( avian) -like 1), GeneBank accession No: AK001720(FLJ10858, Nei endonuclease Vlll-like 3(E. coli)), GeneBank accession No: AY032677 (POLQ, Polymerase (DNA directed), theta), GeneBank accession No: BC034480 (BLM, Bloom syndrome), GeneBank accession No: BC073161 (RAD51C, RAD51 homolog C(S. cerevisiae)), GeneBank accession No: CR600021(HMGB2, High-mobility group box 2), GeneBank accession No: CR625391 (RAD51AP1 , RAD51 associated protein 1), GeneBank accession No: CR936783 (FLJ40869 , Hypothetical protein LOC284952), GeneBank accession No: DQ140356 (KIAA1596 , Fanconi anemia, complementation group M), GeneBank accession No: NM_001067 (T0P2A, Topoisomerase (DNA) II alpha 17OkDa), GeneBank accession No: NM__001618 (PARPl , Poly (ADP-ribose) polymerase family, member 1), GeneBank accession No: NM_003362 (UNG, Uracil-DNA glycosylase ) , GeneBank accession No: NM_006904 (PRKDC, Protein kinase, DNA-activated, catalytic polypeptide), GeneBank accession No: NM_130398 (EXOl, Exonuclease 1), GeneBank accession No: AB020807 (TLR6, Toll-like receptor 6), GeneBank accession No: AB032980(DCDC2, Doublecortin domain containing 2), GeneBank accession No: AB209866 (TFPI , Tissue factor pathway inhibitor ( lipoprotein-associated coagulation inhibitor)), GeneBank accession No: AK057015 (HSPA4 , Heat shock 7OkDa protein 4), GeneBank accession No: AK095515 ( IFITl , Interferon-induced protein with tetratricopeptide repeats 1), GeneBank accession No: AK122686(IF, I factor ( complement) ), GeneBank accession No: AK123010 (RRM2 , Ribonucleotide reductase M2 polypeptide), GeneBank accession No: BC035582 (TRIM22 , Tripartite motif-containing 22), GeneBank accession No: BX537894 (LOC493869 , Similar to RIKEN cDNA 2310016C16), GeneBank accession No: M14338 (PROSl , Protein S(alpha)), GeneBank accession No: NM_000821 (GGCX, Gamma-glutamyl carboxylase), GeneBank accession No: NM_000963(PTGS2 , Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) ) , GeneBank accession No: NM_001001547 (CD36 , CD36 antigen(collagen type I receptor, thrombospondin receptor)), GeneBank accession No: NM_001512(GSTA4, Glutathione S-transferase A4 ) , GeneBank accession No: NM_001629 (AL0X5AP, Arachidonate 5- lipoxygenase-activating protein), GeneBank accession No: NM_001752 (CAT, Catalase), GeneBank accession No: NM_001837(CCR3, Chemokine(C-C motif) receptor 3), GeneBank accession No: NM_001979 (EPHX2 , Epoxide hydrolase 2, cytoplasmic), GeneBank accession No: NM_001994 (F13B, Coagulation factor XIII, B polypeptide), GeneBank accession No: NM_002182 (ILlRAP, Interleukin 1 receptor accessory protein), GeneBank accession No: NM_006120 (HLA-DMA, Major histocompatibility complex, class II, DM alpha), GeneBank accession No: NM_173216 ( SIATl , ST6 beta-galactosamide alpha-2 , 6-sialyltranferase 1), GeneBank accession No: NM_202002 (FOXMl, Forkhead box Ml), GeneBank accession No: AB163917 (LRAP, Leukocyte-derived arginine aminopeptidase ) , GeneBank accession No: BC027881 ( AFP, Alpha-fetoprotein) , GeneBank accession No: NM_015915 ( SPG3A, Spastic paraplegia 3A(autosomal dominant)), GeneBank accession No: NM_000671(ADH5, Alcohol dehydrogenase 5 (class III), chi polypeptide), GeneBank accession No: J05428 (UGT2B7 , UDP glucuronosyltransferase 2 family, polypeptide B7 ) , GeneBank accession No: NM_000672 ( ADH6 , Alcohol dehydrogenase 6 (class V)), GeneBank accession No: M15943(ADH4, Alcohol dehydrogenase 4 (class II), pi polypeptide), GeneBank accession No: AK223395 (FBPl , Fructose-1 , 6-bisphosphatase 1), GeneBank accession No: NM_000151 (G6PC, Glucose-6- phosphatase, catalytic (glycogen storage disease type I, von Gierke disease)), GeneBank accession No: XM_113962 (KIAA0650 , Structural maintenance of chromosomes flexible hinge domain containing 1), GeneBank accession No: AB020644 ( ACSL6 , Acyl- CoA synthetase long-chain family member 6), GeneBank accession No: AB209907 (PLDl , Phospholipase Dl, phophatidylcholine-specific ) , GeneBank accession No: AF285167 (ABCAl, ATP-binding cassette, sub-family A(ABCl), member 1), GeneBank accession No: AF297872 (TRERFl , Transcriptional regulating factor 1), GeneBank accession No: AF3O3134(ALDH8A1, Aldehyde dehydrogenase 8 family, member Al), GeneBank accession No: AF339053 (PLA2G12B, Phospholipase A2 , group XIIB), GeneBank accession No: AK096018 (HADHSC, L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain), GeneBank accession No: AK124635 (PCSK9, Proprotein convertase subtilisin/kexin type 9), GeneBank accession No: AK127346 ( SIAT9 , ST3 beta-galactoside alpha- 2 , 3-sialyltransferase 5), GeneBank accession No: AL359559 (AGPS , Alkylglycerone phosphate synthase), GeneBank accession No: AY691170 (PLCL3 , Phospholipase C-like 3), GeneBank accession No: BG567934 (APOM, Apolipoprotein M), GeneBank accession No: BX538214 (Cβorf167 , Chromosome 6 open reading frame 167), GeneBank accession No: BX640945 ( FADS2 , Fatty acid desaturase 2), GeneBank accession No: BX648473(PIGK, Phosphatidylinositol glycan, class K), GeneBank accession No: BX648557 ( HSD17B2 , Hydroxysteroid ( 17- beta) dehydrogenase 2), GeneBank accession No: CR749601 (ETNKl, Death-associated protein kinase 3), GeneBank accession No: NM_000859 (HMGCR, 3-hydroxy-3- methylglutaryl-Coenzyme A reductase), GeneBank accession No: NM_001443 (FABPl, Fatty acid binding protein 1, liver), GeneBank accession No: NM_002130 (HMGCSl , 3-hydroxy-3- methylglutaryl-Coenzyme A synthase l(soluble)), GeneBank accession No: NM_003725 (RODH, Hydroxysteroid( 17-beta) dehydrogenase 6), GeneBank accession No: NM_004845 (PCYTlB, Phosphate cytidylyltransferase 1, choline, beta), GeneBank accession No: NM_014762 (DHCR24 , 24-dehydrocholesterol reductase), GeneBank accession No: NM_020139 (DHRS6 , Dehydrogenase/reductase ( SDR family) member 6), GeneBank accession No: NM_020918 (GPAM, Glycerol-3-phosphate acyltransferase, mitochondrial), GeneBank accession No: NM_032523(OSBPL6, Oxysterol binding protein-like 6), GeneBank accession No: NM_033505 ( SELI , Selenoprotein I), GeneBank accession No: Z28339 (AKRlDl , Aldo-keto reductase family 1, member Dl (delta 4-3-ketosteroid-5-beta- reductase)), GeneBank accession No: AK024899 (ENPP3 , Ectonucleotide pyrophosphatase/ phosphodiesterase 3), GeneBank accession No: AK025546 (PTPN4 , Protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte )), GeneBank accession No: AK124910 (ENPP2 , Ectonucleotide pyrophosphatase/phosphodiesterase 2 ( autotaxin) ) , GeneBank accession No: BC035116 (FLJ35059 fis, CDNA FLJ30761 fis, clone FEBRA2000538) , GeneBank accession No: BC050565 (PASK, PAS domain containing serine/threonine kinase), GeneBank accession No: L13436 (NPR2 , Natriuretic peptide receptor B/guanylate cyclase B(atrionatriuretic peptide receptor B)), GeneBank accession No: NM_001005862 (ERBB2 , V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog ( avian) ), GeneBank accession No: NM_005012 (RORl , Receptor tyrosine kinase-like orphan receptor 1), GeneBank accession No: NM_006035(CDC42BPB, CDC42 binding protein kinase beta(DMPK- like)), GeneBank accession No: NM_014791 (MELK, Maternal embryonic leucine zipper kinase), GeneBank accession No: NM_023028(FGFR2, Fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer yndrome, Jackson-Weiss syndrome)), GeneBank accession No: NM_080836 ( STK35 , Serine/threonine kinase 35), GeneBank accession No: AF419331 (FUSIPl , FUS interacting protein ( serine/arginine-rich) 1), GeneBank accession No: AK091927(SFRS3, Splicing factor, arginine/serine-rich 3), GeneBank accession No: BC010266 (HNRNPAl , Heterogeneous nuclear ribonucleoprotein Al), GeneBank accession No: BCO 12360 (CTAGE5, CTAGE family, member 5), GeneBank accession No: BC036046 (PLRGl , Pleiotropic regulator 1(PRLl homolog, Arabidopsis ) ) , GeneBank accession No: BC065384 (PCFIl, PCFlI, cleavage and polyadenylation factor subunit, homolog(S. cerevisiae) ) , GeneBank accession No: BX537360 (CPSF5 , Nudix( nucleoside diphosphate linked moiety X) -type motif 21), GeneBank accession No: BX537494 (HNRPA2B1 , Heterogeneous nuclear ribonucleoprotein A2/B1), GeneBank accession No: BX647784 (HNRPR, Heterogeneous nuclear ribonucleoprotein R), GeneBank accession No: CA455267 (PPIH, Peptidyl prolyl isomerase H(cyclophilin H)), GeneBank accession No: CR596214 (HNRPAO , Heterogeneous nuclear ribonucleoprotein AO), GeneBank accession No: NM_001326(CSTF3, Hypothetical protein LOC283267), GeneBank accession No: NM_004640 (BATl , HLA-B associated transcript 1), GeneBank accession No: NM_005463 (HNRPDL, Heterogeneous nuclear ribonucleoprotein D-like), GeneBank accession No: NM_006924 (SFRSl, Splicing factor, arginine/serine-rich 1( splicing factor 2, alternate splicing factor)), GeneBank accession No: NM_012426 ( SF3B3 , Splicing factor 3b, subunit 3, 13OkDa), GeneBank accession No: NM_018048 (FLJ10292 , Mago-nashi homolog), GeneBank accession No: NM_030919(C20orf 129, Chromosome 20 open reading frame 129), GeneBank accession No: NM_031370 (HNRPD, Heterogeneous nuclear ribonucleoprotein D(AU-rich element RNA binding protein 1, 37kDa) ) , GeneBank accession No: NM_138933 (ACF, Apobec-1 complementation factor), GeneBank accession No: AB193259 ( ACE2 , Angiotensin I converting enzyme (peptidyl- dipeptidase A) 2), GeneBank accession No: BX648769 (EWSRl , Ewing sarcoma breakpoint region 1), GeneBank accession No: AB023154 (DTX4, Deltex 4 homolog( Drosophila) ) , GeneBank accession No: AL543755 ( VAV3 , Vav 3 oncogene), GeneBank accession No: M75106(CPB2, Carboxypeptidase B2 (plasma, carboxypeptidase U)), GeneBank accession No: NM_021045(ZNF248, Zinc finger protein 248), GeneBank accession No: AB209194 (B4GALT6 , UDP-GaI :betaGlcNAc beta 1,4- galactosyltransferase , polypeptide 6), GeneBank accession No: AF279145 (ANTXRl , Anthrax toxin receptor 1), GeneBank accession No: NM_025074 (FRASl , Fraser syndrome 1), GeneBank accession No: AK025790 (KIF20A, Kinesin family member 20A), GeneBank accession No: NM_006152 (LRMP, Lymphoid-restricted membrane protein), GeneBank accession No: NM_000340(SLC2A2, Solute carrier family 2 ( facilitated glucose transporter), member 2), GeneBank accession No: AF071592(KIF4A, Kinesin family member 4A), GeneBank accession No: NM_013277 (RACGAPl , Rac GTPase activating protein 1), GeneBank accession No: AY043484 ( SCNlA, Sodium channel, voltage-gated, type I, alpha), GeneBank accession No: AY791349(KIF18A, Kinesin family member 18A), GeneBank accession No: NM_018018 ( SLC38A4 , Solute carrier family 38, member 4), GeneBank accession No: AK094603 (FLJ37284 fis, unnamed protein product; Homo sapiens cDNA FLJ37284 fis, clone BRAMY2013590. ) , GeneBank accession No: NM_021069(ARGBP2, Sorbin and SH3 domain containing 2), GeneBank accession No: NM_001005747 (CACNB4 , Calcium channel, voltage-dependent, beta 4 subunit), GeneBank accession No: AJ496568(SLC25A12, Solute carrier family 25 (mitochondrial carrier, Aralar), member 12), GeneBank accession No: NM_030641 (AP0L6, Apolipoprotein L, 6), GeneBank accession No: NM_173512(FLJ39822, Hypothetical protein FLJ39822), GeneBank accession No: NM_000037 (ANKl , Ankyrin 1, erythrocytic), GeneBank accession No: NM_001011554 ( SLC13A3 , Solute carrier family 13 ( sodium-dependent dicarboxylate transporter), member 3), GeneBank accession No: AB091343(C10orf3, Centrosomal protein 55kDa), GeneBank accession No: AK000643 (ASB9 , Ankyrin repeat and SOCS box- containing 9), GeneBank accession No: AK055221 (FBXO5 , F-box protein 5), GeneBank accession No: AK075271 ( SPTLC2L, Serine palmitoyltransferase, long chain base subunit 2- like( aminotransferase 2)), GeneBank accession No: AK122685 (GLUDl, Glutamate dehydrogenase 1), GeneBank accession No: AK127098 (FLJ10706 , Chromosome 1 open reading frame 112), GeneBank accession No: AL133031 (MLRl , Transcription factor MLRl), GeneBank accession No: AY007723(MAL2, MaI, T-cell differentiation protein 2), GeneBank accession No: BC022255 (Spc25 , Spindle pole body component 25 homolog(S. cerevisiae ) ) , GeneBank accession No: BC041882 (ATF7IP2 , Activating transcription factor 7 interacting protein 2), GeneBank accession No: BC052951 (LMNBl, Lamin Bl), GeneBank accession No: BC098313(FLJ20641, Hypothetical protein FLJ20641), GeneBank accession No: NM_001809 (CENPA, Centromere protein A, 17kDa), GeneBank accession No: NM_145061 (C13orf3 , Chromosome 13 open reading frame 3), GeneBank accession No: XM_372695(LOC390859, PREDICTED: Homo sapiens similar to Chain A, Crystal Structure Of The R463a Mutant Of Human Glutamate Dehydrogenase (LOC390859 ), mRNA) . [Claim 4] A kit for identification of exposure to phenanthrene containing a primer set capable of amplifying the genes of claim 1. [Claim 5] The kit according to claim 4, wherein the primer set is composed of at least 2 forward primers and reverse primers selected from the group consisting of sequences represented by SEQ. ID. NO: 1 -NO: 56. [Claim 6] A method for detecting the below genes for the identification of exposure to phenanthrene comprising the following steps: 1) comparing expressions of genes up- or down- regulated by phenanthrene in the experimental group somatic cells and the control group somatic cells; and 2) determining exposure to phenanthrene if the expression of the said gene of step 1) is significantly different from that of the control. GeneBank accession No: NM_004420 (DUSP8 , Dual specificity phosphatase 8), GeneBank accession No: L11329(DUSP2, Dual specificity phosphatase 2), GeneBank accession No: BC094766 (PKNl , Protein kinase Nl), GeneBank accession No: AY247738 (TRIB3 , Tribbles homolog 3(Drosophila) ) , GeneBank accession No: AK129595 (GADD45B, Growth arrest and DNA-damage-inducible, beta), GeneBank accession No: AB208849 ( SHCl , SHC(SrC homology 2 domain containing) transforming protein 1), GeneBank accession No: X02812 (TGFBl, Transforming growth factor, beta l(Camurati- Engelmann disease )) , GeneBank accession No: NM_198951 (TGM2 , Transglutaminase 2(C polypeptide, protein-glutamine-gamma- glutamyltransferase) ), GeneBank accession No: NM_147780(CTSB, Cathepsin B), GeneBank accession No: NM_078467 (CDKNlA, Cyclin-dependent kinase inhibitor lA(p21, Cipl)), GeneBank accession No: NM_033027 (AXUDl , AXINl up- regulated 1), GeneBank accession No: NM_032797 ( AMID, Apoptosis-inducing factor (AIF) -like mitochondrion- associated inducer of death), GeneBank accession No: NM_021960 (MCLl, Myeloid cell leukemia sequence 1(BCL2- related)), GeneBank accession No: NM_016639 (TNFRSF12A, Tumor necrosis factor receptor superfamily, member 12A) , GeneBank accession No: NM_016222 (DDX41 , DEAD(Asp-Glu-Ala- Asp) box polypeptide 41), GeneBank accession No: NM_013246(CLC, Cardiotrophin-like cytokine factor 1), GeneBank accession No: NM_004401 (DFFA, DNA fragmentation factor, 45kDa, alpha polypeptide), GeneBank accession No: NM_004281(BAG3, BCL2-associated athanogene 3), GeneBank accession No: NM_003897 ( IER3 , Immediate early response 3), GeneBank accession No: NM_003806 (HRK, Harakiri, BCL2 interacting protein(contains only BH3 domain)), GeneBank accession No: NM_003639 ( IKBKG, Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma), GeneBank accession No: NM_003311 (PHLDA2 , Pleckstrin homology-like domain, family A, member 2), GeneBank accession No: NM_002737 (PRKCA, Protein kinase C, alpha), GeneBank accession No: NM_002648 (PIMl , Pim-1 oncogene), GeneBank accession No: NM_002507 (NGFR, Nerve growth factor receptor (TNFR superfamily, member 16)), GeneBank accession No: NM_002305 (LGALSl, Lectin, galactoside-binding, soluble, l(galectin I)), GeneBank accession No: NM_001013398 ( IGFBP3 , Insulin-like growth factor binding protein 3), GeneBank accession No: BX640923 (MDM4 , Mdm4 , transformed 3T3 cell double minute 4, p53 binding protein ( mouse )), GeneBank accession No: BX537586 ( STK17A, Serine/threonine kinase 17a( apoptosis-inducing) ) , GeneBank accession No: BG284742(P8, P8 protein (candidate of metastasis I)), GeneBank accession No: BE903247 (PDCD6IP, Programmed cell death 6 interacting protein), GeneBank accession No: BC027949(P2RXl, Purinergic receptor P2X, ligand-gated ion channel, 1), GeneBank accession No: BC006365 (PSEN2 , Presenilin 2 (Alzheimer disease 4)), GeneBank accession No: AY869712(PPP1R13L, Protein phosphatase 1, regulatory ( inhibitor ) subunit 13 like), GeneBank accession No: AY028896 (CARDlO , Caspase recruitment domain family, member 10), GeneBank accession No: AK122614 (PPARD, Peroxisome proliferative activated receptor, delta), GeneBank accession No: AK092872 (ERCC2 , Excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)), GeneBank accession No: AK092808 (RRAGC, Ras-related GTP binding C), GeneBank accession No: AJ001898 (GDNF, Glial cell derived neurotrophic factor), GeneBank accession No: AF220656 (PHLDAl, Pleckstrin homology-like domain, family A, member 1), GeneBank accession No: AF055634 (UNC5C , Unc-5 homolog C(C. elegans)), GeneBank accession No: AB209485 (VEGF, Vascular endothelial growth factor), GeneBank accession No: AB096256 (UNC5B, Unc-5 homolog B(C. elegans)), GeneBank accession No: AB007960 ( SH3GLB1 , SH3- domain GRB2-like endophilin Bl), GeneBank accession No: X06374 (PDGFA, Platelet-derived growth factor alpha polypeptide), GeneBank accession No: S62138 (DDIT3 , DNA- damage-inducible transcript 3), GeneBank accession No: NM_078487(CDKN2B, Cyclin-dependent kinase inhibitor 2B(pl5, inhibits CDK4 ) ) , GeneBank accession No: NM_012127 (CIZl , CDKNlA interacting zinc finger protein 1), GeneBank accession No: NM_005883 (APC2 , Adenomatosis polyposis coli 2), GeneBank accession No: NM_004196 (CDKLl , Cyclin- dependent kinase-like 1 (CDC2-related kinase)), GeneBank accession No: NM_003236 (TGFA, Transforming growth factor, alpha), GeneBank accession No: NM_001261 (CDK9 , Cyclin- dependent kinase 9 (CDC2-related kinase)), GeneBank accession No: NM_001007271 ( DUSP13 , Dual specificity phosphatase 13), GeneBank accession No: CR749511 (PARC, P53- associated parkin-like cytoplasmic protein), GeneBank accession No: CR623038 ( ID2 , Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein), GeneBank accession No: CR618371 (EGFR, Epidermal growth factor receptor ( erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)), GeneBank accession No: BF965144 ( IFITMl , Interferon induced transmembrane protein 1(9-27)), GeneBank accession No: AK127679 (DUSPl , Dual specificity phosphatase 1), GeneBank accession No: AK096276 (CCND3, Cyclin D3), GeneBank accession No: AB209586 (MAPK13 , Mitogen-activated protein kinase 13), GeneBank accession No: AB209465 (PCTKl , PCTAIRE protein kinase 1), GeneBank accession No: Z19588(SKIL, SKI-like), GeneBank accession No: NM_020429 (SMURFl, SMAD specific E3 ubiquitin protein ligase 1), GeneBank accession No: NM_014767 ( SPOCK2 , Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2), GeneBank accession No: NM_005979(S100A13, SlOO calcium binding protein A13), GeneBank accession No: NM_005187 (CBFA2T3 , Core-binding factor, runt domain, alpha subunit 2; translocated to, 3), GeneBank accession No: NM_004364 (CEBPA, CCAAT/enhancer binding protein(C/EBP) , alpha), GeneBank accession No: NM_001769(CD9, CD9 antigen (p24 )), GeneBank accession No: NM_001718(BMP6, Bone morphogenetic protein 6), GeneBank accession No: NM_000641 ( ILIl , Interleukin 11), GeneBank accession No: BX647459 ( SERPINE2 , Serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 2), GeneBank accession No: BQ066037 (RPS19 , Ribosomal protein S19), GeneBank accession No: BE791300 (EDFl , Endothelial differentiation-related factor 1), GeneBank accession No: BC038504 ( SNFlLK, SNFl-like kinase), GeneBank accession No: AL832287 ( ZAP70 , Zeta-chain(TCR) associated protein kinase 7OkDa), GeneBank accession No: AK125742 (PCGFl, Polycomb group ring finger 1), GeneBank accession No: AK124709 (NDRGl , N-myc downstream regulated gene 1), GeneBank accession No: AB011157 (PTDSR, Phosphatidylserine receptor), GeneBank accession No: NM_013255 (MKLNl, Muskelin 1, intracellular mediator containing kelch motifs), GeneBank accession No: NM_006572(GNA13, Guanine nucleotide binding protein (G protein), alpha 13), GeneBank accession No: NM_002211 ( ITGBl , Integrin, beta 1 ( fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2 , MSK12 ) ) , GeneBank accession No: CR601067 (PLAUR, Plasminogen activator, urokinase receptor), GeneBank accession No: BC050456 (THBS4 , Thrombospondin 4), GeneBank accession No: AK027389 (CXCL16 , Chemokine (C-X-C motif) ligand 16), GeneBank accession No: AJ132099 (VNNl , Vanin 1), GeneBank accession No: XM_371354 (FLJ10157 , Hypothetical protein FLJ10157), GeneBank accession No: XM_208313(TPM3, Similar to tropomyosin 4), GeneBank accession No: XM_208270 ( ACR, Acrosin-like protease), GeneBank accession No: NM_203353 (PDLIM7 , PDZ and LIM domain 7 (enigma) ), GeneBank accession No: NM_201382 (PLECl , Plectin 1, intermediate filament binding protein 50OkDa), GeneBank accession No: NM_182961 ( SYNEl , Spectrin repeat containing, nuclear envelope 1), GeneBank accession No: NM_181826 (NF2 , Neurofibromin 2 (bilateral acoustic neuroma)), GeneBank accession No: NM_172069 (PLEKHH2 , Pleckstrin homology domain containing, family H(with MyTH4 domain) member 2), GeneBank accession No: NM_022648 (TNS, Tensin 1), GeneBank accession No: NM_017556 (FBLP-I, Filamin binding LIM protein 1), GeneBank accession No: NM_016081 (KIAA0992 , Palladin, cytoskeletal associated protein) , GeneBank accession No: NM_006617 (NES, Nestin), GeneBank accession No: NM_006262 (PRPH, Peripherin), GeneBank accession No: NM_005100(AKAP12, A kinase (PRKA) anchor protein ( gravin) 12), GeneBank accession No: NM_004368 (CNN2 , Calponin 2), GeneBank accession No: NM_003388 (CYLN2 , Cytoplasmic linker 2), GeneBank accession No: NM_003370 (VASP, Vasodilator- stimulated phosphoprotein) , GeneBank accession No: NM_003128 (SPTBNl, Spectrin, beta, non-erythrocytic 1), GeneBank accession No: NM_002705 (PPL, Periplakin), GeneBank accession No: NM_002475 (MLClSA, Myosin light chain 1 slow a), GeneBank accession No: NM_002018 (FLII, Flightless I homolog(Drosophila) ) , GeneBank accession No: NM_001465 (FYB, FYN binding protein ( FYB-120/130 )), GeneBank accession No: NM_001069(TUBB2, Tubulin, beta 2A), GeneBank accession No: CR625172(MGC8685, Tubulin, beta 2B), GeneBank accession No: CR616919(KRT18, Keratin 18), GeneBank accession No: CR606241 (ACTGl, Actin, gamma 1), GeneBank accession No: CB240572 (MYHIl, Myosin, heavy polypeptide 11, smooth muscle), GeneBank accession No: BX648253 (PTPN3 , Protein tyrosine phosphatase, non-receptor type 3), GeneBank accession No: BX648190 (WDRl , WD repeat domain 1), GeneBank accession No: BX641076 (ACTNl , Actinin, alpha 1), GeneBank accession No: BX537978 (EPB41L1 , Erythrocyte membrane protein band 4.1-like 1), GeneBank accession No: BG121847 (NUDC, Nuclear distribution gene C homolog(A. nidulans)), GeneBank accession No: BC068013 (MYOlC, Myosin IC), GeneBank accession No: BC065499 (MAST2 , Microtubule associated serine/threonine kinase 2), GeneBank accession No: BC051890(TUBG2, Tubulin, gamma 2), GeneBank accession No: BC041874 (MAP1LC3B, Microtubule-associated protein 1 light chain 3 beta), GeneBank accession No: BC012597 (ACTAl , Actin, alpha 1, skeletal muscle), GeneBank accession No: AY484427(KIF17, Kinesin family member 17), GeneBank accession No: AK130546 ( STOML2 , Stomatin(EPB72 ) -like 2), GeneBank accession No: AK124711 (C0R02B, Coronin, actin binding protein, 2B), GeneBank accession No: AK123974 (MYL5 , Myosin, light polypeptide 5, regulatory), GeneBank accession No: AK092792 (LOC389833 , Similar to hypothetical protein MGC27019), GeneBank accession No: AK026518 (MYOHDl , Myosin head domain containing 1), GeneBank accession No: AK024500 (NICAL, Microtubule associated monoxygenase, calponin and LIM domain containing 1), GeneBank accession No: AF085886(FLJ46675, Ribosomal protein L29 pseudogene 2), GeneBank accession No: AB209997 (MY09B, Myosin IXB), GeneBank accession No: Y12692 (WNTIl , Wingless-type MMTV integration site family, member 11), GeneBank accession No: Y11307 (CYR61 , Cysteine-rich, angiogenic inducer, 61), GeneBank accession No: X17033 ( ITGA2 , Integrin, alpha 2(CD49B, alpha 2 subunit of VLA-2 receptor)), GeneBank accession No: U41763 (CLTCLl , Clathrin, heavy polypeptide- like 1), GeneBank accession No: NM_153609 (TMPRSS6 , Transmembrane protease, serine 6), GeneBank accession No: NM_031483(ITCH, Itchy homolog E3 ubiquitin protein ligase (mouse) ), GeneBank accession No: NM_024342 (GRLFl , Glucocorticoid receptor DNA binding factor 1 ) , GeneBank accession No: NM_017555 (EGLN2 , EgI nine homolog 2(C. elegans)), GeneBank accession No: NM_016569 (TBX3 , T-box 3 (ulnar mammary syndrome)), GeneBank accession No: NM_004148 (NINJl, Ninjurin 1), GeneBank accession No: NM_003377 (VEGFB, Vascular endothelial growth factor B), GeneBank accession No: NM_001983 (ERCCl , Excision repair cross-complementing rodent repair deficiency, complementation group 1( includes overlapping antisense sequence)), GeneBank accession No: NM_001552 ( IGFBP4 , Insulin-like growth factor binding protein 4), GeneBank accession No: NM_001430 (EPASl , Endothelial PAS domain protein 1), GeneBank accession No: NM_001300 (KLF6 , Kruppel- like factor 6), GeneBank accession No: NM_001012661 (SLC3A2 , Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2), GeneBank accession No: NM_000596( IGFBPl, Insulin-like growth factor binding protein 1), GeneBank accession No: NM_000474 (TWISTl , Twist homolog 1 ( acrocephalosyndactyly 3; Saethre-Chotzen syndrome ) (Drosophila) ), GeneBank accession No: BX649103 (ChGn, Chondroitin betal,4 N- acetylgalactosaminyltransferase ), GeneBank accession No: BM913048 (TIMPl, TIMP metallopeptidase inhibitor 1), GeneBank accession No: BM904612 ( S100A6 , SlOO calcium binding protein A6 (calcyclin) ) , GeneBank accession No: BM556279(EMP3, Epithelial membrane protein 3), GeneBank accession No: BC015041 (VATl , Family with sequence similarity 82, member C), GeneBank accession No: AY258066 (OKL38 , Pregnancy-induced growth inhibitor), GeneBank accession No: AK126729 (NDRG4 , NDRG family member 4), GeneBank accession No: AK090459 (NFE2L1 , Nuclear factor (erythroid-derived 2)-like 1), GeneBank accession No: AK074163(ROBO4, Roundabout homolog 4, magic roundabout (Drosophila) ), GeneBank accession No: AK024680(FLJ21027 fis, CDNA: FLJ21027 fis, clone CAE07110), GeneBank accession No: AF176422 (HEYl , Hairy/enhancer-of- split related with YRPW motif 1), GeneBank accession No: AF003837 (JAGl, Jagged l(Alagille syndrome)), GeneBank accession No: AB209322 (SEMA3B, Sema domain, immunoglobulin domain(Ig), short basic domain, secreted, ( semaphorin) 3B), GeneBank accession No: AB011150 (NRXNl , Neurexin 1), GeneBank accession No: NM_201589 (MAFA, V-maf musculoaponeurotic fibrosarcoma oncogene homolog A(avian)), GeneBank accession No: NM_052999 (CKLFSFl , CKLF-like MARVEL transmembrane domain containing 1), GeneBank accession No: NM_006644 (HSPHl, Heat shock 105kDa/110kDa protein 1), GeneBank accession No: NM_005438 (FOSLl , FOS-like antigen 1), GeneBank accession No: NM_004996 (ABCCl , ATP-binding cassette, sub-family C(CFTR/MRP), member 1), GeneBank accession No: NM_002658 (PLAU, Plasminogen activator, urokinase), GeneBank accession No: NM_001353 (AKRlCl , Aldo- keto reductase family 1, member Cl (dihydrodiol dehydrogenase 1; 20-alpha( 3-alpha) -hydroxysteroid dehydrogenase)), GeneBank accession No: H18681 (C20orf 139 , Sulfiredoxin 1 homolog(S. cerevisiae) ) , GeneBank accession No: DR004094 (HAMP, Hepcidin antimicrobial peptide), GeneBank accession No: BC082272 (KCNMB3 , Potassium large conductance calcium-activated channel, subfamily M beta member 3), GeneBank accession No: BC040494 (DNAJB2 , DnaJ(Hsp40) homolog, subfamily B, member 2), GeneBank accession No: BC018064 ( ATF6 , Activating transcription factor 6), GeneBank accession No: BC006523 ( SGK2 , Serum/glucocorticoid regulated kinase 2 ) , GeneBank accession No: AK090482 (CXCL12 , Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor I)), GeneBank accession No: AF219946 (TULP4 , Tubby like protein 4), GeneBank accession No: AB209112 ( SLC2A8 , Solute carrier family 2 ,( facilitated glucose transporter) member 8), GeneBank accession No: NM_005242 (F2RL1 , Coagulation factor II (thrombin) receptor-like 1), GeneBank accession No: NM_001002029(C4A, Complement component 4B, telomeric), GeneBank accession No: NM_000539 (RHO, Rhodopsin( opsin 2, rod pigment ) (retinitis pigmentosa 4, autosomal dominant)), GeneBank accession No: BX649164 (PAI , serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), GeneBank accession No: BM918324 (LY96 , Lymphocyte antigen 96), GeneBank accession No: AB209647(NCF2, Neutrophil cytosolic factor 2(65kDa, chronic granulomatous disease, autosomal 2)), GeneBank accession No: NM_152221(CSNK1E, Casein kinase 1, epsilon), GeneBank accession No: NM_017999 (RNF31 , Ring finger protein 31), GeneBank accession No: NM_016819 (OGGl , 8-oxoguanine DNA glycosylase) , GeneBank accession No: NM_016816 (OASl , 2 ',5'- oligoadenylate synthetase 1, 40/46kDa), GeneBank accession No: NM_012235 (SCAP, SREBP cleavage-activating protein), GeneBank accession No: NM_006384 (CIBl , Calcium and integrin binding 1 (calmyrin) ) , GeneBank accession No: NM_001779 (CD58 , CD58 antigen, ( lymphocyte function-associated antigen 3)), GeneBank accession No: CB055213 ( ICOSLG, Inducible T-cell co-stimulator ligand) , GeneBank accession No: BX641029 (MASPl, Mannan-binding lectin serine peptidase 1(C4/C2 activating component of Ra-reactive factor)), GeneBank accession No: BQ053419 (BATF, Basic leucine zipper transcription factor, ATF-like), GeneBank accession No: BC039299 (STIPl, Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein)), GeneBank accession No: AY055760 (DAF, Decay accelerating factor for complement (CD55 , Cromer blood group system)), GeneBank accession No: AK130188 (FGR, Gardner-Rasheed feline sarcoma viral(v-fgr) oncogene homolog), GeneBank accession No: AK095326 (MUS81 , MUS81 endonuclease homolog(yeast ) ) , GeneBank accession No: NM_017670 (OTUBl, OTU domain, ubiquitin aldehyde binding 1), GeneBank accession No: NM_003004 ( SECTMl , Secreted and transmembrane 1), GeneBank accession No: NM_002309 (LIF, Hypothetical protein MGC20647), GeneBank accession No: NM_001421 (ELF4, E74-like factor 4(ets domain transcription factor)), GeneBank accession No: NM_000418 ( IL4R, Interleukin 4 receptor), GeneBank accession No: BI909222 (FCERlG, Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide), GeneBank accession No: BF569086 (NK4, Interleukin 32), GeneBank accession No: BC014470(AZGPl, Alpha-2-glycoprotein 1, zinc), GeneBank accession No: BC020744 (AKR1C4 , Aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol ) , dehydrogenase 4), GeneBank accession No: BQ939577 ( AKR1C3 , Aldo-keto reductase family 1, member C3( 3-alpha hydroxysteroid dehydrogenase, type H)), GeneBank accession No: NM_000499 (CYPlAl , Cytochrome P450, family 1, subfamily A, polypeptide 1), GeneBank accession No: NM_030622 (CYP2S1 , Cytochrome P450, family 2, subfamily S, polypeptide 1), GeneBank accession No: NM_184041 (ALDOA, Aldolase A, fructose-bisphosphate ) , GeneBank accession No: NM_024307 (MGC4171 , Hypothetical protein LOC283901), GeneBank accession No: NM_005336 (HDLBP, High density lipoprotein binding protein( vigilin) ) , GeneBank accession No: NM_002627 (PFKP, Phosphofructokinase, platelet), GeneBank accession No: BX648281 (LDLR, Low density lipoprotein receptor ( familial hypercholesterolemia)), GeneBank accession No: BC069201(FLJ22761, Hexokinase domain containing 1), GeneBank accession No: BC030207 (NR0B2 , Nuclear receptor subfamily 0, group B, member 2), GeneBank accession No: AL833O69(KIAA1434, Hypothetical protein KIAA1434), GeneBank accession No: AK124656 (ENO2 , Enolase 2(gamma, neuronal)), GeneBank accession No: AK094474 (RHOC, Ras homolog gene family, member C), GeneBank accession No: AK093461 ( ISYNAl , Myo-inositol 1-phosphate synthase Al), GeneBank accession No: AB053232(GAL3ST3, Galactose-3-O-sulfotransferase 3), GeneBank accession No: AB045292 (TMEM8 , Transmembrane protein 8 (five membrane-spanning domains)), GeneBank accession No: NM_004753 (DHRS3 , Dehydrogenase/reductase ( SDR family) member 3), GeneBank accession No: NM_002900 (RBP3 , Retinol binding protein 3, interstitial), GeneBank accession No: NM_001995 (ACSLl , Acyl-CoA synthetase long- chain family member 1), GeneBank accession No: NM_000018 ( ACADVL , Acyl-Coenzyme A dehydrogenase, very long chain), GeneBank accession No: BC094756 (CRA, Myotubularin related protein 11), GeneBank accession No: BC050553 (NTE, Neuropathy target esterase), GeneBank accession No: BC033110(HSD17Bl, Hydroxysteroid( 17-beta) dehydrogenase 1), GeneBank accession No: AY268890 (TPPl , Tripeptidyl peptidase I), GeneBank accession No: AK172798 (CPTlA, Carnitine palmitoyltransferase lA(liver)), GeneBank accession No: AK096809(CYP4F8, Cytochrome P450, family 4, subfamily F, polypeptide 8), GeneBank accession No: AK000600 (SIAT7D, ST6 ( alpha-N-acetyl-neuraminyl-2 , 3-beta- galactosyl-1 , 3 ) -N- acetylgalactosaminide alpha-2 , 6-sialyltransferase 4), GeneBank accession No: AB002454 (CYP4F3 , Cytochrome P450, family 4, subfamily F, polypeptide 3), GeneBank accession No: Z29093 (DDRl, Discoidin domain receptor family, member 1), GeneBank accession No: Z25424 (MKNK2 , MAP kinase interacting serine/threonine kinase 2), GeneBank accession No: XM_291277(DKFZp761P0423, Hypothetical protein DKFZp76lP0423) , GeneBank accession No: XM_038150 (MAST3 , Microtubule associated serine/threonine kinase 3), GeneBank accession No: U88357 (ERBB3 , V-erb-b2 erythroblastic leukemia viral oncogene homolog 3(avian)), GeneBank accession No: NM_025195 (TRIBl , Tribbles homolog l(Drosophila) ) , GeneBank accession No: NM_020639 (RIPK4 , Receptor-interacting serine-threonine kinase 4), GeneBank accession No: NM_014172 (PHPTl , Phosphohistidine phosphatase 1), GeneBank accession No: NM_006254 (PRKCD, Protein kinase C, delta), GeneBank accession No: NM_005415 ( SLC20A1 , Solute carrier family 20 (phosphate transporter), member 1), GeneBank accession No: NM_005026 (PIK3CD, Phosphoinositide- 3-kinase, catalytic, delta polypeptide), GeneBank accession No: NM_004431(EPHA2, EPH receptor A2 ) , GeneBank accession No: NM_004419(DUSP5, Dual specificity phosphatase 5), GeneBank accession No: NM_004327 (BCR, Breakpoint cluster region), GeneBank accession No: NM_004231 (ATP6V1F, ATPase, H+ transporting, lysosomal 14kDa, Vl subunit F), GeneBank accession No: NM_004090 (DUSP3 , Dual specificity phosphatase 3 (vaccinia virus phosphatase VHl-related) ) , GeneBank accession No: NM_002843 (PTPRJ, Protein tyrosine phosphatase, receptor type, J), GeneBank accession No: NM_002496 (NDUFS8 , NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa(NADH- coenzyme Q reductase)), GeneBank accession No: NM_001001852(PIM3, Pim-3 oncogene), GeneBank accession No: L76191 ( IRAKI, Interleukin-1 receptor-associated kinase 1), GeneBank accession No: D15049 (PTPRH, Protein tyrosine phosphatase, receptor type, H), GeneBank accession No: BC065207(ATP6V0D2, ATPase, H+ transporting, lysosomal 38kDa, VO subunit d isoform 2), GeneBank accession No: BC035578(STK24, Serine/threonine kinase 24(STE20 homolog, yeast)), GeneBank accession No: BC028724 (DUSP18 , Dual specificity phosphatase 18), GeneBank accession No: AL117482(ULK3, Unc-51-like kinase 3(C. elegans)), GeneBank accession No: AK126879 (PCTK3 , PCTAIRE protein kinase 3), GeneBank accession No: AB209416 ( ILK, Integrin-linked kinase-2), GeneBank accession No: NM_000782 (CYP24A1 , Cytochrome P450, family 24, subfamily A, polypeptide 1), GeneBank accession No: CR597101 ( ZFP36 , Zinc finger protein 36, C3H type, homolog (mouse )), GeneBank accession No: CR936799(FHL2, Four and a half LIM domains 2), GeneBank accession No: M24898 (NRlDl , Nuclear receptor subfamily 1, group D, member 1), GeneBank accession No: AF132818 (KLF5 , Kruppel-like factor 5 ( intestinal )), GeneBank accession No: AK055337(ZNF213, Zinc finger protein 213), GeneBank accession No: BC008834 (PHFl , PHD finger protein 1), GeneBank accession No: AK126918 (GLIS2 , GLIS family zinc finger 2), GeneBank accession No: BC042692 (CTL2 , Solute carrier family 44, member 2), GeneBank accession No: NM_002224(ITPR3, Inositol 1 , 4 , 5-triphosphate receptor, type 3), GeneBank accession No: AK095363 (AQP3, Aquaporin 3), GeneBank accession No: NM_174953 (ATP2A3 , ATPase, Ca++ transporting, ubiquitous), GeneBank accession No: BC042390 (VTIlB, Vesicle transport through interaction with t-SNAREs homolog lB(yeast)), GeneBank accession No: NM_016113 ( TRPV2 , Transient receptor potential cation channel, subfamily V, member 2), GeneBank accession No: BM926478 (RBPl, Retinol binding protein 1, cellular), GeneBank accession No: NM_000069 (CACNAlS, Calcium channel, voltage-dependent, L type, alpha IS subunit), GeneBank accession No: AK002107 (RAB3B, RAB3B, member RAS oncogene family), GeneBank accession No: NM_013321 ( SNX8 , Sorting nexin 8), GeneBank accession No: AK125026 ( SLC6A12 , Solute carrier family 6 (neurotransmitter transporter, betaine/GABA) , member 12), GeneBank accession No: NM_005843(STAM2, Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2), GeneBank accession No: AK092512 (SLC16A5, Solute carrier family 16 (monocarboxylic acid transporters), member 5), GeneBank accession No: U49248(ABCC2, ATP-binding cassette, sub-family C(CFTR/MRP), member 2), GeneBank accession No: AK172792 ( SCNNlA, Sodium channel, nonvoltage-gated 1 alpha), GeneBank accession No: BC044656(CASC3, Cancer susceptibility candidate 3), GeneBank accession No: NM_203403 (C9orf 150 , Chromosome 9 open reading frame 150), GeneBank accession No: NM_080388(S100A16, SlOO calcium binding protein A16), GeneBank accession No: NM_031286 ( SH3BGRL3 , SH3 domain binding glutamic acid-rich protein like 3), GeneBank accession No: NM_022153 (PP2135 , Chromosome 10 open reading frame 54), GeneBank accession No: NM_004864 (GDF15 , Growth differentiation factor 15), GeneBank accession No: NM_003330 (TXNRDl, Thioredoxin reductase 1), GeneBank accession No: NM_001013632 (LOC343521 , Similar to hypothetical protein 4833401D15), GeneBank accession No: BX537968(LOC51149, Hypothetical LOC51149), GeneBank accession No: BU945318 (MT2A, Hypothetical gene supported by X97260; BC070289), GeneBank accession No: BQ683841 ( SlOOAIl , SlOO calcium binding protein All (calgizzarin) ) , GeneBank accession No: BQ276852 (TMSBlO , Thymosin, beta 10), GeneBank accession No: AK126182 (KIAA1949 , KIAA1949), GeneBank accession No: AK124751 (CAPN2 , Calpain 2,(m/II) large subunit), GeneBank accession No: AK095079 (RGC32 , Response gene to complement 32), GeneBank accession No: AB075871(FLJ42654, Golgi transport 1 homolog A(S. cerevisiae ) ) , GeneBank accession No: AK125150 (MAPK8 , Mitogen-activated protein kinase 8), GeneBank accession No: NM_002758 (MAP2K6, Mitogen-activated protein kinase kinase 6), GeneBank accession No: NM_004612 (TGFBRl , Transforming growth factor, beta receptor I(activin A receptor type II- like kinase, 53kDa)), GeneBank accession No: NM_145686 (MAP4K4 , Mitogen-activated protein kinase kinase kinase kinase 4), GeneBank accession No: XM_042066 (MAP3K1 , Mitogen-activated protein kinase kinase kinase 1 ) , GeneBank accession No: AB011123 (TNIK, TRAF2 and NCK interacting kinase), GeneBank accession No: AB209031(C5, Complement component 5), GeneBank accession No: NM_022740 (HIPK2 , Homeodomain interacting protein kinase 2 ) , GeneBank accession No: NM_148957 (TNFRSF19 , Tumor necrosis factor receptor superfamily, member 19), GeneBank accession No: AB208909(ITGB2, Integrin, beta 2(antigen CDl8(p95), lymphocyte function-associated antigen 1; macrophage antigen l(mac-l) beta subunit)), GeneBank accession No: AB209211 (TIAl, TIAl cytotoxic granule-associated RNA binding protein), GeneBank accession No: AB209613 (DNASE1L3 , Deoxyribonuclease I-like 3), GeneBank accession No: AK122825 (HMGBl, High-mobility group box 1), GeneBank accession No: AK127326 (PHF17 , PHD finger protein 17), GeneBank accession No: AK223503 (CASPl , Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) ) , GeneBank accession No: BC013326 (GAS2 , Growth arrest-specific 2), GeneBank accession No: BC047698 ( IL7 , Interleukin I)1 GeneBank accession No: D79987 (ESPLl , Extra spindle poles like 1(S. cerevisiae) ) , GeneBank accession No: NM_000893 (KNGl, Kininogen 1), GeneBank accession No: NM_001012271(BIRC5, Effector cell peptidase receptor 1), GeneBank accession No: NM_004938 (DAPKl , Death-associated protein kinase 1), GeneBank accession No: NM_005879 (TRIP, TRAF interacting protein), GeneBank accession No: NM_014739 (BCLAFl, BCL2-associated transcription factor 1), GeneBank accession No: NM_018947 (CYCS , Cytochrome c, somatic), GeneBank accession No: AB033337 (MPHOSPHl , M-phase phosphoprotein 1), GeneBank accession No: AB209179 (PLKl , Polo-like kinase 1 (Drosophila) ) , GeneBank accession No: AB209337(CDC7, CDC7 cell division cycle 7(S. cerevisiae ) ) , GeneBank accession No: AF053305 (BUBl , BUBl budding uninhibited by benzimidazoles 1 homolog( yeast ) ) , GeneBank accession No: AF053306 (BUBlB, BUBl budding uninhibited by benzimidazoles 1 homolog beta(yeast ) ) , GeneBank accession No: AF345347 (SPAG5, Sperm associated antigen 5), GeneBank accession No: AK092638 (CCNG2 , Cyclin G2 ) , GeneBank accession No: AK222819 (NUSAPl , Nucleolar and spindle associated protein 1), GeneBank accession No: AL833191 (SMC2L1, SMC2 structural maintenance of chromosomes 2-like l(yeast)), GeneBank accession No: AY257469 (CIT, Citron(rho-interacting, serine/threonine kinase 21)), GeneBank accession No: AY367065 (ASPM, Asp( abnormal spindle) -like, microcephaly associated(Drosophila) ) , GeneBank accession No: BCOIlOOO (CDCA5 , Cell division cycle associated 5), GeneBank accession No: BC032677 (UBE2C, Ubiquitin-conjugating enzyme E2C), GeneBank accession No: BC043502 (NEK2, NIMA(never in mitosis gene a)-related kinase 2), GeneBank accession No: BU675073 (PTTGl , Pituitary tumor- transforming 1), GeneBank accession No: BX647885 ( STMNl , Stathmin 1/oncoprotein 18), GeneBank accession No: CR592757 (BRRNl, Barren homolog 1 (Drosophila) ), GeneBank accession No: CR597075 (MAPRE2 , Microtubule-associated protein, RP/EB family, member 2), GeneBank accession No: CR604810(CCNA2, Cyclin A2 ) , GeneBank accession No: CR933728(CDC2, Cell division cycle 2, Gl to S and G2 to M), GeneBank accession No: NM_000919 (PAM, Peptidylglycine alpha-amidating monooxygenase ) , GeneBank accession No: NM_001790(CDC25C, Cell division cycle 25C), GeneBank accession No: NM_001798 (CDK2 , Cyclin-dependent kinase 2), GeneBank accession No: NM_001813 (CENPE, Centromere protein E, 312kDa), GeneBank accession No: NM_003318 (TTK, TTK protein kinase), GeneBank accession No: NM_003981 (PRCl , Protein regulator of cytokinesis 1), GeneBank accession No: NM_004523 (KIFlI, Kinesin family member 11), GeneBank accession No: NM_004701 (CCNB2 , Cyclin B2 ) , GeneBank accession No: NM_005983 ( SKP2 , S-phase kinase-associated protein 2(p45)), GeneBank accession No: NM_006101 (KNTC2 , Kinetochore associated 2), GeneBank accession No: NM_006845(KIF2C, Kinesin family member 2C), GeneBank accession No: NM_007375 ( TARDBP , TAR DNA binding protein), GeneBank accession No: NM_012112 (TPX2 , TPX2 , microtubule- associated, homolog(Xenopus laevis)), GeneBank accession No: NM_014750(DLG7, Discs, large homolog 7 ( Drosophila) ) , GeneBank accession No: NM_015097 (CLASP2 , Cytoplasmic linker associated protein 2), GeneBank accession No: NM_016343 (CENPF, Centromere protein F, 350/400ka(mitosin) ) , GeneBank accession No: NM_016426 (GTSEl , G-2 and S-phase expressed 1), GeneBank accession No: NM_018492 (PBK, PDZ binding kinase), GeneBank accession No: NM_018685 (ANLN, Anillin, actin binding protein ( scraps homolog, Drosophila) ) , GeneBank accession No: NM_020242 (KNSL7 , Kinesin family member 15), GeneBank accession No: NM_031966 (CCNBl , Cyclin Bl), GeneBank accession No: NM_138555 (KIF23, Kinesin family member 23), GeneBank accession No: U65410 (MAD2L1 , MAD2 mitotic arrest deficient-like l(yeast)), GeneBank accession No: AB020656 (CYLD, Cylindromatosis ( turban tumor syndrome)), GeneBank accession No: AF033122 ( SESNl , Sestrin 1), GeneBank accession No: AK074377 (UHRFl , Chromosome 19 open reading frame 31), GeneBank accession No: AK091170 (CDKN2C, Cyclin- dependent kinase inhibitor 2C(pl8, inhibits CDK4 ) ) , GeneBank accession No: AK094323 (NFYC, Nuclear transcription factor Y, gamma), GeneBank accession No: AY366508 (LOH11CR2A, Loss of heterozygosity, 11, chromosomal region 2, gene A), GeneBank accession No: BC033086 (TCF19 , Transcription factor 19(SCl)), GeneBank accession No: BC040303 (PTP4A1 , Protein tyrosine phosphatase type IVA, member 1), GeneBank accession No: BC040991 (TFDP2 , Transcription factor Dp-2(E2F dimerization partner 2)), GeneBank accession No: BC092412(SGOL2, Shugoshin-like 2(S. pombe)), GeneBank accession No: BQ278454 (CKSlB, CDC28 protein kinase regulatory subunit IB), GeneBank accession No: BX649128(SESN3, Sestrin 3), GeneBank accession No: CD049340(AURKB, Aurora kinase B), GeneBank accession No: M89914(NFl, Neurofibromin ^neurofibromatosis, von Recklinghausen disease, Watson disease)), GeneBank accession No: NM_001005414 ( ZWINT, ZWlO interactor antisense), GeneBank accession No: NM_001008491 ( Sep 2, Septin 2), GeneBank accession No: NM_001274 (CHEKl , CHKl checkpoint homolog(S. pombe)), GeneBank accession No: NM_002105(H2AFX, H2A histone family, member X), GeneBank accession No: NM_002388 (MCM3 , MCM3 minichromosome maintenance deficient 3(S. cerevisiae) ) , GeneBank accession No: NM_OO2417(MKI67, Antigen identified by monoclonal antibody Ki-67), GeneBank accession No: NM_002875 (RAD51 , RAD51 homolog(RecA homolog, E. coli)(S. cerevisiae)), GeneBank accession No: NM_003884 (PCAF, P300/CBP-associated factor), GeneBank accession No: NM_004526 (MCM2 , MCM2 minichromosome maintenance deficient 2, mitotin(S. cerevisiae)), GeneBank accession No: NM_004847 (AIFl , Allograft inflammatory factor 1), GeneBank accession No: NM_005915(MCM6, MCM6 minichromosome maintenance deficient 6(MIS5 homolog, S. pombe) (S. cerevisiae)), GeneBank accession No: NM_012090 (MACFl , Microtubule-actin crosslinking factor 1), GeneBank accession No: NM_012415(RAD54B, RAD54 homolog B(S. cerevisiae)), GeneBank accession No: NM_014264 (PLK4 , Polo-like kinase 4(Drosophila) ) , GeneBank accession No: NM_015714 (G0S2 , GO/Glswitch 2), GeneBank accession No: NM_024680 (FLJ23311 , E2F transcription factor 8), GeneBank accession No: XM_034274 (MYBLl, V-myb myeloblastosis viral oncogene homolog( avian) -like 1), GeneBank accession No: AKOO172O(FLJ1O858, Nei endonuclease Vlll-like 3(E. coli)), GeneBank accession No: AY032677 (POLQ, Polymerase ( DNA directed), theta), GeneBank accession No: BC034480 (BLM, Bloom syndrome), GeneBank accession No: BC073161 (RAD51C, RAD51 homolog C(S. cerevisiae ) ) , GeneBank accession No: CR600021(HMGB2, High-mobility group box 2), GeneBank accession No: CR625391 (RAD51AP1 , RAD51 associated protein 1), GeneBank accession No: CR936783 (FLJ40869 , Hypothetical protein LOC284952), GeneBank accession No: DQ140356 (KIAA1596 , Fanconi anemia, complementation group M), GeneBank accession No: NM_001067 (T0P2A, Topoisomerase (DNA) II alpha 17OkDa), GeneBank accession No: NM_001618 (PARPl , Poly (ADP-ribose ) polymerase family, member 1), GeneBank accession No: NM_003362 (UNG, Uracil-DNA glycosylase ) , GeneBank accession No: NM_006904 (PRKDC, Protein kinase, DNA-activated, catalytic polypeptide), GeneBank accession No: NM_130398 (EXOl , Exonuclease 1), GeneBank accession No: AB020807 (TLR6, Toll-like receptor 6), GeneBank accession No: AB032980 (DCDC2 , Doublecortin domain containing 2), GeneBank accession No: AB209866 (TFPI , Tissue factor pathway inhibitor ( lipoprotein-associated coagulation inhibitor)), GeneBank accession No: AK057015 (HSPA4 , Heat shock 7OkDa protein 4), GeneBank accession No: AK095515 ( IFITl , Interferon-induced protein with tetratricopeptide repeats 1), GeneBank accession No: AK122686(IF, I factor ( complement )), GeneBank accession No: AK123010 (RRM2 , Ribonucleotide reductase M2 polypeptide), GeneBank accession No: BC035582 (TRIM22 , Tripartite motif-containing 22), GeneBank accession No: BX537894 (LOC493869 , Similar to RIKEN cDNA 2310016C16), GeneBank accession No: M14338 (PROSl , Protein S(alpha)), GeneBank accession No: NM_000821 (GGCX, Gamma-glutamyl carboxylase), GeneBank accession No: NM_000963(PTGS2, Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase ) ) , GeneBank accession No: NM_001001547 (CD36, CD36 antigen(collagen type I receptor, thrombospondin receptor)), GeneBank accession No: NM_001512 (GSTA4, Glutathione S-transferase A4 ) , GeneBank accession No: NM_001629 ( AL0X5AP, Arachidonate 5- lipoxygenase-activating protein), GeneBank accession No: NM_001752(CAT, Catalase), GeneBank accession No: NM_001837(CCR3, Chemokine(C-C motif) receptor 3), GeneBank accession No: NM_001979 (EPHX2 , Epoxide hydrolase 2, cytoplasmic), GeneBank accession No: NM_001994 ( F13B, Coagulation factor XIII, B polypeptide), GeneBank accession No: NM_002182 (ILlRAP, Interleukin 1 receptor accessory protein), GeneBank accession No: NM_006120 (HLA-DMA, Major histocompatibility complex, class II, DM alpha), GeneBank accession No: NM_173216 ( SIATl , ST6 beta-galactosamide alpha-2 , 6-sialyltranferase 1), GeneBank accession No: NM_202002 (FOXMl, Forkhead box Ml), GeneBank accession No: AB163917 (LRAP, Leukocyte-derived arginine aminopeptidase) , GeneBank accession No: BC027881 ( AFP, Alpha-fetoprotein) , GeneBank accession No: NM_015915 ( SPG3A, Spastic paraplegia 3A(autosomal dominant)), GeneBank accession No: NM_000671(ADH5, Alcohol dehydrogenase 5 (class III), chi polypeptide), GeneBank accession No: J05428 (UGT2B7 , UDP glucuronosyltransferase 2 family, polypeptide B7), GeneBank accession No: NM_000672 ( ADH6 , Alcohol dehydrogenase 6 (class V)), GeneBank accession No: M15943(ADH4, Alcohol dehydrogenase 4 (class II), pi polypeptide), GeneBank accession No: AK223395 (FBPl , Fructose-1 , 6-bisphosphatase 1), GeneBank accession No: NM_000151 (G6PC, Glucose-6- phosphatase, catalytic (glycogen storage disease type I, von Gierke disease)), GeneBank accession No: XM_113962 (KIAA0650 , Structural maintenance of chromosomes flexible hinge domain containing 1), GeneBank accession No: AB020644 (ACSL6 , Acyl- CoA synthetase long-chain family member 6), GeneBank accession No: AB209907 (PLDl , Phospholipase Dl, phophatidylcholine-specific ) , GeneBank accession No: AF285167 (ABCAl, ATP-binding cassette, sub-family A(ABCl), member 1), GeneBank accession No: AF297872 (TRERFl , Transcriptional regulating factor 1), GeneBank accession No: AF303134(ALDH8Al, Aldehyde dehydrogenase 8 family, member Al), GeneBank accession No: AF339053 (PLA2G12B, Phospholipase A2 , group XIIB), GeneBank accession No: AK096018 (HADHSC, L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain), GeneBank accession No: AK124635 (PCSK9 , Proprotein convertase subtilisin/kexin type 9), GeneBank accession No: AK127346 ( SIAT9 , ST3 beta-galactoside alpha- 2 , 3-sialyltransferase 5), GeneBank accession No: AL359559 (AGPS, Alkylglycerone phosphate synthase), GeneBank accession No: AY691170 (PLCL3 , Phospholipase C-like 3), GeneBank accession No: BG567934 (APOM, Apolipoprotein M), GeneBank accession No: BX538214 (C6orf 167 , Chromosome 6 open reading frame 167), GeneBank accession No: BX640945 (FADS2 , Fatty acid desaturase 2), GeneBank accession No: BX648473(PIGK, Phosphatidylinositol glycan, class K), GeneBank accession No: BX648557 ( HSD17B2 , Hydroxysteroid( 17- beta) dehydrogenase 2), GeneBank accession No: CR749601 (ETNKl, Death-associated protein kinase 3), GeneBank accession No: NM_000859 (HMGCR, 3-hydroxy-3- methylglutaryl-Coenzyme A reductase), GeneBank accession No: NM_001443 (FABPl, Fatty acid binding protein 1, liver), GeneBank accession No: NM_002130 (HMGCSl , 3-hydroxy-3- methylglutaryl-Coenzyme A synthase l(soluble)), GeneBank accession No: NM_003725 (RODH, Hydroxysteroid ( 17-beta ) dehydrogenase 6), GeneBank accession No: NM_004845 (PCYTlB, Phosphate cytidylyltransferase 1, choline, beta), GeneBank accession No: NM_014762 (DHCR24 , 24-dehydrocholesterol reductase), GeneBank accession No: NM_020139 (DHRS6 , Dehydrogenase/reductase ( SDR family) member 6), GeneBank accession No: NM_020918 (GPAM, Glycerol-3-phosphate acyltransferase, mitochondrial), GeneBank accession No: NM_032523(OSBPL6, Oxysterol binding protein-like 6), GeneBank accession No: NM_033505 ( SELI , Selenoprotein I), GeneBank accession No: Z28339 (AKRlDl , Aldo-keto reductase family 1, member Dl (delta 4-3-ketosteroid-5-beta- reductase)), GeneBank accession No: AK024899 (ENPP3 , Ectonucleotide pyrophosphatase/phosphodiesterase 3), GeneBank accession No: AK025546 (PTPN4 , Protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte )), GeneBank accession No: AK124910 (ENPP2 , Ectonucleotide pyrophosphatase/phosphodiesterase 2 ( autotaxin) ) , GeneBank accession No: BC035116 (FLJ35059 fis, CDNA FLJ30761 fis, clone FEBRA2000538 ) , GeneBank accession No: BC050565 (PASK, PAS domain containing serine/threonine kinase), GeneBank accession No: L13436 (NPR2 , Natriuretic peptide receptor B/guanylate cyclase B(atrionatriuretic peptide receptor B)), GeneBank accession No: NM_001005862 (ERBB2 , V-erb-b2 erythroblastic leukemia viral oncogene homolog 2 , neuro/glioblastoma derived oncogene homolog( avian) ), GeneBank accession No: NM_005012 (RORl , Receptor tyrosine kinase-like orphan receptor 1), GeneBank accession No: NM_006035(CDC42BPB, CDC42 binding protein kinase beta(DMPK- like)), GeneBank accession No: NM_014791 (MELK, Maternal embryonic leucine zipper kinase), GeneBank accession No: NM_023028(FGFR2, Fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer yndrome, Jackson-Weiss syndrome)), GeneBank accession No: NM_080836 (STK35 , Serine/threonine kinase 35), GeneBank accession No: AF419331 (FUSIPl , FUS interacting protein ( serine/arginine-rich) 1), GeneBank accession No: AK091927 (SFRS3, Splicing factor, arginine/serine-rich 3), GeneBank accession No: BCO 10266 (HNRNPAl , Heterogeneous nuclear ribonucleoprotein Al), GeneBank accession No: BC012360(CTAGE5, CTAGE family, member 5), GeneBank accession No: BC036046 (PLRGl , Pleiotropic regulator 1(PRLl homolog, Arabidopsis ) ) , GeneBank accession No: BC065384 (PCFIl, PCFlI, cleavage and polyadenylation factor subunit, homolog(S. cerevisiae ) ) , GeneBank accession No: BX537360 (CPSF5, Nudix(nucleoside diphosphate linked moiety X) -type motif 21), GeneBank accession No: BX537494 (HNRPA2B1 , Heterogeneous nuclear ribonucleoprotein A2/B1), GeneBank accession No: BX647784 (HNRPR, Heterogeneous nuclear ribonucleoprotein R), GeneBank accession No: CA455267 (PPIH, Peptidyl prolyl isomerase H(cyclophilin H)), GeneBank accession No: CR596214 (HNRPAO , Heterogeneous nuclear ribonucleoprotein AO), GeneBank accession No: NM_001326(CSTF3, Hypothetical protein LOC283267), GeneBank accession No: NM_004640 (BATl , HLA-B associated transcript 1), GeneBank accession No: NM_005463 (HNRPDL, Heterogeneous nuclear ribonucleoprotein D-like), GeneBank accession No: NM_006924 (SFRSl, Splicing factor, arginine/serine-rich 1( splicing factor 2, alternate splicing factor)), GeneBank accession No: NM_012426 ( SF3B3 , Splicing factor 3b, subunit 3, 13OkDa), GeneBank accession No: NM_018048 (FLJ10292 , Mago-nashi homolog) , GeneBank accession No: NM_030919(C20orf 129, Chromosome 20 open reading frame 129), GeneBank accession No: NM_031370 (HNRPD, Heterogeneous nuclear ribonucleoprotein D(AU-rich element RNA binding protein 1, 37kDa) ) , GeneBank accession No: NM_138933 ( ACF, Apobec-1 complementation factor), GeneBank accession No: AB193259(ACE2 , Angiotensin I converting enzyme (peptidyl- dipeptidase A) 2), GeneBank accession No: BX648769 (EWSRl , Ewing sarcoma breakpoint region 1), GeneBank accession No: AB023154(DTX4, Deltex 4 homolog (Drosophila) ), GeneBank accession No: AL543755 ( VAV3 , Vav 3 oncogene), GeneBank accession No: M75106(CPB2, Carboxypeptidase B2 (plasma, carboxypeptidase U)), GeneBank accession No: NM_021045(ZNF248, Zinc finger protein 248), GeneBank accession No: AB209194 (B4GALT6 , UDP-GaI :betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6), GeneBank accession No: AF279145 (ANTXRl , Anthrax toxin receptor 1), GeneBank accession No: NM_025074 (FRASl , Fraser syndrome 1), GeneBank accession No: AK025790 (KIF20A, Kinesin family member 20A), GeneBank accession No: NM_006152 (LRMP, Lymphoid-restricted membrane protein), GeneBank accession No: NM_000340(SLC2A2, Solute carrier family 2 ( facilitated glucose transporter), member 2), GeneBank accession No: AF071592 (KIF4A, Kinesin family member 4A), GeneBank accession No: NM_013277 (RACGAPl, Rac GTPase activating protein 1), GeneBank accession No: AY043484 ( SCNlA, Sodium channel, voltage-gated, type I, alpha), GeneBank accession No: AY791349(KIF18A, Kinesin family member 18A), GeneBank accession No: NM_018018 ( SLC38A4 , Solute carrier family 38, member 4), GeneBank accession No: AK094603 (FLJ37284 fis, unnamed protein product; Homo sapiens cDNA FLJ37284 fis, clone BRAMY2013590. ) , GeneBank accession No: NM_021069(ARGBP2, Sorbin and SH3 domain containing 2), GeneBank accession No: NM_001005747 (CACNB4 , Calcium channel, voltage-dependent, beta 4 subunit), GeneBank accession No: AJ496568(SLC25A12, Solute carrier family 25 (mitochondrial carrier, Aralar), member 12), GeneBank accession No: NM_030641 (APOL6, Apolipoprotein L, 6), GeneBank accession No: NM_173512(FLJ39822, Hypothetical protein FLJ39822), GeneBank accession No: NM_000037 (ANKl , Ankyrin 1, erythrocytic), GeneBank accession No: NM_001011554 ( SLC13A3 , Solute carrier family 13 ( sodium-dependent dicarboxylate transporter), member 3), GeneBank accession No: AB091343(C10orf3, Centrosomal protein 55kDa) , GeneBank accession No: AK000643 (ASB9 , Ankyrin repeat and SOCS box- containing 9), GeneBank accession No: AK055221 (FBXO5 , F-box protein 5), GeneBank accession No: AK075271 ( SPTLC2L, Serine palmitoyltransferase, long chain base subunit 2- like ( aminotransferase 2)), GeneBank accession No: AK122685 (GLUDl, Glutamate dehydrogenase 1), GeneBank accession No: AK127098 (FLJ10706 , Chromosome 1 open reading frame 112), GeneBank accession No: AL133031 (MLRl , Transcription factor MLRl), GeneBank accession No: AY007723(MAL2, MaI, T-cell differentiation protein 2), GeneBank accession No: BC022255 ( Spc25 , Spindle pole body- component 25 homolog(S. cerevisiae) ) , GeneBank accession No: BC041882(ATF7IP2, Activating transcription factor 7 interacting protein 2), GeneBank accession No: BC052951 (LMNBl, Lamin Bl), GeneBank accession No: BC098313(FLJ20641, Hypothetical protein FLJ20641), GeneBank accession No: NM_001809 (CENPA, Centromere protein A, 17kDa), GeneBank accession No: NM_145061 (C13orf3 , Chromosome 13 open reading frame 3), GeneBank accession No: XM_372695(LOC390859, PREDICTED: Homo sapiens similar to Chain A, Crystal Structure Of The R463a Mutant Of Human Glutamate Dehydrogenase (LOC390859 ), mRNA) . [Claim 7] The method according to claim 6, wherein the below genes are up-regulated by exposure to phenanthrene : GeneBank accession No: NM_004420 (DUSP8 , Dual specificity phosphatase 8), GeneBank accession No: L11329(DUSP2, Dual specificity phosphatase 2), GeneBank accession No: BC094766 (PKNl , Protein kinase Nl), GeneBank accession No: AY247738 (TRIB3 , Tribbles homolog 3(Drosophila) ) , GeneBank accession No: AK129595 (GADD45B, Growth arrest and DNA-damage-inducible, beta), GeneBank accession No: AB208849 (SHCl , SHC (Src homology 2 domain containing) transforming protein 1), GeneBank accession No: X02812 (TGFBl , Transforming growth factor, beta l(Camurati- Engelmann disease) ), GeneBank accession No: NM__198951 (TGM2 , Transglutaminase 2(C polypeptide, protein-glutamine-gamma- glutamyltransferase) ), GeneBank accession No: NM_147780(CTSB, Cathepsin B), GeneBank accession No: NM_078467 (CDKNlA, Cyclin-dependent kinase inhibitor lA(p21, Cipl)), GeneBank accession No: NM_033027 (AXUDl , AXINl up- regulated 1), GeneBank accession No: NM_032797 ( AMID, Apoptosis-inducing factor (AIF) -like mitochondrion- associated inducer of death), GeneBank accession No: NM_021960 (MCLl, Myeloid cell leukemia sequence 1(BCL2- related)), GeneBank accession No: NM_016639 (TNFRSF12A, Tumor necrosis factor receptor superfamily, member 12A) , GeneBank accession No: NM_016222 ( DDX41 , DEAD( Asp-Glu-Ala- Asp) box polypeptide 41), GeneBank accession No: NM_013246(CLC, Cardiotrophin-like cytokine factor 1), GeneBank accession No: NM_004401 (DFFA, DNA fragmentation factor, 45kDa, alpha polypeptide), GeneBank accession No: NM_004281(BAG3, BCL2-associated athanogene 3), GeneBank accession No: NM_003897 ( IER3 , Immediate early response 3), GeneBank accession No: NM_003806 (HRK, Harakiri, BCL2 interacting protein (contains only BH3 domain)), GeneBank accession No: NM_003639 ( IKBKG, Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma), GeneBank accession No: NM_003311 (PHLDA2 , Pleckstrin homology-like domain, family A, member 2), GeneBank accession No: NM_002737 (PRKCA, Protein kinase C, alpha), GeneBank accession No: NM_002648 (PIMl , Pim-1 oncogene), GeneBank accession No: NM_002507 (NGFR, Nerve growth factor receptor (TNFR superfamily, member 16)), GeneBank accession No: NM_002305 (LGALSl, Lectin, galactoside-binding, soluble, l(galectin I)), GeneBank accession No: NM_001013398 ( IGFBP3 , Insulin-like growth factor binding protein 3), GeneBank accession No: BX640923 (MDM4 , Mdm4 , transformed 3T3 cell double minute 4, p53 binding protein (mouse )), GeneBank accession No: BX537586 ( STK17A, Serine/threonine kinase 17a( apoptosis-inducing) ) , GeneBank accession No: BG284742(P8, P8 protein ( candidate of metastasis I)), GeneBank accession No: BE903247 (PDCD6IP, Programmed cell death 6 interacting protein), GeneBank accession No: BC027949(P2RXl, Purinergic receptor P2X, ligand-gated ion channel, 1), GeneBank accession No: BC006365 (PSEN2 , Presenilin 2 (Alzheimer disease 4)), GeneBank accession No: AY869712(PPP1R13L, Protein phosphatase 1, regulatory ( inhibitor ) subunit 13 like), GeneBank accession No: AY028896 (CARDlO, Caspase recruitment domain family, member 10), GeneBank accession No: AK122614 (PPARD, Peroxisome proliferative activated receptor, delta), GeneBank accession No: AK092872 (ERCC2 , Excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)), GeneBank accession No: AK092808 (RRAGC, Ras-related GTP binding C), GeneBank accession No: AJ001898 (GDNF, Glial cell derived neurotrophic factor), GeneBank accession No: AF220656 (PHLDAl , Pleckstrin homology-like domain, family A, member 1), GeneBank accession No: AF055634 (UNC5C, Unc-5 homolog C(C. elegans)), GeneBank accession No: AB209485 (VEGF, Vascular endothelial growth factor), GeneBank accession No: AB096256 (UNC5B, Unc-5 homolog B(C. elegans)), GeneBank accession No: AB007960 ( SH3GLB1 , SH3- domain GRB2-like endophilin Bl), GeneBank accession No: X06374 (PDGFA, Platelet-derived growth factor alpha polypeptide), GeneBank accession No: S62138 (DDIT3 , DNA- damage-inducible transcript 3), GeneBank accession No: NM_078487(CDKN2B, Cyclin-dependent kinase inhibitor 2B(pl5, inhibits CDK4 ) ) , GeneBank accession No: NM_012127 (CIZ 1 , CDKNlA interacting zinc finger protein 1), GeneBank accession No: NM_005883 (APC2 , Adenomatosis polyposis coli 2), GeneBank accession No: NM_004196 (CDKLl , Cyclin- dependent kinase-like 1 (CDC2-related kinase)), GeneBank accession No: NM_003236 (TGFA, Transforming growth factor, alpha), GeneBank accession No: NM_001261 (CDK9 , Cyclin- dependent kinase 9 (CDC2-related kinase)), GeneBank accession No: NM_001007271 (DUSP13 , Dual specificity phosphatase 13), GeneBank accession No: CR749511 (PARC, P53- associated parkin-like cytoplasmic protein), GeneBank accession No: CR623038 ( ID2 , Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein) , GeneBank accession No: CR618371 (EGFR, Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)), GeneBank accession No: BF965144 ( IFITMl , Interferon induced transmembrane protein 1(9-27)), GeneBank accession No: AK127679 (DUSPl , Dual specificity phosphatase 1), GeneBank accession No: AK096276 (CCND3 , Cyclin D3 ) , GeneBank accession No: AB209586 (MAPK13 , Mitogen-activated protein kinase 13), GeneBank accession No: AB209465 (PCTKl , PCTAIRE protein kinase 1), GeneBank accession No: Z19588 (SKIL, SKI-like), GeneBank accession No: NM_020429 (SMURFl, SMAD specific E3 ubiquitin protein ligase 1), GeneBank accession No: NM_014767 ( SPOCK2 , Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2), GeneBank accession No: NM_005979(S100A13, SlOO calcium binding protein A13), GeneBank accession No: NM_005187 (CBFA2T3 , Core-binding factor, runt domain, alpha subunit 2; translocated to, 3), GeneBank accession No: NM_004364 (CEBPA, CCAAT/enhancer binding protein ( C/EBP ), alpha), GeneBank accession No: NM_001769(CD9, CD9 antigen(p24 ) ) , GeneBank accession No: NM_001718(BMP6, Bone morphogenetic protein 6), GeneBank accession No: NM_000641 ( ILIl , Interleukin 11), GeneBank accession No: BX647459 ( SERPINE2 , Serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 2), GeneBank accession No: BQ066037 (RPS19, Ribosomal protein S19), GeneBank accession No: BE791300 (EDFl , Endothelial differentiation-related factor 1), GeneBank accession No: BC038504 (SNFlLK, SNFl-like kinase), GeneBank accession No: AL832287 ( ZAP70 , Zeta-chain(TCR) associated protein kinase 7OkDa), GeneBank accession No: AK125742 (PCGFl, Polycomb group ring finger 1), GeneBank accession No: AK124709 (NDRGl , N-myc downstream regulated gene 1), GeneBank accession No: AB011157 (PTDSR, Phosphatidylserine receptor), GeneBank accession No: NM_013255 (MKLNl, Muskelin 1, intracellular mediator containing kelch motifs), GeneBank accession No: NM_006572 (GNA13 , Guanine nucleotide binding protein (G protein), alpha 13), GeneBank accession No: NM_002211 ( ITGBl , Integrin, beta 1 ( fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2 , MSK12)), GeneBank accession No: CR601067 (PLAUR, Plasminogen activator, urokinase receptor), GeneBank accession No: BC050456 (THBS4 , Thrombospondin 4), GeneBank accession No: AK027389 (CXCL16 , Chemokine (C-X-C motif) ligand 16), GeneBank accession No: AJ132099 (VNNl , Vanin 1), GeneBank accession No: XM_371354 (FLJ10157 , Hypothetical protein FLJ10157), GeneBank accession No: XM_208313(TPM3, Similar to tropomyosin 4), GeneBank accession No: XM_208270 ( ACR, Acrosin-like protease), GeneBank accession No: NM_203353 (PDLIM7, PDZ and LIM domain 7(enigma)), GeneBank accession No: NM_201382 (PLECl , Plectin 1, intermediate filament binding protein 50OkDa), GeneBank accession No: NM_182961 ( SYNEl , Spectrin repeat containing, nuclear envelope 1), GeneBank accession No: NM_181826 (NF2 , Neurofibromin 2 (bilateral acoustic neuroma)), GeneBank accession No: NM_172069 (PLEKHH2 , Pleckstrin homology domain containing, family H(with MyTH4 domain) member 2), GeneBank accession No: NM_022648 (TNS , Tensin 1), GeneBank accession No: NM_017556 (FBLP-I, Filamin binding LIM protein 1), GeneBank accession No: NM_016081 (KIAA0992 , Palladin, cytoskeletal associated protein), GeneBank accession No: NM_006617(NES, Nestin), GeneBank accession No: NM_006262 (PRPH, Peripherin ) , GeneBank accession No: NM_OO51OO(AKAP12, A kinase(PRKA) anchor protein ( gravin) 12), GeneBank accession No: NM_004368 (CNN2 , Calponin 2), GeneBank accession No: NM_003388 (CYLN2 , Cytoplasmic linker 2), GeneBank accession No: NM_003370 (VASP, Vasodilator- stimulated phosphoprotein) , GeneBank accession No: NM_003128(SPTBNl, Spectrin, beta, non-erythrocytic 1), GeneBank accession No: NM_002705 (PPL, Periplakin), GeneBank accession No: NM_002475 (MLClSA, Myosin light chain 1 slow a), GeneBank accession No: NM_002018 (FLII , Flightless I homolog(Drosophila) ) , GeneBank accession No: NM_001465 (FYB, FYN binding protein(FYB-120/130 ) ) , GeneBank accession No: NM_001069(TUBB2, Tubulin, beta 2A), GeneBank accession No: CR625172(MGC8685, Tubulin, beta 2B), GeneBank accession No: CR616919(KRT18, Keratin 18), GeneBank accession No: CR606241 (ACTGl, Actin, gamma 1), GeneBank accession No: CB240572 (MYHIl, Myosin, heavy polypeptide 11, smooth muscle), GeneBank accession No: BX648253 (PTPN3 , Protein tyrosine phosphatase, non-receptor type 3), GeneBank accession No: BX648190 (WDRl , WD repeat domain 1), GeneBank accession No: BX641076 (ACTNl , Actinin, alpha 1), GeneBank accession No: BX537978 (EPB41L1 , Erythrocyte membrane protein band 4.1-like 1), GeneBank accession No: BG121847 (NUDC, Nuclear distribution gene C homolog(A. nidulans)), GeneBank accession No: BC068013 (MYOlC, Myosin IC), GeneBank accession No: BC065499 (MAST2 , Microtubule associated serine/threonine kinase 2), GeneBank accession No: BC051890(TUBG2, Tubulin, gamma 2), GeneBank accession No: BCO41874(MAP1LC3B, Microtubule-associated protein 1 light chain 3 beta), GeneBank accession No: BC012597 (ACTAl , Actin, alpha 1, skeletal muscle), GeneBank accession No: AY484427(KIF17, Kinesin family member 17), GeneBank accession No: AK130546 ( STOML2 , Stomatin(EPB72 ) -like 2), GeneBank accession No: AK124711 (CORO2B, Coronin, actin binding protein, 2B), GeneBank accession No: AK123974 (MYL5 , Myosin, light polypeptide 5, regulatory), GeneBank accession No: AK092792 (LOC389833 , Similar to hypothetical protein MGC27019), GeneBank accession No: AK026518 (MYOHDl , Myosin head domain containing 1), GeneBank accession No: AK024500 (NICAL, Microtubule associated monoxygenase, calponin and LIM domain containing 1), GeneBank accession No: AF085886(FLJ46675, Ribosomal protein L29 pseudogene 2), GeneBank accession No: AB209997 (MY09B, Myosin IXB), GeneBank accession No: Y12692 (WNTlI , Wingless-type MMTV integration site family, member 11), GeneBank accession No: Y113O7(CYR61, Cysteine-rich, angiogenic inducer, 61), GeneBank accession No: X17033 ( ITGA2 , Integrin, alpha 2(CD49B, alpha 2 subunit of VLA-2 receptor)), GeneBank accession No: U41763 (CLTCLl , Clathrin, heavy polypeptide- like 1), GeneBank accession No: NM_153609 (TMPRSS6 , Transmembrane protease, serine 6), GeneBank accession No: NM_031483(ITCH, Itchy homolog E3 ubiquitin protein ligase(mouse) ) , GeneBank accession No: NM_024342 (GRLFl , Glucocorticoid receptor DNA binding factor 1 ) , GeneBank accession No: NM_017555 (EGLN2 , EgI nine homolog 2(C. elegans)), GeneBank accession No: NM_016569 (TBX3, T-box 3 (ulnar mammary syndrome)), GeneBank accession No: NM_004148 (NINJl, Ninjurin 1), GeneBank accession No: NM_003377 (VEGFB, Vascular endothelial growth factor B), GeneBank accession No: NM_001983 (ERCCl , Excision repair cross-complementing rodent repair deficiency, complementation group 1( includes overlapping antisense sequence)), GeneBank accession No: NM_001552 ( IGFBP4 , Insulin-like growth factor binding protein 4), GeneBank accession No: NM_001430 (EPASl , Endothelial PAS domain protein 1), GeneBank accession No: NM_001300 (KLF6 , Kruppel- like factor 6), GeneBank accession No: NM_001012661 ( SLC3A2 , Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2), GeneBank accession No: NM_000596( IGFBPl, Insulin-like growth factor binding protein 1), GeneBank accession No: NM_000474 (TWISTl , Twist homolog 1 ( acrocephalosyndactyly 3; Saethre-Chotzen syndrome) (Drosophila) ), GeneBank accession No: BX649103 (ChGn, Chondroitin betal,4 N- acetylgalactosaminyltransferase) , GeneBank accession No: BM913048 (TIMPl, TIMP metallopeptidase inhibitor 1), GeneBank accession No: BM904612 ( S100A6 , SlOO calcium binding protein A6 (calcyclin) ) , GeneBank accession No: BM556279 (EMP3, Epithelial membrane protein 3), GeneBank accession No: BC015041 (VATl , Family with sequence similarity 82, member C), GeneBank accession No: AY258066 (OKL38 , Pregnancy-induced growth inhibitor), GeneBank accession No: AK126729 (NDRG4 , NDRG family member 4), GeneBank accession No: AK090459 (NFE2L1 , Nuclear factor (erythroid-derived 2) -like 1), GeneBank accession No: AK074163(ROBO4, Roundabout homolog 4, magic roundabout (Drosophila) ), GeneBank accession No: AK024680(FLJ21027 fis, CDNA: FLJ21027 fis, clone CAE07110), GeneBank accession No: AF176422 (HEYl , Hairy/enhancer-of- split related with YRPW motif 1), GeneBank accession No: AF003837 (JAGl, Jagged l(Alagille syndrome)), GeneBank accession No: AB209322 ( SEMA3B, Sema domain, immunoglobulin domain(Ig), short basic domain, secreted, ( semaphorin) 3B), GeneBank accession No: AB011150 (NRXNl , Neurexin 1), GeneBank accession No: NM_201589 (MAFA, V-maf musculoaponeurotic fibrosarcoma oncogene homolog A(avian)), GeneBank accession No: NM_052999 (CKLFSFl , CKLF-like MARVEL transmembrane domain containing 1), GeneBank accession No: NM_006644 (HSPHl, Heat shock 105kDa/110kDa protein 1), GeneBank accession No: NM_005438 (FOSLl , FOS-like antigen 1), GeneBank accession No: NM_004996 (ABCCl , ATP-binding cassette, sub-family C(CFTR/MRP), member 1), GeneBank accession No: NM_002658 (PLAU, Plasminogen activator, urokinase), GeneBank accession No: NM_001353 (AKRlCl , Aldo- keto reductase family 1, member Cl (dihydrodiol dehydrogenase 1; 20-alpha( 3-alpha) -hydroxysteroid dehydrogenase)), GeneBank accession No: H18681 (C20orf 139 , Sulfiredoxin 1 homolog(S. cerevisiae ) ) , GeneBank accession No: DR004094 (HAMP, Hepcidin antimicrobial peptide), GeneBank accession No: BC082272 (KCNMB3 , Potassium large conductance calcium-activated channel, subfamily M beta member 3), GeneBank accession No: BC040494 (DNAJB2 , DnaJ(Hsp40) homolog, subfamily B, member 2), GeneBank accession No: BC018064 (ATF6 , Activating transcription factor 6), GeneBank accession No: BC006523 ( SGK2 , Serum/glucocorticoid regulated kinase 2), GeneBank accession No: AK090482 (CXCL12 , Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor I)), GeneBank accession No: AF219946 (TULP4 , Tubby like protein 4), GeneBank accession No: AB209112 ( SLC2A8 , Solute carrier family 2 ,( facilitated glucose transporter) member 8), GeneBank accession No: NM_005242 (F2RL1 , Coagulation factor II (thrombin) receptor-like 1), GeneBank accession No: NM_001002029(C4A, Complement component 4B, telomeric), GeneBank accession No: NM_000539 (RHO, Rhodopsin( opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant)), GeneBank accession No: BX649164 (PAI , serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), GeneBank accession No: BM918324 (LY96 , Lymphocyte antigen 96), GeneBank accession No: AB209647(NCF2, Neutrophil cytosolic factor 2(65kDa, chronic granulomatous disease, autosomal 2)), GeneBank accession No: NM__152221 (CSNKlE, Casein kinase 1, epsilon), GeneBank accession No: NM_017999 (RNF31 , Ring finger protein 31), GeneBank accession No: NM_016819 (OGGl , 8-oxoguanine DNA glycosylase) , GeneBank accession No: NM_016816 (OASl , 2 ',5'- oligoadenylate synthetase 1, 40/46kDa), GeneBank accession No: NM_012235(SCAP, SREBP cleavage-activating protein), GeneBank accession No: NM_006384 (CIBl , Calcium and integrin binding 1 (calmyrin) ) , GeneBank accession No: NM_001779 (CD58 , CD58 antigen, ( lymphocyte function-associated antigen 3)), GeneBank accession No: CB055213 ( ICOSLG, Inducible T-cell co-stimulator ligand) , GeneBank accession No: BX641029 (MASPl , Mannan-binding lectin serine peptidase 1(C4/C2 activating component of Ra-reactive factor)), GeneBank accession No: BQ053419 (BATF, Basic leucine zipper transcription factor, ATF-like), GeneBank accession No: BC039299 (STIPl, Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein)), GeneBank accession No: AY055760 ( DAF, Decay accelerating factor for complement (CD55 , Cromer blood group system)), GeneBank accession No: AK13O188(FGR, Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog), GeneBank accession No: AK095326 (MUS81 , MUS81 endonuclease homolog(yeast ) ) , GeneBank accession No: NM_017670 (OTUBl, OTU domain, ubiquitin aldehyde binding 1), GeneBank accession No: NM_003004 ( SECTMl , Secreted and transmembrane 1), GeneBank accession No: NM_002309 (LIF, Hypothetical protein MGC20647), GeneBank accession No: NM_001421(ELF4, E74-like factor 4(ets domain transcription factor)), GeneBank accession No: NM_000418 ( IL4R, Interleukin 4 receptor), GeneBank accession No: BI909222 (FCERlG, Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide), GeneBank accession No: BF569086(NK4, Interleukin 32), GeneBank accession No: BC014470 (AZGPl, Alpha-2-glycoprotein 1, zinc), GeneBank accession No: BC020744 (AKR1C4 , Aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol) dehydrogenase 4), GeneBank accession No: BQ939577 ( AKR1C3 , Aldo-keto reductase family 1, member C3( 3-alpha hydroxysteroid dehydrogenase, type H)), GeneBank accession No: NM_000499 (CYPlAl , Cytochrome P450, family 1, subfamily A, polypeptide 1), GeneBank accession No: NM_030622 (CYP2S1 , Cytochrome P450, family 2, subfamily S, polypeptide 1), GeneBank accession No: NM_184041 (ALDOA, Aldolase A, fructose-bisphosphate ) , GeneBank accession No: NM_024307 (MGC4171 , Hypothetical protein LOC283901), GeneBank accession No: NM_005336 (HDLBP, High density lipoprotein binding protein( vigilin) ) , GeneBank accession No: NM_002627 (PFKP, Phosphofructokinase, platelet), GeneBank accession No: BX648281 (LDLR, Low density lipoprotein receptor ( familial hypercholesterolemia)), GeneBank accession No: BC069201(FLJ22761, Hexokinase domain containing 1), GeneBank accession No: BC030207 (NR0B2 , Nuclear receptor subfamily 0, group B, member 2), GeneBank accession No: AL833069(KIAA1434, Hypothetical protein KIAA1434), GeneBank accession No: AK124656 (ENO2 , Enolase 2(gamma, neuronal)), GeneBank accession No: AK094474 (RHOC, Ras homolog gene family, member C), GeneBank accession No: AK093461 ( ISYNAl , Myo-inositol 1-phosphate synthase Al), GeneBank accession No: AB053232(GAL3ST3, Galactose-3-O-sulfotransferase 3), GeneBank accession No: AB045292 (TMEM8 , Transmembrane protein 8(five membrane-spanning domains)), GeneBank accession No: NM_004753 (DHRS3 , Dehydrogenase/reductase ( SDR family) member 3), GeneBank accession No: NM_002900 (RBP3 , Retinol binding protein 3, interstitial), GeneBank accession No: NM_001995 (ACSLl , Acyl-CoA synthetase long- chain family member 1), GeneBank accession No: NM_000018 ( ACADVL , Acyl-Coenzyme A dehydrogenase, very long chain), GeneBank accession No: BC094756 (CRA, Myotubularin related protein 11), GeneBank accession No: BC050553 (NTE, Neuropathy target esterase), GeneBank accession No: BCO3311O(HSD17B1, Hydroxysteroid( 17-beta ) dehydrogenase 1), GeneBank accession No: AY268890 (TPPl , Tripeptidyl peptidase I), GeneBank accession No: AK172798 (CPTlA, Carnitine palmitoyltransferase lA(liver)), GeneBank accession No: AK096809(CYP4F8, Cytochrome P450, family 4, subfamily F, polypeptide 8), GeneBank accession No: AK000600 ( SIAT7D, ST6 ( alpha-N-acetyl-neuraminyl-2 , 3-beta- galactosyl-1 , 3 ) -N- acetylgalactosaminide alpha-2 , 6-sialyltransferase 4), GeneBank accession No: AB002454 (CYP4F3 , Cytochrome P450, family 4, subfamily F, polypeptide 3), GeneBank accession No: Z29093 (DDRl, Discoidin domain receptor family, member 1), GeneBank accession No: Z25424 (MKNK2 , MAP kinase interacting serine/threonine kinase 2), GeneBank accession No: XM_291277(DKFZp761P0423, Hypothetical protein DKFZp76lP0423) , GeneBank accession No: XM_038150 (MAST3 , Microtubule associated serine/threonine kinase 3), GeneBank accession No: U88357 (ERBB3 , V-erb-b2 erythroblastic leukemia viral oncogene homolog 3(avian)), GeneBank accession No: NM_025195 (TRIBl , Tribbles homolog l(Drosophila) ) , GeneBank accession No: NM_020639 (RIPK4 , Receptor-interacting serine-threonine kinase 4), GeneBank accession No: NM_014172 (PHPTl, Phosphohistidine phosphatase 1), GeneBank accession No: NM_006254 (PRKCD, Protein kinase C, delta), GeneBank accession No: NM_005415 ( SLC20A1 , Solute carrier family 20(phosphate transporter), member 1), GeneBank accession No: NM_005026 (PIK3CD, Phosphoinositide- 3-kinase, catalytic, delta polypeptide), GeneBank accession No: NM_004431(EPHA2, EPH receptor A2 ) , GeneBank accession No: NM_004419(DUSP5, Dual specificity phosphatase 5), GeneBank accession No: NM_004327 (BCR, Breakpoint cluster region), GeneBank accession No: NM_004231 ( ATP6V1F, ATPase, H+ transporting, lysosomal 14kDa, Vl subunit F), GeneBank accession No: NM_004090 (DUSP3 , Dual specificity phosphatase 3 (vaccinia virus phosphatase VHl-related) ) , GeneBank accession No: NM_002843 (PTPRJ, Protein tyrosine phosphatase, receptor type, J), GeneBank accession No: NM_002496 (NDUFS8 , NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH- coenzyme Q reductase)), GeneBank accession No: NM_001001852(PIM3, Pim-3 oncogene), GeneBank accession No: L76191 ( IRAKI , Interleukin-1 receptor-associated kinase 1), GeneBank accession No: D15049 (PTPRH, Protein tyrosine phosphatase, receptor type, H), GeneBank accession No: BC065207(ATP6V0D2, ATPase, H+ transporting, lysosomal 38kDa, VO subunit d isoform 2), GeneBank accession No: BC035578(STK24, Serine/threonine kinase 24(STE20 homolog, yeast)), GeneBank accession No: BC028724 (DUSP18 , Dual specificity phosphatase 18), GeneBank accession No: AL117482(ULK3, Unc-51-like kinase 3(C. elegans)), GeneBank accession No: AK126879 (PCTK3 , PCTAIRE protein kinase 3), GeneBank accession No: AB209416 ( ILK, Integrin-linked kinase-2), GeneBank accession No: NM_000782 (CYP24A1 , Cytochrome P450, family 24, subfamily A, polypeptide 1), GeneBank accession No: CR597101 ( ZFP36 , Zinc finger protein 36, C3H type, homolog ( mouse) ), GeneBank accession No: CR936799(FHL2, Four and a half LIM domains 2), GeneBank accession No: M24898 (NRlDl , Nuclear receptor subfamily 1, group D, member 1), GeneBank accession No: AF132818 (KLF5 , Kruppel-like factor 5 ( intestinal) ), GeneBank accession No: AK055337(ZNF213, Zinc finger protein 213), GeneBank accession No: BC008834 (PHFl , PHD finger protein 1), GeneBank accession No: AK126918 (GLIS2 , GLIS family zinc finger 2), GeneBank accession No: BC042692 (CTL2 , Solute carrier family 44, member 2), GeneBank accession No: NM_002224 ( ITPR3 , Inositol 1 , 4 , 5-triphosphate receptor, type 3), GeneBank accession No: AK095363 (AQP3 , Aquaporin 3), GeneBank accession No: NM_174953 (ATP2A3, ATPase, Ca++ transporting, ubiquitous), GeneBank accession No: BC042390 (VTIlB, Vesicle transport through interaction with t-SNAREs homolog lB(yeast)), GeneBank accession No: NM_016113 ( TRPV2 , Transient receptor potential cation channel, subfamily V, member 2), GeneBank accession No: BM926478(RBP1, Retinol binding protein 1, cellular), GeneBank accession No: NM_000069 (CACNAlS , Calcium channel, voltage-dependent, L type, alpha IS subunit), GeneBank accession No: AK002107 (RAB3B, RAB3B, member RAS oncogene family), GeneBank accession No: NM_013321 ( SNX8 , Sorting nexin 8), GeneBank accession No: AK125026 ( SLC6A12 , Solute carrier family 6 (neurotransmitter transporter, betaine/GABA) , member 12), GeneBank accession No: NM_005843(STAM2, Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2), GeneBank accession No: AK092512 (SLC16A5, Solute carrier family 16 (monocarboxylic acid transporters), member 5), GeneBank accession No: U49248(ABCC2, ATP-binding cassette, sub-family C(CFTR/MRP), member 2), GeneBank accession No: AK172792 ( SCNNlA, Sodium channel, nonvoltage-gated 1 alpha), GeneBank accession No: BC044656(CASC3, Cancer susceptibility candidate 3), GeneBank accession No: NM_203403 (C9orf150 , Chromosome 9 open reading frame 150), GeneBank accession No: NM_080388(S100A16, SlOO calcium binding protein A16), GeneBank accession No: NM_031286 ( SH3BGRL3 , SH3 domain binding glutamic acid-rich protein like 3), GeneBank accession No: NM_022153 (PP2135, Chromosome 10 open reading frame 54), GeneBank accession No: NM_004864 (GDF15 , Growth differentiation factor 15), GeneBank accession No: NM_003330 (TXNRDl, Thioredoxin reductase 1), GeneBank accession No: NM_001013632 (LOC343521 , Similar to hypothetical protein 4833401D15), GeneBank accession No: BX537968(LOC51149, Hypothetical LOC51149), GeneBank accession No: BU945318 (MT2A, Hypothetical gene supported by X97260; BC070289), GeneBank accession No: BQ683841 (SlOOAIl , SlOO calcium binding protein All (calgizzarin) ) , GeneBank accession No: BQ276852 (TMSBlO , Thymosin, beta 10), GeneBank accession No: AK126182 (KIAA1949 , KIAA1949), GeneBank accession No: AK124751 (CAPN2 , Calpain 2,(m/II) large subunit), GeneBank accession No: AK095079 (RGC32 , Response gene to complement 32), GeneBank accession No: AB075871(FLJ42654, Golgi transport 1 homolog A(S. cerevisiae) ) . [Claim 8] The method according to claim 6, wherein the below genes are down-regulated by exposure to phenanthrene : GeneBank accession No: AK125150 (MAPK8 , Mitogen- activated protein kinase 8), GeneBank accession No: NM_002758 (MAP2K6 , Mitogen-activated protein kinase kinase 6), GeneBank accession No: NM_004612 (TGFBRl , Transforming growth factor, beta receptor I(activin A receptor type II- like kinase, 53kDa)), GeneBank accession No: NM_145686 (MAP4K4 , Mitogen-activated protein kinase kinase kinase kinase 4), GeneBank accession No: XM_042066 (MAP3K1 , Mitogen-activated protein kinase kinase kinase 1 ) , GeneBank accession No: AB011123 (TNIK, TRAF2 and NCK interacting kinase), GeneBank accession No: AB209031(C5, Complement component 5), GeneBank accession No: NM_022740 (HIPK2 , Homeodomain interacting protein kinase 2 ) , GeneBank accession No: NM_148957 (TNFRSF19 , Tumor necrosis factor receptor superfamily, member 19), GeneBank accession No: AB208909(ITGB2, Integrin, beta 2(antigen CD18(p95), lymphocyte function-associated antigen 1; macrophage antigen l(mac-l) beta subunit)), GeneBank accession No: AB209211 (TIAl, TIAl cytotoxic granule-associated RNA binding protein), GeneBank accession No: AB2O9613(DNASE1L3, Deoxyribonuclease I-like 3), GeneBank accession No: AK122825 (HMGBl, High-mobility group box 1), GeneBank accession No: AK127326 (PHF17 , PHD finger protein 17), GeneBank accession No: AK223503 (CASPl , Caspase 1, apoptosis-related cysteine peptidase ( interleukin 1, beta, convertase) ) , GeneBank accession No: BC013326 (GAS2 , Growth arrest-specific 2), GeneBank accession No: BC047698 ( IL7 , Interleukin I)1 GeneBank accession No: D79987 (ESPLl , Extra spindle poles like 1(S. cerevisiae ) ) , GeneBank accession No: NM_000893 (KNGl, Kininogen 1), GeneBank accession No: NM_001012271(BIRC5, Effector cell peptidase receptor 1), GeneBank accession No: NM_004938 (DAPKl , Death-associated protein kinase 1), GeneBank accession No: NM_005879 (TRIP, TRAF interacting protein), GeneBank accession No: NM_014739 (BCLAFl, BCL2-associated transcription factor 1), GeneBank accession No: NM_018947 (CYCS, Cytochrome c, somatic), GeneBank accession No: AB033337 (MPHOSPHl , M-phase phosphoprotein 1), GeneBank accession No: AB209179 (PLKl , Polo-like kinase 1 (Drosophila) ) , GeneBank accession No: AB209337(CDC7, CDC7 cell division cycle 7(S. cerevisiae) ) , GeneBank accession No: AF053305 (BUBl , BUBl budding uninhibited by benzimidazoles 1 homolog( yeast ) ) , GeneBank accession No: AF053306 (BUBlB, BUBl budding uninhibited by benzimidazoles 1 homolog beta ( yeast )), GeneBank accession No: AF345347(SPAG5, Sperm associated antigen 5), GeneBank accession No: AK092638 (CCNG2 , Cyclin G2 ) , GeneBank accession No: AK222819 (NUSAPl , Nucleolar and spindle associated protein 1), GeneBank accession No: AL833191 (SMC2L1, SMC2 structural maintenance of chromosomes 2-like l(yeast)), GeneBank accession No: AY257469 (CIT, Citron ( rho-interacting, serine/threonine kinase 21)), GeneBank accession No: AY367065 (ASPM, Asp(abnormal spindle) -like, microcephaly associated(Drosophila) ) , GeneBank accession No: BCOIlOOO (CDCA5 , Cell division cycle associated 5), GeneBank accession No: BC032677 (UBE2C, Ubiquitin-conjugating enzyme E2C), GeneBank accession No: BC043502 (NEK2 , NIMA(never in mitosis gene a)-related kinase 2), GeneBank accession No: BU675073 (PTTGl , Pituitary tumor- transforming 1), GeneBank accession No: BX647885 ( STMNl , Stathmin 1/oncoprotein 18), GeneBank accession No: CR592757 (BRRNl, Barren homolog 1 (Drosophila) ) , GeneBank accession No: CR597075 (MAPRE2 , Microtubule-associated protein, RP/EB family, member 2), GeneBank accession No: CR604810(CCNA2, Cyclin A2 ) , GeneBank accession No: CR933728(CDC2, Cell division cycle 2, Gl to S and G2 to M), GeneBank accession No: NM_000919 (PAM, Peptidylglycine alpha-amidating monooxygenase ) , GeneBank accession No: NM_001790(CDC25C, Cell division cycle 25C), GeneBank accession No: NM_001798 (CDK2 , Cyclin-dependent kinase 2), GeneBank accession No: NM_001813 (CENPE , Centromere protein E, 312kDa), GeneBank accession No: NM_003318 (TTK, TTK protein kinase), GeneBank accession No: NM_003981 (PRCl , Protein regulator of cytokinesis 1), GeneBank accession No: NM_004523 (KIFIl, Kinesin family member 11), GeneBank accession No: NM_004701 (CCNB2 , Cyclin B2 ) , GeneBank accession No: NM_005983 ( SKP2 , S-phase kinase-associated protein 2(p45)), GeneBank accession No: NM_006101 (KNTC2 , Kinetochore associated 2), GeneBank accession No: NM_006845(KIF2C, Kinesin family member 2C), GeneBank accession No: NM_007375 ( TARDBP , TAR DNA binding protein), GeneBank accession No: NM_012112 (TPX2 , TPX2 , microtubule- associated, homolog(Xenopus laevis)), GeneBank accession No: NM_014750(DLG7, Discs, large homolog 7 (Drosophila) ) , GeneBank accession No: NM_015097 (CLASP2 , Cytoplasmic linker associated protein 2), GeneBank accession No: NM_016343 (CENPF, Centromere protein F, 350/400ka(mitosin) ) , GeneBank accession No: NM_016426 (GTSEl , G-2 and S-phase expressed 1), GeneBank accession No: NM_018492 (PBK, PDZ binding kinase), GeneBank accession No: NM_018685 (ANLN, Anillin, actin binding protein ( scraps homolog, Drosophila)), GeneBank accession No: NM_020242 (KNSL7 , Kinesin family member 15), GeneBank accession No: NM_031966 (CCNBl , Cyclin Bl), GeneBank accession No: NM_138555 (KIF23 , Kinesin family member 23), GeneBank accession No: U65410 (MAD2L1 , MAD2 mitotic arrest deficient-like l(yeast)), GeneBank accession No: AB020656 (CYLD, Cylindromatosis ( turban tumor syndrome)), GeneBank accession No: AF033122 (SESNl , Sestrin 1), GeneBank accession No: AK074377 (UHRFl , Chromosome 19 open reading frame 31), GeneBank accession No: AK091170 (CDKN2C, Cyclin- dependent kinase inhibitor 2C(pl8, inhibits CDK4 ) ) , GeneBank accession No: AK094323 (NFYC, Nuclear transcription factor Y, gamma), GeneBank accession No: AY366508 (LOH11CR2A, Loss of heterozygosity, 11, chromosomal region 2, gene A), GeneBank accession No: BC033086 (TCF19 , Transcription factor 19(SCl)), GeneBank accession No: BC040303 (PTP4A1 , Protein tyrosine phosphatase type IVA, member 1), GeneBank accession No: BC040991 (TFDP2 , Transcription factor Dp-2(E2F dimerization partner 2)), GeneBank accession No: BC092412(SGOL2, Shugoshin-like 2(S. pombe)), GeneBank accession No: BQ278454 (CKSlB, CDC28 protein kinase regulatory subunit IB), GeneBank accession No: BX649128(SESN3, Sestrin 3), GeneBank accession No: CD049340(AURKB, Aurora kinase B), GeneBank accession No: M89914(NF1, Neurofibromin 1 (neurofibromatosis , von Recklinghausen disease, Watson disease)), GeneBank accession No: NM_001005414 (ZWINT, ZWlO interactor antisense), GeneBank accession No: NM_001008491 ( Sep 2, Septin 2), GeneBank accession No: NM_001274 (CHEKl , CHKl checkpoint homolog(S. pombe)), GeneBank accession No: NM_002105(H2AFX, H2A histone family, member X), GeneBank accession No: NM_002388 (MCM3 , MCM3 minichromosome maintenance deficient 3(S. cerevisiae ) ) , GeneBank accession No: NM_OO2417(MKI67, Antigen identified by monoclonal antibody Ki-67), GeneBank accession No: NM_002875 (RAD51 , RAD51 homolog(RecA homolog, E. CoIi)(S. cerevisiae)), GeneBank accession No: NM_003884 (PCAF, P300/CBP-associated factor), GeneBank accession No: NM_004526 (MCM2 , MCM2 minichromosome maintenance deficient 2, mitotin(S. cerevisiae)), GeneBank accession No: NM_004847 (AIFl , Allograft inflammatory factor 1), GeneBank accession No: NM_005915 (MCM6 , MCM6 minichromosome maintenance deficient 6(MIS5 homolog, S. pombe ) ( S . cerevisiae ) ) , GeneBank accession No: NM_012090 (MACFl , Microtubule-actin crosslinking factor 1), GeneBank accession No: NM_012415(RAD54B, RAD54 homolog B(S. cerevisiae)), GeneBank accession No: NM_014264 (PLK4 , Polo-like kinase 4(Drosophila) ) , GeneBank accession No: NM_015714 (G0S2 , GO/Glswitch 2), GeneBank accession No: NM_024680 ( FLJ23311 , E2F transcription factor 8), GeneBank accession No: XM_034274 (MYBLl , V-myb myeloblastosis viral oncogene homolog ( avian) -like 1), GeneBank accession No: AK001720(FLJ10858, Nei endonuclease Vlll-like 3(E. coli)), GeneBank accession No: AY032677 (POLQ, Polymerase (DNA directed), theta), GeneBank accession No: BC034480 (BLM, Bloom syndrome), GeneBank accession No: BC073161 (RAD51C, RAD51 homolog C(S. cerevisiae)), GeneBank accession No: CR600021(HMGB2, High-mobility group box 2), GeneBank accession No: CR625391 (RAD51AP1 , RAD51 associated protein 1), GeneBank accession No: CR936783 (FLJ40869 , Hypothetical protein LOC284952), GeneBank accession No: DQ140356(KIAA1596, Fanconi anemia, complementation group M), GeneBank accession No: NM_001067 (TOP2A, Topoisomerase (DNA) II alpha 17OkDa), GeneBank accession No: NM_001618 (PARPl , Poly ( ADP-ribose) polymerase family, member 1), GeneBank accession No: NM_003362 (UNG, Uracil-DNA glycosylase ) , GeneBank accession No: NM_006904 (PRKDC, Protein kinase, DNA-activated, catalytic polypeptide), GeneBank accession No: NM_130398 (EXOl, Exonuclease 1), GeneBank accession No: AB020807 (TLR6, Toll-like receptor 6), GeneBank accession No: AB032980(DCDC2, Doublecortin domain containing 2), GeneBank accession No: AB209866 (TFPI , Tissue factor pathway inhibitor ( lipoprotein-associated coagulation inhibitor)), GeneBank accession No: AK057015 (HSPA4 , Heat shock 7OkDa protein 4), GeneBank accession No: AK095515 ( IFITl , Interferon-induced protein with tetratricopeptide repeats 1), GeneBank accession No: AK122686(IF, I factor ( complement) ), GeneBank accession No: AK123010 (RRM2 , Ribonucleotide reductase M2 polypeptide), GeneBank accession No: BC035582 (TRIM22 , Tripartite motif-containing 22), GeneBank accession No: BX537894 (LOC493869 , Similar to RIKEN cDNA 2310016C16), GeneBank accession No: M14338 (PROSl , Protein S(alpha)), GeneBank accession No: NM_000821 (GGCX, Gamma-glutamyl carboxylase), GeneBank accession No: NM_000963 (PTGS2 , Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) ) , GeneBank accession No: NM_001001547 (CD36 , CD36 antigen(collagen type I receptor, thrombospondin receptor)), GeneBank accession No: NM_001512(GSTA4, Glutathione S-transferase A4 ) , GeneBank accession No: NM_001629 ( ALOX5AP, Arachidonate 5- lipoxygenase-activating protein), GeneBank accession No: NM_001752(CAT, Catalase), GeneBank accession No: NM_001837(CCR3, Chemokine (C-C motif) receptor 3), GeneBank accession No: NM_001979 (EPHX2 , Epoxide hydrolase 2, cytoplasmic), GeneBank accession No: NM_001994 ( F13B, Coagulation factor XIII, B polypeptide), GeneBank accession No: NM_002182 ( ILlRAP, Interleukin 1 receptor accessory protein), GeneBank accession No: NM_006120 (HLA-DMA, Major histocompatibility complex, class II, DM alpha), GeneBank accession No: NM_173216 ( SIATl , ST6 beta-galactosamide alpha-2 , 6-sialyltranferase 1), GeneBank accession No: NM_202002 (FOXMl, Forkhead box Ml), GeneBank accession No: AB163917 (LRAP, Leukocyte-derived arginine aminopeptidase) , GeneBank accession No: BC027881 ( AFP, Alpha-fetoprotein) , GeneBank accession No: NM_015915 (SPG3A, Spastic paraplegia 3A( autosomal dominant)), GeneBank accession No: NM_000671(ADH5, Alcohol dehydrogenase 5(class III), chi polypeptide), GeneBank accession No: J05428 (UGT2B7 , UDP glucuronosyltransferase 2 family, polypeptide B7 ) , GeneBank accession No: NM_000672 (ADH6, Alcohol dehydrogenase 6 (class V)), GeneBank accession No: M15943(ADH4, Alcohol dehydrogenase 4 (class H)/ pi polypeptide), GeneBank accession No: AK223395 (FBPl , Fructose-1 , 6-bisphosphatase 1), GeneBank accession No: NM_000151 (G6PC, Glucose-6- phosphatase, catalytic ( glycogen storage disease type I, von Gierke disease)), GeneBank accession No: XM_113962 (KIAA0650 , Structural maintenance of chromosomes flexible hinge domain containing 1), GeneBank accession No: AB020644 ( ACSL6 , Acyl- CoA synthetase long-chain family member 6), GeneBank accession No: AB209907 (PLDl , Phospholipase Dl, phophatidylcholine-specific ) , GeneBank accession No: AF285167 (ABCAl, ATP-binding cassette, sub-family A(ABCl), member 1), GeneBank accession No: AF297872 (TRERFl , Transcriptional regulating factor 1), GeneBank accession No: AF3O3134(ALDH8A1, Aldehyde dehydrogenase 8 family, member Al), GeneBank accession No: AF339053 (PLA2G12B, Phospholipase A2 , group XIIB), GeneBank accession No: AK096018 (HADHSC, L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain), GeneBank accession No: AK124635 (PCSK9 , Proprotein convertase subtilisin/kexin type 9), GeneBank accession No: AK127346 ( SIAT9 , ST3 beta-galactoside alpha- 2 , 3-sialyltransferase 5), GeneBank accession No: AL359559 (AGPS, Alkylglycerone phosphate synthase), GeneBank accession No: AY691170 (PLCL3 , Phospholipase C-like 3), GeneBank accession No: BG567934(APOM, Apolipoprotein M), GeneBank accession No: BX538214 (Cβorf 167 , Chromosome 6 open reading frame 167), GeneBank accession No: BX640945 (FADS2 , Fatty acid desaturase 2), GeneBank accession No: BX648473(PIGK, Phosphatidylinositol glycan, class K), GeneBank accession No: BX648557 (HSD17B2 , Hydroxysteroid ( 17- beta) dehydrogenase 2), GeneBank accession No: CR7496O1(ETNK1, Death-associated protein kinase 3), GeneBank accession No: NM_000859 (HMGCR, 3-hydroxy-3- methylglutaryl-Coenzyme A reductase), GeneBank accession No: NM_001443 (FABPl, Fatty acid binding protein 1, liver), GeneBank accession No: NM_002130 (HMGCSl , 3-hydroxy-3- methylglutaryl-Coenzyme A synthase 1 ( soluble) ), GeneBank accession No: NM_003725 (RODH, Hydroxysteroid( 17-beta) dehydrogenase 6), GeneBank accession No: NM_004845 (PCYTlB, Phosphate cytidylyltransferase 1, choline, beta), GeneBank accession No: NM_014762 (DHCR24 , 24-dehydrocholesterol reductase), GeneBank accession No: NM_020139 (DHRS6 , Dehydrogenase/reductase ( SDR family) member 6), GeneBank accession No: NM_020918 (GPAM, Glycerol-3-phosphate acyltransferase, mitochondrial), GeneBank accession No: NM_032523(OSBPL6, Oxysterol binding protein-like 6), GeneBank accession No: NM_033505 (SELI, Selenoprotein I), GeneBank accession No: Z28339 (AKRlDl , Aldo-keto reductase family 1, member Dl (delta 4-3-ketosteroid-5-beta- reductase)), GeneBank accession No: AK024899 (ENPP3 , Ectonucleotide pyrophosphatase/ phosphodiesterase 3), GeneBank accession No: AK025546 (PTPN4 , Protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) ), GeneBank accession No: AK124910 (ENPP2 , Ectonucleotide pyrophosphatase/phosphodiesterase 2 ( autotaxin) ) , GeneBank accession No: BC035116 (FLJ35059 fis, CDNA FLJ30761 fis, clone FEBRA2000538) , GeneBank accession No: BC050565 (PASK, PAS domain containing serine/threonine kinase), GeneBank accession No: L13436(NPR2, Natriuretic peptide receptor B/guanylate cyclase B( atrionatriuretic peptide receptor B)), GeneBank accession No: NM_001005862 (ERBB2 , V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog ( avian) ), GeneBank accession No: NM_005012 (RORl , Receptor tyrosine kinase-like orphan receptor 1), GeneBank accession No: NM_006035(CDC42BPB, CDC42 binding protein kinase beta(DMPK- like)), GeneBank accession No: NM_014791 (MELK, Maternal embryonic leucine zipper kinase), GeneBank accession No: NM_023028(FGFR2, Fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer yndrome, Jackson-Weiss syndrome)), GeneBank accession No: NM_080836 ( STK35 , Serine/threonine kinase 35), GeneBank accession No: AF419331 (FUSIPl , FUS interacting protein( serine/arginine-rich) 1), GeneBank accession No: AK091927(SFRS3, Splicing factor, arginine/serine-rich 3), GeneBank accession No: BC010266 (HNRNPAl , Heterogeneous nuclear ribonucleoprotein Al), GeneBank accession No: BC012360(CTAGE5, CTAGE family, member 5), GeneBank accession No: BC036046 (PLRGl , Pleiotropic regulator 1(PRLl homolog, Arabidopsis ) ) , GeneBank accession No: BC065384 (PCFIl, PCFlI, cleavage and polyadenylation factor subunit, homolog(S. cerevisiae) ) , GeneBank accession No: BX537360 (CPSF5 , Nudix( nucleoside diphosphate linked moiety X) -type motif 21), GeneBank accession No: BX537494 (HNRPA2B1 , Heterogeneous nuclear ribonucleoprotein A2/B1), GeneBank accession No: BX647784 ( HNRPR, Heterogeneous nuclear ribonucleoprotein R), GeneBank accession No: CA455267 (PPIH, Peptidyl prolyl isomerase H(cyclophilin H)), GeneBank accession No: CR596214 (HNRPAO , Heterogeneous nuclear ribonucleoprotein AO), GeneBank accession No: NM_001326(CSTF3, Hypothetical protein LOC283267), GeneBank accession No: NM_004640 (BATl , HLA-B associated transcript 1), GeneBank accession No: NM_005463 (HNRPDL, Heterogeneous nuclear ribonucleoprotein D-like), GeneBank accession No: NM_006924 (SFRSl, Splicing factor, arginine/serine-rich 1( splicing factor 2, alternate splicing factor)), GeneBank accession No: NM_012426 ( SF3B3 , Splicing factor 3b, subunit 3, 13OkDa), GeneBank accession No: NM_018048 (FLJ10292 , Mago-nashi homolog) , GeneBank accession No: NM_030919(C20orf 129, Chromosome 20 open reading frame 129), GeneBank accession No: NM_031370 (HNRPD, Heterogeneous nuclear ribonucleoprotein D(AU-rich element RNA binding protein 1, 37kDa)), GeneBank accession No: NM_138933 ( ACF, Apobec-1 complementation factor), GeneBank accession No: AB193259 ( ACE2 , Angiotensin I converting enzyme (peptidyl- dipeptidase A) 2), GeneBank accession No: BX648769 (EWSRl , Ewing sarcoma breakpoint region 1), GeneBank accession No: AB023154(DTX4, Deltex 4 homolog( Drosophila ) ) , GeneBank accession No: AL543755 ( VAV3 , Vav 3 oncogene), GeneBank accession No: M75106(CPB2, Carboxypeptidase B2 (plasma, carboxypeptidase U)), GeneBank accession No: NM_021045(ZNF248, Zinc finger protein 248), GeneBank accession No: AB209194 (B4GALT6, UDP-GaI :betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6), GeneBank accession No: AF279145 (ANTXRl , Anthrax toxin receptor 1), GeneBank accession No: NM_025074 (FRASl , Fraser syndrome 1), GeneBank accession No: AK025790 (KIF20A, Kinesin family member 20A), GeneBank accession No: NM_006152 (LRMP, Lymphoid-restricted membrane protein), GeneBank accession No: NM_000340(SLC2A2, Solute carrier family 2 ( facilitated glucose transporter), member 2), GeneBank accession No: AF071592 (KIF4A, Kinesin family member 4A), GeneBank accession No: NM_013277 (RACGAPl , Rac GTPase activating protein 1), GeneBank accession No: AY043484 (SCNlA, Sodium channel, voltage-gated, type I, alpha), GeneBank accession No: AY791349(KIF18A, Kinesin family member 18A), GeneBank accession No: NM_018018 ( SLC38A4 , Solute carrier family 38, member 4), GeneBank accession No: AK094603 (FLJ37284 fis, unnamed protein product; Homo sapiens cDNA FLJ37284 fis, clone BRAMY2013590. ) , GeneBank accession No: NM_021069(ARGBP2, Sorbin and SH3 domain containing 2), GeneBank accession No: NM_001005747 (CACNB4 , Calcium channel, voltage-dependent, beta 4 subunit), GeneBank accession No: AJ496568(SLC25A12, Solute carrier family 25 (mitochondrial carrier, Aralar), member 12), GeneBank accession No: NM_030641 (AP0L6, Apolipoprotein L, 6), GeneBank accession No: NM_173512(FLJ39822, Hypothetical protein FLJ39822), GeneBank accession No: NM_000037 (ANKl , Ankyrin 1, erythrocytic), GeneBank accession No: NM_001011554 ( SLC13A3 , Solute carrier family 13 ( sodium-dependent dicarboxylate transporter), member 3), GeneBank accession No: AB091343(C10orf3, Centrosomal protein 55kDa), GeneBank accession No: AK000643 (ASB9 , Ankyrin repeat and SOCS box- containing 9), GeneBank accession No: AK055221 (FBXO5 , F-box protein 5), GeneBank accession No: AK075271 ( SPTLC2L, Serine palmitoyltransferase, long chain base subunit 2- like( aminotransferase 2)), GeneBank accession No: AK122685 (GLUDl, Glutamate dehydrogenase 1), GeneBank accession No: AK127098 (FLJ10706 , Chromosome 1 open reading frame 112), GeneBank accession No: AL133031 (MLRl , Transcription factor MLRl), GeneBank accession No: AY007723(MAL2, MaI, T-cell differentiation protein 2), GeneBank accession No: BC022255 (Spc25 , Spindle pole body component 25 homolog(S. cerevisiae) ) , GeneBank accession No: BC041882(ATF7IP2, Activating transcription factor 7 interacting protein 2), GeneBank accession No: BC052951 (LMNBl, Lamin Bl), GeneBank accession No: BC098313(FLJ20641, Hypothetical protein FLJ20641), GeneBank accession No: NM_001809 (CENPA, Centromere protein A, 17kDa), GeneBank accession No: NM_145061 (C13orf3 , Chromosome 13 open reading frame 3), GeneBank accession No: XM_372695(LOC390859, PREDICTED: Homo sapiens similar to Chain A, Crystal Structure Of The R463a Mutant Of Human Glutamate Dehydrogenase(LOC390859 ) , mRNA) . [Claim 9] The method according to claim 6, wherein the human somatic cell of step 1) is originated from human liver or liver cancer cells or tissues. [Claim lθ] The method according to claim 9, wherein the human liver cancer cell is HepG2. [Claim ll] The method according to claim 6, wherein the gene expression is measured at mRNA level or protein level. [Claim 12] A method for detecting the below genes for the identification of exposure to phenanthrene, comprising the following steps: 1 ) extracting RNAs from the experimental group human somatic cells and the control group human somatic cells; 2) synthesizing cDNAs from the RNAs of the experimental group and the control group of step 1), and labeling the cDNAs with different fluorescent materials; 3) hybridizing the cDNAs labeled with different fluorescent materials in step 2 ) with DNA microarray containing oligonucleotide comprising total length or a part of a gene selected from the group consisting of the genes below or its complementary oligonucleotide; 4 ) analyzing the DNA microarray reacted in step 3 ) ; and 5) determining exposure to phenanthrene by comparing the expression of the gene between the experimental group and the control group, precisely if the gene expression of the experimental group is significantly changed by phenanthrene, compared with that of the control group, it is judged that the gene is exposed to phenanthrene. GeneBank accession No: NM_004420 (DUSP8 , Dual specificity phosphatase 8), GeneBank accession No: L11329(DUSP2, Dual specificity phosphatase 2), GeneBank accession No: BC094766 (PKNl , Protein kinase Nl), GeneBank accession No: AY247738 (TRIB3 , Tribbles homolog 3(Drosophila) ) , GeneBank accession No: AK129595 (GADD45B, Growth arrest and DNA-damage-inducible, beta), GeneBank accession No: AB208849 ( SHCl , SHC(SrC homology 2 domain containing) transforming protein 1), GeneBank accession No: X02812 (TGFBl, Transforming growth factor, beta l(Camurati- Engelmann disease )) , GeneBank accession No: NM_198951 (TGM2 , Transglutaminase 2(C polypeptide, protein-glutamine-gamma- glutamyltransferase) ) , GeneBank accession No: NM_147780 (CTSB, Cathepsin B), GeneBank accession No: NM_078467 (CDKNlA, Cyclin-dependent kinase inhibitor lA(p21, Cipl)), GeneBank accession No: NM_033027 (AXUDl , AXINl up- regulated 1), GeneBank accession No: NM_032797 (AMID, Apoptosis-inducing factor (AIF) -like mitochondrion- associated inducer of death), GeneBank accession No: NM_021960 (MCLl, Myeloid cell leukemia sequence 1(BCL2- related)), GeneBank accession No: NM_016639 (TNFRSF12A, Tumor necrosis factor receptor superfamily, member 12A) , GeneBank accession No: NM_016222 (DDX41 , DEAD( Asp-Glu-Ala- Asp) box polypeptide 41), GeneBank accession No: NM_013246(CLC, Cardiotrophin-like cytokine factor 1), GeneBank accession No: NM_004401 (DFFA, DNA fragmentation factor, 45kDa, alpha polypeptide), GeneBank accession No: NM_004281(BAG3, BCL2-associated athanogene 3), GeneBank accession No: NM_003897 ( IER3, Immediate early response 3), GeneBank accession No: NM_003806 (HRK, Harakiri, BCL2 interacting protein (contains only BH3 domain)), GeneBank accession No: NM_003639 ( IKBKG, Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma), GeneBank accession No: NM_003311 (PHLDA2 , Pleckstrin homology-like domain, family A, member 2), GeneBank accession No: NM_002737 (PRKCA, Protein kinase C, alpha), GeneBank accession No: NM_002648 (PIMl , Pim-1 oncogene), GeneBank accession No: NM_002507 (NGFR, Nerve growth factor receptor (TNFR superfamily, member 16)), GeneBank accession No: NM_002305 (LGALSl, Lectin, galactoside-binding, soluble, l(galectin I)), GeneBank accession No: NM_001013398 ( IGFBP3 , Insulin-like growth factor binding protein 3), GeneBank accession No: BX640923 (MDM4 , Mdm4 , transformed 3T3 cell double minute 4, p53 binding protein (mouse) ) , GeneBank accession No: BX537586 ( STK17A, Serine/threonine kinase 17a( apoptosis-inducing) ) , GeneBank accession No: BG284742(P8, P8 protein ( candidate of metastasis I)), GeneBank accession No: BE903247 (PDCD6IP, Programmed cell death 6 interacting protein), GeneBank accession No: BC027949(P2RXl, Purinergic receptor P2X, ligand-gated ion channel, 1), GeneBank accession No: BC006365 (PSEN2 , Presenilin 2 (Alzheimer disease 4)), GeneBank accession No: AY869712(PPP1R13L, Protein phosphatase 1, regulatory ( inhibitor ) subunit 13 like), GeneBank accession No: AY028896 (CARDlO, Caspase recruitment domain family, member 10), GeneBank accession No: AK122614 (PPARD, Peroxisome proliferative activated receptor, delta), GeneBank accession No: AK092872 (ERCC2 , Excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)), GeneBank accession No: AK092808 (RRAGC, Ras-related GTP binding C), GeneBank accession No: AJ001898 (GDNF, Glial cell derived neurotrophic factor), GeneBank accession No: AF220656 (PHLDAl, Pleckstrin homology-like domain, family A, member 1), GeneBank accession No: AF055634 (UNC5C, Unc-5 homolog C(C. elegans)), GeneBank accession No: AB209485 (VEGF, Vascular endothelial growth factor), GeneBank accession No: AB096256 (UNC5B, Unc-5 homolog B(C. elegans)), GeneBank accession No: AB007960 ( SH3GLB1 , SH3- domain GRB2-like endophilin Bl), GeneBank accession No: X06374 (PDGFA, Platelet-derived growth factor alpha polypeptide), GeneBank accession No: S62138 (DDIT3 , DNA- damage-inducible transcript 3), GeneBank accession No: NM_078487(CDKN2B, Cyclin-dependent kinase inhibitor 2B(pl5, inhibits CDK4 ) ) , GeneBank accession No: NM_012127 (CIZl , CDKNlA interacting zinc finger protein 1), GeneBank accession No: NM_005883 ( APC2 , Adenomatosis polyposis coli 2), GeneBank accession No: NM_004196 (CDKLl , Cyclin- dependent kinase-like 1 (CDC2-related kinase)), GeneBank accession No: NM_003236 (TGFA, Transforming growth factor, alpha), GeneBank accession No: NM_001261 (CDK9 , Cyclin- dependent kinase 9 (CDC2-related kinase)), GeneBank accession No: NM_001007271 (DUSP13 , Dual specificity phosphatase 13), GeneBank accession No: CR749511 (PARC, P53- associated parkin-like cytoplasmic protein), GeneBank accession No: CR623038 ( ID2 , Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein), GeneBank accession No: CR618371 (EGFR, Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)), GeneBank accession No: BF965144 ( IFITMl , Interferon induced transmembrane protein 1(9-27)), GeneBank accession No: AK127679 (DUSPl , Dual specificity phosphatase 1), GeneBank accession No: AK096276 (CCND3 , Cyclin D3 ) , GeneBank accession No: AB209586 (MAPK13 , Mitogen-activated protein kinase 13), GeneBank accession No: AB209465 (PCTKl , PCTAIRE protein kinase 1), GeneBank accession No: Z19588(SKIL, SKI-like), GeneBank accession No: NM_020429 (SMURFl, SMAD specific E3 ubiquitin protein ligase 1), GeneBank accession No: NM_014767 ( SPOCK2 , Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2), GeneBank accession No: NM_005979(S100Al3, SlOO calcium binding protein A13), GeneBank accession No: NM_005187 (CBFA2T3 , Core-binding factor, runt domain, alpha subunit 2; translocated to, 3), GeneBank accession No: NM_004364 (CEBPA, CCAAT/enhancer binding protein ( C/EBP ), alpha), GeneBank accession No: NM_001769(CD9, CD9 antigen(p24 ) ) , GeneBank accession No: NM_001718 (BMP6 , Bone morphogenetic protein 6), GeneBank accession No: NM_000641 ( ILlI , Interleukin 11), GeneBank accession No: BX647459 (SERPINE2 , Serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 2), GeneBank accession No: BQ066037 (RPS19, Ribosomal protein S19), GeneBank accession No: BE791300 (EDFl , Endothelial differentiation-related factor 1), GeneBank accession No: BC038504 ( SNFlLK, SNFl-like kinase), GeneBank accession No: AL832287 ( ZAP70 , Zeta-chain(TCR) associated protein kinase 7OkDa), GeneBank accession No: AK125742 (PCGFl, Polycomb group ring finger 1), GeneBank accession No: AK124709 (NDRGl , N-myc downstream regulated gene 1), GeneBank accession No: AB011157 (PTDSR, Phosphatidylserine receptor), GeneBank accession No: NM_013255 (MKLNl, Muskelin 1, intracellular mediator containing kelch motifs), GeneBank accession No: NM_006572(GNA13, Guanine nucleotide binding protein(G protein), alpha 13), GeneBank accession No: NM_002211 ( ITGBl , Integrin, beta 1 ( fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2 , MSK12)), GeneBank accession No: CR601067 (PLAUR, Plasminogen activator, urokinase receptor), GeneBank accession No: BC050456 (THBS4 , Thrombospondin 4), GeneBank accession No: AK027389 (CXCL16 , Chemokine (C-X-C motif) ligand 16), GeneBank accession No: AJ132099 (VNNl , Vanin 1), GeneBank accession No: XM_371354 (FLJ10157 , Hypothetical protein FLJ10157), GeneBank accession No: XM_208313(TPM3, Similar to tropomyosin 4), GeneBank accession No: XM_208270 ( ACR, Acrosin-like protease), GeneBank accession No: NM_203353 (PDLIM7 , PDZ and LIM domain 7(enigma)), GeneBank accession No: NM_201382 (PLECl , Plectin 1, intermediate filament binding protein 50OkDa), GeneBank accession No: NM_182961 ( SYNEl , Spectrin repeat containing, nuclear envelope 1), GeneBank accession No: NM_181826 (NF2 , Neurofibromin 2 (bilateral acoustic neuroma)), GeneBank accession No: NM_172069 (PLEKHH2 , Pleckstrin homology domain containing, family H (with MyTH4 domain) member 2), GeneBank accession No: NM_022648 (TNS, Tensin 1), GeneBank accession No: NM_017556 (FBLP-I, Filamin binding LIM protein 1), GeneBank accession No: NM_016081 (KIAA0992 , Palladin, cytoskeletal associated protein), GeneBank accession No: NM_006617(NES, Nestin), GeneBank accession No: NM_006262 (PRPH, Peripherin) , GeneBank accession No: NM_005100(AKAP12, A kinase(PRKA) anchor protein ( gravin) 12), GeneBank accession No: NM_004368 (CNN2 , Calponin 2), GeneBank accession No: NM_003388 (CYLN2 , Cytoplasmic linker 2), GeneBank accession No: NM_003370 (VASP, Vasodilator- stimulated phosphoprotein) , GeneBank accession No: NM_003128 (SPTBNl, Spectrin, beta, non-erythrocytic 1), GeneBank accession No: NM_002705 (PPL, Periplakin), GeneBank accession No: NM_002475 (MLClSA, Myosin light chain 1 slow a), GeneBank accession No: NM_002018 (FLII , Flightless I homolog(Drosophila) ) , GeneBank accession No: NM_001465 (FYB, FYN binding protein(FYB-120/130 ) ) , GeneBank accession No: NM_001069(TUBB2, Tubulin, beta 2A), GeneBank accession No: CR625172(MGC8685, Tubulin, beta 2B), GeneBank accession No: CR616919(KRT18, Keratin 18), GeneBank accession No: CR606241 (ACTGl, Actin, gamma 1), GeneBank accession No: CB240572 (MYHIl, Myosin, heavy polypeptide 11, smooth muscle), GeneBank accession No: BX648253 (PTPN3 , Protein tyrosine phosphatase, non-receptor type 3), GeneBank accession No: BX648190 (WDRl , WD repeat domain 1), GeneBank accession No: BX641076 (ACTNl , Actinin, alpha 1), GeneBank accession No: BX537978 (EPB41L1 , Erythrocyte membrane protein band 4.1-like 1), GeneBank accession No: BG121847 (NUDC, Nuclear distribution gene C homolog(A. nidulans)), GeneBank accession No: BC068013 (MYOlC, Myosin IC), GeneBank accession No: BC065499 (MAST2 , Microtubule associated serine/threonine kinase 2), GeneBank accession No: BC051890(TUBG2, Tubulin, gamma 2), GeneBank accession No: BCO41874(MAP1LC3B, Microtubule-associated protein 1 light chain 3 beta), GeneBank accession No: BC012597 (ACTAl , Actin, alpha 1, skeletal muscle), GeneBank accession No: AY484427(KIF17, Kinesin family member 17), GeneBank accession No: AK130546 ( STOML2 , Stomatin(EPB72 ) -like 2), GeneBank accession No: AK124711 (C0R02B, Coronin, actin binding protein, 2B), GeneBank accession No: AK123974 (MYL5 , Myosin, light polypeptide 5, regulatory), GeneBank accession No: AK092792 (LOC389833, Similar to hypothetical protein MGC27019), GeneBank accession No: AK026518 (MYOHDl , Myosin head domain containing 1), GeneBank accession No: AK024500 (NICAL, Microtubule associated monoxygenase, calponin and LIM domain containing 1), GeneBank accession No: AF085886(FLJ46675, Ribosomal protein L29 pseudogene 2), GeneBank accession No: AB209997 (MY09B, Myosin IXB), GeneBank accession No: Y12692 (WNTlI , Wingless-type MMTV integration site family, member 11), GeneBank accession No: Y11307 (CYR61, Cysteine-rich, angiogenic inducer, 61), GeneBank accession No: X17033 ( ITGA2 , Integrin, alpha 2(CD49B, alpha 2 subunit of VLA-2 receptor)), GeneBank accession No: U41763 (CLTCLl , Clathrin, heavy polypeptide- like 1), GeneBank accession No: NM_153609 ( TMPRSS6 , Transmembrane protease, serine 6), GeneBank accession No: NM_031483(ITCH, Itchy homolog E3 ubiquitin protein ligase(mouse) ) , GeneBank accession No: NM_024342 (GRLFl , Glucocorticoid receptor DNA binding factor 1 ) , GeneBank accession No: NM_017555 (EGLN2 , EgI nine homolog 2(C. elegans)), GeneBank accession No: NM_016569 (TBX3 , T-box 3 (ulnar mammary syndrome)), GeneBank accession No: NM_004148 (NINJl, Ninjurin 1), GeneBank accession No: NM_003377 (VEGFB, Vascular endothelial growth factor B), GeneBank accession No: NM_001983 (ERCCl , Excision repair cross-complementing rodent repair deficiency, complementation group 1( includes overlapping antisense sequence)), GeneBank accession No: NM_001552 ( IGFBP4 , Insulin-like growth factor binding protein 4), GeneBank accession No: NM_001430 (EPASl , Endothelial PAS domain protein 1), GeneBank accession No: NM_001300 (KLF6 , Kruppel- like factor 6), GeneBank accession No: NM_001012661 ( SLC3A2 , Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2), GeneBank accession No: NM_000596( IGFBPl, Insulin-like growth factor binding protein 1), GeneBank accession No: NM_000474 (TWISTl , Twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome ) (Drosophila) ), GeneBank accession No: BX649103 (ChGn, Chondroitin betal,4 N- acetylgalactosaminyltransferase) , GeneBank accession No: BM913O48(TIMP1, TIMP metallopeptidase inhibitor 1), GeneBank accession No: BM904612 ( S100A6 , SlOO calcium binding protein A6 (calcyclin) ) , GeneBank accession No: BM556279(EMP3, Epithelial membrane protein 3), GeneBank accession No: BC015041 (VATl , Family with sequence similarity 82, member C), GeneBank accession No: AY258066(OKL38, Pregnancy-induced growth inhibitor), GeneBank accession No: AK126729 (NDRG4 , NDRG family member 4), GeneBank accession No: AK090459 (NFE2L1 , Nuclear factor (erythroid-derived 2) -like 1), GeneBank accession No: AK074163(ROBO4, Roundabout homolog 4, magic roundabout (Drosophila) ), GeneBank accession No: AK024680(FLJ21027 fis, CDNA: FLJ21027 fis, clone CAE07110), GeneBank accession No: AF176422 (HEYl , Hairy/enhancer-of- split related with YRPW motif 1), GeneBank accession No: AF003837 (JAGl, Jagged l(Alagille syndrome)), GeneBank accession No: AB209322 ( SEMA3B, Sema domain, immunoglobulin domain(Ig), short basic domain, secreted, ( semaphorin) 3B), GeneBank accession No: AB011150 (NRXNl , Neurexin 1), GeneBank accession No: NM_201589 (MAFA, V-maf musculoaponeurotic fibrosarcoma oncogene homolog A(avian)), GeneBank accession No: NM_052999 (CKLFSFl , CKLF-like MARVEL transmembrane domain containing 1), GeneBank accession No: NM_006644 (HSPHl, Heat shock 105kDa/110kDa protein 1), GeneBank accession No: NM_005438 (FOSLl , FOS-like antigen 1), GeneBank accession No: NM_004996 (ABCCl , ATP-binding cassette, sub-family C(CFTR/MRP), member 1), GeneBank accession No: NM_002658 (PLAU, Plasminogen activator, urokinase), GeneBank accession No: NM_001353 (AKRlCl , Aldo- keto reductase family 1, member Cl (dihydrodiol dehydrogenase 1; 20-alpha( 3-alpha) -hydroxysteroid dehydrogenase)), GeneBank accession No: H18681 (C20orf 139 , Sulfiredoxin 1 homolog(S. cerevisiae) ) , GeneBank accession No: DR004094 (HAMP, Hepcidin antimicrobial peptide), GeneBank accession No: BC082272 (KCNMB3 , Potassium large conductance calcium-activated channel, subfamily M beta member 3), GeneBank accession No: BC040494 ( DNAJB2 , DnaJ(Hsp40) homolog, subfamily B, member 2), GeneBank accession No: BC018064 ( ATF6 , Activating transcription factor 6), GeneBank accession No: BC006523 ( SGK2 , Serum/glucocorticoid regulated kinase 2 ) , GeneBank accession No: AK090482 (CXCL12 , Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor I)), GeneBank accession No: AF219946 (TULP4 , Tubby like protein 4), GeneBank accession No: AB209112 ( SLC2A8 , Solute carrier family 2 ,( facilitated glucose transporter) member 8), GeneBank accession No: NM_005242 (F2RL1 , Coagulation factor II (thrombin) receptor-like 1), GeneBank accession No: NM_001002029(C4A, Complement component 4B, telomeric), GeneBank accession No: NM_000539 (RHO, Rhodopsin( opsin 2, rod pigment ) (retinitis pigmentosa 4, autosomal dominant)), GeneBank accession No: BX649164 (PAI, serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), GeneBank accession No: BM918324 (LY96 , Lymphocyte antigen 96), GeneBank accession No: AB209647(NCF2, Neutrophil cytosolic factor 2(65kDa, chronic granulomatous disease, autosomal 2)), GeneBank accession No: NM_152221(CSNK1E, Casein kinase 1, epsilon), GeneBank accession No: NM_017999 (RNF31 , Ring finger protein 31), GeneBank accession No: NM__016819 (OGGl , 8-oxoguanine DNA glycosylase) , GeneBank accession No: NM_016816 (OASl , 2 ',5'- oligoadenylate synthetase 1, 40/46kDa), GeneBank accession No: NM_012235(SCAP, SREBP cleavage-activating protein), GeneBank accession No: NM_006384 (CIBl , Calcium and integrin binding 1 (calmyrin) ) , GeneBank accession No: NM_001779 (CD58 , CD58 antigen, ( lymphocyte function-associated antigen 3)), GeneBank accession No: CB055213 ( ICOSLG, Inducible T-cell co-stimulator ligand) , GeneBank accession No: BX641029 (MASPl, Mannan-binding lectin serine peptidase 1(C4/C2 activating component of Ra-reactive factor)), GeneBank accession No: BQ053419 (BATF, Basic leucine zipper transcription factor, ATF-like), GeneBank accession No: BC039299 ( STIPl , Stress-induced-phosphoprotein 1 ( Hsp70/Hsp90-organizing protein)), GeneBank accession No: AY055760 (DAF, Decay accelerating factor for complement (CD55 , Cromer blood group system) ) , GeneBank accession No: AK130188 (FGR, Gardner-Rasheed feline sarcoma viral(v-fgr) oncogene homolog), GeneBank accession No: AK095326 (MUS81 , MUS81 endonuclease homolog(yeast ) ) , GeneBank accession No: NM_017670 (OTUBl, OTU domain, ubiquitin aldehyde binding 1), GeneBank accession No: NM_003004 ( SECTMl , Secreted and transmembrane 1), GeneBank accession No: NM_002309 (LIF, Hypothetical protein MGC20647), GeneBank accession No: NM_001421(ELF4, E74-like factor 4(ets domain transcription factor)), GeneBank accession No: NM_000418 ( IL4R, Interleukin 4 receptor), GeneBank accession No: BI909222 (FCERlG, Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide), GeneBank accession No: BF569086 (NK4, Interleukin 32), GeneBank accession No: BC014470 (AZGPl, Alpha-2-glycoprotein 1, zinc), GeneBank accession No: BC020744 (AKR1C4 , Aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol) , dehydrogenase 4), GeneBank accession No: BQ939577 (AKR1C3 , Aldo-keto reductase family 1, member C3( 3-alpha hydroxysteroid dehydrogenase, type H)), GeneBank accession No: NM_000499 (CYPlAl , Cytochrome P450, family 1, subfamily A, polypeptide 1), GeneBank accession No: NM_030622 (CYP2S1 , Cytochrome P450, family 2, subfamily S, polypeptide 1), GeneBank accession No: NM_184041 (ALDOA, Aldolase A, fructose-bisphosphate ) , GeneBank accession No: NM 024307 (MGC4171 , Hypothetical protein LOC283901), GeneBank accession No: NM_005336 ( HDLBP, High density lipoprotein binding protein( vigilin) ) , GeneBank accession No: NM_002627 (PFKP, Phosphofructokinase, platelet), GeneBank accession No: BX648281 (LDLR, Low density lipoprotein receptor ( familial hypercholesterolemia)), GeneBank accession No: BC069201(FLJ22761, Hexokinase domain containing 1), GeneBank accession No: BC030207 (NR0B2 , Nuclear receptor subfamily 0, group B, member 2), GeneBank accession No: AL833O69(KIAA1434, Hypothetical protein KIAA1434), GeneBank accession No: AK124656 (ENO2 , Enolase 2 (gamma, neuronal)), GeneBank accession No: AK094474 (RHOC, Ras homolog gene family, member C), GeneBank accession No: AK093461 ( ISYNAl , Myo-inositol 1-phosphate synthase Al), GeneBank accession No: AB053232(GAL3ST3, Galactose-3-O-sulf©transferase 3), GeneBank accession No: AB045292 (TMEM8 , Transmembrane protein 8(five membrane-spanning domains)), GeneBank accession No: NM_004753 (DHRS3, Dehydrogenase/reductase (SDR family) member 3), GeneBank accession No: NM_002900 (RBP3 , Retinol binding protein 3, interstitial), GeneBank accession No: NM__001995 (ACSLl , Acyl-CoA synthetase long- chain family member 1), GeneBank accession No: NM_000018 (ACADVL , Acyl-Coenzyme A dehydrogenase, very long chain), GeneBank accession No: BC094756 (CRA, Myotubularin related protein 11), GeneBank accession No: BC050553 (NTE, Neuropathy target esterase), GeneBank accession No: BCO3311O(HSD17B1, Hydroxysteroid( 17-beta ) dehydrogenase 1), GeneBank accession No: AY268890 (TPPl , Tripeptidyl peptidase I), GeneBank accession No: AK172798 (CPTlA, Carnitine palmitoyltransferase lA(liver)), GeneBank accession No: AK096809(CYP4F8, Cytochrome P450, family 4, subfamily F, polypeptide 8), GeneBank accession No: AK000600 ( SIAT7D, ST6 ( alpha-N-acetyl-neuraminyl-2 , 3-beta- galactosyl-1 , 3 ) -N- acetylgalactosaminide alpha-2 , 6-sialyltransferase 4), GeneBank accession No: AB002454 (CYP4F3 , Cytochrome P450, family 4, subfamily F, polypeptide 3), GeneBank accession No: Z29093 (DDRl, Discoidin domain receptor family, member 1), GeneBank accession No: Z25424 (MKNK2 , MAP kinase interacting serine/threonine kinase 2), GeneBank accession No: XM_291277(DKFZp761P0423, Hypothetical protein DKFZp76lP0423) , GeneBank accession No: XM_038150 (MAST3 , Microtubule associated serine/threonine kinase 3), GeneBank accession No: U88357 (ERBB3 , V-erb-b2 erythroblastic leukemia viral oncogene homolog 3(avian)), GeneBank accession No: NM_025195 (TRIBl , Tribbles homolog l(Drosophila) ) , GeneBank accession No: NM_020639 (RIPK4 , Receptor-interacting serine-threonine kinase 4), GeneBank accession No: NM_014172 (PHPTl , Phosphohistidine phosphatase 1), GeneBank accession No: NM_006254 (PRKCD, Protein kinase C, delta), GeneBank accession No: NM_005415 (SLC20A1 , Solute carrier family 20(phosphate transporter), member 1), GeneBank accession No: NM_005026 (PIK3CD, Phosphoinositide- 3-kinase, catalytic, delta polypeptide), GeneBank accession No: NM_004431 (EPHA2, EPH receptor A2 ) , GeneBank accession No: NM_004419(DUSP5, Dual specificity phosphatase 5), GeneBank accession No: NM_004327 (BCR, Breakpoint cluster region), GeneBank accession No: NM_004231 ( ATP6V1F, ATPase, H+ transporting, lysosomal 14kDa, Vl subunit F), GeneBank accession No: NM_004090 (DUSP3 , Dual specificity phosphatase 3 (vaccinia virus phosphatase VHl-related) ) , GeneBank accession No: NM_002843 (PTPRJ, Protein tyrosine phosphatase, receptor type, J), GeneBank accession No: NM_002496 (NDUFS8 , NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH- coenzyme Q reductase)), GeneBank accession No: NM_001001852(PIM3, Pim-3 oncogene), GeneBank accession No: L76191 ( IRAKI , Interleukin-1 receptor-associated kinase 1), GeneBank accession No: D15049 (PTPRH, Protein tyrosine phosphatase, receptor type, H), GeneBank accession No: BC065207(ATP6V0D2, ATPase, H+ transporting, lysosomal 38kDa, VO subunit d isoform 2), GeneBank accession No: BC035578(STK24, Serine/threonine kinase 24(STE20 homolog, yeast)), GeneBank accession No: BC028724 (DUSP18 , Dual specificity phosphatase 18), GeneBank accession No: AL117482(ULK3, Unc-51-like kinase 3(C. elegans)), GeneBank accession No: AK126879 (PCTK3, PCTAIRE protein kinase 3), GeneBank accession No: AB209416 ( ILK, Integrin-linked kinase-2), GeneBank accession No: NM_000782 (CYP24A1 , Cytochrome P450, family 24, subfamily A, polypeptide 1), GeneBank accession No: CR597101 ( ZFP36 , Zinc finger protein 36, C3H type, homolog (mouse )), GeneBank accession No: CR936799(FHL2, Four and a half LIM domains 2), GeneBank accession No: M24898 (NRlDl , Nuclear receptor subfamily 1, group D, member 1), GeneBank accession No: AF132818 (KLF5 , Kruppel-like factor 5 ( intestinal )), GeneBank accession No: AK055337(ZNF213, Zinc finger protein 213), GeneBank accession No: BC008834 (PHFl , PHD finger protein 1), GeneBank accession No: AK126918 (GLIS2 , GLIS family zinc finger 2), GeneBank accession No: BC042692 (CTL2 , Solute carrier family 44, member 2), GeneBank accession No: NM_002224(ITPR3, Inositol 1 , 4 , 5-triphosphate receptor, type 3), GeneBank accession No: AK095363 ( AQP3 , Aquaporin 3), GeneBank accession No: NM_174953 (ATP2A3 , ATPase, Ca++ transporting, ubiquitous), GeneBank accession No: BC042390 (VTIlB, Vesicle transport through interaction with t-SNAREs homolog lB(yeast)), GeneBank accession No: NM_016113 (TRPV2, Transient receptor potential cation channel, subfamily V, member 2), GeneBank accession No: BM926478 (RBPl, Retinol binding protein 1, cellular), GeneBank accession No: NM_000069 (CACNAlS , Calcium channel, voltage-dependent, L type, alpha IS subunit), GeneBank accession No: AK002107 (RAB3B, RAB3B, member RAS oncogene family), GeneBank accession No: NM_013321 ( SNX8 , Sorting nexin 8), GeneBank accession No: AK125026 ( SLC6A12 , Solute carrier family 6 (neurotransmitter transporter, betaine/GABA) , member 12), GeneBank accession No: NM_005843(STAM2, Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2), GeneBank accession No: AK092512 (SLC16A5, Solute carrier family 16 (monocarboxylic acid transporters), member 5), GeneBank accession No: U49248(ABCC2, ATP-binding cassette, sub-family C(CFTR/MRP), member 2), GeneBank accession No: AK172792 ( SCNNlA, Sodium channel, nonvoltage-gated 1 alpha), GeneBank accession No: BC044656(CASC3, Cancer susceptibility candidate 3), GeneBank accession No: NM_203403 (C9orf150 , Chromosome 9 open reading frame 150), GeneBank accession No: NM_080388(S100Al6, SlOO calcium binding protein A16), GeneBank accession No: NM_031286 ( SH3BGRL3 , SH3 domain binding glutamic acid-rich protein like 3 ) , GeneBank accession No: NM_022153 (PP2135 , Chromosome 10 open reading frame 54), GeneBank accession No: NM_004864 (GDF15 , Growth differentiation factor 15), GeneBank accession No: NM_003330 (TXNRDl, Thioredoxin reductase 1), GeneBank accession No: NM_001013632 (LOC343521 , Similar to hypothetical protein 4833401D15), GeneBank accession No: BX537968(LOC51149, Hypothetical LOC51149), GeneBank accession No: BU945318 (MT2A, Hypothetical gene supported by X97260; BC070289), GeneBank accession No: BQ683841 ( SlOOAIl , SlOO calcium binding protein All (calgizzarin) ) , GeneBank accession No: BQ276852 (TMSBlO, Thymosin, beta 10), GeneBank accession No: AK126182 (KIAA1949 , KIAA1949), GeneBank accession No: AK124751 (CAPN2 , Calpain 2,(m/ll) large subunit), GeneBank accession No: AK095079 (RGC32 , Response gene to complement 32), GeneBank accession No: AB075871(FLJ42654, Golgi transport 1 homolog A(S. cerevisiae) ) , GeneBank accession No: AK125150 (MAPK8 , Mitogen-activated protein kinase 8), GeneBank accession No: NM_002758(MAP2K6, Mitogen-activated protein kinase kinase 6), GeneBank accession No: NM_004612 (TGFBRl , Transforming growth factor, beta receptor I(activin A receptor type II- like kinase, 53kDa)), GeneBank accession No: NM_145686 (MAP4K4 , Mitogen-activated protein kinase kinase kinase kinase 4), GeneBank accession No: XM_042066 (MAP3K1 , Mitogen-activated protein kinase kinase kinase 1 ) , GeneBank accession No: AB011123 (TNIK, TRAF2 and NCK interacting kinase), GeneBank accession No: AB209031(C5, Complement component 5), GeneBank accession No: NM_022740 (HIPK2 , Homeodomain interacting protein kinase 2 ) , GeneBank accession No: NM_148957 (TNFRSF19 , Tumor necrosis factor receptor superfamily, member 19), GeneBank accession No: AB208909(ITGB2, Integrin, beta 2(antigen CD18(p95), lymphocyte function-associated antigen 1; macrophage antigen l(mac-l) beta subunit)), GeneBank accession No: AB209211 (TIAl, TIAl cytotoxic granule-associated RNA binding protein), GeneBank accession No: AB209613 (DNASE1L3 , Deoxyribonuclease I-like 3), GeneBank accession No: AK122825 (HMGBl, High-mobility group box 1), GeneBank accession No: AK127326 (PHF17 , PHD finger protein 17), GeneBank accession No: AK223503 (CASPl , Caspase 1, apoptosis-related cysteine peptidase ( interleukin 1, beta, convertase) ) , GeneBank accession No: BC013326 (GAS2 , Growth arrest-specific 2), GeneBank accession No: BC047698 ( IL7 , Interleukin 7), GeneBank accession No: D79987 (ESPLl , Extra spindle poles like 1(S. cerevisiae) ) , GeneBank accession No: NM_000893 (KNGl, Kininogen 1), GeneBank accession No: NM_001012271(BIRC5, Effector cell peptidase receptor 1), GeneBank accession No: NM_004938 (DAPKl , Death-associated protein kinase 1), GeneBank accession No: NM_005879 (TRIP, TRAF interacting protein), GeneBank accession No: NM_014739 (BCLAFl, BCL2-associated transcription factor 1), GeneBank accession No: NM_018947 (CYCS, Cytochrome c, somatic), GeneBank accession No: AB033337 (MPHOSPHl , M-phase phosphoprotein 1), GeneBank accession No: AB209179 (PLKl , Polo-like kinase 1 (Drosophila) ) , GeneBank accession No: AB209337 (CDC7, CDC7 cell division cycle 7(S. cerevisiae)), GeneBank accession No: AF053305 (BUBl , BUBl budding uninhibited by benzimidazoles 1 homolog( yeast ) ) , GeneBank accession No: AF053306 (BUBlB, BUBl budding uninhibited by benzimidazoles 1 homolog beta(yeast ) ) , GeneBank accession No: AF345347(SPAG5, Sperm associated antigen 5), GeneBank accession No: AK092638 (CCNG2 , Cyclin G2 ) , GeneBank accession No: AK222819 (NUSAPl , Nucleolar and spindle associated protein 1), GeneBank accession No: AL833191 ( SMC2L1 , SMC2 structural maintenance of chromosomes 2-like l(yeast)), GeneBank accession No: AY257469 (CIT, Citron(rho-interacting, serine/threonine kinase 21)), GeneBank accession No: AY367065 (ASPM, Asp(abnormal spindle) -like, microcephaly associated(Drosophila) ) , GeneBank accession No: BCOIlOOO (CDCA5 , Cell division cycle associated 5), GeneBank accession No: BC032677 (UBE2C, Ubiquitin-conjugating enzyme E2C), GeneBank accession No: BC043502(NEK2, NIMA(never in mitosis gene a)-related kinase 2), GeneBank accession No: BU675073 (PTTGl , Pituitary tumor- transforming 1), GeneBank accession No: BX647885 ( STMNl , Stathmin 1/oncoprotein 18), GeneBank accession No: CR592757 (BRRNl, Barren homolog 1 (Drosophila) ) , GeneBank accession No: CR597075 (MAPRE2 , Microtubule-associated protein, RP/EB family, member 2), GeneBank accession No: CR604810(CCNA2, Cyclin A2 ) , GeneBank accession No: CR933728(CDC2, Cell division cycle 2, Gl to S and G2 to M), GeneBank accession No: NM_000919 (PAM, Peptidylglycine alpha-amidating monooxygenase ) , GeneBank accession No: NM_001790(CDC25C, Cell division cycle 25C), GeneBank accession No: NM_001798 (CDK2 , Cyclin-dependent kinase 2), GeneBank accession No: NM_001813 (CENPE, Centromere protein E, 312kDa), GeneBank accession No: NM_003318 (TTK, TTK protein kinase), GeneBank accession No: NM_003981 (PRCl , Protein regulator of cytokinesis 1), GeneBank accession No: NM_004523(KIFll, Kinesin family member 11), GeneBank accession No: NM_004701 (CCNB2 , Cyclin B2 ) , GeneBank accession No: NM_005983 ( SKP2 , S-phase kinase-associated protein 2(p45)), GeneBank accession No: NM_006101 (KNTC2 , Kinetochore associated 2), GeneBank accession No: NM_006845(KIF2C, Kinesin family member 2C), GeneBank accession No: NM_007375 ( TARDBP , TAR DNA binding protein), GeneBank accession No: NM_012112 (TPX2 , TPX2 , microtubule- associated, homolog(Xenopus laevis)), GeneBank accession No: NM_014750(DLG7, Discs, large homolog 7 (Drosophila) ) , GeneBank accession No: NM_015097 (CLASP2 , Cytoplasmic linker associated protein 2), GeneBank accession No: NM_016343(CENPF, Centromere protein F, 350/400ka(mitosin) ) , GeneBank accession No: NM_016426 (GTSEl , G-2 and S-phase expressed 1), GeneBank accession No: NM_018492 (PBK, PDZ binding kinase), GeneBank accession No: NM_018685 (ANLN, Anillin, actin binding protein ( scraps homolog, Drosophila)), GeneBank accession No: NM_020242 (KNSL7 , Kinesin family member 15), GeneBank accession No: NM_031966 (CCNBl , Cyclin Bl), GeneBank accession No: NM_138555 (KIF23 , Kinesin family member 23), GeneBank accession No: U65410 (MAD2L1 , MAD2 mitotic arrest deficient-like l(yeast)), GeneBank accession No: AB020656 (CYLD, Cylindromatosis ( turban tumor syndrome)), GeneBank accession No: AF033122 ( SESNl , Sestrin 1), GeneBank accession No: AK074377 (UHRFl , Chromosome 19 open reading frame 31), GeneBank accession No: AK091170 (CDKN2C, Cyclin- dependent kinase inhibitor 2C(pl8, inhibits CDK4 ) ) , GeneBank accession No: AK094323 (NFYC, Nuclear transcription factor Y, gamma), GeneBank accession No: AY366508 (L0H11CR2A, Loss of heterozygosity, 11, chromosomal region 2, gene A), GeneBank accession No: BC033086 (TCF19 , Transcription factor 19(SCl)), GeneBank accession No: BC040303 (PTP4A1 , Protein tyrosine phosphatase type IVA, member 1), GeneBank accession No: BC040991 (TFDP2 , Transcription factor Dp-2(E2F dimerization partner 2)), GeneBank accession No: BC092412(SGOL2, Shugoshin-like 2(S. pombe ) ) , GeneBank accession No: BQ278454 (CKSlB, CDC28 protein kinase regulatory subunit IB), GeneBank accession No: BX649128(SESN3, Sestrin 3), GeneBank accession No: CD049340 (AURKB, Aurora kinase B), GeneBank accession No: M89914(NF1, Neurofibromin 1 (neurofibromatosis , von Recklinghausen disease, Watson disease)), GeneBank accession No: NM_001005414 ( ZWINT, ZWlO interactor antisense), GeneBank accession No: NM_001008491 ( Sep 2, Septin 2), GeneBank accession No: NM_001274 (CHEKl , CHKl checkpoint homolog(S. pombe)), GeneBank accession No: NM_002105(H2AFX, H2A histone family, member X), GeneBank accession No: NM_002388 (MCM3 , MCM3 minichromosome maintenance deficient 3(S. cerevisiae ) ) , GeneBank accession No: NM_OO2417(MKI67, Antigen identified by monoclonal antibody Ki-67), GeneBank accession No: NM_002875 (RAD51 , RAD51 homolog(RecA homolog, E. CoIi)(S. cerevisiae ) ) , GeneBank accession No: NM_003884 (PCAF, P300/CBP-associated factor), GeneBank accession No: NM_004526 (MCM2 , MCM2 minichromosome maintenance deficient 2, mitotin(S. cerevisiae)), GeneBank accession No: NM_004847 (AIFl , Allograft inflammatory factor 1), GeneBank accession No: NM_005915(MCM6, MCM6 minichromosome maintenance deficient 6(MIS5 homolog, S. pombe ) ( S . cerevisiae)), GeneBank accession No: NM_012090 (MACFl , Microtubule-actin crosslinking factor 1), GeneBank accession No: NM_012415(RAD54B, RAD54 homolog B(S. cerevisiae)), GeneBank accession No: NM_014264 (PLK4 , Polo-like kinase 4(Drosophila) ) , GeneBank accession No: NM_015714 (G0S2 , GO/Glswitch 2), GeneBank accession No: NM_024680 (FLJ23311 , E2F transcription factor 8), GeneBank accession No: XM_034274 (MYBLl , V-myb myeloblastosis viral oncogene homolog (avian) -like 1), GeneBank accession No: AK001720(FLJ10858, Nei endonuclease Vlll-like 3(E. coli)), GeneBank accession No: AY032677 (POLQ, Polymerase (DNA directed), theta), GeneBank accession No: BC034480 (BLM, Bloom syndrome), GeneBank accession No: BC073161 (RAD51C, RAD51 homolog C(S. cerevisiae)), GeneBank accession No: CR600021(HMGB2, High-mobility group box 2), GeneBank accession No: CR625391 (RAD51AP1 , RAD51 associated protein 1), GeneBank accession No: CR936783 (FLJ40869 , Hypothetical protein LOC284952), GeneBank accession No: DQ140356 (KIAA1596 , Fanconi anemia, complementation group M), GeneBank accession No: NM_001067 (T0P2A, Topoisomerase ( DNA) II alpha 17OkDa), GeneBank accession No: NM_001618 (PARPl , Poly ( ADP-ribose) polymerase family, member 1), GeneBank accession No: NM_003362 (UNG, Uracil-DNA glycosylase) , GeneBank accession No: NM_006904 (PRKDC, Protein kinase, DNA-activated, catalytic polypeptide), GeneBank accession No: NM_130398 (EXOl, Exonuclease 1), GeneBank accession No: AB020807(TLR6, Toll-like receptor 6), GeneBank accession No: AB032980(DCDC2, Doublecortin domain containing 2), GeneBank accession No: AB209866 (TFPI , Tissue factor pathway inhibitor ( lipoprotein-associated coagulation inhibitor)), GeneBank accession No: AK057015 (HSPA4 , Heat shock 7OkDa protein 4), GeneBank accession No: AK095515 ( IFITl , Interferon-induced protein with tetratricopeptide repeats 1), GeneBank accession No: AK122686(IF, I factor ( complement) ), GeneBank accession No: AK123010 (RRM2 , Ribonucleotide reductase M2 polypeptide), GeneBank accession No: BC035582 (TRIM22 , Tripartite motif-containing 22), GeneBank accession No: BX537894 (LOC493869 , Similar to RIKEN cDNA 2310016C16), GeneBank accession No: M14338 (PROSl , Protein S(alpha)), GeneBank accession No: NM_000821 (GGCX, Gamma-glutamyl carboxylase), GeneBank accession No: NM_000963(PTGS2 , Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase ) ) , GeneBank accession No: NM_001001547 (CD36 , CD36 antigen ( collagen type I receptor, thrombospondin receptor)), GeneBank accession No: NM_001512(GSTA4, Glutathione S-transferase A4 ) , GeneBank accession No: NM_001629 ( ALOX5AP, Arachidonate 5- lipoxygenase-activating protein), GeneBank accession No: NM_001752(CAT, Catalase ) , GeneBank accession No: NM_001837(CCR3, Chemokine (C-C motif) receptor 3), GeneBank accession No: NM_001979 (EPHX2 , Epoxide hydrolase 2, cytoplasmic), GeneBank accession No: NM_001994 (F13B, Coagulation factor XIII, B polypeptide), GeneBank accession No: NM_002182( ILlRAP, Interleukin 1 receptor accessory protein), GeneBank accession No: NM_006120 (HLA-DMA, Major histocompatibility complex, class II, DM alpha), GeneBank accession No: NM_173216 ( SIATl , ST6 beta-galactosamide alpha-2 , 6-sialyltranferase 1), GeneBank accession No: NM_202002 (FOXMl, Forkhead box Ml), GeneBank accession No: AB163917 (LRAP, Leukocyte-derived arginine aminopeptidase ) , GeneBank accession No: BC027881 ( AFP, Alpha-fetoprotein) , GeneBank accession No: NM_015915 ( SPG3A, Spastic paraplegia 3A( autosomal dominant)), GeneBank accession No: NM_000671(ADH5, Alcohol dehydrogenase 5(class III), chi polypeptide), GeneBank accession No: J05428 (UGT2B7 , UDP glucuronosyltransferase 2 family, polypeptide B7), GeneBank accession No: NM_000672 (ADH6 , Alcohol dehydrogenase 6(class V)), GeneBank accession No: M15943(ADH4, Alcohol dehydrogenase 4 (class H), pi polypeptide), GeneBank accession No: AK223395 (FBPl , Fructose-1 , 6-bisphosphatase 1), GeneBank accession No: NM_000151 (G6PC, Glucose-6- phosphatase, catalytic ( glycogen storage disease type I, von Gierke disease)), GeneBank accession No: XM_113962 (KIAA0650 , Structural maintenance of chromosomes flexible hinge domain containing 1), GeneBank accession No: AB020644 (ACSL6 , Acyl- CoA synthetase long-chain family member 6), GeneBank accession No: AB209907 (PLDl , Phospholipase Dl, phophatidylcholine-specific ) , GeneBank accession No: AF285167 (ABCAl, ATP-binding cassette, sub-family A(ABCl), member 1), GeneBank accession No: AF297872 (TRERFl , Transcriptional regulating factor 1), GeneBank accession No: AF3O3134(ALDH8A1, Aldehyde dehydrogenase 8 family, member Al), GeneBank accession No: AF339053 (PLA2G12B, Phospholipase A2 , group XIIB), GeneBank accession No: AK096018 (HADHSC, L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain), GeneBank accession No: AK124635 (PCSK9 , Proprotein convertase subtilisin/kexin type 9), GeneBank accession No: AK127346 ( SIAT9 , ST3 beta-galactoside alpha- 2 , 3-sialyltransferase 5), GeneBank accession No: AL359559 (AGPS, Alkylglycerone phosphate synthase), GeneBank accession No: AY691170 (PLCL3 , Phospholipase C-like 3), GeneBank accession No: BG567934 (APOM, Apolipoprotein M), GeneBank accession No: BX538214 (C6orf 167 , Chromosome 6 open reading frame 167), GeneBank accession No: BX640945 (FADS2 , Fatty acid desaturase 2), GeneBank accession No: BX648473(PIGK, Phosphatidylinositol glycan, class K), GeneBank accession No: BX648557 (HSD17B2 , Hydroxysteroid( 17- beta) dehydrogenase 2), GeneBank accession No: CR749601 (ETNKl, Death-associated protein kinase 3), GeneBank accession No: NM_000859 (HMGCR, 3-hydroxy-3- methylglutaryl-Coenzyme A reductase), GeneBank accession No: NM_001443 (FABPl, Fatty acid binding protein 1, liver), GeneBank accession No: NM_002130 (HMGCSl , 3-hydroxy-3- methylglutaryl-Coenzyme A synthase l(soluble)), GeneBank accession No: NM_003725 (RODH, Hydroxysteroid ( 17-beta) dehydrogenase 6), GeneBank accession No: NM_004845 (PCYTlB, Phosphate cytidylyltransferase 1, choline, beta), GeneBank accession No: NM_014762 (DHCR24 , 24-dehydrocholesterol reductase), GeneBank accession No: NM_020139 (DHRS6 , Dehydrogenase/reductase (SDR family) member 6), GeneBank accession No: NM_020918 (GPAM, Glycerol-3-phosphate acyltransferase, mitochondrial), GeneBank accession No: NM__032523(OSBPL6, Oxysterol binding protein-like 6), GeneBank accession No: NM_033505 (SELI, Selenoprotein I), GeneBank accession No: Z28339 (AKRlDl , Aldo-keto reductase family 1, member Dl (delta 4-3-ketosteroid-5-beta- reductase) ) , GeneBank accession No: AK024899 (ENPP3 , Ectonucleotide pyrophosphatase/phosphodiesterase 3), GeneBank accession No: AK025546 (PTPN4 , Protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) ), GeneBank accession No: AK124910 (ENPP2 , Ectonucleotide pyrophosphatase/phosphodiesterase 2 ( autotaxin) ) , GeneBank accession No: BC035116 (FLJ35059 fis, CDNA FLJ30761 fis, clone FEBRA2000538) , GeneBank accession No: BC050565 (PASK, PAS domain containing serine/threonine kinase), GeneBank accession No: L13436(NPR2, Natriuretic peptide receptor B/guanylate cyclase B(atrionatriuretic peptide receptor B)), GeneBank accession No: NM_001005862 (ERBB2 , V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog ( avian) ), GeneBank accession No: NM_005012 (RORl , Receptor tyrosine kinase-like orphan receptor 1), GeneBank accession No: NM_006035(CDC42BPB, CDC42 binding protein kinase beta(DMPK- like)), GeneBank accession No: NM_014791 (MELK, Maternal embryonic leucine zipper kinase), GeneBank accession No: NM_023028(FGFR2, Fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer yndrome, Jackson-Weiss syndrome)), GeneBank accession No: NM_080836 ( STK35 , Serine/threonine kinase 35), GeneBank accession No: AF419331 (FUSIPl , FUS interacting protein ( serine/arginine-rich) 1), GeneBank accession No: AK091927 (SFRS3, Splicing factor, arginine/serine-rich 3), GeneBank accession No: BC010266 (HNRNPAl , Heterogeneous nuclear ribonucleoprotein Al), GeneBank accession No: BC012360(CTAGE5, CTAGE family, member 5), GeneBank accession No: BC036046 (PLRGl , Pleiotropic regulator 1(PRLl homolog, Arabidopsis ) ) , GeneBank accession No: BC065384 (PCFIl, PCFlI, cleavage and polyadenylation factor subunit, homolog(S. cerevisiae) ) , GeneBank accession No: BX537360(CPSF5, Nudix(nucleoside diphosphate linked moiety X) -type motif 21), GeneBank accession No: BX537494 (HNRPA2B1 , Heterogeneous nuclear ribonucleoprotein A2/B1), GeneBank accession No: BX647784 (HNRPR, Heterogeneous nuclear ribonucleoprotein R), GeneBank accession No: CA455267 (PPIH, Peptidyl prolyl isomerase H(cyclophilin H)), GeneBank accession No: CR596214 (HNRPAO , Heterogeneous nuclear ribonucleoprotein AO), GeneBank accession No: NM_001326(CSTF3, Hypothetical protein LOC283267), GeneBank accession No: NM_004640 (BATl , HLA-B associated transcript 1), GeneBank accession No: NM_005463 (HNRPDL, Heterogeneous nuclear ribonucleoprotein D-like), GeneBank accession No: NM_006924 (SFRSl, Splicing factor, arginine/serine-rich 1( splicing factor 2, alternate splicing factor)), GeneBank accession No: NM_012426 ( SF3B3 , Splicing factor 3b, subunit 3, 13OkDa), GeneBank accession No: NM_018048 (FLJ10292 , Mago-nashi homolog) , GeneBank accession No: NM_030919(C20orf129, Chromosome 20 open reading frame 129), GeneBank accession No: NM_031370 (HNRPD, Heterogeneous nuclear ribonucleoprotein D(AU-rich element RNA binding protein 1, 37kDa)), GeneBank accession No: NM_138933 ( ACF, Apobec-1 complementation factor), GeneBank accession No: AB193259 (ACE2 , Angiotensin I converting enzyme (peptidyl- dipeptidase A) 2), GeneBank accession No: BX648769 (EWSRl , Ewing sarcoma breakpoint region 1), GeneBank accession No: AB023154 (DTX4, Deltex 4 homolog ( Drosophila) ), GeneBank accession No: AL543755 ( VAV3 , Vav 3 oncogene), GeneBank accession No: M75106(CPB2, Carboxypeptidase B2 (plasma, carboxypeptidase U)), GeneBank accession No: NM_021045(ZNF248, Zinc finger protein 248), GeneBank accession No: AB209194 (B4GALT6 , UDP-GaI :betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6), GeneBank accession No: AF279145 (ANTXRl , Anthrax toxin receptor 1), GeneBank accession No: NM_025074 (FRASl , Fraser syndrome 1), GeneBank accession No: AK025790 (KIF20A, Kinesin family member 20A), GeneBank accession No: NM_006152 (LRMP, Lymphoid-restricted membrane protein), GeneBank accession No: NM_000340(SLC2A2, Solute carrier family 2 ( facilitated glucose transporter), member 2), GeneBank accession No: AF071592(KIF4A, Kinesin family member 4A), GeneBank accession No: NM_013277 (RACGAPl , Rac GTPase activating protein 1), GeneBank accession No: AY043484 ( SCNlA, Sodium channel, voltage-gated, type I, alpha), GeneBank accession No: AY791349(KIF18A, Kinesin family member 18A), GeneBank accession No: NM_018018 ( SLC38A4 , Solute carrier family 38, member 4), GeneBank accession No: AK094603 (FLJ37284 fis, unnamed protein product; Homo sapiens cDNA FLJ37284 fis, clone BRAMY2013590. ) , GeneBank accession No: NM_021069(ARGBP2, Sorbin and SH3 domain containing 2), GeneBank accession No: NM_001005747 (CACNB4 , Calcium channel, voltage-dependent, beta 4 subunit), GeneBank accession No: AJ496568(SLC25A12, Solute carrier family 25 (mitochondrial carrier, Aralar), member 12), GeneBank accession No: NM_030641 (AP0L6, Apolipoprotein L, 6), GeneBank accession No: NM_173512 (FLJ39822, Hypothetical protein FLJ39822), GeneBank accession No: NM_000037 (ANKl , Ankyrin 1, erythrocytic), GeneBank accession No: NM_001011554 ( SLC13A3 , Solute carrier family 13 ( sodium-dependent dicarboxylate transporter), member 3), GeneBank accession No: AB091343(C10orf3, Centrosomal protein 55kDa), GeneBank accession No: AK000643 ( ASB9 , Ankyrin repeat and SOCS box- containing 9), GeneBank accession No: AK055221 (FBX05 , F-box protein 5), GeneBank accession No: AK075271 ( SPTLC2L, Serine palmitoyltransferase, long chain base subunit 2- like ( aminotransferase 2)), GeneBank accession No: AK122685 (GLUDl, Glutamate dehydrogenase 1), GeneBank accession No: AK127098 (FLJ10706 , Chromosome 1 open reading frame 112), GeneBank accession No: AL133031 (MLRl , Transcription factor MLRl), GeneBank accession No: AY007723(MAL2, MaI, T-cell differentiation protein 2), GeneBank accession No: BC022255 ( Spc25 , Spindle pole body component 25 homolog(S. cerevisiae) ) , GeneBank accession No: BC041882 (ATF7IP2, Activating transcription factor 7 interacting protein 2), GeneBank accession No: BC052951 (LMNBl, Lamin Bl), GeneBank accession No: BC098313(FLJ20641, Hypothetical protein FLJ20641), GeneBank accession No: NM_001809 (CENPA, Centromere protein A, 17kDa), GeneBank accession No: NM_145061 (C13orf3 , Chromosome 13 open reading frame 3), GeneBank accession No: XM_372695(LOC390859, PREDICTED: Homo sapiens similar to Chain A, Crystal Structure Of The R463a Mutant Of Human Glutamate Dehydrogenase (LOC390859 ), mRNA) . [Claim 13] The method according to claim 12, wherein the below genes are up-regulated by exposure to phenanthrene : GeneBank accession No: NM_004420 (DUSP8 , Dual specificity phosphatase 8), GeneBank accession No: L11329(DUSP2, Dual specificity phosphatase 2), GeneBank accession No: BC094766 (PKNl , Protein kinase Nl), GeneBank accession No: AY247738 (TRIB3 , Tribbles homolog 3(Drosophila) ) , GeneBank accession No: AK129595 (GADD45B, Growth arrest and DNA-damage-inducible, beta), GeneBank accession No: AB208849 ( SHCl , SHC(SrC homology 2 domain containing) transforming protein 1), GeneBank accession No: X02812 (TGFBl, Transforming growth factor, beta l(Camurati- Engelmann disease) ) , GeneBank accession No: NM_198951 (TGM2 , Transglutaminase 2(C polypeptide, protein-glutamine-gamma- glutamyltransferase) ), GeneBank accession No: NM_147780(CTSB, Cathepsin B), GeneBank accession No: NM_078467 (CDKNlA, Cyclin-dependent kinase inhibitor lA(p21, Cipl)), GeneBank accession No: NM_033027 (AXUDl , AXINl up- regulated 1), GeneBank accession No: NM_032797 ( AMID, Apoptosis-inducing factor (AIF) -like mitochondrion- associated inducer of death), GeneBank accession No: NM_021960 (MCLl, Myeloid cell leukemia sequence 1(BCL2- related)), GeneBank accession No: NM_016639 (TNFRSF12A, Tumor necrosis factor receptor superfamily, member 12A), GeneBank accession No: NM_016222 (DDX41 , DEAD( Asp-Glu-Ala- Asp) box polypeptide 41), GeneBank accession No: NM_013246 (CLC, Cardiotrophin-like cytokine factor 1), GeneBank accession No: NM_004401 (DFFA, DNA fragmentation factor, 45kDa, alpha polypeptide), GeneBank accession No: NM_004281(BAG3, BCL2-associated athanogene 3), GeneBank accession No: NM_003897 ( IER3 , Immediate early response 3), GeneBank accession No: NM_003806 (HRK, Harakiri, BCL2 interacting protein (contains only BH3 domain)), GeneBank accession No: NM_003639 ( IKBKG, Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma), GeneBank accession No: NM_003311 (PHLDA2 , Pleckstrin homology-like domain, family A, member 2), GeneBank accession No: NM_002737 (PRKCA, Protein kinase C, alpha), GeneBank accession No: NM_002648 (PIMl , Pim-1 oncogene), GeneBank accession No: NM_002507 (NGFR, Nerve growth factor receptor(TNFR superfamily, member 16)), GeneBank accession No: NM_002305 (LGALSl , Lectin, galactoside-binding, soluble, l(galectin I)), GeneBank accession No: NM_001013398 ( IGFBP3 , Insulin-like growth factor binding protein 3), GeneBank accession No: BX640923 (MDM4 , Mdm4 , transformed 3T3 cell double minute 4, p53 binding protein (mouse )), GeneBank accession No: BX537586 ( STK17A, Serine/threonine kinase 17a( apoptosis-inducing) ) , GeneBank accession No: BG284742(P8, P8 protein (candidate of metastasis I)), GeneBank accession No: BE903247 (PDCD6IP, Programmed cell death 6 interacting protein), GeneBank accession No: BC027949(P2RXl, Purinergic receptor P2X, ligand-gated ion channel, 1), GeneBank accession No: BC006365 (PSEN2 , Presenilin 2 (Alzheimer disease 4)), GeneBank accession No: AY869712(PPP1R13L, Protein phosphatase 1, regulatory ( inhibitor ) subunit 13 like), GeneBank accession No: AY028896 (CARDlO, Caspase recruitment domain family, member 10), GeneBank accession No: AK122614 (PPARD, Peroxisome proliferative activated receptor, delta), GeneBank accession No: AK092872 (ERCC2 , Excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)), GeneBank accession No: AK092808 (RRAGC, Ras-related GTP binding C), GeneBank accession No: AJ001898 (GDNF, Glial cell derived neurotrophic factor), GeneBank accession No: AF220656 (PHLDAl, Pleckstrin homology-like domain, family A, member 1), GeneBank accession No: AF055634 (UNC5C, Unc-5 homolog C(C. elegans)), GeneBank accession No: AB209485(VEGF, Vascular endothelial growth factor), GeneBank accession No: AB096256 (UNC5B, Unc-5 homolog B(C. elegans)), GeneBank accession No: AB007960 ( SH3GLB1 , SH3- domain GRB2-like endophilin Bl), GeneBank accession No: X06374 (PDGFA, Platelet-derived growth factor alpha polypeptide), GeneBank accession No: S62138 (DDIT3 , DNA- damage-inducible transcript 3), GeneBank accession No: NM_078487(CDKN2B, Cyclin-dependent kinase inhibitor 2B(pl5, inhibits CDK4 ) ) , GeneBank accession No: NM_012127 (CIZl , CDKNlA interacting zinc finger protein 1), GeneBank accession No: NM_005883 ( APC2 , Adenomatosis polyposis coli 2), GeneBank accession No: NM_004196 (CDKLl , Cyclin- dependent kinase-like 1 (CDC2-related kinase)), GeneBank accession No: NM_003236 (TGFA, Transforming growth factor, alpha), GeneBank accession No: NM_001261 (CDK9 , Cyclin- dependent kinase 9 (CDC2-related kinase)), GeneBank accession No: NM_001007271 (DUSP13 , Dual specificity phosphatase 13), GeneBank accession No: CR749511 (PARC, P53- associated parkin-like cytoplasmic protein), GeneBank accession No: CR623038 ( ID2 , Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein) , GeneBank accession No: CR618371 (EGFR, Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)), GeneBank accession No: BF965144 ( IFITMl , Interferon induced transmembrane protein 1(9-27)), GeneBank accession No: AK127679 (DUSPl , Dual specificity phosphatase 1), GeneBank accession No: AK096276 (CCND3 , Cyclin D3 ) , GeneBank accession No: AB209586 (MAPK13 , Mitogen-activated protein kinase 13), GeneBank accession No: AB209465 (PCTKl , PCTAIRE protein kinase 1), GeneBank accession No: Z19588(SKIL, SKI-like), GeneBank accession No: NM_020429 (SMURFl, SMAD specific E3 ubiquitin protein ligase 1), GeneBank accession No: NM_014767 ( SPOCK2 , Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2), GeneBank accession No: NM_OO5979(S1OOA13, SlOO calcium binding protein A13), GeneBank accession No: NM_005187 (CBFA2T3 , Core-binding factor, runt domain, alpha subunit 2; translocated to, 3), GeneBank accession No: NM_004364 (CEBPA, CCAAT/enhancer binding protein(C/EBP) , alpha), GeneBank accession No: NM_001769(CD9, CD9 antigen (p24 )), GeneBank accession No: NM_001718 (BMP6 , Bone morphogenetic protein 6), GeneBank accession No: NM_000641 ( ILlI , Interleukin 11), GeneBank accession No: BX647459 ( SERPINE2 , Serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 2), GeneBank accession No: BQ066037 (RPS19 , Ribosomal protein S19), GeneBank accession No: BE791300 (EDFl , Endothelial differentiation-related factor 1), GeneBank accession No: BC038504 ( SNFlLK, SNFl-like kinase), GeneBank accession No: AL832287 ( ZAP70 , Zeta-chain(TCR) associated protein kinase 7OkDa), GeneBank accession No: AK125742 (PCGFl, Polycomb group ring finger 1), GeneBank accession No: AK124709 (NDRGl , N-myc downstream regulated gene 1), GeneBank accession No: AB011157 (PTDSR, Phosphatidylserine receptor), GeneBank accession No: NM_013255 (MKLNl, Muskelin 1, intracellular mediator containing kelch motifs), GeneBank accession No: NM_006572 (GNA13, Guanine nucleotide binding protein(G protein), alpha 13), GeneBank accession No: NM_002211 ( ITGBl , Integrin, beta 1 ( fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2 , MSK12)), GeneBank accession No: CR601067 (PLAUR, Plasminogen activator, urokinase receptor), GeneBank accession No: BC050456 (THBS4 , Thrombospondin 4), GeneBank accession No: AK027389 (CXCL16 , Chemokine (C-X-C motif) ligand 16), GeneBank accession No: AJ132099 (VNNl , Vanin 1), GeneBank accession No: XM_371354 (FLJ10157 , Hypothetical protein FLJ10157), GeneBank accession No: XM_208313(TPM3, Similar to tropomyosin 4), GeneBank accession No: XM_208270 ( ACR, Acrosin-like protease), GeneBank accession No: NM_203353 (PDLIM7 , PDZ and LIM domain 7(enigma)), GeneBank accession No: NM_201382 (PLECl , Plectin 1, intermediate filament binding protein 50OkDa), GeneBank accession No: NM_182961 ( SYNEl , Spectrin repeat containing, nuclear envelope 1), GeneBank accession No: NM_181826 (NF2 , Neurofibromin 2 (bilateral acoustic neuroma)), GeneBank accession No: NM_172069 (PLEKHH2 , Pleckstrin homology domain containing, family H (with MyTH4 domain) member 2), GeneBank accession No: NM_022648 (TNS , Tensin 1), GeneBank accession No: NM_017556 (FBLP-I, Filamin binding LIM protein 1), GeneBank accession No: NM_016081 (KIAA0992 , Palladin, cytoskeletal associated protein), GeneBank accession No: NM_006617(NES, Nestin), GeneBank accession No: NM_006262 (PRPH, Peripherin), GeneBank accession No: NM_OO51OO(AKAP12, A kinase(PRKA) anchor protein (gravin) 12), GeneBank accession No: NM_004368 (CNN2 , Calponin 2), GeneBank accession No: NM_003388 (CYLN2 , Cytoplasmic linker 2), GeneBank accession No: NM_003370 (VASP, Vasodilator- stimulated phosphoprotein) , GeneBank accession No: NM_003128(SPTBNl, Spectrin, beta, non-erythrocytic 1), GeneBank accession No: NM_002705 (PPL, Periplakin) , GeneBank accession No: NM_002475 (MLClSA, Myosin light chain 1 slow a), GeneBank accession No: NM_002018 (FLII , Flightless I homolog(Drosophila) ) , GeneBank accession No: NM_001465 ( FYB, FYN binding protein(FYB-120/130 ) ) , GeneBank accession No: NM_001069(TUBB2, Tubulin, beta 2A), GeneBank accession No: CR625172 (MGC8685, Tubulin, beta 2B), GeneBank accession No: CR616919(KRT18, Keratin 18), GeneBank accession No: CR606241 (ACTGl, Actin, gamma 1), GeneBank accession No: CB240572 (MYHIl, Myosin, heavy polypeptide 11, smooth muscle), GeneBank accession No: BX648253 (PTPN3 , Protein tyrosine phosphatase, non-receptor type 3), GeneBank accession No: BX648190 (WDRl , WD repeat domain 1), GeneBank accession No: BX641076 (ACTNl , Actinin, alpha 1), GeneBank accession No: BX537978 (EPB41L1 , Erythrocyte membrane protein band 4.1-like 1), GeneBank accession No: BG121847 (NUDC, Nuclear distribution gene C homolog(A. nidulans)), GeneBank accession No: BC068013 (MYOlC, Myosin IC), GeneBank accession No: BC065499 (MAST2 , Microtubule associated serine/threonine kinase 2), GeneBank accession No: BC051890(TUBG2, Tubulin, gamma 2), GeneBank accession No: BCO41874(MAP1LC3B, Microtubule-associated protein 1 light chain 3 beta), GeneBank accession No: BC012597 (ACTAl , Actin, alpha 1, skeletal muscle), GeneBank accession No: AY484427(KIF17, Kinesin family member 17), GeneBank accession No: AK130546 ( STOML2 , Stomatin(EPB72 ) -like 2), GeneBank accession No: AK124711 (CORO2B, Coronin, actin binding protein, 2B), GeneBank accession No: AK123974 (MYL5 , Myosin, light polypeptide 5, regulatory), GeneBank accession No: AK092792 (LOC389833 , Similar to hypothetical protein MGC27019), GeneBank accession No: AK026518 (MYOHDl , Myosin head domain containing 1), GeneBank accession No: AK024500 (NICAL, Microtubule associated monoxygenase, calponin and LIM domain containing 1), GeneBank accession No: AF085886(FLJ46675, Ribosomal protein L29 pseudogene 2), GeneBank accession No: AB209997 (MY09B, Myosin IXB), GeneBank accession No: Y12692 (WNTlI , Wingless-type MMTV integration site family, member 11), GeneBank accession No: Y11307 (CYR61 , Cysteine-rich, angiogenic inducer, 61), GeneBank accession No: X17033 ( ITGA2 , Integrin, alpha 2(CD49B, alpha 2 subunit of VLA-2 receptor)), GeneBank accession No: U41763 (CLTCLl , Clathrin, heavy polypeptide- like 1), GeneBank accession No: NM_153609 (TMPRSS6 , Transmembrane protease, serine 6), GeneBank accession No: NM_031483(ITCH, Itchy homolog E3 ubiquitin protein ligase(mouse) ) , GeneBank accession No: NM_024342 (GRLFl , Glucocorticoid receptor DNA binding factor 1 ) , GeneBank accession No: NM_017555 (EGLN2 , EgI nine homolog 2(C. elegans)), GeneBank accession No: NM_016569 (TBX3 , T-box 3 (ulnar mammary syndrome)), GeneBank accession No: NM_004148 (NINJl, Ninjurin 1), GeneBank accession No: NM_003377 (VEGFB, Vascular endothelial growth factor B), GeneBank accession No: NM_001983 (ERCCl , Excision repair cross-complementing rodent repair deficiency, complementation group 1( includes overlapping antisense sequence)), GeneBank accession No: NM_001552 ( IGFBP4 , Insulin-like growth factor binding protein 4), GeneBank accession No: NM_001430 (EPASl , Endothelial PAS domain protein 1), GeneBank accession No: NM_001300 (KLF6 , Kruppel- like factor 6), GeneBank accession No: NM_001012661 ( SLC3A2 , Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2), GeneBank accession No: NM_000596( IGFBPl, Insulin-like growth factor binding protein 1), GeneBank accession No: NM_000474 (TWISTl , Twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) (Drosophila) ), GeneBank accession No: BX649103(ChGn, Chondroitin betal,4 N- acetylgalactosaminyltransferase ), GeneBank accession No: BM913048 (TIMPl, TIMP metallopeptidase inhibitor 1), GeneBank accession No: BM904612 ( S100A6 , SlOO calcium binding protein A6 (calcyclin) ) , GeneBank accession No: BM556279 (EMP3, Epithelial membrane protein 3), GeneBank accession No: BC015041 (VATl , Family with sequence similarity 82, member C), GeneBank accession No: AY258066(OKL38, Pregnancy-induced growth inhibitor), GeneBank accession No: AK126729 (NDRG4 , NDRG family member 4), GeneBank accession No: AK090459 (NFE2L1 , Nuclear factor (erythroid-derived 2)-like 1), GeneBank accession No: AK074163(ROBO4, Roundabout homolog 4, magic roundabout ( Drosophila) ), GeneBank accession No: AK024680(FLJ21027 fis, CDNA: FLJ21027 fis, clone CAE07110), GeneBank accession No: AF176422 (HEYl , Hairy/enhancer-of- split related with YRPW motif 1), GeneBank accession No: AF003837 (JAGl, Jagged l(Alagille syndrome)), GeneBank accession No: AB209322 ( SEMA3B, Sema domain, immunoglobulin domain(Ig), short basic domain, secreted, ( semaphorin) 3B), GeneBank accession No: AB011150 (NRXNl , Neurexin 1), GeneBank accession No: NM_201589 (MAFA, V-maf musculoaponeurotic fibrosarcoma oncogene homolog A(avian)), GeneBank accession No: NM_052999 (CKLFSFl , CKLF-like MARVEL transmembrane domain containing 1), GeneBank accession No: NM_006644 (HSPHl, Heat shock 105kDa/110kDa protein 1), GeneBank accession No: NM_005438 (FOSLl , FOS-like antigen 1), GeneBank accession No: NM_004996 (ABCCl , ATP-binding cassette, sub-family C(CFTR/MRP), member 1), GeneBank accession No: NM_002658 (PLAU, Plasminogen activator, urokinase), GeneBank accession No: NM_001353 (AKRlCl , Aldo- keto reductase family 1, member Cl (dihydrodiol dehydrogenase 1; 20-alpha( 3-alpha) -hydroxysteroid dehydrogenase)), GeneBank accession No: H18681 (C20orf 139 , Sulfiredoxin 1 homolog(S. cerevisiae) ) , GeneBank accession No: DR004094 (HAMP, Hepcidin antimicrobial peptide), GeneBank accession No: BC082272 (KCNMB3 , Potassium large conductance calcium-activated channel, subfamily M beta member 3), GeneBank accession No: BC040494 (DNAJB2 , DnaJ(Hsp40) homolog, subfamily B, member 2), GeneBank accession No: BC018064 (ATF6 , Activating transcription factor 6), GeneBank accession No: BC006523 ( SGK2 , Serum/glucocorticoid regulated kinase 2 ) , GeneBank accession No: AK090482 (CXCL12 , Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor I)), GeneBank accession No: AF219946 (TULP4 , Tubby like protein 4), GeneBank accession No: AB209112 ( SLC2A8 , Solute carrier family 2 ,( facilitated glucose transporter) member 8), GeneBank accession No: NM_005242 (F2RL1 , Coagulation factor II (thrombin) receptor-like 1), GeneBank accession No: NM_001002029(C4A, Complement component 4B, telomeric), GeneBank accession No: NM_000539 (RHO, Rhodopsin( opsin 2, rod pigment ) (retinitis pigmentosa 4, autosomal dominant)), GeneBank accession No: BX649164 (PAI , serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), GeneBank accession No: BM918324 (LY96 , Lymphocyte antigen 96), GeneBank accession No: AB209647(NCF2, Neutrophil cytosolic factor 2(65kDa, chronic granulomatous disease, autosomal 2)), GeneBank accession No: NM_152221 (CSNKlE, Casein kinase 1, epsilon) , GeneBank accession No: NM_017999 (RNF31 , Ring finger protein 31), GeneBank accession No: NM_016819 (OGGl , 8-oxoguanine DNA glycosylase ) , GeneBank accession No: NM_016816 (OASl , 2',5'- oligoadenylate synthetase 1, 40/46kDa), GeneBank accession No: NM_012235 (SCAP, SREBP cleavage-activating protein), GeneBank accession No: NM_006384 (CIBl , Calcium and integrin binding 1 (calmyrin) ) , GeneBank accession No: NM_001779 (CD58 , CD58 antigen, ( lymphocyte function-associated antigen 3)), GeneBank accession No: CB055213 ( ICOSLG, Inducible T-cell co-stimulator ligand) , GeneBank accession No: BX641029 (MASPl , Mannan-binding lectin serine peptidase 1(C4/C2 activating component of Ra-reactive factor)), GeneBank accession No: BQ053419 (BATF, Basic leucine zipper transcription factor, ATF-like), GeneBank accession No: BC039299 ( STIPl , Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein)), GeneBank accession No: AY055760(DAF, Decay accelerating factor for complement (CD55 , Cromer blood group system)), GeneBank accession No: AK130188(FGR, Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog), GeneBank accession No: AK095326 (MUS81 , MUS81 endonuclease homolog (yeast ) ) , GeneBank accession No: NM_017670 (OTUBl, OTU domain, ubiquitin aldehyde binding 1), GeneBank accession No: NM_003004 ( SECTMl , Secreted and transmembrane 1), GeneBank accession No: NM_002309 (LIF, Hypothetical protein MGC20647), GeneBank accession No: NM_001421 (ELF4, E74-like factor 4(ets domain transcription factor)), GeneBank accession No: NM_000418 ( IL4R, Interleukin 4 receptor), GeneBank accession No: BI909222 (FCERlG, Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide), GeneBank accession No: BF569086(NK4, Interleukin 32), GeneBank accession No: BC014470 (AZGPl, Alpha-2-glycoprotein 1, zinc), GeneBank accession No: BC020744 (AKR1C4 , Aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol ), dehydrogenase 4), GeneBank accession No: BQ939577 ( AKR1C3 , Aldo-keto reductase family 1, member C3( 3-alpha hydroxysteroid dehydrogenase, type II)), GeneBank accession No: NM_000499 (CYPlAl , Cytochrome P450, family 1, subfamily A, polypeptide 1), GeneBank accession No: NM_030622 (CYP2S1 , Cytochrome P450, family 2, subfamily S, polypeptide 1), GeneBank accession No: NM_184041 (ALDOA, Aldolase A, fructose-bisphosphate ) , GeneBank accession No: NM_024307 (MGC4171 , Hypothetical protein LOC283901), GeneBank accession No: NM_005336 ( HDLBP, High density lipoprotein binding protein( vigilin) ) , GeneBank accession No: NM_002627 (PFKP, Phosphofructokinase, platelet), GeneBank accession No: BX648281 (LDLR, Low density lipoprotein receptor ( familial hypercholesterolemia)), GeneBank accession No: BC069201 (FLJ22761, Hexokinase domain containing 1), GeneBank accession No: BC030207 (NR0B2 , Nuclear receptor subfamily 0, group B, member 2), GeneBank accession No: AL833069(KIAA1434, Hypothetical protein KIAA1434), GeneBank accession No: AK124656 (ENO2 , Enolase 2 (gamma, neuronal)), GeneBank accession No: AK094474 (RHOC, Ras homolog gene family, member C), GeneBank accession No: AK093461 ( ISYNAl , Myo-inositol 1-phosphate synthase Al), GeneBank accession No: AB053232(GAL3ST3, Galactose-3-O-sulfotransferase 3), GeneBank accession No: AB045292 (TMEM8 , Transmembrane protein 8(five membrane-spanning domains)), GeneBank accession No: NM_004753 (DHRS3 , Dehydrogenase/reductase ( SDR family) member 3), GeneBank accession No: NM_002900 (RBP3 , Retinol binding protein 3, interstitial), GeneBank accession No: NM_001995 (ACSLl , Acyl-CoA synthetase long- chain family member 1), GeneBank accession No: NM_000018 ( ACADVL , Acyl-Coenzyme A dehydrogenase, very long chain), GeneBank accession No: BC094756 (CRA, Myotubularin related protein 11), GeneBank accession No: BC050553 (NTE , Neuropathy target esterase), GeneBank accession No: BC033110(HSD17Bl, Hydroxysteroid( 17-beta) dehydrogenase 1), GeneBank accession No: AY268890 (TPPl , Tripeptidyl peptidase I), GeneBank accession No: AK172798 (CPTlA, Carnitine palmitoyltransferase lA(liver)), GeneBank accession No: AK096809(CYP4F8, Cytochrome P450, family 4, subfamily F, polypeptide 8), GeneBank accession No: AK000600 ( SIAT7D, ST6 ( alpha-N-acetyl-neuraminyl-2 , 3-beta- galactosyl-1 , 3 ) -N- acetylgalactosaminide alpha-2 , 6-sialyltransferase 4), GeneBank accession No: AB002454 (CYP4F3 , Cytochrome P450, family 4, subfamily F, polypeptide 3), GeneBank accession No: Z29093 (DDRl, Discoidin domain receptor family, member 1), GeneBank accession No: Z25424 (MKNK2 , MAP kinase interacting serine/threonine kinase 2), GeneBank accession No: XM_291277(DKFZp76lP0423, Hypothetical protein DKFZp76lP0423) , GeneBank accession No: XM_038150 (MAST3 , Microtubule associated serine/threonine kinase 3), GeneBank accession No: U88357 (ERBB3 , V-erb-b2 erythroblastic leukemia viral oncogene homolog 3(avian)), GeneBank accession No: NM_025195 (TRIBl , Tribbles homolog l(Drosophila) ) , GeneBank accession No: NM_020639 (RIPK4 , Receptor-interacting serine-threonine kinase 4), GeneBank accession No: NM_014172 (PHPTl , Phosphohistidine phosphatase 1), GeneBank accession No: NM_006254 (PRKCD, Protein kinase C, delta), GeneBank accession No: NM_005415 ( SLC20A1 , Solute carrier family 20(phosphate transporter), member 1), GeneBank accession No: NM_005026 (PIK3CD, Phosphoinositide- 3-kinase, catalytic, delta polypeptide), GeneBank accession No: NM_004431(EPHA2, EPH receptor A2 ) , GeneBank accession No: NM_004419(DUSP5, Dual specificity phosphatase 5), GeneBank accession No: NM_004327 (BCR, Breakpoint cluster region), GeneBank accession No: NM_004231 (ATP6V1F, ATPase, H+ transporting, lysosomal 14kDa, Vl subunit F), GeneBank accession No: NM_004090 (DUSP3 , Dual specificity phosphatase 3 (vaccinia virus phosphatase VHl-related) ) , GeneBank accession No: NM_002843 (PTPRJ, Protein tyrosine phosphatase, receptor type, J), GeneBank accession No: NM_002496 (NDUFS8 , NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH- coenzyme Q reductase)), GeneBank accession No: NM_001001852(PIM3, Pim-3 oncogene), GeneBank accession No: L76191 ( IRAKI , Interleukin-1 receptor-associated kinase 1), GeneBank accession No: D15049 (PTPRH, Protein tyrosine phosphatase, receptor type, H), GeneBank accession No: BC065207(ATP6V0D2, ATPase, H+ transporting, lysosomal 38kDa, VO subunit d isoform 2), GeneBank accession No: BC035578(STK24, Serine/threonine kinase 24(STE20 homolog, yeast)), GeneBank accession No: BC028724 (DUSP18 , Dual specificity phosphatase 18), GeneBank accession No: AL117482(ULK3, Unc-51-like kinase 3(C. elegans)), GeneBank accession No: AK126879 (PCTK3 , PCTAIRE protein kinase 3), GeneBank accession No: AB209416 ( ILK, Integrin-linked kinase-2), GeneBank accession No: NM_000782 (CYP24A1 , Cytochrome P450, family 24, subfamily A, polypeptide 1), GeneBank accession No: CR597101 (ZFP36, Zinc finger protein 36, C3H type, homolog(mouse) ), GeneBank accession No: CR936799(FHL2, Four and a half LIM domains 2), GeneBank accession No: M24898 (NRlDl , Nuclear receptor subfamily 1, group D, member 1), GeneBank accession No: AF132818 (KLF5 , Kruppel-like factor 5 ( intestinal )), GeneBank accession No: AK055337(ZNF213, Zinc finger protein 213), GeneBank accession No: BC008834 (PHFl , PHD finger protein 1), GeneBank accession No: AK126918 (GLIS2 , GLIS family zinc finger 2), GeneBank accession No: BC042692 (CTL2 , Solute carrier family 44, member 2), GeneBank accession No: NM_002224(ITPR3, Inositol 1 , 4 , 5-triphosphate receptor, type 3), GeneBank accession No: AK095363 (AQP3 , Aquaporin 3), GeneBank accession No: NM_174953 ( ATP2A3 , ATPase, Ca++ transporting, ubiquitous), GeneBank accession No: BC042390 (VTIlB, Vesicle transport through interaction with t-SNAREs homolog lB(yeast)), GeneBank accession No: NM_016113(TRPV2, Transient receptor potential cation channel, subfamily V, member 2), GeneBank accession No: BM926478 (RBPl, Retinol binding protein 1, cellular), GeneBank accession No: NM_000069 (CACNAlS, Calcium channel, voltage-dependent, L type, alpha IS subunit), GeneBank accession No: AK002107 (RAB3B, RAB3B, member RAS oncogene family), GeneBank accession No: NM_013321 ( SNX8 , Sorting nexin 8), GeneBank accession No: AK125026 ( SLC6A12 , Solute carrier family 6 (neurotransmitter transporter, betaine/GABA) , member 12), GeneBank accession No: NM_005843(STAM2, Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2), GeneBank accession No: AK092512 (SLC16A5, Solute carrier family 16 (monocarboxylic acid transporters), member 5), GeneBank accession No: U49248(ABCC2, ATP-binding cassette, sub-family C(CFTR/MRP), member 2), GeneBank accession No: AK172792 ( SCNNlA, Sodium channel, nonvoltage-gated 1 alpha), GeneBank accession No: BC044656(CASC3, Cancer susceptibility candidate 3), GeneBank accession No: NM_203403 (C9orf150 , Chromosome 9 open reading frame 150), GeneBank accession No: NM_080388(S100A16, SlOO calcium binding protein A16), GeneBank accession No: NM_031286 ( SH3BGRL3 , SH3 domain binding glutamic acid-rich protein like 3 ) , GeneBank accession No: NM_022153 (PP2135, Chromosome 10 open reading frame 54), GeneBank accession No: NM_004864 (GDF15 , Growth differentiation factor 15), GeneBank accession No: NM_003330 (TXNRDl, Thioredoxin reductase 1), GeneBank accession No: NM_001013632 (LOC343521 , Similar to hypothetical protein 4833401D15), GeneBank accession No: BX537968(LOC51149, Hypothetical LOC51149), GeneBank accession No: BU945318 (MT2A, Hypothetical gene supported by X97260; BC070289), GeneBank accession No: BQ683841 ( SlOOAIl , SlOO calcium binding protein All (calgizzarin) ) , GeneBank accession No: BQ276852 (TMSBlO , Thymosin, beta 10), GeneBank accession No: AK126182 (KIAA1949 , KIAA1949), GeneBank accession No: AK124751 (CAPN2 , Calpain 2,(m/ll) large subunit), GeneBank accession No: AK095079 (RGC32 , Response gene to complement 32), GeneBank accession No: AB075871(FLJ42654, Golgi transport 1 homolog A(S. cerevisiae ) ) . [Claim 14] The method according to claim 12, wherein the below genes are down-regulated by exposure to phenanthrene : GeneBank accession No: AK125150 (MAPK8 , Mitogen- activated protein kinase 8), GeneBank accession No: NM_002758 (MAP2K6 , Mitogen-activated protein kinase kinase 6), GeneBank accession No: NM_004612 (TGFBRl , Transforming growth factor, beta receptor I(activin A receptor type II- like kinase, 53kDa)), GeneBank accession No: NM_145686(MAP4K4, Mitogen-activated protein kinase kinase kinase kinase 4), GeneBank accession No: XM_042066 (MAP3K1 , Mitogen-activated protein kinase kinase kinase 1 ) , GeneBank accession No: AB011123 (TNIK, TRAF2 and NCK interacting kinase), GeneBank accession No: AB209031(C5, Complement component 5), GeneBank accession No: NM_022740 (HIPK2 , Homeodomain interacting protein kinase 2), GeneBank accession No: NM_148957 (TNFRSF19 , Tumor necrosis factor receptor superfamily, member 19), GeneBank accession No: AB208909(ITGB2, Integrin, beta 2(antigen CDl8(p95), lymphocyte function-associated antigen 1; macrophage antigen l(mac-l) beta subunit)), GeneBank accession No: AB209211 (TIAl, TIAl cytotoxic granule-associated RNA binding protein), GeneBank accession No: AB209613 ( DNASE1L3 , Deoxyribonuclease I-like 3), GeneBank accession No: AK122825 (HMGBl, High-mobility group box 1), GeneBank accession No: AK127326 (PHF17 , PHD finger protein 17), GeneBank accession No: AK223503 (CASPl , Caspase 1, apoptosis-related cysteine peptidase ( interleukin 1, beta, convertase) ) , GeneBank accession No: BC013326 (GAS2 , Growth arrest-specific 2), GeneBank accession No: BC047698 ( IL7 , Interleukin I)1 GeneBank accession No: D79987 (ESPLl , Extra spindle poles like 1(S. cerevisiae) ) , GeneBank accession No: NM_000893 (KNGl, Kininogen 1), GeneBank accession No: NM_001012271(BIRC5, Effector cell peptidase receptor 1), GeneBank accession No: NM_004938 (DAPKl , Death-associated protein kinase 1), GeneBank accession No: NM_005879 (TRIP, TRAF interacting protein), GeneBank accession No: NM_014739 (BCLAFl, BCL2-associated transcription factor 1), GeneBank accession No: NM_018947 (CYCS, Cytochrome c, somatic), GeneBank accession No: AB033337 (MPHOSPHl , M-phase phosphoprotein 1), GeneBank accession No: AB209179 (PLKl , Polo-like kinase 1 (Drosophila) ) , GeneBank accession No: AB209337(CDC7, CDC7 cell division cycle 7(S. cerevisiae)), GeneBank accession No: AF053305 (BUBl , BUBl budding uninhibited by benzimidazoles 1 homolog(yeast ) ) , GeneBank accession No: AF053306 (BUBlB, BUBl budding uninhibited by benzimidazoles 1 homolog beta(yeast ) ) , GeneBank accession No: AF345347 (SPAG5, Sperm associated antigen 5), GeneBank accession No: AK092638 (CCNG2 , Cyclin G2 ) , GeneBank accession No: AK222819 (NUSAPl , Nucleolar and spindle associated protein 1), GeneBank accession No: AL833191 (SMC2L1, SMC2 structural maintenance of chromosomes 2-like l(yeast)), GeneBank accession No: AY257469 (CIT, Citron(rho-interacting, serine/threonine kinase 21)), GeneBank accession No: AY367065 (ASPM, Asp(abnormal spindle) -like, microcephaly associated(Drosophila) ) , GeneBank accession No: BCOIlOOO (CDCA5, Cell division cycle associated 5), GeneBank accession No: BC032677 (UBE2C, Ubiquitin-conjugating enzyme E2C), GeneBank accession No: BC043502 (NEK2, NIMA(never in mitosis gene a)-related kinase 2), GeneBank accession No: BU675073 (PTTGl , Pituitary tumor- transforming 1), GeneBank accession No: BX647885 ( STMNl , Stathmin 1/oncoprotein 18), GeneBank accession No: CR592757 (BRRNl, Barren homolog 1 (Drosophila) ) , GeneBank accession No: CR597075 (MAPRE2 , Microtubule-associated protein, RP/EB family, member 2), GeneBank accession No: CR604810(CCNA2, Cyclin A2 ) , GeneBank accession No: CR933728(CDC2, Cell division cycle 2, Gl to S and G2 to M), GeneBank accession No: NM_000919 (PAM, Peptidylglycine alpha-amidating monooxygenase) , GeneBank accession No: NM_001790(CDC25C, Cell division cycle 25C), GeneBank accession No: NM_001798 (CDK2 , Cyclin-dependent kinase 2), GeneBank accession No: NM_001813 (CENPE , Centromere protein E, 312kDa), GeneBank accession No: NM_003318 (TTK, TTK protein kinase), GeneBank accession No: NM_003981 (PRCl , Protein regulator of cytokinesis 1), GeneBank accession No: NM_004523 (KIFIl, Kinesin family member 11), GeneBank accession No: NM_004701 (CCNB2 , Cyclin B2 ) , GeneBank accession No: NM_005983 ( SKP2 , S-phase kinase-associated protein 2(p45)), GeneBank accession No: NM_006101 (KNTC2 , Kinetochore associated 2), GeneBank accession No: NM_006845(KIF2C, Kinesin family member 2C), GeneBank accession No: NM_007375 ( TARDBP , TAR DNA binding protein), GeneBank accession No: NM_012112 (TPX2 , TPX2 , microtubule- associated, homolog(Xenopus laevis)), GeneBank accession No: NM_014750(DLG7, Discs, large homolog 7 ( Drosophila) ) , GeneBank accession No: NM_015097 (CLASP2 , Cytoplasmic linker associated protein 2), GeneBank accession No: NM_016343 (CENPF, Centromere protein F, 350/400ka(mitosin) ) , GeneBank accession No: NM_016426 (GTSEl , G-2 and S-phase expressed 1), GeneBank accession No: NM_018492 (PBK, PDZ binding kinase), GeneBank accession No: NM_018685 (ANLN, Anillin, actin binding protein ( scraps homolog, Drosophila)), GeneBank accession No: NM_020242 (KNSL7 , Kinesin family member 15), GeneBank accession No: NM_031966 (CCNBl , Cyclin Bl), GeneBank accession No: NM_138555 (KIF23 , Kinesin family member 23), GeneBank accession No: U65410 (MAD2L1 , MAD2 mitotic arrest deficient-like l(yeast)), GeneBank accession No: AB020656 (CYLD, Cylindromatosis ( turban tumor syndrome)), GeneBank accession No: AF033122 ( SESNl , Sestrin 1), GeneBank accession No: AK074377 (UHRFl , Chromosome 19 open reading frame 31), GeneBank accession No: AK091170 (CDKN2C, Cyclin- dependent kinase inhibitor 2C(pl8, inhibits CDK4 ) ) , GeneBank accession No: AK094323 (NFYC, Nuclear transcription factor Y, gamma), GeneBank accession No: AY366508 (L0H11CR2A, Loss of heterozygosity, 11, chromosomal region 2, gene A), GeneBank accession No: BC033086 (TCF19 , Transcription factor 19(SCl)), GeneBank accession No: BC040303 (PTP4A1 , Protein tyrosine phosphatase type IVA, member 1), GeneBank accession No: BC040991 (TFDP2 , Transcription factor Dp-2(E2F dimerization partner 2)), GeneBank accession No: BC092412(SGOL2, Shugoshin-like 2(S. pombe)), GeneBank accession No: BQ278454 (CKSlB, CDC28 protein kinase regulatory subunit IB), GeneBank accession No: BX649128(SESN3, Sestrin 3), GeneBank accession No: CD049340 (AURKB, Aurora kinase B), GeneBank accession No: M89914(NF1, Neurofibromin 1 (neurofibromatosis , von Recklinghausen disease, Watson disease)), GeneBank accession No: NM_001005414 ( ZWINT, ZWlO interactor antisense), GeneBank accession No: NM_001008491 ( Sep 2, Septin 2), GeneBank accession No: NM_001274 (CHEKl , CHKl checkpoint homolog(S. pombe ) ) , GeneBank accession No: NM_002105(H2AFX, H2A histone family, member X), GeneBank accession No: NM_002388 (MCM3 , MCM3 minichromosome maintenance deficient 3(S. cerevisiae ) ) , GeneBank accession No: NM_OO2417(MKI67, Antigen identified by monoclonal antibody Ki-67), GeneBank accession No: NM_002875 (RAD51 , RAD51 homolog(RecA homolog, E. CoIi)(S. cerevisiae)), GeneBank accession No: NM_003884 (PCAF, P300/CBP-associated factor), GeneBank accession No: NM_004526 (MCM2 , MCM2 minichromosome maintenance deficient 2, mitotin(S. cerevisiae)), GeneBank accession No: NM_004847 (AIFl , Allograft inflammatory factor 1), GeneBank accession No: NM_005915 (MCM6 , MCM6 minichromosome maintenance deficient 6(MIS5 homolog, S. pombe ) ( S . cerevisiae)), GeneBank accession No: NM_012090 (MACFl , Microtubule-actin crosslinking factor 1), GeneBank accession No: NM_012415(RAD54B, RAD54 homolog B(S. cerevisiae)), GeneBank accession No: NM_014264 (PLK4 , Polo-like kinase 4(Drosophila) ) , GeneBank accession No: NM_015714 (G0S2 , GO/Glswitch 2), GeneBank accession No: NM_024680 ( FLJ23311 , E2F transcription factor 8), GeneBank accession No: XM_034274 (MYBLl , V-myb myeloblastosis viral oncogene homolog ( avian) -like 1), GeneBank accession No: AK001720(FLJl0858, Nei endonuclease Vlll-like 3(E. coli)), GeneBank accession No: AY032677 (POLQ, Polymerase (DNA directed), theta), GeneBank accession No: BC034480 (BLM, Bloom syndrome), GeneBank accession No: BC073161 (RAD51C, RAD51 homolog C(S. cerevisiae ) ) , GeneBank accession No: CR600021(HMGB2, High-mobility group box 2), GeneBank accession No: CR625391 (RAD51AP1 , RAD51 associated protein 1), GeneBank accession No: CR936783 (FLJ40869 , Hypothetical protein LOC284952), GeneBank accession No: DQ140356 (KIAA1596 , Fanconi anemia, complementation group M), GeneBank accession No: NM_001067 (T0P2A, Topoisomerase (DNA) II alpha 17OkDa), GeneBank accession No: NM_001618 (PARPl , Poly ( ADP-ribose) polymerase family, member 1), GeneBank accession No: NM_003362 (UNG, Uracil-DNA glycosylase) , GeneBank accession No: NM_006904 (PRKDC, Protein kinase, DNA-activated, catalytic polypeptide), GeneBank accession No: NM_130398 (EXOl, Exonuclease 1), GeneBank accession No: AB020807 (TLR6 , Toll-like receptor 6), GeneBank accession No: AB032980(DCDC2 , Doublecortin domain containing 2), GeneBank accession No: AB209866 (TFPI, Tissue factor pathway- inhibitor ( lipoprotein-associated coagulation inhibitor)), GeneBank accession No: AK057015 (HSPA4 , Heat shock 7OkDa protein 4), GeneBank accession No: AK095515 ( IFITl , Interferon-induced protein with tetratricopeptide repeats 1), GeneBank accession No: AK122686(IF, I factor (complement) ), GeneBank accession No: AK123010 (RRM2 , Ribonucleotide reductase M2 polypeptide), GeneBank accession No: BC035582 (TRIM22 , Tripartite motif-containing 22), GeneBank accession No: BX537894 (LOC493869 , Similar to RIKEN cDNA 2310016C16), GeneBank accession No: M14338 (PROSl , Protein S(alpha)), GeneBank accession No: NM_000821 (GGCX, Gamma-glutamyl carboxylase), GeneBank accession No: NM_000963 (PTGS2, Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) ) , GeneBank accession No: NM_001001547 (CD36 , CD36 antigen(collagen type I receptor, thrombospondin receptor)), GeneBank accession No: NM_001512(GSTA4, Glutathione S-transferase A4 ) , GeneBank accession No: NM_001629 (AL0X5AP, Arachidonate 5- lipoxygenase-activating protein), GeneBank accession No: NM_001752(CAT, Catalase), GeneBank accession No: NM_001837(CCR3, Chemokine (C-C motif) receptor 3), GeneBank accession No: NM_001979 (EPHX2 , Epoxide hydrolase 2, cytoplasmic), GeneBank accession No: NM_001994 ( F13B, Coagulation factor XIII, B polypeptide), GeneBank accession No: NM_002182( ILlRAP, Interleukin 1 receptor accessory protein), GeneBank accession No: NM_006120 (HLA-DMA, Major histocompatibility complex, class II, DM alpha), GeneBank accession No: NM_173216 ( SIATl , ST6 beta-galactosamide alpha-2 , 6-sialyltranferase 1), GeneBank accession No: NM_202002 (FOXMl, Forkhead box Ml), GeneBank accession No: AB163917 (LRAP, Leukocyte-derived arginine aminopeptidase) , GeneBank accession No: BC027881 (AFP, Alpha-fetoprotein) , GeneBank accession No: NM_015915 ( SPG3A, Spastic paraplegia 3A( autosomal dominant)), GeneBank accession No: NM_000671(ADH5, Alcohol dehydrogenase 5 (class III), chi polypeptide), GeneBank accession No: J05428 (UGT2B7 , UDP glucuronosyltransferase 2 family, polypeptide B7 ) , GeneBank accession No: NM_000672 (ADH6 , Alcohol dehydrogenase 6 (class V)), GeneBank accession No: M15943(ADH4, Alcohol dehydrogenase 4(class II), pi polypeptide), GeneBank accession No: AK223395 (FBPl , Fructose-1 , 6-bisphosphatase 1), GeneBank accession No: NM_000151 (G6PC, Glucose-6- phosphatase, catalytic ( glycogen storage disease type I, von Gierke disease)), GeneBank accession No: XM_113962 (KIAA0650 , Structural maintenance of chromosomes flexible hinge domain containing 1), GeneBank accession No: AB020644 (ACSL6 , Acyl- CoA synthetase long-chain family member 6), GeneBank accession No: AB209907 (PLDl , Phospholipase Dl, phophatidylcholine-specific ) , GeneBank accession No: AF285167 (ABCAl, ATP-binding cassette, sub-family A(ABCl), member 1), GeneBank accession No: AF297872 (TRERFl , Transcriptional regulating factor 1), GeneBank accession No: AF3O3134(ALDH8A1, Aldehyde dehydrogenase 8 family, member Al), GeneBank accession No: AF339053 (PLA2G12B, Phospholipase A2 , group XIIB), GeneBank accession No: AK096018 (HADHSC, L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain), GeneBank accession No: AK124635 (PCSK9 , Proprotein convertase subtilisin/kexin type 9), GeneBank accession No: AK127346 ( SIAT9 , ST3 beta-galactoside alpha- 2 , 3-sialyltransferase 5), GeneBank accession No: AL359559 (AGPS, Alkylglycerone phosphate synthase), GeneBank accession No: AY691170 (PLCL3 , Phospholipase C-like 3), GeneBank accession No: BG567934 (APOM, Apolipoprotein M), GeneBank accession No: BX538214 (Cβorf167 , Chromosome 6 open reading frame 167), GeneBank accession No: BX640945 (FADS2 , Fatty acid desaturase 2), GeneBank accession No: BX648473(PIGK, Phosphatidylinositol glycan, class K), GeneBank accession No: BX648557 (HSD17B2 , Hydroxysteroid( 17- beta) dehydrogenase 2), GeneBank accession No: CR749601 (ETNKl, Death-associated protein kinase 3), GeneBank accession No: NM_000859 (HMGCR, 3-hydroxy-3- methylglutaryl-Coenzyme A reductase), GeneBank accession No: NM_001443(FABPl, Fatty acid binding protein 1, liver), GeneBank accession No: NM_002130 (HMGCSl , 3-hydroxy-3- methylglutaryl-Coenzyme A synthase l(soluble)), GeneBank accession No: NM_003725 (RODH, Hydroxysteroid( 17-beta) dehydrogenase 6), GeneBank accession No: NM_004845 (PCYTlB, Phosphate cytidylyltransferase 1, choline, beta), GeneBank accession No: NM_014762 (DHCR24 , 24-dehydrocholesterol reductase), GeneBank accession No: NM_020139 ( DHRS6 , Dehydrogenase/reductase ( SDR family) member 6), GeneBank accession No: NM_020918 (GPAM, Glycerol-3-phosphate acyltransferase, mitochondrial), GeneBank accession No: NM_032523(OSBPL6, Oxysterol binding protein-like 6), GeneBank accession No: NM_033505 ( SELI , Selenoprotein I), GeneBank accession No: Z28339 (AKRlDl , Aldo-keto reductase family 1, member Dl (delta 4-3-ketosteroid-5-beta- reductase)), GeneBank accession No: AK024899 (ENPP3 , Ectonucleotide pyrophosphatase/ phosphodiesterase 3), GeneBank accession No: AK025546 (PTPN4 , Protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte )), GeneBank accession No: AK124910 (ENPP2 , Ectonucleotide pyrophosphatase/phosphodiesterase 2 ( autotaxin) ) , GeneBank accession No: BC035116 (FLJ35059 fis, CDNA FLJ30761 fis, clone FEBRA2000538 ) , GeneBank accession No: BC050565 (PASK, PAS domain containing serine/threonine kinase), GeneBank accession No: L13436(NPR2, Natriuretic peptide receptor B/guanylate cyclase B( atrionatriuretic peptide receptor B)), GeneBank accession No: NM_001005862 (ERBB2 , V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog ( avian) ), GeneBank accession No: NM_005012 (RORl , Receptor tyrosine kinase-like orphan receptor 1), GeneBank accession No: NM_006035(CDC42BPB, CDC42 binding protein kinase beta(DMPK- like)), GeneBank accession No: NM_014791 (MELK, Maternal embryonic leucine zipper kinase), GeneBank accession No: NM_023028(FGFR2, Fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer yndrome, Jackson-Weiss syndrome)), GeneBank accession No: NM_080836 ( STK35 , Serine/threonine kinase 35), GeneBank accession No: AF419331 (FUSIPl , FUS interacting protein(serine/arginine-rich) 1), GeneBank accession No: AK091927(SFRS3, Splicing factor, arginine/serine-rich 3), GeneBank accession No: BCO 10266 (HNRNPAl , Heterogeneous nuclear ribonucleoprotein Al), GeneBank accession No: BC012360(CTAGE5, CTAGE family, member 5), GeneBank accession No: BC036046 (PLRGl , Pleiotropic regulator 1(PRLl homolog, Arabidopsis ) ) , GeneBank accession No: BC065384 (PCFIl, PCFIl, cleavage and polyadenylation factor subunit, homolog(S. cerevisiae ) ) , GeneBank accession No: BX537360(CPSF5, Nudix( nucleoside diphosphate linked moiety X) -type motif 21), GeneBank accession No: BX537494 (HNRPA2B1 , Heterogeneous nuclear ribonucleoprotein A2/B1), GeneBank accession No: BX647784 (HNRPR, Heterogeneous nuclear ribonucleoprotein R), GeneBank accession No: CA455267 (PPIH, Peptidyl prolyl isomerase H(cyclophilin H)), GeneBank accession No: CR596214 ( HNRPAO , Heterogeneous nuclear ribonucleoprotein AO), GeneBank accession No: NM_001326(CSTF3, Hypothetical protein LOC283267), GeneBank accession No: NM_004640 (BATl , HLA-B associated transcript 1), GeneBank accession No: NM_005463 (HNRPDL, Heterogeneous nuclear ribonucleoprotein D-like), GeneBank accession No: NM_006924 (SFRSl, Splicing factor, arginine/serine-rich 1( splicing factor 2, alternate splicing factor)), GeneBank accession No: NM_012426 ( SF3B3 , Splicing factor 3b, subunit 3, 13OkDa), GeneBank accession No: NM_018048 (FLJ10292 , Mago-nashi homolog), GeneBank accession No: NM_030919(C20orf129, Chromosome 20 open reading frame 129), GeneBank accession No: NM_031370 (HNRPD, Heterogeneous nuclear ribonucleoprotein D(AU-rich element RNA binding protein 1, 37kDa)), GeneBank accession No: NM_138933 (ACF, Apobec-1 complementation factor), GeneBank accession No: AB193259 ( ACE2 , Angiotensin I converting enzyme (peptidyl- dipeptidase A) 2), GeneBank accession No: BX648769 (EWSRl , Ewing sarcoma breakpoint region 1), GeneBank accession No: AB023154 (DTX4, Deltex 4 homolog ( Drosophila) ), GeneBank accession No: AL543755 ( VAV3 , Vav 3 oncogene), GeneBank accession No: M75106(CPB2, Carboxypeptidase B2 (plasma, carboxypeptidase U) ) , GeneBank accession No: NM_021045(ZNF248, Zinc finger protein 248), GeneBank accession No: AB209194 (B4GALT6 , UDP-GaI :betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6), GeneBank accession No: AF279145 (ANTXRl , Anthrax toxin receptor 1), GeneBank accession No: NM_025074 (FRASl , Fraser syndrome 1), GeneBank accession No: AK025790 (KIF20A, Kinesin family member 20A), GeneBank accession No: NM_006152 (LRMP, Lymphoid-restricted membrane protein), GeneBank accession No: NM_000340(SLC2A2, Solute carrier family 2 ( facilitated glucose transporter), member 2), GeneBank accession No: AF071592(KIF4A, Kinesin family member 4A), GeneBank accession No: NM_013277 (RACGAPl , Rac GTPase activating protein 1), GeneBank accession No: AY043484 ( SCNlA, Sodium channel, voltage-gated, type I, alpha), GeneBank accession No: AY791349(KIF18A, Kinesin family member 18A), GeneBank accession No: NM_018018 ( SLC38A4 , Solute carrier family 38, member 4), GeneBank accession No: AK094603 (FLJ37284 fis, unnamed protein product; Homo sapiens cDNA FLJ37284 fis, clone BRAMY2013590. ) , GeneBank accession No: NM_021069(ARGBP2, Sorbin and SH3 domain containing 2), GeneBank accession No: NM_001005747 (CACNB4 , Calcium channel, voltage-dependent, beta 4 subunit), GeneBank accession No: AJ496568(SLC25A12, Solute carrier family 25 (mitochondrial carrier, Aralar), member 12), GeneBank accession No: NM_030641 (AP0L6, Apolipoprotein L, 6), GeneBank accession No: NM_173512 (FLJ39822, Hypothetical protein FLJ39822), GeneBank accession No: NM_000037 (ANKl , Ankyrin 1, erythrocytic), GeneBank accession No: NM_001011554 ( SLC13A3 , Solute carrier family 13 ( sodium-dependent dicarboxylate transporter), member 3), GeneBank accession No: AB091343(C10orf3, Centrosomal protein 55kDa), GeneBank accession No: AK000643 (ASB9 , Ankyrin repeat and SOCS box- containing 9), GeneBank accession No: AK055221 ( FBXO5 , F-box protein 5), GeneBank accession No: AK075271 (SPTLC2L, Serine palmitoyltransferase, long chain base subunit 2- like ( aminotransferase 2)), GeneBank accession No: AK122685 (GLUDl, Glutamate dehydrogenase 1), GeneBank accession No: AK127098 (FLJ10706 , Chromosome 1 open reading frame 112), GeneBank accession No: AL133031 (MLRl , Transcription factor MLRl), GeneBank accession No: AY007723(MAL2, MaI, T-cell differentiation protein 2), GeneBank accession No: BC022255 ( Spc25 , Spindle pole body component 25 homolog(S. cerevisiae ) ) , GeneBank accession No: BC041882(ATF7IP2, Activating transcription factor 7 interacting protein 2), GeneBank accession No: BC052951 (LMNBl, Lamin Bl), GeneBank accession No: BC098313(FLJ20641, Hypothetical protein FLJ20641), GeneBank accession No: NM_001809 (CENPA, Centromere protein A, 17kDa), GeneBank accession No: NM_145061 (C13orf3 , Chromosome 13 open reading frame 3), GeneBank accession No: XM_372695(LOC390859, PREDICTED: Homo sapiens similar to Chain A, Crystal Structure Of The R463a Mutant Of Human Glutamate Dehydrogenase (LOC390859 ), mRNA) . [Claim 15] The method according to claim 12, wherein the human somatic cell of step 1) is originated from human liver or liver cancer cells or tissues. [Claim 16] The method according to claim 15, wherein the human liver cancer cell is HepG2. [Claim 17] The method according to claim 12, wherein the fluorescent material of step 3) is selected from the group consisting of Cy3 , Cy5, FITC (poly L-lysine-fluorescein isothiocyanate) , RITC (rhodamine-B-isothiocyanate) and rhodamine . [Claim 18] A method for detecting the below genes for the identification of exposure to phenanthrene, comprising the following steps: 1 ) extracting RNAs from the experimental group human somatic cells and the control group human somatic cells; 2) performing real-time RT-PCR (reverse transcript polymerase chain reaction) with the RNAs of step 1) using a primer set capable of amplifying a gene selected from the group consisting of the genes below; and 3 ) determining exposure to phenanthrene by comparing gene expressions, precisely if the gene expression in the experimental group exposed to phenanthrene is significantly changed, compared with that of the control group, it is judged that the gene is exposed to phenanthrene. GeneBank accession No: NM_004420 (DUSP8 , Dual specificity phosphatase 8), GeneBank accession No: L11329(DUSP2 , Dual specificity phosphatase 2), GeneBank accession No: BC094766 (PKNl , Protein kinase Nl), GeneBank accession No: AY247738 (TRIB3 , Tribbles homolog 3(Drosophila) ) , GeneBank accession No: AK129595 (GADD45B, Growth arrest and DNA-damage-inducible, beta), GeneBank accession No: AB208849 ( SHCl , SHC(SrC homology 2 domain containing) transforming protein 1), GeneBank accession No: X02812 (TGFBl, Transforming growth factor, beta l(Camurati- Engelmann disease )) , GeneBank accession No: NM_198951 (TGM2 , Transglutaminase 2(C polypeptide, protein-glutamine-gamma- glutamyltransferase) ), GeneBank accession No: NM_147780(CTSB, Cathepsin B), GeneBank accession No: NM_078467 (CDKNlA, Cyclin-dependent kinase inhibitor lA(p21, Cipl)), GeneBank accession No: NM_033027 (AXUDl , AXINl up- regulated 1), GeneBank accession No: NM_032797 (AMID, Apoptosis-inducing factor (AIF) -like mitochondrion- associated inducer of death), GeneBank accession No: NM_021960 (MCLl, Myeloid cell leukemia sequence 1(BCL2- related)), GeneBank accession No: NM__016639 (TNFRSF12A, Tumor necrosis factor receptor superfamily, member 12A), GeneBank accession No: NM_016222 (DDX41 , DEAD(Asp-Glu-Ala- Asp) box polypeptide 41), GeneBank accession No: NM_013246(CLC, Cardiotrophin-like cytokine factor 1), GeneBank accession No: NM_004401 (DFFA, DNA fragmentation factor, 45kDa, alpha polypeptide), GeneBank accession No: NM_004281(BAG3, BCL2-associated athanogene 3), GeneBank accession No: NM_003897 ( IER3 , Immediate early response 3), GeneBank accession No: NM_003806 (HRK, Harakiri, BCL2 interacting protein (contains only BH3 domain)), GeneBank accession No: NM_003639( IKBKG, Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma), GeneBank accession No: NM_003311 (PHLDA2 , Pleckstrin homology-like domain, family A, member 2), GeneBank accession No: NM_002737 (PRKCA, Protein kinase C, alpha), GeneBank accession No: NM_002648 (PIMl , Pim-1 oncogene), GeneBank accession No: NM_002507 (NGFR, Nerve growth factor receptor (TNFR superfamily, member 16)), GeneBank accession No: NM_002305 (LGALSl, Lectin, galactoside-binding, soluble, l(galectin I)), GeneBank accession No: NM_001013398 ( IGFBP3 , Insulin-like growth factor binding protein 3), GeneBank accession No: BX640923 (MDM4 , Mdm4 , transformed 3T3 cell double minute 4, p53 binding protein (mouse )), GeneBank accession No: BX537586 ( STK17A, Serine/threonine kinase 17a( apoptosis-inducing) ) , GeneBank accession No: BG284742(P8, P8 protein ( candidate of metastasis I)), GeneBank accession No: BE903247 (PDCD6IP, Programmed cell death 6 interacting protein), GeneBank accession No: BC027949(P2RXl, Purinergic receptor P2X, ligand-gated ion channel, 1), GeneBank accession No: BC006365 (PSEN2 , Presenilin 2 (Alzheimer disease 4)), GeneBank accession No: AY869712(PPP1R13L, Protein phosphatase 1, regulatory (inhibitor) subunit 13 like), GeneBank accession No: AY028896 (CARDlO, Caspase recruitment domain family, member 10), GeneBank accession No: AK122614 (PPARD, Peroxisome proliferative activated receptor, delta), GeneBank accession No: AK092872 (ERCC2 , Excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)), GeneBank accession No: AK092808 (RRAGC, Ras-related GTP binding C), GeneBank accession No: AJ001898 (GDNF, Glial cell derived neurotrophic factor), GeneBank accession No: AF220656 (PHLDAl, Pleckstrin homology-like domain, family A, member 1), GeneBank accession No: AF055634 (UNC5C, Unc-5 homolog C(C. elegans)), GeneBank accession No: AB209485(VEGF, Vascular endothelial growth factor), GeneBank accession No: AB096256 (UNC5B, Unc-5 homolog B(C. elegans)), GeneBank accession No: AB007960 ( SH3GLB1 , SH3- domain GRB2-like endophilin Bl), GeneBank accession No: X06374 (PDGFA, Platelet-derived growth factor alpha polypeptide), GeneBank accession No: S62138 ( DDIT3 , DNA- damage-inducible transcript 3), GeneBank accession No: NM_078487(CDKN2B, Cyclin-dependent kinase inhibitor 2B(pl5, inhibits CDK4 ) ) , GeneBank accession No: NM_012127 (CIZl , CDKNlA interacting zinc finger protein 1), GeneBank accession No: NM_005883 (APC2 , Adenomatosis polyposis coli 2), GeneBank accession No: NM_004196 (CDKLl , Cyclin- dependent kinase-like 1 (CDC2-related kinase)), GeneBank accession No: NM_003236 (TGFA, Transforming growth factor, alpha), GeneBank accession No: NM_001261 (CDK9 , Cyclin- dependent kinase 9 (CDC2-related kinase)), GeneBank accession No: NM_001007271 (DUSP13 , Dual specificity phosphatase 13), GeneBank accession No: CR749511 (PARC, P53- ' associated parkin-like cytoplasmic protein), GeneBank accession No: CR623038 ( ID2 , Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein), GeneBank accession No: CR618371 (EGFR, Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)), GeneBank accession No: BF965144 ( IFITMl , Interferon induced transmembrane protein 1(9-27)), GeneBank accession No: AK127679 ( DUSPl , Dual specificity phosphatase 1), GeneBank accession No: AK096276 (CCND3 , Cyclin D3 ) , GeneBank accession No: AB209586 (MAPK13 , Mitogen-activated protein kinase 13), GeneBank accession No: AB209465 (PCTKl , PCTAIRE protein kinase 1), GeneBank accession No: Z19588 (SKIL, SKI-like), GeneBank accession No: NM_020429 (SMURFl, SMAD specific E3 ubiquitin protein ligase 1), GeneBank accession No: NM_014767 ( SPOCK2 , Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2), GeneBank accession No: NM_005979(S100A13, SlOO calcium binding protein A13), GeneBank accession No: NM_005187 (CBFA2T3 , Core-binding factor, runt domain, alpha subunit 2; translocated to, 3), GeneBank accession No: NM_004364 (CEBPA, CCAAT/enhancer binding protein ( C/EBP ), alpha), GeneBank accession No: NM_001769(CD9, CD9 antigen (p24 )), GeneBank accession No: NM_001718(BMP6, Bone morphogenetic protein 6), GeneBank accession No: NM_000641 ( ILlI , Interleukin 11), GeneBank accession No: BX647459 ( SERPINE2 , Serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 2), GeneBank accession No: BQ066037 (RPS19 , Ribosomal protein S19), GeneBank accession No: BE791300 (EDFl , Endothelial differentiation-related factor 1), GeneBank accession No: BC038504 ( SNFlLK, SNFl-like kinase), GeneBank accession No: AL832287 ( ZAP70 , Zeta-chain(TCR) associated protein kinase 7OkDa), GeneBank accession No: AK125742 (PCGFl, Polycomb group ring finger 1), GeneBank accession No: AK124709 (NDRGl , N-myc downstream regulated gene 1), GeneBank accession No: AB011157 (PTDSR, Phosphatidylserine receptor), GeneBank accession No: NM_013255 (MKLNl, Muskelin 1, intracellular mediator containing kelch motifs), GeneBank accession No: NM_006572 (GNA13, Guanine nucleotide binding protein(G protein), alpha 13), GeneBank accession No: NM_002211 ( ITGBl , Integrin, beta 1 ( fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)), GeneBank accession No: CR601067 (PLAUR, Plasminogen activator, urokinase receptor), GeneBank accession No: BC050456 (THBS4 , Thrombospondin 4), GeneBank accession No: AK027389 (CXCL16 , Chemokine (C-X-C motif) ligand 16), GeneBank accession No: AJ132099 (VNNl , Vanin 1), GeneBank accession No: XM_371354 (FLJ10157 , Hypothetical protein FLJ10157), GeneBank accession No: XM_208313(TPM3, Similar to tropomyosin 4), GeneBank accession No: XM_208270 (ACR, Acrosin-like protease), GeneBank accession No: NM_203353 (PDLIM7 , PDZ and LIM domain 7(enigma)), GeneBank accession No: NM_201382 (PLECl , Plectin 1, intermediate filament binding protein 50OkDa), GeneBank accession No: NM_182961 ( SYNEl , Spectrin repeat containing, nuclear envelope 1), GeneBank accession No: NM__181826 (NF2 , Neurofibromin 2 (bilateral acoustic neuroma)), GeneBank accession No: NM_172069 (PLEKHH2 , Pleckstrin homology domain containing, family H(with MyTH4 domain) member 2), GeneBank accession No: NM_022648 (TNS , Tensin 1), GeneBank accession No: NM_017556 (FBLP-I, Filamin binding LIM protein 1), GeneBank accession No: NM_016081 (KIAA0992 , Palladin, cytoskeletal associated protein), GeneBank accession No: NM_006617 (NES, Nestin), GeneBank accession No: NM_006262 (PRPH, Peripherin), GeneBank accession No: NM_005100(AKAP12, A kinase (PRKA) anchor protein ( gravin) 12), GeneBank accession No: NM_004368 (CNN2 , Calponin 2), GeneBank accession No: NM_003388 (CYLN2 , Cytoplasmic linker 2), GeneBank accession No: NM_003370 (VASP, Vasodilator- stimulated phosphoprotein) , GeneBank accession No: NM_003128 (SPTBNl, Spectrin, beta, non-erythrocytic 1), GeneBank accession No: NM_002705 (PPL, Periplakin), GeneBank accession No: NM_002475 (MLClSA, Myosin light chain 1 slow a), GeneBank accession No: NM_002018(FLII, Flightless I homolog(Drosophila) ) , GeneBank accession No: NM_001465 ( FYB, FYN binding protein(FYB-120/130 ) ) , GeneBank accession No: NM_001069(TUBB2, Tubulin, beta 2A), GeneBank accession No: CR625172(MGC8685, Tubulin, beta 2B), GeneBank accession No: CR616919(KRT18, Keratin 18), GeneBank accession No: CR606241 (ACTGl, Actin, gamma 1), GeneBank accession No: CB240572 (MYHIl, Myosin, heavy polypeptide 11, smooth muscle), GeneBank accession No: BX648253 (PTPN3 , Protein tyrosine phosphatase, non-receptor type 3), GeneBank accession No: BX648190 (WDRl , WD repeat domain 1), GeneBank accession No: BX641076 (ACTNl , Actinin, alpha 1), GeneBank accession No: BX537978 (EPB41L1 , Erythrocyte membrane protein band 4.1-like 1), GeneBank accession No: BG121847 (NUDC, Nuclear distribution gene C homolog(A. nidulans)), GeneBank accession No: BC068013 (MYOlC, Myosin IC), GeneBank accession No: BC065499 (MAST2 , Microtubule associated serine/threonine kinase 2), GeneBank accession No: BC051890(TUBG2, Tubulin, gamma 2), GeneBank accession No: BCO41874(MAP1LC3B, Microtubule-associated protein 1 light chain 3 beta), GeneBank accession No: BC012597 (ACTAl , Actin, alpha 1, skeletal muscle), GeneBank accession No: AY484427(KIF17, Kinesin family member 17), GeneBank accession No: AK130546 ( ST0ML2 , Stomatin(EPB72 ) -like 2), GeneBank accession No: AK124711 (CORO2B, Coronin, actin binding protein, 2B), GeneBank accession No: AK123974 (MYL5 , Myosin, light polypeptide 5, regulatory), GeneBank accession No: AK092792 (LOC389833 , Similar to hypothetical protein MGC27019), GeneBank accession No: AK026518 (MYOHDl , Myosin head domain containing 1), GeneBank accession No: AK024500 (NICAL, Microtubule associated monoxygenase, calponin and LIM domain containing 1), GeneBank accession No: AF085886(FLJ46675, Ribosomal protein L29 pseudogene 2), GeneBank accession No: AB209997 (MYO9B, Myosin IXB), GeneBank accession No: Y12692 (WNTIl , Wingless-type MMTV integration site family, member 11), GeneBank accession No: Y11307 (CYR61, Cysteine-rich, angiogenic inducer, 61), GeneBank accession No: X17033 ( ITGA2 , Integrin, alpha 2(CD49B, alpha 2 subunit of VLA-2 receptor)), GeneBank accession No: U41763 (CLTCLl , Clathrin, heavy polypeptide- like 1), GeneBank accession No: NM_153609 (TMPRSS6 , Transmembrane protease, serine 6), GeneBank accession No: NM_031483(ITCH, Itchy homolog E3 ubiquitin protein ligase(mouse) ) , GeneBank accession No: NM_024342 (GRLFl , Glucocorticoid receptor DNA binding factor 1 ) , GeneBank accession No: NM_017555 (EGLN2 , EgI nine homolog 2(C. elegans)), GeneBank accession No: NM_016569 (TBX3 , T-box 3 (ulnar mammary syndrome)), GeneBank accession No: NM_004148 (NINJl, Ninjurin 1), GeneBank accession No: NM_003377 (VEGFB, Vascular endothelial growth factor B), GeneBank accession No: NM_001983 (ERCCl, Excision repair cross-complementing rodent repair deficiency, complementation group 1( includes overlapping antisense sequence)), GeneBank accession No: NM_001552 ( IGFBP4 , Insulin-like growth factor binding protein 4 ) , GeneBank accession No: NM_001430 (EPASl , Endothelial PAS domain protein 1), GeneBank accession No: NM_001300 (KLF6 , Kruppel- like factor 6), GeneBank accession No: NM_001012661 (SLC3A2 , Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2), GeneBank accession No: NM_000596( IGFBPl, Insulin-like growth factor binding protein 1), GeneBank accession No: NM_000474 (TWISTl , Twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome ) (Drosophila) ), GeneBank accession No: BX649103 (ChGn, Chondroitin betal,4 N- acetylgalactosaminyltransferase) , GeneBank accession No: BM913048 (TIMPl, TIMP metallopeptidase inhibitor 1), GeneBank accession No: BM904612 ( S100A6 , SlOO calcium binding protein A6 (calcyclin) ) , GeneBank accession No: BM556279(EMP3, Epithelial membrane protein 3), GeneBank accession No: BC015041 (VATl , Family with sequence similarity 82, member C), GeneBank accession No: AY258066(OKL38, Pregnancy-induced growth inhibitor), GeneBank accession No: AK126729 (NDRG4 , NDRG family member 4), GeneBank accession No: AK090459(NFE2Ll, Nuclear factor (erythroid-derived 2) -like 1), GeneBank accession No: AK074163 (ROBO4, Roundabout homolog 4, magic roundabout ( Drosophila) ), GeneBank accession No: AK024680(FLJ21027 fis, CDNA: FLJ21027 fis, clone CAE07110), GeneBank accession No: AF176422 (HEYl , Hairy/enhancer-of- split related with YRPW motif 1), GeneBank accession No: AF003837 (JAGl, Jagged l(Alagille syndrome)), GeneBank accession No: AB209322 ( SEMA3B, Sema domain, immunoglobulin domain(Ig), short basic domain, secreted, ( semaphorin) 3B), GeneBank accession No: AB011150 (NRXNl , Neurexin 1), GeneBank accession No: NM_201589 (MAFA, V-maf musculoaponeurotic fibrosarcoma oncogene homolog A(avian)), GeneBank accession No: NM_052999 (CKLFSFl , CKLF-like MARVEL transmembrane domain containing 1), GeneBank accession No: NM_006644 (HSPHl, Heat shock 105kDa/110kDa protein 1), GeneBank accession No: NM_005438 (FOSLl , FOS-like antigen 1), GeneBank accession No: NM_004996 (ABCCl , ATP-binding cassette, sub-family C(CFTR/MRP), member 1), GeneBank accession No: NM_002658 (PLAU, Plasminogen activator, urokinase), GeneBank accession No: NM_001353 (AKRlCl , Aldo- keto reductase family 1, member Cl (dihydrodiol dehydrogenase 1; 20-alpha( 3-alpha) -hydroxysteroid dehydrogenase)), GeneBank accession No: H18681 (C20orf139 , Sulfiredoxin 1 homolog(S. cerevisiae ) ) , GeneBank accession No: DR004094 (HAMP, Hepcidin antimicrobial peptide), GeneBank accession No: BC082272 (KCNMB3 , Potassium large conductance calcium-activated channel, subfamily M beta member 3), GeneBank accession No: BC040494 ( DNAJB2 , DnaJ(Hsp40) homolog, subfamily B, member 2), GeneBank accession No: BC018064 (ATF6 , Activating transcription factor 6), GeneBank accession No: BC006523 ( SGK2 , Serum/glucocorticoid regulated kinase 2 ) , GeneBank accession No: AK090482 (CXCL12 , Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor I)), GeneBank accession No: AF219946 (TULP4 , Tubby like protein 4), GeneBank accession No: AB209112 (SLC2A8, Solute carrier family 2 ,( facilitated glucose transporter) member 8), GeneBank accession No: NM_005242 (F2RL1 , Coagulation factor II ( thrombin) receptor-like 1), GeneBank accession No: NM_001002029(C4A, Complement component 4B, telomeric), GeneBank accession No: NM_000539 (RHO, Rhodopsin( opsin 2, rod pigment ) (retinitis pigmentosa 4, autosomal dominant)), GeneBank accession No: BX649164 (PAI , serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), GeneBank accession No: BM918324 (LY96 , Lymphocyte antigen 96), GeneBank accession No: AB209647(NCF2, Neutrophil cytosolic factor 2(65kDa, chronic granulomatous disease, autosomal 2)), GeneBank accession No: NM_152221 (CSNKlE, Casein kinase 1, epsilon), GeneBank accession No: NM_017999 (RNF31 , Ring finger protein 31), GeneBank accession No: NM_016819 (OGGl , 8-oxoguanine DNA glycosylase) , GeneBank accession No: NM_016816 (OASl, 2 ',5'- oligoadenylate synthetase 1, 40/46kDa) , GeneBank accession No: NM_012235(SCAP, SREBP cleavage-activating protein), GeneBank accession No: NM_006384 (CIBl , Calcium and integrin binding 1 (calmyrin) ) , GeneBank accession No: NM_001779 (CD58 , CD58 antigen, (lymphocyte function-associated antigen 3)), GeneBank accession No: CB055213 ( ICOSLG, Inducible T-cell co-stimulator ligand) , GeneBank accession No: BX641029 (MASPl , Mannan-binding lectin serine peptidase 1(C4/C2 activating component of Ra-reactive factor)), GeneBank accession No: BQ053419 (BATF, Basic leucine zipper transcription factor, ATF-like), GeneBank accession No: BC039299 ( STIPl , Stress-induced-phosphoprotein 1 ( Hsp70/Hsp90-organizing protein)), GeneBank accession No: AY055760 ( DAF, Decay accelerating factor for complement (CD55 , Cromer blood group system)), GeneBank accession No: AK130188(FGR, Gardner-Rasheed feline sarcoma viral(v-fgr) oncogene homolog) , GeneBank accession No: AK095326 (MUS81 , MUS81 endonuclease homolog ( yeast )), GeneBank accession No: NM_017670 (OTUBl, OTU domain, ubiquitin aldehyde binding 1), GeneBank accession No: NM_003004 ( SECTMl , Secreted and transmembrane 1), GeneBank accession No: NM_002309 (LIF, Hypothetical protein MGC20647), GeneBank accession No: NM_001421(ELF4, E74-like factor 4(ets domain transcription factor)), GeneBank accession No: NM_000418 ( IL4R, Interleukin 4 receptor), GeneBank accession No: BI909222 (FCERlG, Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide), GeneBank accession No: BF569086(NK4, Interleukin 32), GeneBank accession No: BC014470(AZGPl, Alpha-2-glycoprotein 1, zinc), GeneBank accession No: BC020744 (AKR1C4 , Aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol ) , dehydrogenase 4), GeneBank accession No: BQ939577 ( AKR1C3 , Aldo-keto reductase family 1, member C3( 3-alpha hydroxysteroid dehydrogenase, type II)), GeneBank accession No: NM_000499 (CYPlAl , Cytochrome P450, family 1, subfamily A, polypeptide 1), GeneBank accession No: NM_030622 (CYP2S1 , Cytochrome P450, family 2, subfamily S, polypeptide 1), GeneBank accession No: NM_184041 (ALDOA, Aldolase A, fructose-bisphosphate ) , GeneBank accession No: NM_024307 (MGC4171 , Hypothetical protein LOC283901), GeneBank accession No: NM_005336 (HDLBP, High density lipoprotein binding protein( vigilin) ) , GeneBank accession No: NM_002627 (PFKP, Phosphofructokinase, platelet), GeneBank accession No: BX648281 (LDLR, Low density lipoprotein receptor ( familial hypercholesterolemia)), GeneBank accession No: BC069201(FLJ22761, Hexokinase domain containing 1), GeneBank accession No: BC030207 (NR0B2 , Nuclear receptor subfamily 0, group B, member 2), GeneBank accession No: AL833O69(KIAA1434, Hypothetical protein KIAA1434), GeneBank accession No: AK124656 (ENO2 , Enolase 2 (gamma, neuronal)), GeneBank accession No: AK094474 (RHOC, Ras homolog gene family, member C), GeneBank accession No: AK093461 ( ISYNAl , Myo-inositol 1-phosphate synthase Al), GeneBank accession No: AB053232(GAL3ST3, Galactose-3-O-sulfotransferase 3), GeneBank accession No: AB045292 (TMEM8, Transmembrane protein 8 ( five membrane-spanning domains)), GeneBank accession No: NM_004753 (DHRS3 , Dehydrogenase/reductase ( SDR family) member 3), GeneBank accession No: NM_002900 (RBP3 , Retinol binding protein 3, interstitial), GeneBank accession No: NM_001995 (ACSLl , Acyl-CoA synthetase long- chain family member 1), GeneBank accession No: NM_000018 ( ACADVL , Acyl-Coenzyme A dehydrogenase, very long chain), GeneBank accession No: BC094756 (CRA, Myotubularin related protein 11), GeneBank accession No: BC050553 (NTE, Neuropathy target esterase), GeneBank accession No: BC033110(HSD17Bl, Hydroxysteroid ( 17-beta) dehydrogenase 1), GeneBank accession No: AY268890 (TPPl , Tripeptidyl peptidase I), GeneBank accession No: AK172798 (CPTlA, Carnitine palmitoyltransferase lA(liver)), GeneBank accession No: AK096809(CYP4F8, Cytochrome P450, family 4, subfamily F, polypeptide 8), GeneBank accession No: AK000600 ( SIAT7D, ST6 ( alpha-N-acetyl-neuraminyl-2 , 3-beta- galactosyl-1 , 3 ) -N- acetylgalactosaminide alpha-2, 6-sialyltransferase 4), GeneBank accession No: AB002454 (CYP4F3 , Cytochrome P450, family 4, subfamily F, polypeptide 3), GeneBank accession No: Z29093 (DDRl, Discoidin domain receptor family, member 1), GeneBank accession No: Z25424 (MKNK2 , MAP kinase interacting serine/threonine kinase 2), GeneBank accession No: XM_291277(DKFZp761P0423, Hypothetical protein DKFZp76lP0423) , GeneBank accession No: XM_038150 (MAST3 , Microtubule associated serine/threonine kinase 3), GeneBank accession No: U88357 (ERBB3 , V-erb-b2 erythroblastic leukemia viral oncogene homolog 3(avian)), GeneBank accession No: NM_025195 (TRIBl , Tribbles homolog l(Drosophila) ) , GeneBank accession No: NM_020639 (RIPK4 , Receptor-interacting serine-threonine kinase 4), GeneBank accession No: NM_014172 (PHPTl , Phosphohistidine phosphatase 1), GeneBank accession No: NM_006254 (PRKCD, Protein kinase C, delta), GeneBank accession No: NM_005415 ( SLC20A1 , Solute carrier family 20(phosphate transporter), member 1), GeneBank accession No: NM_005026 (PIK3CD, Phosphoinositide- 3-kinase, catalytic, delta polypeptide), GeneBank accession No: NM_004431(EPHA2, EPH receptor A2 ) , GeneBank accession No: NM_004419(DUSP5, Dual specificity phosphatase 5), GeneBank accession No: NM_004327 (BCR, Breakpoint cluster region), GeneBank accession No: NM_004231 (ATP6V1F, ATPase, H+ transporting, lysosomal 14kDa, Vl subunit F), GeneBank accession No: NM_004090 (DUSP3 , Dual specificity phosphatase 3 (vaccinia virus phosphatase VHl-related) ) , GeneBank accession No: NM_002843 (PTPRJ, Protein tyrosine phosphatase, receptor type, J), GeneBank accession No: NM_002496 (NDUFS8 , NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH- coenzyme Q reductase)), GeneBank accession No: NM_001001852 (PIM3, Pim-3 oncogene), GeneBank accession No: L76191 ( IRAKI , Interleukin-1 receptor-associated kinase 1), GeneBank accession No: D15049 (PTPRH, Protein tyrosine phosphatase, receptor type, H), GeneBank accession No: BC065207(ATP6V0D2, ATPase, H+ transporting, lysosomal 38kDa, VO subunit d isoform 2), GeneBank accession No: BC035578(STK24, Serine/threonine kinase 24(STE20 homolog, yeast)), GeneBank accession No: BC028724 (DUSP18 , Dual specificity phosphatase 18), GeneBank accession No: AL117482(ULK3, Unc-51-like kinase 3(C. elegans)), GeneBank accession No: AK126879 (PCTK3 , PCTAIRE protein kinase 3), GeneBank accession No: AB209416 ( ILK, Integrin-linked kinase-2), GeneBank accession No: NM_000782 (CYP24A1 , Cytochrome P450, family 24, subfamily A, polypeptide 1), GeneBank accession No: CR597101 ( ZFP36 , Zinc finger protein 36, C3H type, homolog ( mouse) ), GeneBank accession No: CR936799(FHL2, Four and a half LIM domains 2), GeneBank accession No: M24898 (NRlDl , Nuclear receptor subfamily 1, group D, member 1), GeneBank accession No: AF132818 (KLF5 , Kruppel-like factor 5 ( intestinal )), GeneBank accession No: AK055337(ZNF213, Zinc finger protein 213), GeneBank accession No: BC008834 (PHFl, PHD finger protein 1), GeneBank accession No: AK126918 (GLIS2 , GLIS family zinc finger 2), GeneBank accession No: BC042692 (CTL2 , Solute carrier family 44, member 2), GeneBank accession No: NM_002224(ITPR3, Inositol 1 , 4 , 5-triphosphate receptor, type 3), GeneBank accession No: AK095363 (AQP3, Aquaporin 3), GeneBank accession No: NM_174953 ( ATP2A3 , ATPase, Ca++ transporting, ubiquitous), GeneBank accession No: BC042390 (VTIlB, Vesicle transport through interaction with t-SNAREs homolog lB(yeast)), GeneBank accession No: NM_016113(TRPV2, Transient receptor potential cation channel, subfamily V, member 2), GeneBank accession No: BM926478 (RBPl, Retinol binding protein 1, cellular), GeneBank accession No: NM_000069 (CACNAlS , Calcium channel, voltage-dependent, L type, alpha IS subunit), GeneBank accession No: AK002107 (RAB3B, RAB3B, member RAS oncogene family), GeneBank accession No: NM_013321 ( SNX8 , Sorting nexin 8), GeneBank accession No: AK125026 ( SLC6A12 , Solute carrier family 6 (neurotransmitter transporter, betaine/GABA) , member 12), GeneBank accession No: NM_005843(STAM2, Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2), GeneBank accession No: AK092512(SLC16A5, Solute carrier family 16 (monocarboxylic acid transporters), member 5), GeneBank accession No: U49248(ABCC2, ATP-binding cassette, sub-family C(CFTR/MRP), member 2), GeneBank accession No: AK172792 (SCNNlA, Sodium channel, nonvoltage-gated 1 alpha), GeneBank accession No: BC044656(CASC3, Cancer susceptibility candidate 3), GeneBank accession No: NM_203403 (C9orf 150 , Chromosome 9 open reading frame 150), GeneBank accession No: NM_O8O388(S1OOA16, SlOO calcium binding protein A16), GeneBank accession No: NM_031286 (SH3BGRL3, SH3 domain binding glutamic acid-rich protein like 3), GeneBank accession No: NM_022153 (PP2135 , Chromosome 10 open reading frame 54), GeneBank accession No: NM_004864 (GDF15 , Growth differentiation factor 15), GeneBank accession No: NM_003330 (TXNRDl, Thioredoxin reductase 1), GeneBank accession No: NM_001013632 (LOC343521 , Similar to hypothetical protein 4833401D15), GeneBank accession No: BX537968(LOC51149, Hypothetical LOC51149), GeneBank accession No: BU945318 (MT2A, Hypothetical gene supported by X97260; BC070289), GeneBank accession No: BQ683841 ( SlOOAlI , SlOO calcium binding protein All (calgizzarin) ) , GeneBank accession No: BQ276852 (TMSBlO , Thymosin, beta 10), GeneBank accession No: AK126182 (KIAA1949 , KIAA1949), GeneBank accession No: AK124751 (CAPN2 , Calpain 2,(m/II) large subunit), GeneBank accession No: AK095079 (RGC32 , Response gene to complement 32), GeneBank accession No: AB075871(FLJ42654, Golgi transport 1 homolog A(S. cerevisiae) ) , GeneBank accession No: AK125150 (MAPK8 , Mitogen-activated protein kinase 8), GeneBank accession No: NM_002758 (MAP2K6 , Mitogen-activated protein kinase kinase 6), GeneBank accession No: NM_004612 (TGFBRl, Transforming growth factor, beta receptor I(activin A receptor type II- like kinase, 53kDa)), GeneBank accession No: NM_145686 (MAP4K4 , Mitogen-activated protein kinase kinase kinase kinase 4), GeneBank accession No: XM_042066 (MAP3K1 , Mitogen-activated protein kinase kinase kinase 1), GeneBank accession No: AB011123 (TNIK, TRAF2 and NCK interacting kinase), GeneBank accession No: AB209031(C5, Complement component 5), GeneBank accession No: NM_022740 (HIPK2 , Homeodomain interacting protein kinase 2 ) , GeneBank accession No: NM_148957 (TNFRSF19 , Tumor necrosis factor receptor superfamily, member 19), GeneBank accession No: AB208909(ITGB2, Integrin, beta 2(antigen CD18(p95), lymphocyte function-associated antigen 1; macrophage antigen l(mac-l) beta subunit)), GeneBank accession No: AB209211 (TIAl, TIAl cytotoxic granule-associated RNA binding protein), GeneBank accession No: AB209613 (DNASE1L3 , Deoxyribonuclease I-like 3), GeneBank accession No: AK122825 (HMGBl, High-mobility group box 1), GeneBank accession No: AK127326 (PHF17 , PHD finger protein 17), GeneBank accession No: AK223503 (CASPl , Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase ) ) , GeneBank accession No: BC013326 (GAS2 , Growth arrest-specific 2), GeneBank accession No: BC047698 ( IL7 , Interleukin 7), GeneBank accession No: D79987 (ESPLl , Extra spindle poles like 1(S. cerevisiae ) ) , GeneBank accession No: NM_000893 (KNGl, Kininogen 1), GeneBank accession No: NM_001012271(BIRC5, Effector cell peptidase receptor 1), GeneBank accession No: NM_004938 (DAPKl , Death-associated protein kinase 1), GeneBank accession No: NM_005879 (TRIP, TRAF interacting protein), GeneBank accession No: NM_014739 (BCLAFl, BCL2-associated transcription factor 1), GeneBank accession No: NM_018947 (CYCS, Cytochrome c, somatic), GeneBank accession No: AB033337 (MPHOSPHl , M-phase phosphoprotein 1), GeneBank accession No: AB209179 (PLKl , Polo-like kinase 1 (Drosophila) ) , GeneBank accession No: AB209337(CDC7, CDC7 cell division cycle 7(S. cerevisiae) ) , GeneBank accession No: AF053305 (BUBl , BUBl budding uninhibited by benzimidazoles 1 homolog( yeast ) ) , GeneBank accession No: AF053306 (BUBlB, BUBl budding uninhibited by benzimidazoles 1 homolog beta(yeast ) ) , GeneBank accession No: AF345347(SPAG5, Sperm associated antigen 5), GeneBank accession No: AK092638 (CCNG2 , Cyclin G2 ) , GeneBank accession No: AK222819 (NUSAPl , Nucleolar and spindle associated protein 1), GeneBank accession No: AL833191 ( SMC2L1 , SMC2 structural maintenance of chromosomes 2-like l(yeast)), GeneBank accession No: AY257469 (CIT, Citron(rho-interacting, serine/threonine kinase 21)), GeneBank accession No: AY367065 (ASPM, Asp(abnormal spindle) -like, microcephaly associated(Drosophila) ) , GeneBank accession No: BCOIlOOO (CDCA5 , Cell division cycle associated 5), GeneBank accession No: BC032677 (UBE2C, Ubiquitin-conjugating enzyme E2C), GeneBank accession No: BC043502(NEK2, NIMA(never in mitosis gene a)-related kinase 2), GeneBank accession No: BU675073 (PTTGl , Pituitary tumor- transforming 1), GeneBank accession No: BX647885 ( STMNl , Stathmin 1/oncoprotein 18), GeneBank accession No: CR592757 (BRRNl, Barren homolog 1 (Drosophila) ), GeneBank accession No: CR597075 (MAPRE2 , Microtubule-associated protein, RP/EB family, member 2), GeneBank accession No: CR604810(CCNA2 , Cyclin A2 ) , GeneBank accession No: CR933728(CDC2, Cell division cycle 2, Gl to S and G2 to M), GeneBank accession No: NM_000919 (PAM, Peptidylglycine alpha-amidating monooxygenase ) , GeneBank accession No: NM_001790(CDC25C, Cell division cycle 25C), GeneBank accession No: NM_001798 (CDK2 , Cyclin-dependent kinase 2), GeneBank accession No: NM_001813 (CENPE, Centromere protein E, 312kDa), GeneBank accession No: NM_003318(TTK, TTK protein kinase), GeneBank accession No: NM_003981 (PRCl , Protein regulator of cytokinesis 1), GeneBank accession No: NM_004523 (KIFIl, Kinesin family member 11), GeneBank accession No: NM_004701 (CCNB2 , Cyclin B2 ) , GeneBank accession No: NM_005983 ( SKP2 , S-phase kinase-associated protein 2(p45)), GeneBank accession No: NM_006101 (KNTC2 , Kinetochore associated 2), GeneBank accession No: NM_006845(KIF2C, Kinesin family member 2C), GeneBank accession No: NM_007375 ( TARDBP , TAR DNA binding protein), GeneBank accession No: NM_012112 (TPX2 , TPX2, microtubule- associated, homolog(Xenopus laevis)), GeneBank accession No: NM_014750(DLG7, Discs, large homolog 7 (Drosophila) ) , GeneBank accession No: NM_015097 (CLASP2 , Cytoplasmic linker associated protein 2), GeneBank accession No: NM_016343 (CENPF, Centromere protein F, 350/400ka(mitosin) ) , GeneBank accession No: NM_016426 (GTSEl , G-2 and S-phase expressed 1), GeneBank accession No: NM_018492 (PBK, PDZ binding kinase), GeneBank accession No: NM_018685 (ANLN, Anillin, actin binding protein ( scraps homolog, Drosophila) ) , GeneBank accession No: NM_020242 (KNSL7 , Kinesin family member 15), GeneBank accession No: NM_031966 (CCNBl , Cyclin Bl), GeneBank accession No: NM_138555 (KIF23, Kinesin family member 23), GeneBank accession No: U65410 (MAD2L1 , MAD2 mitotic arrest deficient-like l(yeast)), GeneBank accession No: AB020656 (CYLD, Cylindromatosis ( turban tumor syndrome)), GeneBank accession No: AF033122 ( SESNl , Sestrin 1), GeneBank accession No: AK074377 (UHRFl , Chromosome 19 open reading frame 31), GeneBank accession No: AK091170 (CDKN2C, Cyclin- dependent kinase inhibitor 2C(pl8, inhibits CDK4 ) ) , GeneBank accession No: AK094323 (NFYC, Nuclear transcription factor Y, gamma), GeneBank accession No: AY366508 (LOH11CR2A, Loss of heterozygosity, 11, chromosomal region 2, gene A), GeneBank accession No: BC033086 (TCF19 , Transcription factor 19(SCl)), GeneBank accession No: BC040303 (PTP4A1 , Protein tyrosine phosphatase type IVA, member 1), GeneBank accession No: BC040991 (TFDP2 , Transcription factor Dp-2(E2F dimerization partner 2)), GeneBank accession No: BC092412(SGOL2, Shugoshin-like 2(S. pombe ) ) , GeneBank accession No: BQ278454 (CKSlB, CDC28 protein kinase regulatory subunit IB), GeneBank accession No: BX649128(SESN3, Sestrin 3), GeneBank accession No: CD049340 (AURKB, Aurora kinase B), GeneBank accession No: M89914(NFl, Neurofibromin 1 (neurofibromatosis , von Recklinghausen disease, Watson disease)), GeneBank accession No: NM_001005414 ( ZWINT, ZWlO interactor antisense), GeneBank accession No: NM_001008491 ( Sep 2, Septin 2), GeneBank accession No: NM_001274 (CHEKl , CHKl checkpoint homolog(S. pombe)), GeneBank accession No: NM_002105(H2AFX, H2A histone family, member X), GeneBank accession No: NM_002388 (MCM3 , MCM3 minichromosome maintenance deficient 3(S. cerevisiae ) ) , GeneBank accession No: NM_OO2417(MKI67, Antigen identified by monoclonal antibody Ki-67), GeneBank accession No: NM_002875 (RAD51 , RAD51 homolog(RecA homolog, E. coli)(S. cerevisiae)), GeneBank accession No: NM_003884 (PCAF, P300/CBP-associated factor), GeneBank accession No: NM_004526 (MCM2 , MCM2 minichromosome maintenance deficient 2, mitotin(S. cerevisiae)), GeneBank accession No: NM_004847 (AIFl , Allograft inflammatory factor 1), GeneBank accession No: NM_005915 (MCM6 , MCM6 minichromosome maintenance deficient 6(MIS5 homolog, S. pombe ) ( S . cerevisiae)), GeneBank accession No: NM_012090 (MACFl , Microtubule-actin crosslinking factor 1), GeneBank accession No: NM_012415(RAD54B, RAD54 homolog B(S. cerevisiae)), GeneBank accession No: NM_014264 (PLK4 , Polo-like kinase 4 (Drosophila) ) , GeneBank accession No: NM_015714 (G0S2 , GO/Glswitch 2), GeneBank accession No: NM_024680 ( FLJ23311 , E2F transcription factor 8), GeneBank accession No: XM_034274 (MYBLl , V-myb myeloblastosis viral oncogene homolog( avian) -like 1), GeneBank accession No: AKOO172O(FLJ1O858, Nei endonuclease Vlll-like 3(E. coli)), GeneBank accession No: AY032677 (POLQ, Polymerase (DNA directed), theta), GeneBank accession No: BC034480 (BLM, Bloom syndrome), GeneBank accession No: BC073161 (RAD51C, RAD51 homolog C(S. cerevisiae) ) , GeneBank accession No: CR600021(HMGB2, High-mobility group box 2), GeneBank accession No: CR625391 (RAD51AP1 , RAD51 associated protein 1), GeneBank accession No: CR936783 (FLJ40869 , Hypothetical protein LOC284952), GeneBank accession No: DQ140356 (KIAA1596 , Fanconi anemia, complementation group M), GeneBank accession No: NM_001067 (T0P2A, Topoisomerase ( DNA) II alpha 17OkDa), GeneBank accession No: NM_001618 (PARPl , Poly ( ADP-ribose) polymerase family, member 1), GeneBank accession No: NM_003362 (UNG, Uracil-DNA glycosylase ) , GeneBank accession No: NM_006904 (PRKDC, Protein kinase, DNA-activated, catalytic polypeptide), GeneBank accession No: NM_130398 (EXOl, Exonuclease 1), GeneBank accession No: AB020807(TLR6, Toll-like receptor 6), GeneBank accession No: AB032980(DCDC2, Doublecortin domain containing 2), GeneBank accession No: AB209866 (TFPI , Tissue factor pathway inhibitor ( lipoprotein-associated coagulation inhibitor)), GeneBank accession No: AK057015 (HSPA4 , Heat shock 7OkDa protein 4), GeneBank accession No: AK095515 ( IFITl , Interferon-induced protein with tetratricopeptide repeats 1), GeneBank accession No: AK122686(IF, I factor (complement )), GeneBank accession No: AK123010 (RRM2 , Ribonucleotide reductase M2 polypeptide), GeneBank accession No: BC035582 (TRIM22 , Tripartite motif-containing 22), GeneBank accession No: BX537894 (LOC493869 , Similar to RIKEN cDNA 2310016C16), GeneBank accession No: M14338 (PROSl , Protein S(alpha)), GeneBank accession No: NM_000821 (GGCX, Gamma-glutamyl carboxylase), GeneBank accession No: NM_000963 (PTGS2, Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) ) , GeneBank accession No: NM_001001547 (CD36 , CD36 antigen(collagen type I receptor, thrombospondin receptor)), GeneBank accession No: NM_001512(GSTA4, Glutathione S-transferase A4 ) , GeneBank accession No: NM_001629 (AL0X5AP, Arachidonate 5- lipoxygenase-activating protein), GeneBank accession No: NM_001752(CAT, Catalase), GeneBank accession No: NM_001837(CCR3, Chemokine (C-C motif) receptor 3), GeneBank accession No: NM_001979 (EPHX2 , Epoxide hydrolase 2, cytoplasmic), GeneBank accession No: NM_001994 (F13B, Coagulation factor XIII, B polypeptide), GeneBank accession No: NM_002182 ( ILlRAP, Interleukin 1 receptor accessory protein), GeneBank accession No: NM_006120 (HLA-DMA, Major histocompatibility complex, class II, DM alpha), GeneBank accession No: NM_173216 ( SIATl , ST6 beta-galactosamide alpha-2 , 6-sialyltranferase 1), GeneBank accession No: NM_202002 (FOXMl, Forkhead box Ml), GeneBank accession No: AB163917 (LRAP, Leukocyte-derived arginine aminopeptidase) , GeneBank accession No: BC027881 ( AFP, Alpha-fetoprotein) , GeneBank accession No: NM_015915 ( SPG3A, Spastic paraplegia 3A(autosomal dominant)), GeneBank accession No: NM_000671(ADH5, Alcohol dehydrogenase 5 (class III), chi polypeptide), GeneBank accession No: J05428 (UGT2B7 , UDP glucuronosyltransferase 2 family, polypeptide B7 ) , GeneBank accession No: NM_000672 (ADH6 , Alcohol dehydrogenase 6 (class V)), GeneBank accession No: M15943(ADH4, Alcohol dehydrogenase 4 (class II), pi polypeptide), GeneBank accession No: AK223395 (FBPl , Fructose-1 , 6-bisphosphatase 1), GeneBank accession No: NM_000151 (G6PC, Glucose-6- phosphatase, catalytic (glycogen storage disease type I, von Gierke disease)), GeneBank accession No: XM_113962 (KIAA0650 , Structural maintenance of chromosomes flexible hinge domain containing 1), GeneBank accession No: AB020644 ( ACSL6 , Acyl- CoA synthetase long-chain family member 6), GeneBank accession No: AB209907 (PLDl , Phospholipase Dl, phophatidylcholine-specific) , GeneBank accession No: AF285167 (ABCAl, ATP-binding cassette, sub-family A(ABCl), member 1), GeneBank accession No: AF297872 (TRERFl , Transcriptional regulating factor 1), GeneBank accession No: AF3O3134(ALDH8A1, Aldehyde dehydrogenase 8 family, member Al), GeneBank accession No: AF339053 (PLA2G12B, Phospholipase A2 , group XIIB), GeneBank accession No: AK096018 (HADHSC, L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain), GeneBank accession No: AK124635 (PCSK9 , Proprotein convertase subtilisin/kexin type 9), GeneBank accession No: AK127346 ( SIAT9 , ST3 beta-galactoside alpha- 2 , 3-sialyltransferase 5), GeneBank accession No: AL359559(AGPS, Alkylglycerone phosphate synthase), GeneBank accession No: AY691170 (PLCL3 , Phospholipase C-like 3), GeneBank accession No: BG567934 (APOM, Apolipoprotein M), GeneBank accession No: BX538214 (Cβorf167 , Chromosome 6 open reading frame 167), GeneBank accession No: BX640945 (FADS2 , Fatty acid desaturase 2), GeneBank accession No: BX648473(PIGK, Phosphatidylinositol glycan, class K), GeneBank accession No: BX648557 (HSD17B2 , Hydroxysteroid( 17- beta) dehydrogenase 2), GeneBank accession No: CR7496O1(ETNK1, Death-associated protein kinase 3), GeneBank accession No: NM_000859 (HMGCR, 3-hydroxy-3- methylglutaryl-Coenzyme A reductase), GeneBank accession No: NM_001443 (FABPl, Fatty acid binding protein 1, liver), GeneBank accession No: NM_002130 (HMGCSl , 3-hydroxy-3- methylglutaryl-Coenzyme A synthase l(soluble)), GeneBank accession No: NM_003725 (RODH, Hydroxysteroid( 17-beta) dehydrogenase 6), GeneBank accession No: NM_004845 (PCYTlB, Phosphate cytidylyltransferase 1, choline, beta), GeneBank accession No: NM_014762 (DHCR24 , 24-dehydrocholesterol reductase), GeneBank accession No: NM_020139 ( DHRS6 , Dehydrogenase/reductase ( SDR family) member 6), GeneBank accession No: NM_020918 ( GPAM, Glycerol-3-phosphate acyltransferase, mitochondrial), GeneBank accession No: NM_032523(OSBPL6, Oxysterol binding protein-like 6), GeneBank accession No: NM_033505 ( SELI , Selenoprotein I), GeneBank accession No: Z28339 (AKRlDl , Aldo-keto reductase family 1, member Dl (delta 4-3-ketosteroid-5-beta- reductase)), GeneBank accession No: AK024899 (ENPP3 , Ectonucleotide pyrophosphatase/phosphodiesterase 3), GeneBank accession No: AK025546 (PTPN4 , Protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte )), GeneBank accession No: AK124910 (ENPP2 , Ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin) ) , GeneBank accession No: BC035116 (FLJ35059 fis, CDNA FLJ30761 fis, clone FEBRA2000538) , GeneBank accession No: BC050565 (PASK, PAS domain containing serine/threonine kinase), GeneBank accession No: L13436 (NPR2 , Natriuretic peptide receptor B/guanylate cyclase B(atrionatriuretic peptide receptor B)), GeneBank accession No: NM_001005862 (ERBB2 , V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog ( avian) ), GeneBank accession No: NM_005012 (RORl , Receptor tyrosine kinase-like orphan receptor 1), GeneBank accession No: NM_006035(CDC42BPB, CDC42 binding protein kinase beta(DMPK- like)), GeneBank accession No: NM_014791 (MELK, Maternal embryonic leucine zipper kinase), GeneBank accession No: NM_023028(FGFR2, Fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer yndrome, Jackson-Weiss syndrome)), GeneBank accession No: NM_080836 (STK35 , Serine/threonine kinase 35), GeneBank accession No: AF419331 (FUSIPl , FUS interacting protein( serine/arginine-rich) 1), GeneBank accession No: AK091927(SFRS3, Splicing factor, arginine/serine-rich 3), GeneBank accession No: BC010266 (HNRNPAl , Heterogeneous nuclear ribonucleoprotein Al), GeneBank accession No: BC012360(CTAGE5, CTAGE family, member 5), GeneBank accession No: BC036046 (PLRGl , Pleiotropic regulator 1(PRLl homolog, Arabidopsis ) ) , GeneBank accession No: BC065384 (PCFIl, PCFIl, cleavage and polyadenylation factor subunit, homolog(S. cerevisiae) ) , GeneBank accession No: BX537360(CPSF5, Nudix( nucleoside diphosphate linked moiety X) -type motif 21), GeneBank accession No: BX537494 (HNRPA2B1 , Heterogeneous nuclear ribonucleoprotein A2/B1), GeneBank accession No: BX647784 (HNRPR, Heterogeneous nuclear ribonucleoprotein R), GeneBank accession No: CA455267 (PPIH, Peptidyl prolyl isomerase H(cyclophilin H)), GeneBank accession No: CR596214 (HNRPAO , Heterogeneous nuclear ribonucleoprotein AO), GeneBank accession No: NM_001326(CSTF3, Hypothetical protein LOC283267), GeneBank accession No: NM_004640 (BATl , HLA-B associated transcript 1), GeneBank accession No: NM_005463 (HNRPDL, Heterogeneous nuclear ribonucleoprotein D-like), GeneBank accession No: NM_006924 (SFRSl, Splicing factor, arginine/serine-rich 1( splicing factor 2, alternate splicing factor)), GeneBank accession No: NM_012426 ( SF3B3 , Splicing factor 3b, subunit 3, 13OkDa), GeneBank accession No: NM_018048 (FLJ10292 , Mago-nashi homolog), GeneBank accession No: NM_030919(C20orf129, Chromosome 20 open reading frame 129), GeneBank accession No: NM_031370 (HNRPD, Heterogeneous nuclear ribonucleoprotein D(AU-rich element RNA binding protein 1, 37kDa)), GeneBank accession No: NM_138933 ( ACF, Apobec-1 complementation factor), GeneBank accession No: AB193259 ( ACE2 , Angiotensin I converting enzyme (peptidyl- dipeptidase A) 2), GeneBank accession No: BX648769 (EWSRl , Ewing sarcoma breakpoint region 1), GeneBank accession No: AB023154 (DTX4, Deltex 4 homolog (Drosophila) ), GeneBank accession No: AL543755 (VAV3, Vav 3 oncogene), GeneBank accession No: M75106(CPB2, Carboxypeptidase B2 (plasma, carboxypeptidase U)), GeneBank accession No: NM_021045(ZNF248, Zinc finger protein 248), GeneBank accession No: AB209194 (B4GALT6 , UDP-GaI :betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6), GeneBank accession No: AF279145 (ANTXRl , Anthrax toxin receptor 1), GeneBank accession No: NM_025074 (FRASl , Fraser syndrome 1), GeneBank accession No: AK025790 (KIF20A, Kinesin family member 20A), GeneBank accession No: NM_006152 (LRMP, Lymphoid-restricted membrane protein), GeneBank accession No: NM_000340(SLC2A2, Solute carrier family 2 ( facilitated glucose transporter), member 2), GeneBank accession No: AF071592(KIF4A, Kinesin family member 4A), GeneBank accession No: NM_013277 (RACGAPl , Rac GTPase activating protein 1), GeneBank accession No: AY043484 ( SCNlA, Sodium channel, voltage-gated, type I, alpha), GeneBank accession No: AY791349(KIF18A, Kinesin family member 18A), GeneBank accession No: NM_018018 ( SLC38A4 , Solute carrier family 38, member 4), GeneBank accession No: AK094603 (FLJ37284 fis, unnamed protein product; Homo sapiens cDNA FLJ37284 fis, clone BRAMY2013590. ) , GeneBank accession No: NM_021069(ARGBP2, Sorbin and SH3 domain containing 2), GeneBank accession No: NM_001005747 (CACNB4 , Calcium channel, voltage-dependent, beta 4 subunit), GeneBank accession No: AJ496568(SLC25A12, Solute carrier family 25 (mitochondrial carrier, Aralar), member 12), GeneBank accession No: NM_030641 (APOL6 , Apolipoprotein L, 6), GeneBank accession No: NM_173512(FLJ39822, Hypothetical protein FLJ39822), GeneBank accession No: NM_000037 (ANKl, Ankyrin 1, erythrocytic), GeneBank accession No: NM_001011554 ( SLC13A3 , Solute carrier family 13 ( sodium-dependent dicarboxylate transporter), member 3), GeneBank accession No: AB091343(C10orf3, Centrosomal protein 55kDa), GeneBank accession No: AK000643 (ASB9 , Ankyrin repeat and SOCS box- containing 9), GeneBank accession No: AK055221 (FBX05, F-box protein 5), GeneBank accession No: AK075271 ( SPTLC2L, Serine palmitoyltransferase, long chain base subunit 2- like ( aminotransferase 2)), GeneBank accession No: AK122685 (GLUDl, Glutamate dehydrogenase 1), GeneBank accession No: AK127098 (FLJ10706 , Chromosome 1 open reading frame 112), GeneBank accession No: AL133031 (MLRl , Transcription factor MLRl), GeneBank accession No: AY007723(MAL2, MaI, T-cell differentiation protein 2), GeneBank accession No: BC022255 (Spc25 , Spindle pole body component 25 homolog(S. cerevisiae) ) , GeneBank accession No: BC041882 (ATF7IP2, Activating transcription factor 7 interacting protein 2), GeneBank accession No: BC052951 (LMNBl, Lamin Bl), GeneBank accession No: BC098313(FLJ20641, Hypothetical protein FLJ20641), GeneBank accession No: NM_001809 (CENPA, Centromere protein A, 17kDa), GeneBank accession No: NM_145061 (C13orf3, Chromosome 13 open reading frame 3), GeneBank accession No: XM_372695(LOC390859, PREDICTED: Homo sapiens similar to Chain A, Crystal Structure Of The R463a Mutant Of Human Glutamate Dehydrogenase(LOC390859 ) , mRNA) . [Claim 19] The method according to claim 18, wherein the below genes are up-regulated by exposure to phenanthrene : GeneBank accession No: NM_004420 (DUSP8 , Dual specificity phosphatase 8), GeneBank accession No: L11329(DUSP2, Dual specificity phosphatase 2), GeneBank accession No: BC094766 (PKNl , Protein kinase Nl), GeneBank accession No: AY247738 (TRIB3 , Tribbles homolog 3(Drosophila) ) , GeneBank accession No: AK129595 (GADD45B, Growth arrest and DNA-damage-inducible, beta), GeneBank accession No: AB208849 ( SHCl , SHC(SrC homology 2 domain containing) transforming protein 1), GeneBank accession No: X02812 (TGFBl, Transforming growth factor, beta l(Camurati- Engelmann disease) ), GeneBank accession No: NM_198951 (TGM2 , Transglutaminase 2(C polypeptide, protein-glutamine-gamma- glutamyltransferase) ), GeneBank accession No: NM_147780 (CTSB, Cathepsin B), GeneBank accession No: NM_078467 (CDKNlA, Cyclin-dependent kinase inhibitor lA(p21, Cipl)), GeneBank accession No: NM_033027 (AXUDl , AXINl up- regulated 1), GeneBank accession No: NM_032797 (AMID, Apoptosis-inducing factor (AIF) -like mitochondrion- associated inducer of death), GeneBank accession No: NM_021960 (MCLl, Myeloid cell leukemia sequence 1(BCL2- related)), GeneBank accession No: NM_016639 (TNFRSF12A, Tumor necrosis factor receptor superfamily, member 12A) , GeneBank accession No: NM_016222 (DDX41 , DEAD(Asp-Glu-Ala- Asp) box polypeptide 41), GeneBank accession No: NM_013246(CLC, Cardiotrophin-like cytokine factor 1), GeneBank accession No: NM_004401 (DFFA, DNA fragmentation factor, 45kDa, alpha polypeptide), GeneBank accession No: NM__004281(BAG3, BCL2-associated athanogene 3), GeneBank accession No: NM_003897 ( IER3 , Immediate early response 3), GeneBank accession No: NM_003806 (HRK, Harakiri, BCL2 interacting protein (contains only BH3 domain)), GeneBank accession No: NM_003639 ( IKBKG, Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma), GeneBank accession No: NM_003311 (PHLDA2 , Pleckstrin homology-like domain, family A, member 2), GeneBank accession No: NM_002737 (PRKCA, Protein kinase C, alpha), GeneBank accession No: NM_002648 (PIMl , Pim-1 oncogene), GeneBank accession No: NM_002507 (NGFR, Nerve growth factor receptor (TNFR superfamily, member 16)), GeneBank accession No: NM_002305 (LGALSl , Lectin, galactoside-binding, soluble, l(galectin I)), GeneBank accession No: NM_001013398 ( IGFBP3 , Insulin-like growth factor binding protein 3), GeneBank accession No: BX640923 (MDM4 , Mdm4 , transformed 3T3 cell double minute 4, p53 binding protein (mouse) ), GeneBank accession No: BX537586 (STK17A, Serine/threonine kinase 17a ( apoptosis-inducing) ) , GeneBank accession No: BG284742(P8, P8 protein ( candidate of metastasis I)), GeneBank accession No: BE903247 (PDCD6IP, Programmed cell death 6 interacting protein), GeneBank accession No: BC027949(P2RXl, Purinergic receptor P2X, ligand-gated ion channel, 1), GeneBank accession No: BC006365 (PSEN2 , Presenilin 2 (Alzheimer disease 4)), GeneBank accession No: AY869712(PPP1R13L, Protein phosphatase 1, regulatory (inhibitor) subunit 13 like), GeneBank accession No: AY028896(CARD10, Caspase recruitment domain family, member 10), GeneBank accession No: AK122614 (PPARD, Peroxisome proliferative activated receptor, delta), GeneBank accession No: AK092872 (ERCC2 , Excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)), GeneBank accession No: AK092808 (RRAGC, Ras-related GTP binding C), GeneBank accession No: AJ001898 (GDNF, Glial cell derived neurotrophic factor), GeneBank accession No: AF220656 (PHLDAl, Pleckstrin homology-like domain, family A, member 1), GeneBank accession No: AF055634 (UNC5C, Unc-5 homolog C(C. elegans)), GeneBank accession No: AB209485(VEGF, Vascular endothelial growth factor), GeneBank accession No: AB096256 (UNC5B, Unc-5 homolog B(C. elegans)), GeneBank accession No: AB007960 ( SH3GLB1 , SH3- domain GRB2-like endophilin Bl), GeneBank accession No: X06374 (PDGFA, Platelet-derived growth factor alpha polypeptide), GeneBank accession No: S62138 (DDIT3 , DNA- damage-inducible transcript 3), GeneBank accession No: NM_078487(CDKN2B, Cyclin-dependent kinase inhibitor 2B(pl5, inhibits CDK4 ) ) , GeneBank accession No: NM_012127 (CIZl , CDKNlA interacting zinc finger protein 1), GeneBank accession No: NM_005883 (APC2 , Adenomatosis polyposis coli 2), GeneBank accession No: NM_004196 (CDKLl , Cyclin- dependent kinase-like 1 (CDC2-related kinase)), GeneBank accession No: NM_003236 (TGFA, Transforming growth factor, alpha), GeneBank accession No: NM_001261 (CDK9 , Cyclin- dependent kinase 9 (CDC2-related kinase)), GeneBank accession No: NM_001007271 (DUSP13 , Dual specificity phosphatase 13), GeneBank accession No: CR749511 (PARC, P53- associated parkin-like cytoplasmic protein), GeneBank accession No: CR623038 ( ID2 , Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein) , GeneBank accession No: CR618371 (EGFR, Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)), GeneBank accession No: BF965144 ( IFITMl , Interferon induced transmembrane protein 1(9-27)), GeneBank accession No: AK127679 (DUSPl , Dual specificity phosphatase 1), GeneBank accession No: AK096276 (CCND3 , Cyclin D3 ) , GeneBank accession No: AB209586 (MAPK13 , Mitogen-activated protein kinase 13), GeneBank accession No: AB209465 (PCTKl , PCTAIRE protein kinase 1), GeneBank accession No: Z19588(SKIL, SKI-like), GeneBank accession No: NM__020429 (SMURFl, SMAD specific E3 ubiquitin protein ligase 1), GeneBank accession No: NM_014767 ( SPOCK2 , Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2), GeneBank accession No: NM_005979(S100A13, SlOO calcium binding protein A13), GeneBank accession No: NM_005187(CBFA2T3, Core-binding factor, runt domain, alpha subunit 2; translocated to, 3), GeneBank accession No: NM_004364 (CEBPA, CCAAT/enhancer binding protein ( C/EBP ), alpha), GeneBank accession No: NM_001769(CD9, CD9 antigen(p24 ) ) , GeneBank accession No: NM_001718 (BMP6, Bone morphogenetic protein 6), GeneBank accession No: NM_000641 ( ILlI , Interleukin 11), GeneBank accession No: BX647459 ( SERPINE2 , Serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 2), GeneBank accession No: BQ066037 (RPS19 , Ribosomal protein S19), GeneBank accession No: BE791300 (EDFl , Endothelial differentiation-related factor 1), GeneBank accession No: BC038504 ( SNFlLK, SNFl-like kinase), GeneBank accession No: AL832287 ( ZAP70 , Zeta-chain(TCR) associated protein kinase 7OkDa), GeneBank accession No: AK125742 (PCGFl, Polycomb group ring finger 1), GeneBank accession No: AK124709 (NDRGl , N-myc downstream regulated gene 1), GeneBank accession No: AB011157 (PTDSR, Phosphatidylserine receptor), GeneBank accession No: NM_013255 (MKLNl, Muskelin 1, intracellular mediator containing kelch motifs), GeneBank accession No: NM_OO6572(GNA13, Guanine nucleotide binding protein(G protein), alpha 13), GeneBank accession No: NM_002211 ( ITGBl , Integrin, beta 1 ( fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2 , MSK12 ) ) , GeneBank accession No: CR601067 (PLAUR, Plasminogen activator, urokinase receptor), GeneBank accession No: BC050456 (THBS4 , Thrombospondin 4), GeneBank accession No: AK027389 (CXCL16 , Chemokine (C-X-C motif) ligand 16), GeneBank accession No: AJ132099 (VNNl , Vanin 1), GeneBank accession No: XM_371354 (FLJ10157 , Hypothetical protein FLJ10157), GeneBank accession No: XM_208313(TPM3, Similar to tropomyosin 4), GeneBank accession No: XM_208270 (ACR, Acrosin-like protease), GeneBank accession No: NM_203353 (PDLIM7 , PDZ and LIM domain 7(enigma)), GeneBank accession No: NM_201382 (PLECl , Plectin 1, intermediate filament binding protein 50OkDa), GeneBank accession No: NM_182961 ( SYNEl , Spectrin repeat containing, nuclear envelope 1), GeneBank accession No: NM_181826 (NF2, Neurofibromin 2 (bilateral acoustic neuroma)), GeneBank accession No: NM_172069 (PLEKHH2 , Pleckstrin homology domain containing, family H(with MyTH4 domain) member 2), GeneBank accession No: NM_022648 (TNS, Tensin 1), GeneBank accession No: NM_017556 (FBLP-I, Filamin binding LIM protein 1), GeneBank accession No: NM_016081 (KIAA0992 , Palladin, cytoskeletal associated protein), GeneBank accession No: NM_006617 (NES, Nestin), GeneBank accession No: NM_006262 (PRPH, Peripherin), GeneBank accession No: NM_OO51OO(AKAP12, A kinase(PRKA) anchor protein (gravin) 12), GeneBank accession No: NM_004368 (CNN2 , Calponin 2), GeneBank accession No: NM_003388 (CYLN2 , Cytoplasmic linker 2), GeneBank accession No: NM_003370 (VASP, Vasodilator- stimulated phosphoprotein) , GeneBank accession No: NM_003128 (SPTBNl, Spectrin, beta, non-erythrocytic 1), GeneBank accession No: NM_002705 (PPL, Periplakin), GeneBank accession No: NM_002475 (MLClSA, Myosin light chain 1 slow a), GeneBank accession No: NM_002018 (FLII , Flightless I homolog(Drosophila) ) , GeneBank accession No: NM_001465 (FYB, FYN binding protein(FYB-120/130 ) ) , GeneBank accession No: NM_001069(TUBB2, Tubulin, beta 2A), GeneBank accession No: CR625172 (MGC8685, Tubulin, beta 2B), GeneBank accession No: CR616919(KRT18, Keratin 18), GeneBank accession No: CR606241 (ACTGl, Actin, gamma 1), GeneBank accession No: CB240572 (MYHIl, Myosin, heavy polypeptide 11, smooth muscle), GeneBank accession No: BX648253 (PTPN3 , Protein tyrosine phosphatase, non-receptor type 3), GeneBank accession No: BX648190 (WDRl , WD repeat domain 1), GeneBank accession No: BX641076 (ACTNl , Actinin, alpha 1), GeneBank accession No: BX537978 (EPB41L1 , Erythrocyte membrane protein band 4.1-like 1), GeneBank accession No: BG121847 (NUDC, Nuclear distribution gene C homolog(A. nidulans)), GeneBank accession No: BC068013 (MYOlC, Myosin IC), GeneBank accession No: BC065499 (MAST2 , Microtubule associated serine/threonine kinase 2), GeneBank accession No: BC051890(TUBG2, Tubulin, gamma 2), GeneBank accession No: BC041874(MAPlLC3B, Microtubule-associated protein 1 light chain 3 beta), GeneBank accession No: BC012597 (ACTAl , Actin, alpha 1, skeletal muscle), GeneBank accession No: AY484427(KIF17, Kinesin family member 17), GeneBank accession No: AK130546 ( STOML2 , Stomatin(EPB72 ) -like 2), GeneBank accession No: AK124711 (CORO2B, Coronin, actin binding protein, 2B), GeneBank accession No: AK123974 (MYL5 , Myosin, light polypeptide 5, regulatory), GeneBank accession No: AK092792 (LOC389833 , Similar to hypothetical protein MGC27019), GeneBank accession No: AK026518 (MYOHDl , Myosin head domain containing 1), GeneBank accession No: AK024500 (NICAL, Microtubule associated monoxygenase, calponin and LIM domain containing 1), GeneBank accession No: AF085886(FLJ46675, Ribosomal protein L29 pseudogene 2), GeneBank accession No: AB209997 (MY09B, Myosin IXB), GeneBank accession No: Y12692 (WNTIl , Wingless-type MMTV integration site family, member 11), GeneBank accession No: Y11307 (CYR61 , Cysteine-rich, angiogenic inducer, 61), GeneBank accession No: X17033 ( ITGA2 , Integrin, alpha 2(CD49B, alpha 2 subunit of VLA-2 receptor)), GeneBank accession No: U41763 (CLTCLl , Clathrin, heavy polypeptide- like 1), GeneBank accession No: NM_153609 (TMPRSS6 , Transmembrane protease, serine 6), GeneBank accession No: NM_031483(ITCH, Itchy homolog E3 ubiquitin protein ligase(mouse) ) , GeneBank accession No: NM_024342 (GRLFl , Glucocorticoid receptor DNA binding factor 1 ) , GeneBank accession No: NM_017555 (EGLN2 , EgI nine homolog 2(C. elegans)), GeneBank accession No: NM_016569 (TBX3 , T-box 3 (ulnar mammary syndrome)), GeneBank accession No: NM_004148 (NINJl, Ninjurin 1), GeneBank accession No: NM_003377 (VEGFB, Vascular endothelial growth factor B), GeneBank accession No: NM_001983 (ERCCl , Excision repair cross-complementing rodent repair deficiency, complementation group 1( includes overlapping antisense sequence)), GeneBank accession No: NM_001552 ( IGFBP4 , Insulin-like growth factor binding protein 4), GeneBank accession No: NM_001430 (EPASl , Endothelial PAS domain protein 1), GeneBank accession No: NM_001300 (KLF6 , Kruppel- like factor 6), GeneBank accession No: NM_001012661 ( SLC3A2 , Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2), GeneBank accession No: NM_000596( IGFBPl, Insulin-like growth factor binding protein 1), GeneBank accession No: NM_000474 (TWISTl , Twist homolog 1 ( acrocephalosyndactyly 3; Saethre-Chotzen syndrome ) (Drosophila) ), GeneBank accession No: BX649103 (ChGn, Chondroitin betal,4 N- acetylgalactosaminyltransferase ), GeneBank accession No: BM913048 (TIMPl, TIMP metallopeptidase inhibitor 1), GeneBank accession No: BM904612 ( S100A6 , SlOO calcium binding protein A6 (calcyclin) ) , GeneBank accession No: BM556279(EMP3, Epithelial membrane protein 3), GeneBank accession No: BC015041 (VATl , Family with sequence similarity 82, member C), GeneBank accession No: AY258066 (OKL38 , Pregnancy-induced growth inhibitor), GeneBank accession No: AK126729 (NDRG4 , NDRG family member 4), GeneBank accession No: AK090459 (NFE2L1 , Nuclear factor (erythroid-derived 2) -like 1), GeneBank accession No: AK074163(ROBO4, Roundabout homolog 4, magic roundabout (Drosophila) ), GeneBank accession No: AK024680(FLJ21027 fis, CDNA: FLJ21027 fis, clone CAE07110), GeneBank accession No: AF176422 (HEYl , Hairy/enhancer-of- split related with YRPW motif 1), GeneBank accession No: AF003837 (JAGl, Jagged l(Alagille syndrome)), GeneBank accession No: AB209322 ( SEMA3B, Sema domain, immunoglobulin domain(Ig), short basic domain, secreted, ( semaphorin) 3B), GeneBank accession No: AB011150 (NRXNl , Neurexin 1), GeneBank accession No: NM_201589 (MAFA, V-maf musculoaponeurotic fibrosarcoma oncogene homolog A(avian)), GeneBank accession No: NM_052999 (CKLFSFl , CKLF-like MARVEL transmembrane domain containing 1), GeneBank accession No: NM_006644 (HSPHl, Heat shock 105kDa/110kDa protein 1), GeneBank accession No: NM_005438 (FOSLl , FOS-like antigen 1), GeneBank accession No: NM_004996 (ABCCl , ATP-binding cassette, sub-family C (CFTR/MRP ) , member 1), GeneBank accession No: NM_002658 (PLAU, Plasminogen activator, urokinase), GeneBank accession No: NM_001353 (AKRlCl , Aldo- keto reductase family 1, member Cl (dihydrodiol dehydrogenase 1; 20-alpha( 3-alpha) -hydroxysteroid dehydrogenase)), GeneBank accession No: H18681 (C20orf 139 , Sulfiredoxin 1 homolog(S. cerevisiae) ) , GeneBank accession No: DR004094 (HAMP, Hepcidin antimicrobial peptide), GeneBank accession No: BC082272 (KCNMB3 , Potassium large conductance calcium-activated channel, subfamily M beta member 3), GeneBank accession No: BC040494 (DNAJB2 , DnaJ(Hsp40) homolog, subfamily B, member 2), GeneBank accession No: BC018064 (ATF6 , Activating transcription factor 6), GeneBank accession No: BC006523 ( SGK2 , Serum/glucocorticoid regulated kinase 2 ) , GeneBank accession No: AK090482 (CXCL12 , Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor I)), GeneBank accession No: AF219946 (TULP4 , Tubby like protein 4), GeneBank accession No: AB209112 ( SLC2A8 , Solute carrier family 2 , (facilitated glucose transporter) member 8), GeneBank accession No: NM_005242 (F2RL1 , Coagulation factor II (thrombin) receptor-like 1), GeneBank accession No: NM_001002029(C4A, Complement component 4B, telomeric), GeneBank accession No: NM__000539 (RHO, Rhodopsin( opsin 2, rod pigment ) (retinitis pigmentosa 4, autosomal dominant)), GeneBank accession No: BX649164 (PAI, serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), GeneBank accession No: BM918324 (LY96 , Lymphocyte antigen 96), GeneBank accession No: AB209647(NCF2, Neutrophil cytosolic factor 2(65kDa, chronic granulomatous disease, autosomal 2)), GeneBank accession No: NM_152221 (CSNKlE, Casein kinase 1, epsilon) , GeneBank accession No: NM_017999 (RNF31 , Ring finger protein 31), GeneBank accession No: NM_016819 (OGGl , 8-oxoguanine DNA glycosylase) , GeneBank accession No: NM_016816 (OASl , 2 ',5'- oligoadenylate synthetase 1, 40/46kDa), GeneBank accession No: NM_012235(SCAP, SREBP cleavage-activating protein), GeneBank accession No: NM_006384 (CIBl , Calcium and integrin binding 1 (calmyrin) ) , GeneBank accession No: NM_001779 (CD58 , CD58 antigen, (lymphocyte function-associated antigen 3)), GeneBank accession No: CB055213 ( ICOSLG, Inducible T-cell co-stimulator ligand), GeneBank accession No: BX641029 (MASPl , Mannan-binding lectin serine peptidase 1(C4/C2 activating component of Ra-reactive factor)), GeneBank accession No: BQ053419 (BATF, Basic leucine zipper transcription factor, ATF-like), GeneBank accession No: BC039299 (STIPl, Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein)), GeneBank accession No: AY055760 (DAF, Decay accelerating factor for complement (CD55 , Cromer blood group system)), GeneBank accession No: AK130188 (FGR, Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog), GeneBank accession No: AK095326 (MUS81 , MUS81 endonuclease homolog(yeast ) ) , GeneBank accession No: NM_017670 (OTUBl, OTU domain, ubiquitin aldehyde binding 1), GeneBank accession No: NM_003004 ( SECTMl , Secreted and transmembrane 1), GeneBank accession No: NM_002309 (LIF, Hypothetical protein MGC20647), GeneBank accession No: NM_001421 (ELF4, E74-like factor 4(ets domain transcription factor)), GeneBank accession No: NM_000418 ( IL4R, Interleukin 4 receptor), GeneBank accession No: BI909222 (FCERlG, Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide), GeneBank accession No: BF569086(NK4, Interleukin 32), GeneBank accession No: BC014470 (AZGPl, Alpha-2-glycoprotein 1, zinc), GeneBank accession No: BC020744 ( AKR1C4 , Aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol) , dehydrogenase 4), GeneBank accession No: BQ939577 (AKR1C3 , Aldo-keto reductase family 1, member C3( 3-alpha hydroxysteroid dehydrogenase, type H)), GeneBank accession No: NM_000499 (CYPlAl , Cytochrome P450, family 1, subfamily A, polypeptide 1), GeneBank accession No: NM_030622 (CYP2S1 , Cytochrome P450, family 2, subfamily S, polypeptide 1), GeneBank accession No: NM_184041 (ALDOA, Aldolase A, fructose-bisphosphate) , GeneBank accession No: NM_024307 (MGC4171 , Hypothetical protein LOC283901), GeneBank accession No: NM_005336 ( HDLBP, High density lipoprotein binding protein( vigilin) ) , GeneBank accession No: NM_002627 (PFKP, Phosphofructokinase, platelet), GeneBank accession No: BX648281 (LDLR, Low density lipoprotein receptor ( familial hypercholesterolemia)), GeneBank accession No: BC069201(FLJ22761, Hexokinase domain containing 1), GeneBank accession No: BC030207 (NR0B2 , Nuclear receptor subfamily 0, group B, member 2), GeneBank accession No: AL833O69(KIAA1434, Hypothetical protein KIAA1434), GeneBank accession No: AK124656 (ENO2 , Enolase 2 (gamma, neuronal)), GeneBank accession No: AK094474 (RHOC, Ras homolog gene family, member C), GeneBank accession No: AK093461 ( ISYNAl , Myo-inositol 1-phosphate synthase Al), GeneBank accession No: AB053232 (GAL3ST3, Galactose-3-O-sulfotransferase 3), GeneBank accession No: AB045292 (TMEM8 , Transmembrane protein 8(five membrane-spanning domains)), GeneBank accession No: NM_004753 (DHRS3 , Dehydrogenase/reductase ( SDR family) member 3), GeneBank accession No: NM_002900 (RBP3 , Retinol binding protein 3, interstitial), GeneBank accession No: NM_001995 (ACSLl , Acyl-CoA synthetase long- chain family member 1), GeneBank accession No: NM_000018 (ACADVL , Acyl-Coenzyme A dehydrogenase, very long chain), GeneBank accession No: BC094756 (CRA, Myotubularin related protein 11), GeneBank accession No: BC050553 (NTE , Neuropathy target esterase), GeneBank accession No: BC033110(HSD17Bl, Hydroxysteroid( 17-beta) dehydrogenase 1), GeneBank accession No: AY268890 (TPPl, Tripeptidyl peptidase I), GeneBank accession No: AK172798 (CPTlA, Carnitine palmitoyltransferase lA(liver)), GeneBank accession No: AK096809(CYP4F8, Cytochrome P450, family 4, subfamily F, polypeptide 8), GeneBank accession No: AK000600 ( SIAT7D, ST6 ( alpha-N-acetyl-neuraminyl-2 , 3-beta- galactosyl-1 , 3 ) -N- acetylgalactosaminide alpha-2 , 6-sialyltransferase 4), GeneBank accession No: AB002454 (CYP4F3 , Cytochrome P450, family 4, subfamily F, polypeptide 3), GeneBank accession No: Z29093 (DDRl, Discoidin domain receptor family, member 1), GeneBank accession No: Z25424 (MKNK2 , MAP kinase interacting serine/threonine kinase 2), GeneBank accession No: XM_291277(DKFZp761P0423, Hypothetical protein DKFZp761P0423) , GeneBank accession No: XM_038150 (MAST3 , Microtubule associated serine/threonine kinase 3), GeneBank accession No: U88357 (ERBB3 , V-erb-b2 erythroblastic leukemia viral oncogene homolog 3(avian)), GeneBank accession No: NM_025195 (TRIBl , Tribbles homolog l(Drosophila) ) , GeneBank accession No: NM_020639 (RIPK4 , Receptor-interacting serine-threonine kinase 4), GeneBank accession No: NM_014172 (PHPTl , Phosphohistidine phosphatase 1), GeneBank accession No: NM_006254 (PRKCD, Protein kinase C, delta), GeneBank accession No: NM_005415 ( SLC20A1 , Solute carrier family 20 (phosphate transporter), member 1), GeneBank accession No: NM_005026 (PIK3CD, Phosphoinositide- 3-kinase, catalytic, delta polypeptide), GeneBank accession No: NM_004431(EPHA2, EPH receptor A2 ) , GeneBank accession No: NM_004419(DUSP5, Dual specificity phosphatase 5), GeneBank accession No: NM_004327 (BCR, Breakpoint cluster region), GeneBank accession No: NM_004231 (ATP6V1F, ATPase, H+ transporting, lysosomal 14kDa, Vl subunit F), GeneBank accession No: NM_004090 (DUSP3 , Dual specificity phosphatase 3 (vaccinia virus phosphatase VHl-related) ) , GeneBank accession No: NM_002843 (PTPRJ, Protein tyrosine phosphatase, receptor type, J), GeneBank accession No: NM_002496 (NDUFS8 , NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH- coenzyme Q reductase)), GeneBank accession No: NM_001001852(PIM3, Pim-3 oncogene), GeneBank accession No: L76191 ( IRAKI, Interleukin-l receptor-associated kinase 1), GeneBank accession No: D15049 (PTPRH, Protein tyrosine phosphatase, receptor type, H), GeneBank accession No: BC065207(ATP6V0D2, ATPase, H+ transporting, lysosomal 38kDa, VO subunit d isoform 2), GeneBank accession No: BC035578(STK24, Serine/threonine kinase 24(STE20 homolog, yeast)), GeneBank accession No: BC028724 (DUSP18 , Dual specificity phosphatase 18), GeneBank accession No: AL117482(ULK3, Unc-51-like kinase 3(C. elegans)), GeneBank accession No: AK126879 (PCTK3 , PCTAIRE protein kinase 3), GeneBank accession No: AB209416 ( ILK, Integrin-linked kinase-2), GeneBank accession No: NM_000782 (CYP24A1 , Cytochrome P450, family 24, subfamily A, polypeptide 1), GeneBank accession No: CR597101 ( ZFP36 , Zinc finger protein 36, C3H type, homolog ( mouse) ), GeneBank accession No: CR936799(FHL2, Four and a half LIM domains 2), GeneBank accession No: M24898 (NRlDl , Nuclear receptor subfamily 1, group D, member 1), GeneBank accession No: AF132818 (KLF5 , Kruppel-like factor 5 ( intestinal )), GeneBank accession No: AK055337(ZNF213, Zinc finger protein 213), GeneBank accession No: BC008834 (PHFl , PHD finger protein 1), GeneBank accession No: AK126918 (GLIS2 , GLIS family zinc finger 2), GeneBank accession No: BC042692 (CTL2 , Solute carrier family 44, member 2), GeneBank accession No: NM_002224 (ITPR3, Inositol 1 , 4 , 5-triphosphate receptor, type 3), GeneBank accession No: AK095363 (AQP3 , Aquaporin 3), GeneBank accession No: NM_174953 (ATP2A3 , ATPase, Ca++ transporting, ubiquitous), GeneBank accession No: BC042390 (VTIlB, Vesicle transport through interaction with t-SNAREs homolog lB(yeast)), GeneBank accession No: NM_016113 (TRPV2, Transient receptor potential cation channel, subfamily V, member 2), GeneBank accession No: BM926478 (RBPl, Retinol binding protein 1, cellular), GeneBank accession No: NM_000069 (CACNAlS , Calcium channel, voltage-dependent, L type, alpha IS subunit), GeneBank accession No: AK002107 (RAB3B, RAB3B, member RAS oncogene family), GeneBank accession No: NM_013321 ( SNX8 , Sorting nexin 8), GeneBank accession No: AK125026 ( SLC6A12 , Solute carrier family 6 (neurotransmitter transporter, betaine/GABA) , member 12), GeneBank accession No: NM_005843(STAM2, Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2), GeneBank accession No: AK092512 (SLC16A5, Solute carrier family 16 (monocarboxylic acid transporters), member 5), GeneBank accession No: U49248(ABCC2, ATP-binding cassette, sub-family C(CFTR/MRP), member 2), GeneBank accession No: AK172792 ( SCNNlA, Sodium channel, nonvoltage-gated 1 alpha), GeneBank accession No: BC044656(CASC3, Cancer susceptibility candidate 3), GeneBank accession No: NM_203403 (C9orf 150 , Chromosome 9 open reading frame 150), GeneBank accession No: NM_O8O388(S1OOA16, SlOO calcium binding protein A16), GeneBank accession No: NM_031286 (SH3BGRL3, SH3 domain binding glutamic acid-rich protein like 3), GeneBank accession No: NM_022153 (PP2135, Chromosome 10 open reading frame 54), GeneBank accession No: NM_004864 (GDF15 , Growth differentiation factor 15), GeneBank accession No: NM_003330 (TXNRDl, Thioredoxin reductase 1), GeneBank accession No: NM_001013632 (LOC343521 , Similar to hypothetical protein 4833401D15), GeneBank accession No: BX537968(LOC51149, Hypothetical LOC51149), GeneBank accession No: BU945318 (MT2A, Hypothetical gene supported by X97260; BC070289), GeneBank accession No: BQ683841 (SlOOAIl , SlOO calcium binding protein All (calgizzarin) ) , GeneBank accession No: BQ276852 (TMSBlO , Thymosin, beta 10), GeneBank accession No: AK126182 (KIAA1949 , KIAA1949), GeneBank accession No: AK124751 (CAPN2 , Calpain 2,(m/II) large subunit), GeneBank accession No: AK095079 (RGC32 , Response gene to complement 32), GeneBank accession No: AB075871(FLJ42654, Golgi transport 1 homolog A(S. cerevisiae ) ) . [Claim 20] The method according to claim 18, wherein the below genes are down-regulated by exposure to phenanthrene : GeneBank accession No: AK125150 (MAPK8 , Mitogen- activated protein kinase 8), GeneBank accession No: NM_002758(MAP2K6, Mitogen-activated protein kinase kinase 6), GeneBank accession No: NM_004612 (TGFBRl , Transforming growth factor, beta receptor I(activin A receptor type II- like kinase, 53kDa)), GeneBank accession No: NM_145686 (MAP4K4 , Mitogen-activated protein kinase kinase kinase kinase 4), GeneBank accession No: XM_042066 (MAP3K1 , Mitogen-activated protein kinase kinase kinase 1 ) , GeneBank accession No: ABO 11123 (TNIK, TRAF2 and NCK interacting kinase), GeneBank accession No: AB209031(C5, Complement component 5), GeneBank accession No: NM_022740 (HIPK2 , Homeodomain interacting protein kinase 2 ) , GeneBank accession No: NM_148957 (TNFRSF19 , Tumor necrosis factor receptor superfamily, member 19), GeneBank accession No: AB208909(ITGB2, Integrin, beta 2(antigen CD18(p95), lymphocyte function-associated antigen 1; macrophage antigen l(mac-l) beta subunit)), GeneBank accession No: AB209211 (TIAl, TIAl cytotoxic granule-associated RNA binding protein), GeneBank accession No: AB209613 (DNASE1L3 , Deoxyribonuclease I-like 3), GeneBank accession No: AK122825(HMGB1, High-mobility group box 1), GeneBank accession No: AK127326 (PHF17 , PHD finger protein 17), GeneBank accession No: AK223503 (CASPl , Caspase 1, apoptosis-related cysteine peptidase ( interleukin 1, beta, convertase) ) , GeneBank accession No: BC013326 (GAS2 , Growth arrest-specific 2), GeneBank accession No: BC047698 ( IL7 , Interleukin 7), GeneBank accession No: D79987 (ESPLl , Extra spindle poles like 1(S. cerevisiae) ) , GeneBank accession No: NM_000893 (KNGl, Kininogen 1), GeneBank accession No: NM_001012271(BIRC5, Effector cell peptidase receptor 1), GeneBank accession No: NM_004938 (DAPKl , Death-associated protein kinase 1), GeneBank accession No: NM_005879 (TRIP, TRAF interacting protein), GeneBank accession No: NM_014739 (BCLAFl, BCL2-associated transcription factor 1), GeneBank accession No: NM_018947 (CYCS, Cytochrome c, somatic), GeneBank accession No: AB033337 (MPHOSPHl , M-phase phosphoprotein 1), GeneBank accession No: AB209179 (PLKl , Polo-like kinase 1 (Drosophila) ) , GeneBank accession No: AB209337(CDC7, CDC7 cell division cycle 7(S. cerevisiae ) ) , GeneBank accession No: AF053305 (BUBl , BUBl budding uninhibited by benzimidazoles 1 homolog( yeast ) ) , GeneBank accession No: AF053306 (BUBlB, BUBl budding uninhibited by benzimidazoles 1 homolog beta(yeast ) ) , GeneBank accession No: AF345347 (SPAG5, Sperm associated antigen 5), GeneBank accession No: AK092638 (CCNG2 , Cyclin G2 ) , GeneBank accession No: AK222819 (NUSAPl , Nucleolar and spindle associated protein 1), GeneBank accession No: AL833191 (SMC2L1, SMC2 structural maintenance of chromosomes 2-like 1 (yeast)), GeneBank accession No: AY257469(CIT, Citron(rho-interacting, serine/threonine kinase 21)), GeneBank accession No: AY367065 (ASPM, Asp(abnormal spindle)-like, microcephaly associated(Drosophila) ) , GeneBank accession No: BCOIlOOO (CDCA5 , Cell division cycle associated 5), GeneBank accession No: BC032677 (UBE2C, Ubiquitin-conjugating enzyme E2C), GeneBank accession No: BC043502 (NEK2 , NIMA(never in mitosis gene a)-related kinase 2), GeneBank accession No: BU675073 (PTTGl , Pituitary tumor- transforming 1), GeneBank accession No: BX647885 ( STMNl , Stathmin 1/oncoprotein 18), GeneBank accession No: CR592757 (BRRNl, Barren homolog 1 (Drosophila) ) , GeneBank accession No: CR597075 (MAPRE2 , Microtubule-associated protein, RP/EB family, member 2), GeneBank accession No: CR604810(CCNA2, Cyclin A2 ) , GeneBank accession No: CR933728(CDC2, Cell division cycle 2, Gl to S and G2 to M), GeneBank accession No: NM_000919 (PAM, Peptidylglycine alpha-amidating monooxygenase) , GeneBank accession No: NM_001790(CDC25C, Cell division cycle 25C), GeneBank accession No: NM_001798 (CDK2 , Cyclin-dependent kinase 2), GeneBank accession No: NM_001813 (CENPE, Centromere protein E, 312kDa), GeneBank accession No: NM_003318 (TTK, TTK protein kinase), GeneBank accession No: NM_003981 (PRCl , Protein regulator of cytokinesis 1), GeneBank accession No: NM_004523 (KIFIl, Kinesin family member 11), GeneBank accession No: NM_004701 (CCNB2 , Cyclin B2 ) , GeneBank accession No: NM_005983 ( SKP2 , S-phase kinase-associated protein 2(p45)), GeneBank accession No: NM_006101 (KNTC2 , Kinetochore associated 2), GeneBank accession No: NM_006845(KIF2C, Kinesin family member 2C), GeneBank accession No: NM_007375 (TARDBP, TAR DNA binding protein), GeneBank accession No: NM__012112 (TPX2 , TPX2 , microtubule- associated, homolog(Xenopus laevis)), GeneBank accession No: NM_014750(DLG7, Discs, large homolog 7 (Drosophila) ) , GeneBank accession No: NM_015097 (CLASP2 , Cytoplasmic linker associated protein 2), GeneBank accession No: NM_016343 (CENPF, Centromere protein F, 350/400ka(mitosin) ) , GeneBank accession No: NM_016426 (GTSEl , G-2 and S-phase expressed 1), GeneBank accession No: NM_018492 (PBK, PDZ binding kinase), GeneBank accession No: NM_018685 (ANLN, Anillin, actin binding protein ( scraps homolog, Drosophila)), GeneBank accession No: NM_020242 (KNSL7 , Kinesin family member 15), GeneBank accession No: NM_031966 (CCNBl , Cyclin Bl), GeneBank accession No: NM_138555 (KIF23 , Kinesin family member 23), GeneBank accession No: U65410 (MAD2L1 , MAD2 mitotic arrest deficient-like l(yeast)), GeneBank accession No: AB020656(CYLD, Cylindromatosis (turban tumor syndrome)), GeneBank accession No: AF033122 ( SESNl , Sestrin 1), GeneBank accession No: AK074377 (UHRFl , Chromosome 19 open reading frame 31), GeneBank accession No: AK091170 (CDKN2C, Cyclin- dependent kinase inhibitor 2C(pl8, inhibits CDK4 ) ) , GeneBank accession No: AK094323 (NFYC, Nuclear transcription factor Y, gamma), GeneBank accession No: AY366508 (L0H11CR2A, Loss of heterozygosity, 11, chromosomal region 2, gene A), GeneBank accession No: BC033086 (TCF19 , Transcription factor 19(SCl)), GeneBank accession No: BC040303 (PTP4A1 , Protein tyrosine phosphatase type IVA, member 1), GeneBank accession No: BC040991 (TFDP2 , Transcription factor Dp-2(E2F dimerization partner 2)), GeneBank accession No: BC092412(SGOL2, Shugoshin-like 2(S. pombe ) ) , GeneBank accession No: BQ278454 (CKSlB, CDC28 protein kinase regulatory subunit IB), GeneBank accession No: BX649128(SESN3, Sestrin 3), GeneBank accession No: CD049340 (AURKB, Aurora kinase B), GeneBank accession No: M89914(NF1, Neurofibromin 1 ( neurofibromatosis , von Recklinghausen disease, Watson disease)), GeneBank accession No: NM_001005414 ( ZWINT, ZWlO interactor antisense), GeneBank accession No: NM_001008491 ( Sep 2, Septin 2), GeneBank accession No: NM_001274 (CHEKl , CHKl checkpoint homolog(S. pombe)), GeneBank accession No: NM_002105(H2AFX, H2A histone family, member X), GeneBank accession No: NM_002388 (MCM3 , MCM3 minichromosome maintenance deficient 3(S. cerevisiae) ) , GeneBank accession No: NM_OO2417(MKI67, Antigen identified by monoclonal antibody Ki-67), GeneBank accession No: NM_002875 (RAD51 , RAD51 homolog(RecA homolog, E. CoIi)(S. cerevisiae)), GeneBank accession No: NM_003884 (PCAF, P300/CBP-associated factor), GeneBank accession No: NM_004526 (MCM2 , MCM2 minichromosome maintenance deficient 2, mitotin(S. cerevisiae)), GeneBank accession No: NM_004847 (AIFl , Allograft inflammatory factor 1), GeneBank accession No: NM_005915 (MCM6 , MCM6 minichromosome maintenance deficient 6(MIS5 homolog, S. pombe ) ( S . cerevisiae) ) , GeneBank accession No: NM_012090 (MACFl , Microtubule-actin crosslinking factor 1), GeneBank accession No: NM_012415(RAD54B, RAD54 homolog B(S. cerevisiae)), GeneBank accession No: NM_014264 (PLK4 , Polo-like kinase 4(Drosophila) ) , GeneBank accession No: NM_015714 (G0S2 , GO/Glswitch 2), GeneBank accession No: NM_024680 ( FLJ23311 , E2F transcription factor 8), GeneBank accession No: XM_034274 (MYBLl , V-myb myeloblastosis viral oncogene homolog ( avian) -like 1), GeneBank accession No: AK001720(FLJ10858, Nei endonuclease Vlll-like 3(E. coli)), GeneBank accession No: AY032677 (POLQ, Polymerase (DNA directed), theta), GeneBank accession No: BC034480 (BLM, Bloom syndrome), GeneBank accession No: BC073161 (RAD51C, RAD51 homolog C(S. cerevisiae)), GeneBank accession No: CR600021(HMGB2, High-mobility group box 2), GeneBank accession No: CR625391 (RAD51AP1 , RAD51 associated protein 1), GeneBank accession No: CR936783 (FLJ40869 , Hypothetical protein LOC284952), GeneBank accession No: DQ140356 (KIAA1596 , Fanconi anemia, complementation group M), GeneBank accession No: NM_001067 (T0P2A, Topoisomerase ( DNA) II alpha 17OkDa), GeneBank accession No: NM_001618 (PARPl , Poly (ADP-ribose) polymerase family, member 1), GeneBank accession No: NM_003362 (UNG, Uracil-DNA glycosylase) , GeneBank accession No: NM_006904 (PRKDC, Protein kinase, DNA-activated, catalytic polypeptide), GeneBank accession No: NM_130398(EXOl, Exonuclease 1), GeneBank accession No: AB020807 (TLR6 , Toll-like receptor 6), GeneBank accession No: AB032980(DCDC2, Doublecortin domain containing 2), GeneBank accession No: AB209866 (TFPI, Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)), GeneBank accession No: AK057015 (HSPA4 , Heat shock 7OkDa protein 4), GeneBank accession No: AK095515 ( IFITl , Interferon-induced protein with tetratricopeptide repeats 1), GeneBank accession No: AK122686(IF, I factor (complement )), GeneBank accession No: AK123010 (RRM2 , Ribonucleotide reductase M2 polypeptide), GeneBank accession No: BC035582 (TRIM22 , Tripartite motif-containing 22), GeneBank accession No: BX537894 (LOC493869 , Similar to RIKEN cDNA 2310016C16), GeneBank accession No: M14338 (PROSl , Protein S(alpha)), GeneBank accession No: NM_000821 (GGCX, Gamma-glutamyl carboxylase), GeneBank accession No: NM_000963 (PTGS2, Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase ) ) , GeneBank accession No: NM_001001547 (CD36 , CD36 antigen(collagen type I receptor, thrombospondin receptor)), GeneBank accession No: NM_001512(GSTA4, Glutathione S-transferase A4 ) , GeneBank accession No: NM_001629 ( AL0X5AP, Arachidonate 5- lipoxygenase-activating protein), GeneBank accession No: NM_001752(CAT, Catalase), GeneBank accession No: NM_001837(CCR3, Chemokine(C-C motif) receptor 3), GeneBank accession No: NM_001979 (EPHX2 , Epoxide hydrolase 2, cytoplasmic), GeneBank accession No: NM_001994 (F13B, Coagulation factor XIII, B polypeptide), GeneBank accession No: NM_002182 (ILlRAP, Interleukin 1 receptor accessory protein), GeneBank accession No: NM_006120 (HLA-DMA, Major histocompatibility complex, class II, DM alpha), GeneBank accession No: NM_173216 ( SIATl , ST6 beta-galactosamide alpha-2 , 6-sialyltranferase 1), GeneBank accession No: NM_202002 (FOXMl, Forkhead box Ml), GeneBank accession No: AB163917 (LRAP, Leukocyte-derived arginine aminopeptidase) , GeneBank accession No: BC027881 ( AFP, Alpha-fetoprotein) , GeneBank accession No: NM_015915 ( SPG3A, Spastic paraplegia 3A(autosomal dominant)), GeneBank accession No: NM_000671(ADH5, Alcohol dehydrogenase 5 (class III), chi polypeptide), GeneBank accession No: J05428 (UGT2B7 , UDP glucuronosyltransferase 2 family, polypeptide B7 ) , GeneBank accession No: NM_000672 ( ADH6 , Alcohol dehydrogenase β(class V)), GeneBank accession No: M15943(ADH4, Alcohol dehydrogenase 4 (class II), pi polypeptide), GeneBank accession No: AK223395 (FBPl , Fructose-1 , 6-bisphosphatase 1), GeneBank accession No: NM_000151 (G6PC, Glucose-6- phosphatase, catalytic (glycogen storage disease type I, von Gierke disease)), GeneBank accession No: XM_113962 (KIAA0650 , Structural maintenance of chromosomes flexible hinge domain containing 1), GeneBank accession No: AB020644 (ACSL6 , Acyl- CoA synthetase long-chain family member 6), GeneBank accession No: AB209907 (PLDl , Phospholipase Dl, phophatidylcholine-specific ) , GeneBank accession No: AF285167 (ABCAl, ATP-binding cassette, sub-family A(ABCl), member 1), GeneBank accession No: AF297872 (TRERFl , Transcriptional regulating factor 1), GeneBank accession No: AF3O3134(ALDH8A1, Aldehyde dehydrogenase 8 family, member Al), GeneBank accession No: AF339053 (PLA2G12B, Phospholipase A2 , group XIIB), GeneBank accession No: AK096018 (HADHSC, L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain), GeneBank accession No: AK124635 (PCSK9 , Proprotein convertase subtilisin/kexin type 9), GeneBank accession No: AK127346 ( SIAT9 , ST3 beta-galactoside alpha- 2 , 3-sialyltransferase 5), GeneBank accession No: AL359559 (AGPS, Alkylglycerone phosphate synthase), GeneBank accession No: AY691170 (PLCL3 , Phospholipase C-like 3), GeneBank accession No: BG567934 (APOM, Apolipoprotein M), GeneBank accession No: BX538214 (Cβorf 167 , Chromosome 6 open reading frame 167), GeneBank accession No: BX640945 (FADS2 , Fatty acid desaturase 2), GeneBank accession No: BX648473(PIGK, Phosphatidylinositol glycan, class K), GeneBank accession No: BX648557 ( HSD17B2 , Hydroxysteroid( 17- beta) dehydrogenase 2), GeneBank accession No: CR749601 (ETNKl, Death-associated protein kinase 3), GeneBank accession No: NM_000859 (HMGCR, 3-hydroxy-3- methylglutaryl-Coenzyme A reductase), GeneBank accession No: NM_001443 (FABPl, Fatty acid binding protein 1, liver), GeneBank accession No: NM_002130 (HMGCSl , 3-hydroxy-3- methylglutaryl-Coenzyme A synthase l(soluble)), GeneBank accession No: NM_003725 (RODH, Hydroxysteroid( 17-beta) dehydrogenase 6), GeneBank accession No: NM_004845 (PCYTlB, Phosphate cytidylyltransferase 1, choline, beta), GeneBank accession No: NM_014762 (DHCR24 , 24-dehydrocholesterol reductase), GeneBank accession No: NM_020139 (DHRS6 , Dehydrogenase/reductase ( SDR family) member 6), GeneBank accession No: NM_020918 (GPAM, Glycerol-3-phosphate acyltransferase, mitochondrial), GeneBank accession No: NM_032523(OSBPL6, Oxysterol binding protein-like 6), GeneBank accession No: NM_033505 ( SELI , Selenoprotein I), GeneBank accession No: Z28339 (AKRlDl , Aldo-keto reductase family 1, member Dl (delta 4-3-ketosteroid-5-beta- reductase)), GeneBank accession No: AK024899 (ENPP3 , Ectonucleotide pyrophosphatase/ phosphodiesterase 3), GeneBank accession No: AK025546 (PTPN4 , Protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) ), GeneBank accession No: AK124910 (ENPP2 , Ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin) ) , GeneBank accession No: BC035116 (FLJ35059 fis, CDNA FLJ30761 fis, clone FEBRA2000538 ) , GeneBank accession No: BC050565 (PASK, PAS domain containing serine/threonine kinase), GeneBank accession No: L13436(NPR2, Natriuretic peptide receptor B/guanylate cyclase B(atrionatriuretic peptide receptor B)), GeneBank accession No: NM_001005862 (ERBB2 , V-erb-b2 erythroblastic leukemia viral oncogene homolog 2 , neuro/glioblastoma derived oncogene homolog ( avian) ), GeneBank accession No: NM_005012 (RORl , Receptor tyrosine kinase-like orphan receptor 1), GeneBank accession No: NM_006035(CDC42BPB, CDC42 binding protein kinase beta(DMPK- like)), GeneBank accession No: NM_014791 (MELK, Maternal embryonic leucine zipper kinase), GeneBank accession No: NM_023028(FGFR2, Fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer yndrome, Jackson-Weiss syndrome)), GeneBank accession No: NM_080836 (STK35 , Serine/threonine kinase 35), GeneBank accession No: AF419331 (FUSIPl , FUS interacting protein ( serine/arginine-rich ) 1), GeneBank accession No: AK091927(SFRS3, Splicing factor, arginine/serine-rich 3), GeneBank accession No: BC010266 (HNRNPAl , Heterogeneous nuclear ribonucleoprotein Al), GeneBank accession No: BC012360(CTAGE5, CTAGE family, member 5), GeneBank accession No: BC036046 (PLRGl , Pleiotropic regulator 1(PRLl homolog, Arabidopsis ) ) , GeneBank accession No: BC065384 (PCFIl, PCFlI, cleavage and polyadenylation factor subunit, homolog(S. cerevisiae) ) , GeneBank accession No: BX537360 (CPSF5 , Nudix( nucleoside diphosphate linked moiety X) -type motif 21), GeneBank accession No: BX537494 (HNRPA2B1 , Heterogeneous nuclear ribonucleoprotein A2/B1), GeneBank accession No: BX647784 (HNRPR, Heterogeneous nuclear ribonucleoprotein R), GeneBank accession No: CA455267 (PPIH, Peptidyl prolyl isomerase H(cyclophilin H)), GeneBank accession No: CR596214 (HNRPAO , Heterogeneous nuclear ribonucleoprotein AO), GeneBank accession No: NM_001326(CSTF3, Hypothetical protein LOC283267), GeneBank accession No: NM_004640 (BATl , HLA-B associated transcript 1), GeneBank accession No: NM_005463 (HNRPDL, Heterogeneous nuclear ribonucleoprotein D-like), GeneBank accession No: NM_006924 (SFRSl, Splicing factor, arginine/serine-rich 1( splicing factor 2, alternate splicing factor)), GeneBank accession No: NM_012426 ( SF3B3 , Splicing factor 3b, subunit 3, 13OkDa), GeneBank accession No: NM_018048 (FLJ10292 , Mago-nashi homolog) , GeneBank accession No: NM_030919(C20orfl29, Chromosome 20 open reading frame 129), GeneBank accession No: NM_031370 (HNRPD, Heterogeneous nuclear ribonucleoprotein D(AU-rich element RNA binding protein 1, 37kDa)), GeneBank accession No: NM_138933 ( ACF, Apobec-1 complementation factor), GeneBank accession No: AB193259 (ACE2 , Angiotensin I converting enzyme (peptidyl- dipeptidase A) 2), GeneBank accession No: BX648769 (EWSRl , Ewing sarcoma breakpoint region 1), GeneBank accession No: AB023154(DTX4, Deltex 4 homolog(Drosophila) ) , GeneBank accession No: AL543755 ( VAV3 , Vav 3 oncogene), GeneBank accession No: M75106(CPB2, Carboxypeptidase B2 (plasma, carboxypeptidase U) ) , GeneBank accession No: NM_021045(ZNF248, Zinc finger protein 248), GeneBank accession No: AB209194 (B4GALT6 , UDP-GaI :betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6), GeneBank accession No: AF279145 (ANTXRl , Anthrax toxin receptor 1), GeneBank accession No: NM_025074 (FRASl , Fraser syndrome 1), GeneBank accession No: AK025790 (KIF20A, Kinesin family member 20A), GeneBank accession No: NM_006152 (LRMP, Lymphoid-restricted membrane protein), GeneBank accession No: NM_000340(SLC2A2, Solute carrier family 2 ( facilitated glucose transporter), member 2), GeneBank accession No: AF071592(KIF4A, Kinesin family member 4A), GeneBank accession No: NM_013277 (RACGAPl , Rac GTPase activating protein 1), GeneBank accession No: AY043484 (SCNlA, Sodium channel, voltage-gated, type I, alpha), GeneBank accession No: AY791349(KIF18A, Kinesin family member 18A), GeneBank accession No: NM_018018 ( SLC38A4 , Solute carrier family 38, member 4), GeneBank accession No: AK094603 (FLJ37284 fis, unnamed protein product; Homo sapiens cDNA FLJ37284 fis, clone BRAMY2013590. ) , GeneBank accession No: NM_021069(ARGBP2, Sorbin and SH3 domain containing 2), GeneBank accession No: NM_001005747 (CACNB4 , Calcium channel, voltage-dependent, beta 4 subunit), GeneBank accession No: AJ496568(SLC25A12 , Solute carrier family 25 (mitochondrial carrier, Aralar), member 12), GeneBank accession No: NM_030641 (AP0L6, Apolipoprotein L, 6), GeneBank accession No: NM_173512(FLJ39822, Hypothetical protein FLJ39822), GeneBank accession No: NM_000037 (ANKl , Ankyrin 1, erythrocytic), GeneBank accession No: NM_001011554 ( SLC13A3 , Solute carrier family 13 ( sodium-dependent dicarboxylate transporter), member 3), GeneBank accession No: AB091343(C10orf3, Centrosomal protein 55kDa), GeneBank accession No: AK000643 (ASB9 , Ankyrin repeat and SOCS box- containing 9), GeneBank accession No: AK055221 (FBXO5 , F-box protein 5), GeneBank accession No: AK075271 ( SPTLC2L, Serine palmitoyltransferase, long chain base subunit 2- like ( aminotransferase 2)), GeneBank accession No: AK122685 (GLUDl, Glutamate dehydrogenase 1), GeneBank accession No: AK127098 (FLJ10706 , Chromosome 1 open reading frame 112), GeneBank accession No: AL133031 (MLRl , Transcription factor MLRl), GeneBank accession No: AY007723(MAL2, MaI, T-cell differentiation protein 2), GeneBank accession No: BC022255 (Spc25 , Spindle pole body component 25 homolog(S. cerevisiae) ) , GeneBank accession No: BC041882(ATF7IP2, Activating transcription factor 7 interacting protein 2), GeneBank accession No: BC052951 (LMNBl, Lamin Bl), GeneBank accession No: BC098313(FLJ20641, Hypothetical protein FLJ20641), GeneBank accession No: NM_001809 (CENPA, Centromere protein A, 17kDa), GeneBank accession No: NM_145061 (C13orf3 , Chromosome 13 open reading frame 3), GeneBank accession No: XM_372695(LOC390859, PREDICTED: Homo sapiens similar to Chain A, Crystal Structure Of The R463a Mutant Of Human Glutamate Dehydrogenase (LOC390859 ), mRNA) . [Claim 2l] The method according to claim 18, wherein the human somatic cell of step 1) is originated from human liver or liver cancer cells or tissues. [Claim 22] The method according to claim 21, wherein the human liver cancer cell is HepG2. [Claim 23] The method according to claim 18, wherein the primer set of step 2 ) is composed of at least 2 forward primers and reverse primers selected from the group consisting of sequences represented by SEQ. ID. NO: 1 -NO: 56. |
[invention Title]
KITS FOR IDENTIFICATION OF EXPOSURE TO PHENANTHRENE AND THE METHOD OF IDENTIFICATION OF EXPOSURE TO PHENANTHRENE
[Technical Field]
The present invention relates to a kit for identification of exposure to phenanthrene and a method for identification of exposure to phenanthrene, more precisely, a kit for identification of exposure to phenanthrene using a gene up-regulated or down-regulated by phenanthrene, one of polycyclic aromatic hydrocarbons, and a method for identification of exposure to phenanthrene using the same.
[Background Art]
Phenanthrene, one of polycyclic aromatic hydrocarbons, is a glossy, colorless blue fluorescent platy crystal, which has a structure of fused ring composed of three benzene rings. Phenanthrene is an isomer of anthracene.
It was first found in coal tar by R. Fittig of Germany in
1872. It is largely included in anthracene oil extracted from coal tar and is separated by precise distillation.
When phenanthrene is oxidized by chromic acid, phenanthraquinone is generated. When it is reduced, hydrogenated compounds are generated in each stage. Phenanthrene is a synthetic raw material for dyes, plastics, insecticides and medical supplies, but it is not commercially produced or used but produced for the purpose of organic matter synthesis or studies in the field of chemistry. To measure exposure to phenanthrene in the environment, major facilities expected to discharge phenanthrene by the research of distribution of aromatic hydrocarbons (PAHs) of industrial stack gas are selected and examined. As a result, 1.2 ppb of phenanthrene was detected in cupola and some phenanthrene was also detected in boiler (The Report of National Institute of Environmental Research, Korea 1996). PAH concentration in the air of domestic cities was also investigated. As a result, 0.31 ng/m 3 of PAH was detected in residential area of Seoul and 0.36 ng/m 3 of PAH was detected in Taepyeong- dong, Daejeon (Ministry of Environment, 1997). In overseas studies, PAH concentration in the air in New York, USA, was confirmed to be 0.4 ng/m 3 (1974), PAH concentration in Osaka, Japan was 100 ng/m 3 (1977-4978), and PAH concentration in Paris, France was 28 ng/m 3 (1981-1982) (Edoardo, The Science of the Total Environment, 116:119-135, 1992).
Phenanthrene is converted into phenanthrene-9 , 10- oxide and phenanthrene- 1 , 2-diol-3 , 4-epoxide by epoxidation. Phenanthrene is sensitive to skin and harmful to human since it causes dermatitis, bronchitis, cough, dyspnea, bronchial tumor and renal tumor in human. According to the classification of carcinogenicity made by International Agency for Research on Cancer (IARC), UN, it belongs to Group 3, indicating it is classified as a non-carcinogenic substance in human (there is insufficient evidence of carcinogenicity in humans).
There have been a few studies reporting carcinogenicity of polycyclic aromatic hydrocarbons and gene expression changes thereby, but most of them are limited to the representative polycyclic aromatic hydrocarbon, benzo[ a]pyrene . Even if phenanthrene has carcinogenicity in human, there are not enough data to evaluate risk in human and methods for screening exposure to phenanthrene are limited to a couple of classical methods such as GC-MS (Gas Chromatography-Mass Spectrometer) or HPLC (High Performance Liquid Chromatography). GC-MS or HPLC facilitates quantification. However, to do so, proper conditions for analysis have to be determined and high price equipments are necessary. Therefore, it is an urgent and important request to establish and utilize molecular index for screening toxicity in human by evaluating risk quick enough using fast and easy screening methods such as real-time RT-PCR (reverse transcript polymerase chain reaction) using primers or DNA micro-array chip to take measure and control exposure to phenanthrene.
Diverse genome nucleotide sequencing projects including 6 mammals and 292 microorganisms have been completed and reported to NCBI (National Center for Biotechnology Information). Based on a huge amount of data obtained thereby, studies on genome-wide expression have been actively undergoing to examine functions of genes . DNA microarray enables the analysis of expressions of thousands of genes at a time (Schena, M., et al., Proc . Natl. Acad. Sci. USA 93:10614-10619, 1996).
Microarray is prepared by integrating cDNA (complementary DNA) or 20-25 base pair long oligonucleotides on a glass plate. cDNA microarray is produced in laboratories at schools or companies including Agilent, Genomic Solutions, etc, by mechanically fixing cDNA collections on a chip or via ink jetting (Sellheyer K. et. al., J. Am. Acad. Dermatol. 51:681-692, 2004). Oligonucleotide microarray is prepared by direct synthesis on a chip using photolithography by Affymetrix Co. Agilent Co., etc. also produce oligonucleotide microarray by fixing synthetic oligonucleotides on a chip (Sellheyer, K. et. al., J. Am. Acad. Dermatol. 51:681-692, 2004).
To analyze gene expression, RNA is extracted from a sample such as tissues and hybridized with oligonucleotide on DNA microarray. The obtained RNA is labeled with fluorescence or isotope and then converted into cDNA. According to oligo-microarray, control and experimental groups are labeled with different fluorescences (for example, Cye3 and Cye5) and hybridized on a same chip, followed by optical image scanning to measure the strength of fluorescence. Gene expression is determined by the ratio of fluorescence strength between the two (Somasundaram, K. et al., Genomics Proteomics 1:1-10, 2002) .
By integrating with high-tech-toxicogenomics based on recent DNA microarray techniques, it is now possible to analyze gene expression pattern or quantify gene expression in specific tissues or cells vulnerable by medicines and newly developed drugs or any other chemicals including representative environmental pollutants. Therefore, by investigating the expression pattern of a specific gene in a specific cell, side effects of a drug and genes causing harmful action in relation to environmental pollutants can be predicted, by which mechanisms of molecules involved in harmful action of pollutants and mechanisms of effect and side-effect of a drug can be better understood, facilitating screening and identification of a material causing side effects or toxicity.
The present inventors applied phenanthrene expression profiles in human liver cancer cell line HepG2 using oligo- microarray on which 44,000 human genes are integrated to screen genes up-regulated or down-regulated by phenanthrene. And the present inventors further investigated the expression patterns of such genes by real-time RT-PCR. At last the present inventors completed this invention by- providing a kit for identification of exposure to phenanthrene using the said gene up-regulated or down- regulated specifically by phenanthrene as a biomarker and a method for identification of exposure to phenanthrene.
[Disclosure] [Technical Problem]
It is an object of the present invention to provide a kit for identification of exposure to phenanthrene using a gene up-regulated or down-regulated specifically by phenanthrene and a method for identification of exposure to phenanthrene using the said gene.
[Technical Solution] To achieve the above object, the present invention provides a kit for identification of exposure to phenanthrene comprising oligonucleotide containing total length or a part of a gene up-regulated or down-regulated by phenanthrene or its complementary oligonucleotide. The present invention also provides a kit for identification of exposure to phenanthrene containing a primer set capable of amplifying the said gene.
The present invention further provides a method for identification of exposure to phenanthrene using the said gene.
Hereinafter, the present invention is described in detail.
The present invention provides a kit for identification of exposure to phenanthrene comprising oligonucleotide containing total length or a part of a gene selected from the group consisting of the following genes or its complementary oligonucleotide: GeneBank accession No: NM_004420 (DUSP8 , Dual specificity phosphatase 8), GeneBank accession No: L11329(DUSP2, Dual specificity phosphatase 2), GeneBank accession No: BC094766 (PKNl , Protein kinase Nl), GeneBank accession No: AY247738 (TRIB3, Tribbles homolog 3(Drosophila) ) , GeneBank accession No: AK129595 (GADD45B, Growth arrest and DNA-damage-inducible, beta), GeneBank accession No: AB208849 ( SHCl , SHC(Src homology 2 domain containing) transforming protein 1), GeneBank accession No: X02812 (TGFBl, Transforming growth factor, beta l(Camurati- Engelmann disease) ), GeneBank accession No: NM_198951 (TGM2 , Transglutaminase 2(C polypeptide, protein-glutamine-gamma- glutamyltransferase) ), GeneBank accession No: NM_147780(CTSB, Cathepsin B), GeneBank accession No: NM_078467 (CDKNlA, Cyclin-dependent kinase inhibitor lA(p21, Cipl)), GeneBank accession No: NM_033027 (AXUDl , AXINl up- regulated 1), GeneBank accession No: NM_032797 (AMID, Apoptosis-inducing factor (AIF) -like mitochondrion- associated inducer of death), GeneBank accession No: NM_021960 (MCLl, Myeloid cell leukemia sequence 1(BCL2- related)), GeneBank accession No: NM_016639 (TNFRSF12A, Tumor necrosis factor receptor superfamily , member 12A) , GeneBank accession No: NM_016222 (DDX41 , DEAD( Asp-Glu-Ala- Asp) box polypeptide 41), GeneBank accession No: NM_013246 (CLC, Cardiotrophin-like cytokine factor 1), GeneBank accession No: NM_004401 (DFFA, DNA fragmentation factor, 45kDa, alpha polypeptide), GeneBank accession No: NM_004281(BAG3, BCL2-associated athanogene 3), GeneBank accession No: NM_003897( IER3, Immediate early response 3), GeneBank accession No: NM_003806 (HRK, Harakiri, BCL2 interacting protein (contains only BH3 domain)), GeneBank accession No: NM_003639 ( IKBKG, Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma), GeneBank accession No: NM_003311 ( PHLDA2 , Pleckstrin homology-like domain, family A, member 2), GeneBank accession No: NM_002737 (PRKCA, Protein kinase C, alpha), GeneBank accession No: NM_002648 (PIMl , Pim-1 oncogene), GeneBank accession No: NM_002507 (NGFR, Nerve growth factor receptor (TNFR superfamily, member 16)), GeneBank accession No: NM_002305 (LGALSl, Lectin, galactoside-binding, soluble, l(galectin I)), GeneBank accession No: NM_001013398 ( IGFBP3 , Insulin-like growth factor binding protein 3), GeneBank accession No: BX640923 (MDM4 , Mdm4 , transformed 3T3 cell double minute 4, p53 binding protein (mouse) ) , GeneBank accession No: BX537586 ( STK17A, Serine/threonine kinase 17a(apoptosis-inducing) ) , GeneBank accession No: BG284742(P8, P8 protein (candidate of metastasis I)), GeneBank accession No: BE903247 (PDCD6IP, Programmed cell death 6 interacting protein), GeneBank accession No: BC027949(P2RXl, Purinergic receptor P2X, ligand-gated ion channel, 1), GeneBank accession No: BC006365 (PSEN2 , Presenilin 2 (Alzheimer disease 4)), GeneBank accession No: AY869712(PPP1R13L, Protein phosphatase 1, regulatory (inhibitor) subunit 13 like), GeneBank accession No: AY028896(CARD10, Caspase recruitment domain family, member 10), GeneBank accession No: AK122614 (PPARD, Peroxisome proliferative activated receptor, delta), GeneBank accession No: AK092872 (ERCC2 , Excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)), GeneBank accession No: AK092808 (RRAGC, Ras-related GTP binding C), GeneBank accession No: AJ001898 (GDNF, Glial cell derived neurotrophic factor), GeneBank accession No: AF220656 (PHLDAl, Pleckstrin homology-like domain, family A, member 1), GeneBank accession No: AF055634 (UNC5C, Unc-5 homolog C(C. elegans)), GeneBank accession No: AB209485 (VEGF, Vascular endothelial growth factor), GeneBank accession No: AB096256 (UNC5B, Unc-5 homolog B(C. elegans)), GeneBank accession No: AB007960 (SH3GLB1 , SH3- domain GRB2-like endophilin Bl), GeneBank accession No: X06374 (PDGFA, Platelet-derived growth factor alpha polypeptide), GeneBank accession No: S62138 ( DDIT3 , DNA- damage-inducible transcript 3), GeneBank accession No: NM_078487(CDKN2B, Cyclin-dependent kinase inhibitor 2B(pl5, inhibits CDK4 ) ) , GeneBank accession No: NM_012127 (CIZl , CDKNlA interacting zinc finger protein 1), GeneBank accession No: NM_005883 (APC2 , Adenomatosis polyposis coli 2), GeneBank accession No: NM_004196 (CDKLl , Cyclin- dependent kinase-like 1 (CDC2-related kinase)), GeneBank accession No: NM_003236 (TGFA, Transforming growth factor, alpha), GeneBank accession No: NM_001261 (CDK9 , Cyclin- dependent kinase 9 (CDC2-related kinase)), GeneBank accession No: NM_001007271 (DUSP13 , Dual specificity phosphatase 13), GeneBank accession No: CR749511 (PARC, P53- associated parkin-like cytoplasmic protein), GeneBank accession No: CR623038 ( ID2 , Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein), GeneBank accession No: CR618371 (EGFR, Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)), GeneBank accession No: BF965144 ( IFITMl , Interferon induced transmembrane protein 1(9-27)), GeneBank accession No: AK127679 (DUSPl , Dual specificity phosphatase 1), GeneBank accession No: AK096276 (CCND3 , Cyclin D3 ) , GeneBank accession No: AB209586 (MAPK13, Mitogen-activated protein kinase 13), GeneBank accession No: AB209465 (PCTKl , PCTAIRE protein kinase 1), GeneBank accession No: Z19588(SKIL, SKI-like), GeneBank accession No: NM_020429 (SMURFl, SMAD specific E3 ubiquitin protein ligase 1), GeneBank accession No: NM_014767 (SPOCK2 , Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2), GeneBank accession No: NM_005979(S100A13, SlOO calcium binding protein A13), GeneBank accession No: NM_005187 (CBFA2T3 , Core-binding factor, runt domain, alpha subunit 2; translocated to, 3), GeneBank accession No: NM_004364 (CEBPA, CCAAT/enhancer binding protein ( C/EBP ), alpha), GeneBank accession No: NM_001769(CD9, CD9 antigen (p24 )), GeneBank accession No: NM_001718 (BMP6 , Bone morphogenetic protein 6), GeneBank accession No: NM_000641 ( ILIl , Interleukin 11), GeneBank accession No: BX647459 ( SERPINE2 , Serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 2), GeneBank accession No: BQ066037 (RPS19 , Ribosomal protein S19), GeneBank accession No: BE791300 (EDFl , Endothelial differentiation-related factor 1), GeneBank accession No: BC038504 ( SNFlLK, SNFl-like kinase), GeneBank accession No: AL832287 ( ZAP70 , Zeta-chain (TCR) associated protein kinase 7OkDa), GeneBank accession No: AK125742 (PCGFl, Polycomb group ring finger 1), GeneBank accession No: AK124709 (NDRGl , N-myc downstream regulated gene 1), GeneBank accession No: AB011157 (PTDSR, Phosphatidylserine receptor), GeneBank accession No: NM_013255 (MKLNl, Muskelin 1, intracellular mediator containing kelch motifs), GeneBank accession No: NM_006572 (GNA13, Guanine nucleotide binding protein(G protein), alpha 13), GeneBank accession No: NM_002211 ( ITGBl , Integrin, beta 1 ( fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2 , MSK12)), GeneBank accession No: CR601067 (PLAUR, Plasminogen activator, urokinase receptor), GeneBank accession No: BC050456 (THBS4 , Thrombospondin 4), GeneBank accession No: AK027389 (CXCL16 , Chemokine (C-X-C motif) ligand 16), GeneBank accession No: AJ132099 (VNNl , Vanin 1), GeneBank accession No: XM_371354 (FLJ10157 , Hypothetical protein FLJ10157), GeneBank accession No: XM_208313(TPM3, Similar to tropomyosin 4), GeneBank accession No: XM_208270(ACR, Acrosin-like protease), GeneBank accession No: NM_203353(PDLIM7, PDZ and LIM domain 7(enigma)), GeneBank accession No: NM_201382 (PLECl , Plectin 1, intermediate filament binding protein 50OkDa), GeneBank accession No: NM_182961 ( SYNEl , Spectrin repeat containing, nuclear envelope 1), GeneBank accession No: NM_181826 (NF2 , Neurofibromin 2 (bilateral acoustic neuroma)), GeneBank accession No: NM_172069 (PLEKHH2 , Pleckstrin homology domain containing, family H (with MyTH4 domain) member 2), GeneBank accession No: NM_022648 (TNS , Tensin 1), GeneBank accession No: NM_017556(FBLP-l, Filamin binding LIM protein 1), GeneBank accession No: NM_016081 (KIAA0992 , Palladin, cytoskeletal associated protein), GeneBank accession No: NM_006617 (NES, Nestin), GeneBank accession No: NM_006262 (PRPH, Peripherin), GeneBank accession No: NM_OO51OO(AKAP12, A kinase(PRKA) anchor protein ( gravin) 12), GeneBank accession No: NM_004368 (CNN2 , Calponin 2), GeneBank accession No: NM_003388 (CYLN2 , Cytoplasmic linker 2), GeneBank accession No: NM_003370 (VASP, Vasodilator- stimulated phosphoprotein) , GeneBank accession No: NM_003128 (SPTBNl, Spectrin, beta, non-erythrocytic 1), GeneBank accession No: NM_002705 (PPL, Periplakin), GeneBank accession No: NM_002475 (MLClSA, Myosin light chain 1 slow a), GeneBank accession No: NM_002018 (FLII, Flightless I homolog(Drosophila) ) , GeneBank accession No: NM_001465 (FYB, FYN binding protein( FYB-120/130 ) ) , GeneBank accession No: NM_001069(TUBB2, Tubulin, beta 2A), GeneBank accession No: CR625172(MGC8685, Tubulin, beta 2B), GeneBank accession No: CR616919(KRT18, Keratin 18), GeneBank accession No: CR606241 (ACTGl , Actin, gamma 1), GeneBank accession No: CB240572 (MYHIl, Myosin, heavy polypeptide 11, smooth muscle), GeneBank accession No: BX648253 (PTPN3 , Protein tyrosine phosphatase, non-receptor type 3), GeneBank accession No: BX648190 (WDRl , WD repeat domain 1), GeneBank accession No: BX641076 (ACTNl , Actinin, alpha 1), GeneBank accession No: BX537978 (EPB41L1 , Erythrocyte membrane protein band 4.1-like 1), GeneBank accession No: BG121847 (NUDC, Nuclear distribution gene C homolog(A. nidulans)), GeneBank accession No: BC068013 (MYOlC, Myosin IC), GeneBank accession No: BC065499 (MAST2 , Microtubule associated serine/threonine kinase 2), GeneBank accession No: BC051890(TUBG2, Tubulin, gamma 2), GeneBank accession No: BCO41874(MAP1LC3B, Microtubule-associated protein 1 light chain 3 beta), GeneBank accession No: BC012597 (ACTAl , Actin, alpha 1, skeletal muscle), GeneBank accession No: AY484427(KIF17, Kinesin family member 17), GeneBank accession No: AK130546 ( STOML2 , Stomatin(EPB72 ) -like 2), GeneBank accession No: AK124711 (CORO2B, Coronin, actin binding protein, 2B), GeneBank accession No: AK123974 (MYL5 , Myosin, light polypeptide 5, regulatory), GeneBank accession No: AK092792 (LOC389833 , Similar to hypothetical protein MGC27019), GeneBank accession No: AK026518 (MYOHDl , Myosin head domain containing 1), GeneBank accession No: AK024500 (NICAL, Microtubule associated monoxygenase, calponin and LIM domain containing 1), GeneBank accession No: AF085886(FLJ46675, Ribosomal protein L29 pseudogene 2), GeneBank accession No: AB209997 (MYO9B, Myosin IXB), GeneBank accession No: Y12692 (WNTIl , Wingless-type MMTV integration site family, member 11), GeneBank accession No: Y11307 (CYR61, Cysteine-rich, angiogenic inducer, 61), GeneBank accession No: X17033 ( ITGA2 , Integrin, alpha 2(CD49B, alpha 2 subunit of VLA-2 receptor)), GeneBank accession No: U41763 (CLTCLl , Clathrin, heavy polypeptide- like 1), GeneBank accession No: NM_153609 (TMPRSS6 , Transmembrane protease, serine 6), GeneBank accession No: NM_031483(ITCH, Itchy homolog E3 ubiquitin protein ligase(mouse) ) , GeneBank accession No: NM_024342 (GRLFl , Glucocorticoid receptor DNA binding factor 1 ) , GeneBank accession No: NM_017555 (EGLN2 , EgI nine homolog 2(C. elegans)), GeneBank accession No: NM_016569 (TBX3 , T-box 3 (ulnar mammary syndrome)), GeneBank accession No: NM_004148 (NINJl, Ninjurin 1), GeneBank accession No: NM_003377 (VEGFB, Vascular endothelial growth factor B), GeneBank accession No: NM_001983 (ERCCl , Excision repair cross-complementing rodent repair deficiency, complementation group 1( includes overlapping antisense sequence)), GeneBank accession No: NM_001552 ( IGFBP4 , Insulin-like growth factor binding protein 4), GeneBank accession No: NM_001430 (EPASl , Endothelial PAS domain protein 1), GeneBank accession No: NM_001300 (KLF6 , Kruppel- like factor 6), GeneBank accession No: NM_001012661 (SLC3A2 , Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2), GeneBank accession No: NM_000596( IGFBPl, Insulin-like growth factor binding protein 1), GeneBank accession No: NM_000474 (TWISTl , Twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) (Drosophila) ), GeneBank accession No: BX649103 (ChGn, Chondroitin betal,4 N- acetylgalactosaminyltransferase ), GeneBank accession No: BM913048 (TIMPl, TIMP metallopeptidase inhibitor 1), GeneBank accession No: BM904612 (S100A6, SlOO calcium binding protein A6 (calcyclin) ) , GeneBank accession No: BM556279(EMP3, Epithelial membrane protein 3), GeneBank accession No: BC015041 (VATl , Family with sequence similarity 82, member C), GeneBank accession No: AY258066(OKL38, Pregnancy-induced growth inhibitor), GeneBank accession No: AK126729 (NDRG4 , NDRG family member 4), GeneBank accession No: AK090459 (NFE2L1 , Nuclear factor (erythroid-derived 2) -like 1), GeneBank accession No: AKO 74163 (R0B04 , Roundabout homolog 4, magic roundabout (Drosophila) ), GeneBank accession No: AK024680(FLJ21027 fis, CDNA: FLJ21027 fis, clone CAE07110), GeneBank accession No: AF176422 (HEYl , Hairy/enhancer-of- split related with YRPW motif 1), GeneBank accession No: AF003837 (JAGl, Jagged l(Alagille syndrome)), GeneBank accession No: AB209322 (SEMA3B, Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B), GeneBank accession No: AB011150 (NRXNl , Neurexin 1), GeneBank accession No: NM_201589 (MAFA, V-maf musculoaponeurotic fibrosarcoma oncogene homolog A(avian)), GeneBank accession No: NM_052999 (CKLFSFl , CKLF-like MARVEL transmembrane domain containing 1), GeneBank accession No: NM_006644 (HSPHl, Heat shock 105kDa/110kDa protein 1), GeneBank accession No: NM_005438 (FOSLl , FOS-like antigen 1), GeneBank accession No: NM_004996 (ABCCl , ATP-binding cassette, sub-family C(CFTR/MRP), member 1), GeneBank accession No: NM_002658 (PLAU, Plasminogen activator, urokinase), GeneBank accession No: NM_001353 (AKRlCl, Aldo- keto reductase family 1, member Cl (dihydrodiol dehydrogenase 1; 20-alpha( 3-alpha) -hydroxysteroid dehydrogenase)), GeneBank accession No: H18681 (C20orf 139 , Sulfiredoxin 1 homolog(S. cerevisiae) ) , GeneBank accession No: DR004094 (HAMP, Hepcidin antimicrobial peptide), GeneBank accession No: BC082272 (KCNMB3 , Potassium large conductance calcium-activated channel, subfamily M beta member 3), GeneBank accession No: BC040494 (DNAJB2 , DnaJ(Hsp40) homolog, subfamily B, member 2), GeneBank accession No: BC018064 (ATF6 , Activating transcription factor 6), GeneBank accession No: BC006523 ( SGK2 , Serum/glucocorticoid regulated kinase 2), GeneBank accession No: AK090482 (CXCL12 , Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor I)), GeneBank accession No: AF219946 (TULP4 , Tubby like protein A) 1 GeneBank accession No: AB209112 ( SLC2A8 , Solute carrier family 2 ,( facilitated glucose transporter) member 8), GeneBank accession No: NM_005242 (F2RL1 , Coagulation factor II (thrombin) receptor-like 1), GeneBank accession No: NM_001002029(C4A, Complement component 4B, telomeric), GeneBank accession No: NM_000539 (RHO, Rhodopsin( opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant)), GeneBank accession No: BX649164 (PAI , serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), GeneBank accession No: BM918324 (LY96 , Lymphocyte antigen 96), GeneBank accession No: AB209647(NCF2, Neutrophil cytosolic factor 2(65kDa, chronic granulomatous disease, autosomal 2)), GeneBank accession No: NM_152221 (CSNKlE, Casein kinase 1, epsilon), GeneBank accession No: NM_017999 (RNF31, Ring finger protein 31), GeneBank accession No: NM_016819 (OGGl , 8-oxoguanine DNA glycosylase) , GeneBank accession No: NM_016816 (OASl , 2 ',5'- oligoadenylate synthetase 1, 40/46kDa), GeneBank accession No: NM_012235(SCAP, SREBP cleavage-activating protein), GeneBank accession No: NM_006384 (CIBl , Calcium and integrin binding 1 (calmyrin) ) , GeneBank accession No: NM_001779 (CD58 , CD58 antigen, ( lymphocyte function-associated antigen 3)), GeneBank accession No: CB055213 ( ICOSLG, Inducible T-cell co-stimulator ligand) , GeneBank accession No: BX641029 (MASPl , Mannan-binding lectin serine peptidase 1(C4/C2 activating component of Ra-reactive factor)), GeneBank accession No: BQ053419 (BATF, Basic leucine zipper transcription factor, ATF-like), GeneBank accession No: BC039299 (STIPl, Stress-induced-phosphoprotein
1 (Hsp70/Hsp90-organizing protein)), GeneBank accession No: AY055760 (DAF, Decay accelerating factor for complement (CD55, Cromer blood group system)), GeneBank accession No: AK130188 (FGR, Gardner-Rasheed feline sarcoma viral(v-fgr) oncogene homolog) , GeneBank accession No: AK095326 (MUS81 , MUS81 endonuclease homolog(yeast ) ) , GeneBank accession No: NM_017670 (OTUBl, OTU domain, ubiquitin aldehyde binding 1), GeneBank accession No: NM_003004 (SECTMl , Secreted and transmembrane 1), GeneBank accession No: NM_002309 (LIF, Hypothetical protein MGC20647), GeneBank accession No: NM_001421(ELF4, E74-like factor 4(ets domain transcription factor)), GeneBank accession No: NM_000418 ( IL4R, Interleukin 4 receptor), GeneBank accession No: BI909222 (FCERlG, Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide), GeneBank accession No: BF569086(NK4, Interleukin 32), GeneBank accession No: BC014470 (AZGPl, Alpha-2-glycoprotein 1, zinc), GeneBank accession No: BC020744 ( AKR1C4 , Aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol ) , dehydrogenase 4), GeneBank accession No: BQ939577 ( AKR1C3 , Aldo-keto reductase family 1, member C3( 3-alpha hydroxysteroid dehydrogenase, type H)), GeneBank accession No: NM_000499 (CYPlAl , Cytochrome P450, family 1, subfamily A, polypeptide 1), GeneBank accession No: NM_030622 (CYP2S1 , Cytochrome P450, family 2, subfamily S, polypeptide 1), GeneBank accession No: NM_184041 (ALDOA, Aldolase A, fructose-bisphosphate ) , GeneBank accession No: NM_024307(MGC4171, Hypothetical protein LOC283901), GeneBank accession No: NM_005336 (HDLBP, High density lipoprotein binding protein( vigilin) ) , GeneBank accession No: NM_002627 (PFKP, Phosphofructokinase, platelet), GeneBank accession No: BX648281 (LDLR, Low density lipoprotein receptor ( familial hypercholesterolemia)), GeneBank accession No: BC069201(FLJ22761, Hexokinase domain containing 1), GeneBank accession No: BC030207 (NR0B2 , Nuclear receptor subfamily 0, group B, member 2), GeneBank accession No: AL833O69(KIAA1434, Hypothetical protein KIAA1434), GeneBank accession No: AK124656 (ENO2 , Enolase 2(gamma, neuronal)), GeneBank accession No: AK094474 (RHOC, Ras homolog gene family, member C), GeneBank accession No: AK093461 ( ISYNAl , Myo-inositol 1-phosphate synthase Al), GeneBank accession No: AB053232 (GAL3ST3, Galactose-3-O-sulfotransferase 3), GeneBank accession No: AB045292 (TMEM8 , Transmembrane protein 8 ( five membrane-spanning domains)), GeneBank accession No: NM_004753 (DHRS3 , Dehydrogenase/reductase ( SDR family) member 3), GeneBank accession No: NM_002900 (RBP3 , Retinol binding protein 3, interstitial), GeneBank accession No: NM_001995 (ACSLl , Acyl-CoA synthetase long- chain family member 1), GeneBank accession No: NM_000018 (ACADVL , Acyl-Coenzyme A dehydrogenase, very long chain), GeneBank accession No: BC094756(CRA, Myotubularin related protein 11), GeneBank accession No: BC050553 (NTE, Neuropathy target esterase), GeneBank accession No: BCO3311O(HSD17B1, Hydroxysteroid( 17-beta) dehydrogenase 1), GeneBank accession No: AY268890 (TPPl , Tripeptidyl peptidase I), GeneBank accession No: AK172798 (CPTlA, Carnitine palmitoyltransferase lA(liver)), GeneBank accession No: AK096809(CYP4F8, Cytochrome P450, family 4, subfamily F, polypeptide 8), GeneBank accession No: AK000600 ( SIAT7D, ST6 ( alpha-N-acetyl-neuraminyl-2 , 3-beta- galactosyl-1 , 3 ) -N- acetylgalactosaminide alpha-2 , 6-sialyltransferase 4), GeneBank accession No: AB002454 (CYP4F3 , Cytochrome P450, family 4, subfamily F, polypeptide 3), GeneBank accession No: Z29093 (DDRl, Discoidin domain receptor family, member 1), GeneBank accession No: Z25424 (MKNK2 , MAP kinase interacting serine/threonine kinase 2), GeneBank accession No: XM_291277(DKFZp76lP0423, Hypothetical protein DKFZp761P0423) , GeneBank accession No: XM_038150 (MAST3 , Microtubule associated serine/threonine kinase 3), GeneBank accession No: U88357 (ERBB3 , V-erb-b2 erythroblastic leukemia viral oncogene homolog 3(avian)), GeneBank accession No: NM_025195 (TRIBl , Tribbles homolog l(Drosophila) ) , GeneBank accession No: NM_020639 (RIPK4 , Receptor-interacting serine-threonine kinase 4 ) , GeneBank accession No: NM_014172 (PHPTl , Phosphohistidine phosphatase 1), GeneBank accession No: NM_006254 (PRKCD, Protein kinase C, delta), GeneBank accession No: NM_005415 ( SLC20A1 , Solute carrier family 20 (phosphate transporter), member 1), GeneBank accession No: NM_005026 (PIK3CD, Phosphoinositide- 3-kinase, catalytic, delta polypeptide), GeneBank accession No: NM_004431(EPHA2, EPH receptor A2 ) , GeneBank accession No: NM_004419(DUSP5, Dual specificity phosphatase 5), GeneBank accession No: NM_004327 (BCR, Breakpoint cluster region), GeneBank accession No: NM_004231 (ATP6V1F, ATPase, H+ transporting, lysosomal 14kDa, Vl subunit F), GeneBank accession No: NM_004090 (DUSP3 , Dual specificity phosphatase 3 (vaccinia virus phosphatase VHl-related) ) , GeneBank accession No: NM_002843 (PTPRJ, Protein tyrosine phosphatase, receptor type, J), GeneBank accession No: NM_002496 (NDUFS8, NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH- coenzyme Q reductase)), GeneBank accession No: NM_001001852(PIM3, Pim-3 oncogene), GeneBank accession No: L76191 ( IRAKI , Interleukin-1 receptor-associated kinase 1), GeneBank accession No: D15049 (PTPRH, Protein tyrosine phosphatase, receptor type, H), GeneBank accession No: BC065207(ATP6V0D2, ATPase, H+ transporting, lysosomal 38kDa, VO subunit d isoform 2), GeneBank accession No: BC035578(STK24, Serine/threonine kinase 24(STE20 homolog, yeast)), GeneBank accession No: BC028724 (DUSP18, Dual specificity phosphatase 18), GeneBank accession No: AL117482(ULK3, Unc-51-like kinase 3(C. elegans)), GeneBank accession No: AK126879 (PCTK3 , PCTAIRE protein kinase 3), GeneBank accession No: AB209416 ( ILK, Integrin-linked kinase-2), GeneBank accession No: NM_000782 (CYP24A1 , Cytochrome P450, family 24, subfamily A, polypeptide 1), GeneBank accession No: CR597101 ( ZFP36 , Zinc finger protein 36, C3H type, homolog (mouse )), GeneBank accession No: CR936799(FHL2, Four and a half LIM domains 2), GeneBank accession No: M24898 (NRlDl , Nuclear receptor subfamily 1, group D, member 1), GeneBank accession No: AF132818 (KLF5 , Kruppel-like factor 5 ( intestinal )), GeneBank accession No: AK055337(ZNF213, Zinc finger protein 213), GeneBank accession No: BC008834 (PHFl , PHD finger protein 1), GeneBank accession No: AK126918 (GLIS2 , GLIS family zinc finger 2), GeneBank accession No: BC042692 (CTL2 , Solute carrier family 44, member 2), GeneBank accession No: NM_002224(ITPR3, Inositol 1 , 4 , 5-triphosphate receptor, type 3), GeneBank accession No: AK095363 (AQP3 , Aquaporin 3), GeneBank accession No: NM_174953 ( ATP2A3 , ATPase, Ca++ transporting, ubiquitous), GeneBank accession No: BC042390 (VTIlB, Vesicle transport through interaction with t-SNAREs homolog lB(yeast)), GeneBank accession No: NM_016113 ( TRPV2 , Transient receptor potential cation channel, subfamily V, member 2), GeneBank accession No: BM926478 (RBPl, Retinol binding protein 1, cellular), GeneBank accession No: NM_000069 (CACNAlS, Calcium channel, voltage-dependent, L type, alpha IS subunit), GeneBank accession No: AK002107 (RAB3B, RAB3B, member RAS oncogene family), GeneBank accession No: NM_013321 ( SNX8 , Sorting nexin 8), GeneBank accession No: AK125026 ( SLC6A12 , Solute carrier family 6 (neurotransmitter transporter, betaine/GABA) , member 12), GeneBank accession No: NM_005843(STAM2, Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2), GeneBank accession No: AK092512 (SLC16A5, Solute carrier family 16 (monocarboxylic acid transporters), member 5), GeneBank accession No: U49248(ABCC2, ATP-binding cassette, sub-family C(CFTR/MRP), member 2), GeneBank accession No: AK172792 ( SCNNlA, Sodium channel, nonvoltage-gated 1 alpha), GeneBank accession No: BC044656(CASC3, Cancer susceptibility candidate 3), GeneBank accession No: NM_203403 (C9orf 150 , Chromosome 9 open reading frame 150), GeneBank accession No: NM_080388(S100A16, SlOO calcium binding protein A16), GeneBank accession No: NM_031286 ( SH3BGRL3 , SH3 domain binding glutamic acid-rich protein like 3), GeneBank accession No: NM_022153(PP2135, Chromosome 10 open reading frame 54), GeneBank accession No: NM_004864 (GDF15, Growth differentiation factor 15), GeneBank accession No: NM_003330 (TXNRDl, Thioredoxin reductase 1), GeneBank accession No: NM_001013632 (LOC343521 , Similar to hypothetical protein 4833401D15), GeneBank accession No: BX537968(LOC51149, Hypothetical LOC51149), GeneBank accession No: BU945318 (MT2A, Hypothetical gene supported by X97260; BC070289), GeneBank accession No: BQ683841 (SlOOAlI , SlOO calcium binding protein All (calgizzarin) ) , GeneBank accession No: BQ276852 (TMSBlO , Thymosin, beta 10), GeneBank accession No: AK126182 (KIAA1949 , KIAA1949), GeneBank accession No: AK124751 (CAPN2 , Calpain 2,(m/ll) large subunit), GeneBank accession No: AK095079 (RGC32 , Response gene to complement 32), GeneBank accession No: AB075871(FLJ42654, Golgi transport 1 homolog A(S. cerevisiae ) ) , GeneBank accession No: AK125150 (MAPK8 , Mitogen-activated protein kinase 8), GeneBank accession No: NM_002758 (MAP2K6 , Mitogen-activated protein kinase kinase 6), GeneBank accession No: NM_004612 (TGFBRl , Transforming growth factor, beta receptor I(activin A receptor type II- like kinase, 53kDa)), GeneBank accession No: NM_145686 (MAP4K4, Mitogen-activated protein kinase kinase kinase kinase 4), GeneBank accession No: XM_042066 (MAP3K1, Mitogen-activated protein kinase kinase kinase 1), GeneBank accession No: AB011123 (TNIK, TRAF2 and NCK interacting kinase), GeneBank accession No: AB209031(C5, Complement component 5), GeneBank accession No: NM_022740 (HIPK2 , Homeodomain interacting protein kinase 2 ) , GeneBank accession No: NM_148957 (TNFRSF19, Tumor necrosis factor receptor superfamily, member 19), GeneBank accession No: AB208909(ITGB2, Integrin, beta 2 (antigen CDl8(p95), lymphocyte function-associated antigen 1; macrophage antigen l(mac-l) beta subunit)), GeneBank accession No: AB209211 (TIAl, TIAl cytotoxic granule-associated RNA binding protein), GeneBank accession No: AB209613 ( DNASE1L3 , Deoxyribonuclease I-like 3), GeneBank accession No: AK122825 (HMGBl, High-mobility group box 1), GeneBank accession No: AK127326 (PHF17 , PHD finger protein 17), GeneBank accession No: AK223503 (CASPl , Caspase 1, apoptosis-related cysteine peptidase ( interleukin 1, beta, convertase) ) , GeneBank accession No: BC013326 (GAS2 , Growth arrest-specific 2), GeneBank accession No: BC047698 ( IL7 , Interleukin I) 1 GeneBank accession No: D79987 (ESPLl , Extra spindle poles like 1(S. cerevisiae) ) , GeneBank accession No: NM_000893 (KNGl, Kininogen 1), GeneBank accession No: NM_001012271(BIRC5, Effector cell peptidase receptor 1), GeneBank accession No: NM_004938 (DAPKl , Death-associated protein kinase 1), GeneBank accession No: NM_005879 (TRIP, TRAF interacting protein), GeneBank accession No: NM_014739 (BCLAFl, BCL2-associated transcription factor 1), GeneBank accession No: NM_018947 (CYCS, Cytochrome c, somatic), GeneBank accession No: AB033337 (MPHOSPHl , M-phase phosphoprotein 1), GeneBank accession No: AB209179 (PLKl , Polo-like kinase 1 (Drosophila) ) , GeneBank accession No: AB209337(CDC7, CDC7 cell division cycle 7(S. cerevisiae)), GeneBank accession No: AF053305 (BUBl, BUBl budding uninhibited by benzimidazoles 1 homolog( yeast ) ) , GeneBank accession No: AF053306 (BUBlB, BUBl budding uninhibited by benzimidazoles 1 homolog beta(yeast ) ) , GeneBank accession No: AF345347 (SPAG5, Sperm associated antigen 5), GeneBank accession No: AK092638 (CCNG2 , Cyclin G2 ) , GeneBank accession No: AK222819 (NUSAPl, Nucleolar and spindle associated protein 1), GeneBank accession No: AL833191 (SMC2L1, SMC2 structural maintenance of chromosomes 2-like l(yeast)), GeneBank accession No: AY257469 (CIT, Citron (rho-interacting, serine/threonine kinase 21)), GeneBank accession No: AY367065 (ASPM, Asp( abnormal spindle) -like, microcephaly associated(Drosophila) ) , GeneBank accession No: BCOIlOOO (CDCA5 , Cell division cycle associated 5), GeneBank accession No: BC032677 (UBE2C, Ubiquitin-conjugating enzyme E2C), GeneBank accession No: BC043502 (NEK2 , NIMA(never in mitosis gene a)-related kinase 2), GeneBank accession No: BU675073 (PTTGl , Pituitary tumor- transforming 1), GeneBank accession No: BX647885 ( STMNl , Stathmin 1/oncoprotein 18), GeneBank accession No: CR592757 (BRRNl, Barren homolog 1 (Drosophila) ) , GeneBank accession No: CR597075 (MAPRE2 , Microtubule-associated protein, RP/EB family, member 2), GeneBank accession No: CR604810(CCNA2, Cyclin A2 ) , GeneBank accession No: CR933728(CDC2, Cell division cycle 2, Gl to S and G2 to M), GeneBank accession No: NM_000919 (PAM, Peptidylglycine alpha-amidating monooxygenase) , GeneBank accession No: NM_001790(CDC25C, Cell division cycle 25C), GeneBank accession No: NM_001798 (CDK2 , Cyclin-dependent kinase 2), GeneBank accession No: NM_001813 (CENPE , Centromere protein E, 312kDa), GeneBank accession No: NM_003318 (TTK, TTK protein kinase), GeneBank accession No: NM_003981 (PRCl , Protein regulator of cytokinesis 1), GeneBank accession No: NM_004523 (KIFIl, Kinesin family member 11), GeneBank accession No: NM_004701 (CCNB2 , Cyclin B2 ) , GeneBank accession No: NM_005983 ( SKP2 , S-phase kinase-associated protein 2(p45)), GeneBank accession No: NM_006101 (KNTC2 , Kinetochore associated 2), GeneBank accession No: NM_006845(KIF2C, Kinesin family member 2C), GeneBank accession No: NM_007375 (TARDBP, TAR DNA binding protein), GeneBank accession No: NM_012112 (TPX2 , TPX2 , microtubule- associated, homolog(Xenopus laevis)), GeneBank accession No: NM_014750(DLG7, Discs, large homolog 7 (Drosophila) ) , GeneBank accession No: NM_015097 (CLASP2 , Cytoplasmic linker associated protein 2), GeneBank accession No: NM_016343 (CENPF, Centromere protein F, 350/400ka(mitosin) ) , GeneBank accession No: NM_016426 (GTSEl , G-2 and S-phase expressed 1), GeneBank accession No: NM_018492 (PBK, PDZ binding kinase), GeneBank accession No: NM_018685 (ANLN, Anillin, actin binding protein ( scraps homolog, Drosophila)), GeneBank accession No: NM_020242 (KNSL7 , Kinesin family member 15), GeneBank accession No: NM_031966 (CCNBl , Cyclin Bl), GeneBank accession No: NM_138555 (KIF23 , Kinesin family member 23), GeneBank accession No: U65410 (MAD2L1 , MAD2 mitotic arrest deficient-like l(yeast)), GeneBank accession No: AB020656 (CYLD, Cylindromatosis ( turban tumor syndrome)), GeneBank accession No: AF033122 ( SESNl , Sestrin 1), GeneBank accession No: AK074377 (UHRFl , Chromosome 19 open reading frame 31), GeneBank accession No: AK091170 (CDKN2C, Cyclin- dependent kinase inhibitor 2C(pl8, inhibits CDK4 ) ) , GeneBank accession No: AK094323 (NFYC, Nuclear transcription factor Y, gamma), GeneBank accession No: AY366508 (LOH11CR2A, Loss of heterozygosity, 11, chromosomal region 2, gene A), GeneBank accession No: BC033086 (TCF19 , Transcription factor 19(SCl)), GeneBank accession No: BC040303 (PTP4A1 , Protein tyrosine phosphatase type IVA, member 1), GeneBank accession No: BC040991 (TFDP2 , Transcription factor Dp-2(E2F dimerization partner 2)), GeneBank accession No: BC092412(SGOL2, Shugoshin-like 2(S. pombe)), GeneBank accession No: BQ278454 (CKSlB, CDC28 protein kinase regulatory subunit IB), GeneBank accession No: BX649128(SESN3, Sestrin 3), GeneBank accession No: CD049340 (AURKB, Aurora kinase B), GeneBank accession No: M89914(NF1, Neurofibromin 1 ( neurofibromatosis , von Recklinghausen disease, Watson disease)), GeneBank accession No: NM_001005414 ( ZWINT, ZWlO interactor antisense), GeneBank accession No: NM_001008491 ( Sep 2, Septin 2), GeneBank accession No: NM_001274 (CHEKl , CHKl checkpoint homolog(S. pombe)), GeneBank accession No: NM_002105(H2AFX, H2A histone family, member X), GeneBank accession No: NM_002388 (MCM3 , MCM3 minichromosome maintenance deficient 3(S. cerevisiae ) ) , GeneBank accession No: NM_OO2417(MKI67, Antigen identified by monoclonal antibody Ki-67), GeneBank accession No: NM_002875 (RAD51 , RAD51 homolog(RecA homolog, E. CoIi)(S. cerevisiae) ) , GeneBank accession No: NM_003884 (PCAF, P300/CBP-associated factor), GeneBank accession No: NM_004526 (MCM2 , MCM2 minichromosome maintenance deficient 2, mitotin(S. cerevisiae)), GeneBank accession No: NM_004847 (AIFl , Allograft inflammatory factor 1), GeneBank accession No: NM_005915 (MCM6 , MCM6 minichromosome maintenance deficient 6(MIS5 homolog, S. pombe ) ( S . cerevisiae)), GeneBank accession No: NM_012090 (MACFl , Microtubule-actin crosslinking factor 1), GeneBank accession No: NM_012415(RAD54B, RAD54 homolog B(S. cerevisiae)), GeneBank accession No: NM_014264 (PLK4 , Polo-like kinase 4(Drosophila) ) , GeneBank accession No: NM_015714 (G0S2 , GO/Glswitch 2), GeneBank accession No: NM_024680 (FLJ23311 , E2F transcription factor 8), GeneBank accession No: XM_034274 (MYBLl, V-myb myeloblastosis viral oncogene homolog ( avian) -like 1), GeneBank accession No: AK001720(FLJ10858, Nei endonuclease Vlll-like 3(E. coli)), GeneBank accession No: AY032677 (POLQ, Polymerase (DNA directed), theta), GeneBank accession No: BC034480 (BLM, Bloom syndrome), GeneBank accession No: BC073161 (RAD51C, RAD51 homolog C(S. cerevisiae)), GeneBank accession No: CR600021(HMGB2, High-mobility group box 2), GeneBank accession No: CR625391 (RAD51AP1 , RAD51 associated protein 1), GeneBank accession No: CR936783 (FLJ40869 , Hypothetical protein LOC284952), GeneBank accession No: DQ140356 (KIAA1596 , Fanconi anemia, complementation group M), GeneBank accession No: NM_001067 (TOP2A, Topoisomerase (DNA) II alpha 17OkDa), GeneBank accession No: NM_001618 (PARPl , Poly ( ADP-ribose) polymerase family, member 1), GeneBank accession No: NM_003362 (UNG, Uracil-DNA glycosylase ) , GeneBank accession No: NM_006904 (PRKDC, Protein kinase, DNA-activated, catalytic polypeptide), GeneBank accession No: NM_130398 (EXOl, Exonuclease 1), GeneBank accession No: AB020807(TLR6, Toll-like receptor 6), GeneBank accession No: AB032980(DCDC2, Doublecortin domain containing 2), GeneBank accession No: AB209866 (TFPI, Tissue factor pathway- inhibitor ( lipoprotein-associated coagulation inhibitor)), GeneBank accession No: AK057015 (HSPA4 , Heat shock 7OkDa protein 4), GeneBank accession No: AK095515 ( IFITl , Interferon-induced protein with tetratricopeptide repeats 1), GeneBank accession No: AK122686(IF, I factor ( complement) ), GeneBank accession No: AK123010 (RRM2 , Ribonucleotide reductase M2 polypeptide), GeneBank accession No: BC035582 (TRIM22 , Tripartite motif-containing 22), GeneBank accession No: BX537894 (LOC493869 , Similar to RIKEN cDNA 2310016C16), GeneBank accession No: M14338 (PROSl , Protein S(alpha)), GeneBank accession No: NM_000821 (GGCX, Gamma-glutamyl carboxylase), GeneBank accession No: NM_000963(PTGS2, Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) ) , GeneBank accession No: NM_001001547 (CD36 , CD36 antigen(collagen type I receptor, thrombospondin receptor)), GeneBank accession No: NM_001512(GSTA4, Glutathione S-transferase A4 ) , GeneBank accession No: NM_001629 (AL0X5AP, Arachidonate 5- lipoxygenase-activating protein), GeneBank accession No: NM_001752(CAT, Catalase), GeneBank accession No: NM_001837(CCR3, Chemokine (C-C motif) receptor 3), GeneBank accession No: NM_001979 (EPHX2 , Epoxide hydrolase 2, cytoplasmic), GeneBank accession No: NM_001994 (F13B, Coagulation factor XIII, B polypeptide), GeneBank accession No: NM_002182 ( ILlRAP, Interleukin 1 receptor accessory protein), GeneBank accession No: NM_006120 (HLA-DMA, Major histocompatibility complex, class II, DM alpha), GeneBank accession No: NM_173216 ( SIATl , ST6 beta-galactosamide alpha-2 , 6-sialyltranferase 1), GeneBank accession No: NM_202002 (FOXMl, Forkhead box Ml), GeneBank accession No: AB163917 (LRAP, Leukocyte-derived arginine aminopeptidase) , GeneBank accession No: BC027881 (AFP, Alpha-fetoprotein) , GeneBank accession No: NM_015915 ( SPG3A, Spastic paraplegia 3A( autosomal dominant)), GeneBank accession No: NM_000671(ADH5, Alcohol dehydrogenase 5 (class III), chi polypeptide), GeneBank accession No: J05428 (UGT2B7 , UDP glucuronosyltransferase 2 family, polypeptide B7 ) , GeneBank accession No: NM_000672 (ADH6 , Alcohol dehydrogenase 6 (class V)), GeneBank accession No: M15943(ADH4, Alcohol dehydrogenase 4 (class II), pi polypeptide), GeneBank accession No: AK223395 (FBPl , Fructose-1 , 6-bisphosphatase 1), GeneBank accession No: NM_000151 (G6PC, Glucose-6- phosphatase, catalytic (glycogen storage disease type I, von Gierke disease)), GeneBank accession No: XM_113962 (KIAA0650 , Structural maintenance of chromosomes flexible hinge domain containing 1), GeneBank accession No: AB020644 ( ACSL6 , Acyl- CoA synthetase long-chain family member 6), GeneBank accession No: AB209907 (PLDl , Phospholipase Dl, phophatidylcholine-specific ) , GeneBank accession No: AF285167 (ABCAl, ATP-binding cassette, sub-family A(ABCl), member 1), GeneBank accession No: AF297872 (TRERFl , Transcriptional regulating factor 1), GeneBank accession No: AF3O3134(ALDH8A1, Aldehyde dehydrogenase 8 family, member Al), GeneBank accession No: AF339053 (PLA2G12B, Phospholipase A2 , group XIIB), GeneBank accession No: AK096018 (HADHSC, L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain), GeneBank accession No: AK124635 (PCSK9, Proprotein convertase subtilisin/kexin type 9), GeneBank accession No: AK127346 ( SIAT9 , ST3 beta-galactoside alpha- 2 , 3-sialyltransferase 5), GeneBank accession No: AL359559 (AGPS, Alkylglycerone phosphate synthase), GeneBank accession No: AY691170 (PLCL3 , Phospholipase C-like 3), GeneBank accession No: BG567934 (APOM, Apolipoprotein M), GeneBank accession No: BX538214 (Cβorf 167 , Chromosome 6 open reading frame 167), GeneBank accession No: BX640945 (FADS2 , Fatty acid desaturase 2), GeneBank accession No: BX648473 (PIGK, Phosphatidylinositol glycan, class K), GeneBank accession No: BX648557 (HSD17B2 , Hydroxysteroid( 17- beta) dehydrogenase 2), GeneBank accession No: CR749601 (ETNKl , Death-associated protein kinase 3), GeneBank accession No: NM_000859 (HMGCR, 3-hydroxy-3- methylglutaryl-Coenzyme A reductase), GeneBank accession No: NM_001443 (FABPl, Fatty acid binding protein 1, liver), GeneBank accession No: NM_002130 (HMGCSl , 3-hydroxy-3- methylglutaryl-Coenzyme A synthase l(soluble)), GeneBank accession No: NM_003725 (RODH, Hydroxysteroid( 17-beta) dehydrogenase 6), GeneBank accession No: NM_004845 (PCYTlB, Phosphate cytidylyltransferase 1, choline, beta), GeneBank accession No: NM_014762 (DHCR24 , 24-dehydrocholesterol reductase), GeneBank accession No: NM_020139 (DHRS6 , Dehydrogenase/reductase ( SDR family) member 6), GeneBank accession No: NM_020918 (GPAM, Glycerol-3-phosphate acyltransferase, mitochondrial), GeneBank accession No: NM_032523(OSBPL6, Oxysterol binding protein-like 6), GeneBank accession No: NM_033505 ( SELI , Selenoprotein I), GeneBank accession No: Z28339 (AKRlDl , Aldo-keto reductase family 1, member Dl (delta 4-3-ketosteroid-5-beta- reductase)), GeneBank accession No: AK024899 (ENPP3 , Ectonucleotide pyrophosphatase/phosphodiesterase 3), GeneBank accession No: AK025546 (PTPN4 , Protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) ), GeneBank accession No: AK124910 (ENPP2 , Ectonucleotide pyrophosphatase/phosphodiesterase 2 ( autotaxin) ) , GeneBank accession No: BC035116 (FLJ35059 fis, CDNA FLJ30761 fis, clone FEBRA2000538) , GeneBank accession No: BC050565 (PASK, PAS domain containing serine/threonine kinase), GeneBank accession No: L13436(NPR2, Natriuretic peptide receptor B/guanylate cyclase B( atrionatriuretic peptide receptor B)), GeneBank accession No: NM_001005862 (ERBB2 , V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog ( avian) ), GeneBank accession No: NM_005012 (RORl, Receptor tyrosine kinase-like orphan receptor 1), GeneBank accession No: NM_006035(CDC42BPB, CDC42 binding protein kinase beta(DMPK- like)), GeneBank accession No: NM_014791 (MELK, Maternal embryonic leucine zipper kinase), GeneBank accession No: NM_023028(FGFR2, Fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer yndrome, Jackson-Weiss syndrome)), GeneBank accession No: NM_080836 ( STK35 , Serine/threonine kinase 35), GeneBank accession No: AF419331 (FUSIPl , FUS interacting protein( serine/arginine-rich) 1), GeneBank accession No: AK091927 (SFRS3, Splicing factor, arginine/serine-rich 3), GeneBank accession No: BCO 10266 (HNRNPAl , Heterogeneous nuclear ribonucleoprotein Al), GeneBank accession No: BC012360(CTAGE5, CTAGE family, member 5), GeneBank accession No: BC036046 (PLRGl , Pleiotropic regulator 1(PRLl homolog, Arabidopsis ) ) , GeneBank accession No: BC065384 (PCFIl, PCFlI, cleavage and polyadenylation factor subunit, homolog(S. cerevisiae) ) , GeneBank accession No: BX537360(CPSF5, Nudix( nucleoside diphosphate linked moiety X) -type motif 21), GeneBank accession No: BX537494 (HNRPA2B1 , Heterogeneous nuclear ribonucleoprotein A2/B1), GeneBank accession No: BX647784 (HNRPR, Heterogeneous nuclear ribonucleoprotein R), GeneBank accession No: CA455267 (PPIH, Peptidyl prolyl isomerase H(cyclophilin H)), GeneBank accession No: CR596214 (HNRPAO , Heterogeneous nuclear ribonucleoprotein AO), GeneBank accession No: NM_001326(CSTF3, Hypothetical protein LOC283267), GeneBank accession No: NM_004640 (BATl , HLA-B associated transcript 1), GeneBank accession No: NM_005463 (HNRPDL, Heterogeneous nuclear ribonucleoprotein D-like), GeneBank accession No: NM_006924(SFRSl, Splicing factor, arginine/serine-rich 1( splicing factor 2, alternate splicing factor)), GeneBank accession No: NM_012426 ( SF3B3 , Splicing factor 3b, subunit 3, 13OkDa), GeneBank accession No: NM_018048 (FLJ10292 , Mago-nashi homolog), GeneBank accession No: NM_030919(C20orf 129, Chromosome 20 open reading frame 129), GeneBank accession No: NM_031370 (HNRPD, Heterogeneous nuclear ribonucleoprotein D(AU-rich element RNA binding protein 1, 37kDa)), GeneBank accession No: NM_138933 (ACF, Apobec-1 complementation factor), GeneBank accession No: AB193259(ACE2, Angiotensin I converting enzyme (peptidyl- dipeptidase A) 2), GeneBank accession No: BX648769 (EWSRl , Ewing sarcoma breakpoint region 1), GeneBank accession No: AB023154(DTX4, Deltex 4 homolog ( Drosophila) ), GeneBank accession No: AL543755 ( VAV3 , Vav 3 oncogene), GeneBank accession No: M75106 (CPB2 , Carboxypeptidase B2 (plasma, carboxypeptidase U)), GeneBank accession No: NM_021045(ZNF248, Zinc finger protein 248), GeneBank accession No: AB209194 (B4GALT6 , UDP-GaI :betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6), GeneBank accession No: AF279145 (ANTXRl , Anthrax toxin receptor 1), GeneBank accession No: NM_025074 (FRASl , Fraser syndrome 1), GeneBank accession No: AK025790 (KIF20A, Kinesin family member 20A), GeneBank accession No: NM_006152 (LRMP, Lymphoid-restricted membrane protein), GeneBank accession No: NM_000340(SLC2A2, Solute carrier family 2 ( facilitated glucose transporter), member 2), GeneBank accession No: AF071592(KIF4A, Kinesin family member 4A), GeneBank accession No: NM_013277 (RACGAPl , Rac GTPase activating protein 1), GeneBank accession No: AY043484 ( SCNlA, Sodium channel, voltage-gated, type I, alpha), GeneBank accession No: AY791349(KIF18A, Kinesin family member 18A), GeneBank accession No: NM_018018 ( SLC38A4 , Solute carrier family 38, member 4), GeneBank accession No: AK094603 (FLJ37284 fis, unnamed protein product; Homo sapiens cDNA FLJ37284 fis, clone BRAMY2013590. ) , GeneBank accession No: NM_021069(ARGBP2, Sorbin and SH3 domain containing 2), GeneBank accession No: NM_001005747 (CACNB4 , Calcium channel, voltage-dependent, beta 4 subunit), GeneBank accession No: AJ496568(SLC25A12, Solute carrier family 25 (mitochondrial carrier, Aralar), member 12), GeneBank accession No: NM_030641 (AP0L6, Apolipoprotein L, 6), GeneBank accession No: NM_173512(FLJ39822, Hypothetical protein FLJ39822), GeneBank accession No: NM_000037 (ANKl , Ankyrin 1, erythrocytic), GeneBank accession No: NM_001011554 ( SLC13A3 , Solute carrier family 13 ( sodium-dependent dicarboxylate transporter), member 3), GeneBank accession No: AB091343(C10orf3, Centrosomal protein 55kDa) , GeneBank accession No: AK000643 (ASB9 , Ankyrin repeat and SOCS box- containing 9), GeneBank accession No: AK055221 ( FBXO5 , F-box protein 5), GeneBank accession No: AK075271 ( SPTLC2L, Serine palmitoyltransferase, long chain base subunit 2- like( aminotransferase 2)), GeneBank accession No: AK122685 (GLUDl, Glutamate dehydrogenase 1), GeneBank accession No: AK127098(FLJ10706, Chromosome 1 open reading frame 112), GeneBank accession No: AL133031 (MLRl , Transcription factor MLRl), GeneBank accession No: AY007723(MAL2, MaI, T-cell differentiation protein 2), GeneBank accession No: BC022255 (Spc25 , Spindle pole body component 25 homolog(S. cerevisiae ) ) , GeneBank accession No: BC041882(ATF7IP2, Activating transcription factor 7 interacting protein 2), GeneBank accession No: BC052951 (LMNBl, Lamin Bl), GeneBank accession No: BC098313(FLJ20641, Hypothetical protein FLJ20641), GeneBank accession No: NM_001809 (CENPA, Centromere protein A, 17kDa), GeneBank accession No: NM_145061 (C13orf3 , Chromosome 13 open reading frame 3), GeneBank accession No: XM_372695(LOC390859, PREDICTED: Homo sapiens similar to Chain A, Crystal Structure Of The R463a Mutant Of Human Glutamate Dehydrogenase(LOC390859 ) , mRNA) .
Among the above genes, those up-regulated by the exposure to phenanthrene are as follows:
GeneBank accession No: NM_004420 (DUSP8 , Dual specificity phosphatase 8), GeneBank accession No:
L11329(DUSP2, Dual specificity phosphatase 2), GeneBank accession No: BC094766 (PKNl , Protein kinase Nl), GeneBank accession No: AY247738 (TRIB3, Tribbles homolog 3(Drosophila) ) , GeneBank accession No: AK129595 (GADD45B, Growth arrest and DNA-damage-inducible, beta), GeneBank accession No: AB208849 ( SHCl , SHC(SrC homology 2 domain containing) transforming protein 1), GeneBank accession No: X02812 (TGFBl, Transforming growth factor, beta l(Camurati- Engelmann disease) ), GeneBank accession No: NM_198951 (TGM2 , Transglutaminase 2(C polypeptide, protein-glutamine-gamma- glutamyltransferase) ), GeneBank accession No: NM_147780 (CTSB, Cathepsin B), GeneBank accession No: NM_078467 (CDKNlA, Cyclin-dependent kinase inhibitor lA(p21, Cipl)), GeneBank accession No: NM_033027 (AXUDl , AXINl up- regulated 1), GeneBank accession No: NM_032797 ( AMID, Apoptosis-inducing factor (AIF) -like mitochondrion- associated inducer of death), GeneBank accession No: NM_021960 (MCLl, Myeloid cell leukemia sequence 1(BCL2- related)), GeneBank accession No: NM_016639 (TNFRSF12A, Tumor necrosis factor receptor superfamily, member 12A) , GeneBank accession No: NM_016222 (DDX41 , DEAD(Asp-Glu-Ala- Asp) box polypeptide 41), GeneBank accession No: NM_013246 (CLC, Cardiotrophin-like cytokine factor 1), GeneBank accession No: NM_004401 (DFFA, DNA fragmentation factor, 45kDa, alpha polypeptide), GeneBank accession No: NM_004281(BAG3, BCL2-associated athanogene 3), GeneBank accession No: NM_003897 ( IER3 , Immediate early response 3), GeneBank accession No: NM_003806 (HRK, Harakiri, BCL2 interacting protein (contains only BH3 domain)), GeneBank accession No: NM_003639 ( IKBKG, Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma), GeneBank accession No: NM_003311 (PHLDA2 , Pleckstrin homology-like domain, family A, member 2), GeneBank accession No: NM_002737 (PRKCA, Protein kinase C, alpha), GeneBank accession No: NM_002648 (PIMl , Pim-1 oncogene), GeneBank accession No: NM_002507 (NGFR, Nerve growth factor receptor (TNFR superfamily, member 16)), GeneBank accession No: NM_002305 (LGALSl, Lectin, galactoside-binding, soluble, l(galectin I)), GeneBank accession No: NM_001013398 ( IGFBP3 , Insulin-like growth factor binding protein 3), GeneBank accession No: BX640923 (MDM4 , Mdm4 , transformed 3T3 cell double minute 4, p53 binding protein (mouse )), GeneBank accession No: BX537586 ( STK17A, Serine/threonine kinase 17a( apoptosis-inducing) ) , GeneBank accession No: BG284742(P8, P8 protein (candidate of metastasis I)), GeneBank accession No: BE903247 (PDCD6IP, Programmed cell death 6 interacting protein), GeneBank accession No: BC027949(P2RXl, Purinergic receptor P2X, ligand-gated ion channel, 1), GeneBank accession No: BC006365 (PSEN2 , Presenilin 2 (Alzheimer disease 4)), GeneBank accession No: AY869712(PPP1R13L, Protein phosphatase 1, regulatory ( inhibitor ) subunit 13 like), GeneBank accession No: AY028896 (CARDlO, Caspase recruitment domain family, member 10), GeneBank accession No: AK122614 (PPARD, Peroxisome proliferative activated receptor, delta), GeneBank accession No: AK092872 (ERCC2 , Excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)), GeneBank accession No: AK092808 (RRAGC, Ras-related GTP binding C), GeneBank accession No: AJ001898 (GDNF, Glial cell derived neurotrophic factor), GeneBank accession No: AF220656 (PHLDAl, Pleckstrin homology-like domain, family A, member 1), GeneBank accession No: AF055634 (UNC5C, Unc-5 homolog C(C. elegans)), GeneBank accession No: AB209485(VEGF, Vascular endothelial growth factor), GeneBank accession No: AB096256 (UNC5B, Unc-5 homolog B(C. elegans)), GeneBank accession No: AB007960 ( SH3GLB1 , SH3- domain GRB2-like endophilin Bl), GeneBank accession No: X06374 (PDGFA, Platelet-derived growth factor alpha polypeptide), GeneBank accession No: S62138 (DDIT3 , DNA- damage-inducible transcript 3), GeneBank accession No: NM_078487(CDKN2B, Cyclin-dependent kinase inhibitor 2B(pl5, inhibits CDK4 ) ) , GeneBank accession No: NM_012127 (CIZl , CDKNlA interacting zinc finger protein 1), GeneBank accession No: NM_005883 ( APC2 , Adenomatosis polyposis coli 2), GeneBank accession No: NM_004196 (CDKLl , Cyclin- dependent kinase-like 1 (CDC2-related kinase)), GeneBank accession No: NM_003236 (TGFA, Transforming growth factor, alpha), GeneBank accession No: NM_001261 (CDK9 , Cyclin- dependent kinase 9 (CDC2-related kinase)), GeneBank accession No: NM_001007271 (DUSP13, Dual specificity phosphatase 13), GeneBank accession No: CR749511 (PARC, P53- associated parkin-like cytoplasmic protein), GeneBank accession No: CR623038 ( ID2 , Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein), GeneBank accession No: CR618371 (EGFR, Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)), GeneBank accession No: BF965144 ( IFITMl , Interferon induced transmembrane protein 1(9-27)), GeneBank accession No: AK127679 (DUSPl , Dual specificity phosphatase 1), GeneBank accession No: AK096276 (CCND3 , Cyclin D3 ) , GeneBank accession No: AB209586 (MAPK13 , Mitogen-activated protein kinase 13), GeneBank accession No: AB209465 (PCTKl , PCTAIRE protein kinase 1), GeneBank accession No: Z19588(SKIL, SKI-like), GeneBank accession No: NM_020429 (SMURFl, SMAD specific E3 ubiquitin protein ligase 1), GeneBank accession No: NM_014767 ( SPOCK2 , Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2), GeneBank accession No: NM_005979(S100A13, SlOO calcium binding protein A13), GeneBank accession No: NM_005187 (CBFA2T3 , Core-binding factor, runt domain, alpha subunit 2; translocated to, 3), GeneBank accession No: NM_004364 (CEBPA, CCAAT/enhancer binding protein(C/EBP) , alpha), GeneBank accession No: NM_001769(CD9, CD9 antigen ( p24 )), GeneBank accession No: NM_001718 ( BMP6 , Bone morphogenetic protein 6), GeneBank accession No: NM_000641 ( ILlI , Interleukin 11), GeneBank accession No: BX647459 (SERPINE2 , Serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 2), GeneBank accession No: BQ066037 (RPS19 , Ribosomal protein S19), GeneBank accession No: BE791300 (EDFl , Endothelial differentiation-related factor 1), GeneBank accession No: BC038504 (SNFlLK, SNFl-like kinase), GeneBank accession No: AL832287 ( ZAP70 , Zeta-chain (TCR) associated protein kinase 7OkDa), GeneBank accession No: AK125742 (PCGFl, Polycomb group ring finger 1), GeneBank accession No: AK124709 (NDRGl , N-myc downstream regulated gene 1), GeneBank accession No: AB011157 (PTDSR, Phosphatidylserine receptor), GeneBank accession No: NM_013255 (MKLNl, Muskelin 1, intracellular mediator containing kelch motifs), GeneBank accession No: NM_006572 (GNA13 , Guanine nucleotide binding protein(G protein), alpha 13), GeneBank accession No: NM_002211 ( ITGBl , Integrin, beta 1 ( fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2 , MSK12)), GeneBank accession No: CR601067 (PLAUR, Plasminogen activator, urokinase receptor), GeneBank accession No: BC050456 (THBS4 , Thrombospondin 4), GeneBank accession No: AK027389 (CXCL16 , Chemokine (C-X-C motif) ligand 16), GeneBank accession No: AJ132099 (VNNl , Vanin 1), GeneBank accession No: XM_371354 (FLJ10157 , Hypothetical protein FLJ10157), GeneBank accession No: XM_208313(TPM3, Similar to tropomyosin 4), GeneBank accession No: XM_208270 (ACR, Acrosin-like protease), GeneBank accession No: NM_203353 (PDLIM7 , PDZ and LIM domain 7(enigma)), GeneBank accession No: NM_201382 (PLECl , Plectin 1, intermediate filament binding protein 50OkDa), GeneBank accession No: NM_182961 ( SYNEl , Spectrin repeat containing, nuclear envelope 1), GeneBank accession No: NM_181826 (NF2 , Neurofibromin 2 (bilateral acoustic neuroma)), GeneBank accession No: NM_172069 (PLEKHH2 , Pleckstrin homology domain containing, family H (with MyTH4 domain) member 2), GeneBank accession No: NM_022648 (TNS, Tensin 1), GeneBank accession No: NM_017556 (FBLP-I, Filamin binding LIM protein 1), GeneBank accession No: NM_016081 (KIAA0992 , Palladin, cytoskeletal associated protein), GeneBank accession No: NM_006617 (NES, Nestin), GeneBank accession No: NM__006262 (PRPH, Peripherin), GeneBank accession No: NM_OO51OO(AKAP12, A kinase(PRKA) anchor protein ( gravin) 12), GeneBank accession No: NM_004368 (CNN2 , Calponin 2), GeneBank accession No: NM_003388 (CYLN2 , Cytoplasmic linker 2), GeneBank accession No: NM_003370 (VASP, Vasodilator- stimulated phosphoprotein) , GeneBank accession No: NM_003128 (SPTBNl, Spectrin, beta, non-erythrocytic 1), GeneBank accession No: NM_002705 (PPL, Periplakin), GeneBank accession No: NM_002475 (MLClSA, Myosin light chain 1 slow a), GeneBank accession No: NM_002018 (FLII , Flightless I homolog(Drosophila) ) , GeneBank accession No: NM_001465 (FYB, FYN binding protein(FYB-120/130 ) ) , GeneBank accession No: NM_001069(TUBB2, Tubulin, beta 2A), GeneBank accession No: CR625172 (MGC8685, Tubulin, beta 2B), GeneBank accession No: CR616919(KRT18, Keratin 18), GeneBank accession No: CR606241 (ACTGl, Actin, gamma 1), GeneBank accession No: CB240572 (MYHIl, Myosin, heavy polypeptide 11, smooth muscle), GeneBank accession No: BX648253 (PTPN3, Protein tyrosine phosphatase, non-receptor type 3), GeneBank accession No: BX648190 (WDRl , WD repeat domain 1), GeneBank accession No: BX641076 (ACTNl , Actinin, alpha 1), GeneBank accession No: BX537978 (EPB41L1 , Erythrocyte membrane protein band 4.1-like 1), GeneBank accession No: BG121847 (NUDC, Nuclear distribution gene C homolog(A. nidulans)), GeneBank accession No: BC068013 (MYOlC, Myosin IC), GeneBank accession No: BC065499 (MAST2 , Microtubule associated serine/threonine kinase 2), GeneBank accession No: BC051890(TUBG2, Tubulin, gamma 2), GeneBank accession No: BCO41874(MAP1LC3B, Microtubule-associated protein 1 light chain 3 beta), GeneBank accession No: BC012597 (ACTAl , Actin, alpha 1, skeletal muscle), GeneBank accession No: AY484427(KIF17, Kinesin family member 17), GeneBank accession No: AK130546 ( STOML2 , Stomatin(EPB72 ) -like 2), GeneBank accession No: AK124711 (CORO2B, Coronin, actin binding protein, 2B), GeneBank accession No: AK123974 (MYL5 , Myosin, light polypeptide 5, regulatory), GeneBank accession No: AK092792 (LOC389833 , Similar to hypothetical protein MGC27019), GeneBank accession No: AK026518 (MYOHDl , Myosin head domain containing 1), GeneBank accession No: AK024500 (NICAL, Microtubule associated monoxygenase, calponin and LIM domain containing 1), GeneBank accession No: AF085886(FLJ46675, Ribosomal protein L29 pseudogene 2), GeneBank accession No: AB209997 (MY09B, Myosin IXB), GeneBank accession No: Y12692 (WNTIl , Wingless-type MMTV integration site family, member 11), GeneBank accession No: Y11307 (CYR61 , Cysteine-rich, angiogenic inducer, 61), GeneBank accession No: X17033 ( ITGA2 , Integrin, alpha 2(CD49B, alpha 2 subunit of VLA-2 receptor)), GeneBank accession No: U41763 (CLTCLl , Clathrin, heavy polypeptide- like 1), GeneBank accession No: NM_153609 (TMPRSS6 , Transmembrane protease, serine 6), GeneBank accession No: NM_031483(ITCH, Itchy homolog E3 ubiquitin protein ligase(mouse) ) , GeneBank accession No: NM_024342 (GRLFl , Glucocorticoid receptor DNA binding factor 1 ) , GeneBank accession No: NM_017555 (EGLN2 , EgI nine homolog 2(C. elegans)), GeneBank accession No: NM_016569 (TBX3 , T-box 3(ulnar mammary syndrome)), GeneBank accession No: NM_004148 (NINJl, Ninjurin 1), GeneBank accession No: NM_003377 (VEGFB, Vascular endothelial growth factor B), GeneBank accession No: NM_001983 (ERCCl , Excision repair cross-complementing rodent repair deficiency, complementation group 1( includes overlapping antisense sequence)), GeneBank accession No: NM_001552 ( IGFBP4 , Insulin-like growth factor binding protein 4), GeneBank accession No: NM_001430 (EPASl , Endothelial PAS domain protein 1), GeneBank accession No: NM_001300 (KLF6 , Kruppel- like factor 6), GeneBank accession No: NM_001012661 ( SLC3A2 , Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2), GeneBank accession No: NM_000596( IGFBPl, Insulin-like growth factor binding protein 1), GeneBank accession No: NM_000474 (TWISTl , Twist homolog 1 ( acrocephalosyndactyly 3; Saethre-Chotzen syndrome )( Drosophila) ), GeneBank accession No: BX649103 (ChGn, Chondroitin betal,4 N- acetylgalactosaminyltransferase) , GeneBank accession No: BM913O48(TIMP1, TIMP metallopeptidase inhibitor 1), GeneBank accession No: BM904612 (S100A6, SlOO calcium binding protein A6 (calcyclin) ) , GeneBank accession No: BM556279(EMP3, Epithelial membrane protein 3), GeneBank accession No: BC015041 (VATl , Family with sequence similarity 82, member C), GeneBank accession No: AY258066(OKL38, Pregnancy-induced growth inhibitor), GeneBank accession No: AK126729 (NDRG4 , NDRG family member 4), GeneBank accession No: AK090459 (NFE2L1 , Nuclear factor (erythroid-derived 2) -like 1), GeneBank accession No: AK074163 (R0B04, Roundabout homolog 4, magic roundabout (Drosophila) ), GeneBank accession No: AK024680(FLJ21027 fis, CDNA: FLJ21027 fis, clone CAE07110), GeneBank accession No: AF176422 (HEYl , Hairy/enhancer-of- split related with YRPW motif 1), GeneBank accession No: AF003837 (JAGl, Jagged l(Alagille syndrome)), GeneBank accession No: AB209322 (SEMA3B, Sema domain, immunoglobulin domain(Ig), short basic domain, secreted, ( semaphorin) 3B), GeneBank accession No: AB011150 (NRXNl , Neurexin 1), GeneBank accession No: NM_201589 (MAFA, V-maf musculoaponeurotic fibrosarcoma oncogene homolog A(avian)), GeneBank accession No: NM_052999 (CKLFSFl , CKLF-like MARVEL transmembrane domain containing 1), GeneBank accession No: NM_006644 (HSPHl, Heat shock 105kDa/110kDa protein 1), GeneBank accession No: NM_005438 (FOSLl , FOS-like antigen 1), GeneBank accession No: NM_004996 (ABCCl, ATP-binding cassette, sub-family C(CFTR/MRP), member 1), GeneBank accession No: NM_002658 (PLAU, Plasminogen activator, urokinase), GeneBank accession No: NM_001353 (AKRlCl , Aldo- keto reductase family 1, member Cl (dihydrodiol dehydrogenase 1; 20-alpha( 3-alpha) -hydroxysteroid dehydrogenase)), GeneBank accession No: H18681 (C20orf 139 , Sulfiredoxin 1 homolog(S. cerevisiae) ) , GeneBank accession No: DR004094 (HAMP, Hepcidin antimicrobial peptide), GeneBank accession No: BC082272 (KCNMB3 , Potassium large conductance calcium-activated channel, subfamily M beta member 3), GeneBank accession No: BC040494 (DNAJB2 , DnaJ(Hsp40) homolog, subfamily B, member 2), GeneBank accession No: BC018064 (ATF6 , Activating transcription factor 6), GeneBank accession No: BC006523 ( SGK2 , Serum/glucocorticoid regulated kinase 2), GeneBank accession No: AK090482 (CXCL12 , Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor I)), GeneBank accession No: AF219946 (TULP4 , Tubby like protein 4), GeneBank accession No: AB209112 ( SLC2A8 , Solute carrier family 2 ,( facilitated glucose transporter) member 8), GeneBank accession No: NM_005242 (F2RL1 , Coagulation factor II (thrombin) receptor-like 1), GeneBank accession No: NM_001002029(C4A, Complement component 4B, telomeric), GeneBank accession No: NM_000539 (RHO, Rhodopsin( opsin 2, rod pigment ) (retinitis pigmentosa 4, autosomal dominant)), GeneBank accession No: BX649164 (PAI, serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), GeneBank accession No: BM918324 (LY96 , Lymphocyte antigen 96), GeneBank accession No: AB209647(NCF2, Neutrophil cytosolic factor 2(65kDa, chronic granulomatous disease, autosomal 2)), GeneBank accession No: NM_152221 (CSNKlE, Casein kinase 1, epsilon), GeneBank accession No: NM_017999 (RNF31 , Ring finger protein 31), GeneBank accession No: NM_016819 (OGGl , 8-oxoguanine DNA glycosylase) , GeneBank accession No: NM_016816 (OASl , 2', 5'- oligoadenylate synthetase 1, 40/46kDa), GeneBank accession No: NM_012235(SCAP, SREBP cleavage-activating protein), GeneBank accession No: NM_006384 (CIBl , Calcium and integrin binding 1 (calmyrin) ) , GeneBank accession No: NM_001779 (CD58 , CD58 antigen, ( lymphocyte function-associated antigen 3)), GeneBank accession No: CB055213 ( ICOSLG, Inducible T-cell co-stimulator ligand) , GeneBank accession No: BX641029 (MASPl, Mannan-binding lectin serine peptidase 1(C4/C2 activating component of Ra-reactive factor)), GeneBank accession No: BQ053419 (BATF, Basic leucine zipper transcription factor, ATF-like), GeneBank accession No: BC039299 (STIPl, Stress-induced-phosphoprotein
1 (Hsp70/Hsp90-organizing protein)), GeneBank accession No: AY055760 (DAF, Decay accelerating factor for complement (CD55 , Cromer blood group system) ) , GeneBank accession No: AK130188(FGR, Gardner-Rasheed feline sarcoma viral(v-fgr) oncogene homolog), GeneBank accession No: AK095326 (MUS81 , MUS81 endonuclease homolog(yeast ) ) , GeneBank accession No: NM_017670 (OTUBl, OTU domain, ubiquitin aldehyde binding 1), GeneBank accession No: NM_003004 (SECTMl , Secreted and transmembrane 1), GeneBank accession No: NM_002309 (LIF, Hypothetical protein MGC20647), GeneBank accession No: NM__001421(ELF4, E74-like factor 4(ets domain transcription factor)), GeneBank accession No: NM_000418 ( IL4R, Interleukin 4 receptor), GeneBank accession No: BI9O9222(FCER1G, Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide), GeneBank accession No: BF569086(NK4, Interleukin 32), GeneBank accession No: BC014470 (AZGPl, Alpha-2-glycoprotein 1, zinc), GeneBank accession No: BC020744 ( AKR1C4 , Aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol ) , dehydrogenase 4), GeneBank accession No: BQ939577 (AKR1C3, Aldo-keto reductase family 1, member C3( 3-alpha hydroxysteroid dehydrogenase, type H)), GeneBank accession No: NM_000499 (CYPlAl , Cytochrome P450, family 1, subfamily A, polypeptide 1), GeneBank accession No: NM_030622 (CYP2S1 , Cytochrome P450, family 2, subfamily S, polypeptide 1), GeneBank accession No: NM_184041 (ALDOA, Aldolase A, fructose-bisphosphate) , GeneBank accession No: NM_024307 (MGC4171 , Hypothetical protein LOC283901), GeneBank accession No: NM_005336 ( HDLBP, High density lipoprotein binding protein( vigilin) ) , GeneBank accession No: NM_002627 (PFKP, Phosphofructokinase, platelet), GeneBank accession No: BX648281 (LDLR, Low density lipoprotein receptor ( familial hypercholesterolemia)), GeneBank accession No: BC069201(FLJ22761, Hexokinase domain containing 1), GeneBank accession No: BC030207 (NR0B2 , Nuclear receptor subfamily 0, group B, member 2), GeneBank accession No: AL833O69(KIAA1434, Hypothetical protein KIAA1434), GeneBank accession No: AK124656 (ENO2 , Enolase 2(gamma, neuronal)), GeneBank accession No: AK094474 (RHOC, Ras homolog gene family, member C), GeneBank accession No: AK093461 ( ISYNAl , Myo-inositol 1-phosphate synthase Al), GeneBank accession No: AB053232(GAL3ST3, Galactose-3-O-sulfotransferase 3), GeneBank accession No: AB045292 (TMEM8 , Transmembrane protein 8(five membrane-spanning domains)), GeneBank accession No: NM_004753 (DHRS3 , Dehydrogenase/reductase ( SDR family) member 3), GeneBank accession No: NM_002900 (RBP3 , Retinol binding protein 3, interstitial), GeneBank accession No: NM_001995 (ACSLl , Acyl-CoA synthetase long- chain family member 1), GeneBank accession No: NM_000018 (ACADVL , Acyl-Coenzyme A dehydrogenase, very long chain), GeneBank accession No: BC094756 (CRA, Myotubularin related protein 11), GeneBank accession No: BC050553 (NTE, Neuropathy target esterase), GeneBank accession No: BC033110(HSD17Bl, Hydroxysteroid( 17-beta) dehydrogenase 1), GeneBank accession No: AY268890 (TPPl , Tripeptidyl peptidase I), GeneBank accession No: AK172798 (CPTlA, Carnitine palmitoyltransferase lA(liver)), GeneBank accession No: AK096809(CYP4F8, Cytochrome P450, family 4, subfamily F, polypeptide 8), GeneBank accession No: AK000600 ( SIAT7D, ST6 ( alpha-N-acetyl-neuraminyl-2 , 3-beta- galactosyl-1 , 3 ) -N- acetylgalactosaminide alpha-2 , 6-sialyltransferase 4), GeneBank accession No: AB002454 (CYP4F3 , Cytochrome P450, family 4, subfamily F, polypeptide 3), GeneBank accession No: Z29093 (DDRl, Discoidin domain receptor family, member 1), GeneBank accession No: Z25424 (MKNK2 , MAP kinase interacting serine/threonine kinase 2), GeneBank accession No: XM_291277(DKFZp76lP0423, Hypothetical protein DKFZp761P0423) , GeneBank accession No: XM_038150 (MAST3 , Microtubule associated serine/threonine kinase 3), GeneBank accession No: U88357 (ERBB3 , V-erb-b2 erythroblastic leukemia viral oncogene homolog 3(avian)), GeneBank accession No: NM_025195 (TRIBl , Tribbles homolog l(Drosophila) ) , GeneBank accession No: NM_020639 (RIPK4 , Receptor-interacting serine-threonine kinase 4 ) , GeneBank accession No: NM_014172 (PHPTl , Phosphohistidine phosphatase 1), GeneBank accession No: NM_006254 (PRKCD, Protein kinase C, delta), GeneBank accession No: NM_005415 ( SLC20A1 , Solute carrier family 20(phosphate transporter), member 1), GeneBank accession No: NM_005026 (PIK3CD, Phosphoinositide- 3-kinase, catalytic, delta polypeptide), GeneBank accession No: NM_004431 (EPHA2, EPH receptor A2 ) , GeneBank accession No: NM_004419(DUSP5, Dual specificity phosphatase 5), GeneBank accession No: NM_004327 (BCR, Breakpoint cluster region), GeneBank accession No: NM_004231 ( ATP6V1F, ATPase, H+ transporting, lysosomal 14kDa, Vl subunit F), GeneBank accession No: NM_004090 (DUSP3 , Dual specificity phosphatase 3 (vaccinia virus phosphatase VHl-related) ) , GeneBank accession No: NM_002843 (PTPRJ, Protein tyrosine phosphatase, receptor type, J), GeneBank accession No: NM_002496 (NDUFS8 , NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH- coenzyme Q reductase)), GeneBank accession No: NM_001001852 (PIM3, Pim-3 oncogene), GeneBank accession No: L76191 ( IRAKI , Interleukin-1 receptor-associated kinase 1), GeneBank accession No: D15049 (PTPRH, Protein tyrosine phosphatase, receptor type, H), GeneBank accession No: BC065207(ATP6V0D2, ATPase, H+ transporting, lysosomal 38kDa, VO subunit d isoform 2), GeneBank accession No: BC035578(STK24, Serine/threonine kinase 24(STE20 homolog, yeast)), GeneBank accession No: BC028724 (DUSP18 , Dual specificity phosphatase 18), GeneBank accession No: AL117482(ULK3, Unc-51-like kinase 3(C. elegans)), GeneBank accession No: AK126879 (PCTK3 , PCTAIRE protein kinase 3), GeneBank accession No: AB209416 ( ILK, Integrin-linked kinase-2), GeneBank accession No: NM_000782 (CYP24A1 , Cytochrome P450, family 24, subfamily A, polypeptide 1), GeneBank accession No: CR597101 ( ZFP36 , Zinc finger protein 36, C3H type, homolog (mouse) ), GeneBank accession No: CR936799(FHL2, Four and a half LIM domains 2), GeneBank accession No: M24898 (NRlDl , Nuclear receptor subfamily 1, group D, member 1), GeneBank accession No: AF132818 (KLF5 , Kruppel-like factor 5 ( intestinal )), GeneBank accession No: AK055337(ZNF213, Zinc finger protein 213), GeneBank accession No: BC008834 (PHFl , PHD finger protein 1), GeneBank accession No: AK126918 (GLIS2 , GLIS family zinc finger 2), GeneBank accession No: BC042692 (CTL2, Solute carrier family 44, member 2), GeneBank accession No: NM_002224(ITPR3, Inositol 1 , 4 , 5-triphosphate receptor, type 3), GeneBank accession No: AK095363 (AQP3 , Aquaporin 3), GeneBank accession No: NM_174953 (ATP2A3 , ATPase, Ca++ transporting, ubiquitous), GeneBank accession No: BC042390 (VTIlB, Vesicle transport through interaction with t-SNAREs homolog lB(yeast)), GeneBank accession No: NM_016113 (TRPV2, Transient receptor potential cation channel, subfamily V, member 2), GeneBank accession No: BM926478 (RBPl, Retinol binding protein 1, cellular), GeneBank accession No: NM_000069 (CACNAlS, Calcium channel, voltage-dependent, L type, alpha IS subunit), GeneBank accession No: AK002107 (RAB3B, RAB3B, member RAS oncogene family), GeneBank accession No: NM_013321 ( SNX8 , Sorting nexin 8), GeneBank accession No: AK125026 ( SLC6A12 , Solute carrier family 6 (neurotransmitter transporter, betaine/GABA) , member 12), GeneBank accession No: NM_005843(STAM2, Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2), GeneBank accession No: AK092512 (SLC16A5, Solute carrier family 16 (monocarboxylic acid transporters), member 5), GeneBank accession No: U49248(ABCC2, ATP-binding cassette, sub-family C (CFTR/MRP ) , member 2), GeneBank accession No: AK172792 ( SCNNlA, Sodium channel, nonvoltage-gated 1 alpha), GeneBank accession No: BC044656(CASC3, Cancer susceptibility candidate 3), GeneBank accession No: NM_203403 (C9orf 150 , Chromosome 9 open reading frame 150), GeneBank accession No: NM_O8O388(S1OOA16, SlOO calcium binding protein A16), GeneBank accession No: NM_031286 (SH3BGRL3, SH3 domain binding glutamic acid-rich protein like 3), GeneBank accession No: NM_022153 (PP2135, Chromosome 10 open reading frame 54), GeneBank accession No: NM_004864 (GDF15 , Growth differentiation factor 15), GeneBank accession No: NM_003330 (TXNRDl, Thioredoxin reductase 1), GeneBank accession No: NM_001013632 (LOC343521 , Similar to hypothetical protein 4833401D15), GeneBank accession No: BX537968(LOC51149, Hypothetical LOC51149), GeneBank accession No: BU945318 (MT2A, Hypothetical gene supported by X97260; BC070289), GeneBank accession No: BQ683841 (SlOOAIl , SlOO calcium binding protein All (calgizzarin) ) , GeneBank accession No: BQ276852 (TMSBlO , Thymosin, beta 10), GeneBank accession No: AK126182 (KIAA1949 , KIAA1949), GeneBank accession No: AK124751 (CAPN2 , Calpain 2,(m/II) large subunit), GeneBank accession No: AK095079 (RGC32 , Response gene to complement 32), GeneBank accession No: AB075871(FLJ42654, Golgi transport 1 homolog A(S. cerevisiae) ) .
Among the above genes, those down-regulated by the exposure to phenanthrene are as follows:
GeneBank accession No: AK125150 (MAPK8 , Mitogen- activated protein kinase 8), GeneBank accession No: NM_002758(MAP2K6, Mitogen-activated protein kinase kinase 6), GeneBank accession No: NM_004612 (TGFBRl , Transforming growth factor, beta receptor I(activin A receptor type II- like kinase, 53kDa) ) , GeneBank accession No: NM_145686 (MAP4K4, Mitogen-activated protein kinase kinase kinase kinase 4), GeneBank accession No: XM_042066 (MAP3K1 , Mitogen-activated protein kinase kinase kinase 1), GeneBank accession No: AB011123 (TNIK, TRAF2 and NCK interacting kinase), GeneBank accession No: AB209031(C5, Complement component 5), GeneBank accession No: NM_022740 ( HIPK2 , Homeodomain interacting protein kinase 2), GeneBank accession No: NM_148957 (TNFRSF19 , Tumor necrosis factor receptor superfamily, member 19), GeneBank accession No: AB208909(ITGB2, Integrin, beta 2 (antigen CDl8(p95), lymphocyte function-associated antigen 1; macrophage antigen l(mac-l) beta subunit)), GeneBank accession No: AB209211 (TIAl, TIAl cytotoxic granule-associated RNA binding protein), GeneBank accession No: AB209613 (DNASE1L3 , Deoxyribonuclease i-like 3), GeneBank accession No: AK122825 (HMGBl, High-mobility group box 1), GeneBank accession No: AK127326 (PHF17 , PHD finger protein 17), GeneBank accession No: AK223503 (CASPl , Caspase 1, apoptosis-related cysteine peptidase ( interleukin 1, beta, convertase ) ) , GeneBank accession No: BC013326 (GAS2 , Growth arrest-specific 2), GeneBank accession No: BC047698 ( IL7 , Interleukin 7), GeneBank accession No: D79987 (ESPLl , Extra spindle poles like 1(S. cerevisiae) ) , GeneBank accession No: NM_000893 (KNGl, Kininogen 1), GeneBank accession No: NM_001012271(BIRC5, Effector cell peptidase receptor 1), GeneBank accession No: NM_004938 (DAPKl , Death-associated protein kinase 1), GeneBank accession No: NM_005879 (TRIP, TRAF interacting protein), GeneBank accession No: NM_014739 (BCLAFl, BCL2-associated transcription factor 1), GeneBank accession No: NM_018947 (CYCS, Cytochrome c, somatic), GeneBank accession No: AB033337 (MPHOSPHl , M-phase phosphoprotein 1), GeneBank accession No: AB209179 (PLKl , Polo-like kinase 1 (Drosophila) ) , GeneBank accession No: AB209337(CDC7, CDC7 cell division cycle 7(S. cerevisiae)), GeneBank accession No: AF053305 (BUBl , BUBl budding uninhibited by benzimidazoles 1 homolog( yeast ) ) , GeneBank accession No: AF053306 (BUBlB, BUBl budding uninhibited by benzimidazoles 1 homolog beta(yeast ) ) , GeneBank accession No: AF345347 (SPAG5, Sperm associated antigen 5), GeneBank accession No: AK092638 (CCNG2 , Cyclin G2 ) , GeneBank accession No: AK222819 (NUSAPl , Nucleolar and spindle associated protein 1), GeneBank accession No: AL833191 ( SMC2L1 , SMC2 structural maintenance of chromosomes 2-like l(yeast)), GeneBank accession No: AY257469 (CIT, Citron (rho-interacting, serine/threonine kinase 21)), GeneBank accession No: AY367065 (ASPM, Asp( abnormal spindle) -like, microcephaly associated(Drosophila) ) , GeneBank accession No: BCOIlOOO (CDCA5 , Cell division cycle associated 5), GeneBank accession No: BC032677 (UBE2C, Ubiquitin-conjugating enzyme E2C), GeneBank accession No: BC043502 (NEK2, NIMA(never in mitosis gene a)-related kinase 2), GeneBank accession No: BU675073 (PTTGl , Pituitary tumor- transforming 1), GeneBank accession No: BX647885 ( STMNl , Stathmin 1/oncoprotein 18), GeneBank accession No: CR592757 (BRRNl, Barren homolog 1 (Drosophila) ) , GeneBank accession No: CR597075 (MAPRE2 , Microtubule-associated protein, RP/EB family, member 2), GeneBank accession No: CR604810(CCNA2, Cyclin A2 ) , GeneBank accession No: CR933728(CDC2, Cell division cycle 2, Gl to S and G2 to M), GeneBank accession No: NM_000919 (PAM, Peptidylglycine alpha-amidating monooxygenase ) , GeneBank accession No: NM_001790(CDC25C, Cell division cycle 25C), GeneBank accession No: NM_001798 (CDK2 , Cyclin-dependent kinase 2), GeneBank accession No: NM_001813 (CENPE, Centromere protein E, 312kDa), GeneBank accession No: NM_003318 (TTK, TTK protein kinase), GeneBank accession No: NM_003981 (PRCl , Protein regulator of cytokinesis 1), GeneBank accession No: NM_004523(KIFll, Kinesin family member 11), GeneBank accession No: NM_004701 (CCNB2 , Cyclin B2 ) , GeneBank accession No: NM_005983 ( SKP2 , S-phase kinase-associated protein 2(p45)), GeneBank accession No: NM_006101 (KNTC2 , Kinetochore associated 2), GeneBank accession No: NM_006845(KIF2C, Kinesin family member 2C), GeneBank accession No: NM_007375 (TARDBP, TAR DNA binding protein), GeneBank accession No: NM_012112 (TPX2 , TPX2 , microtubule- associated, homolog(Xenopus laevis)), GeneBank accession No: NM_014750(DLG7, Discs, large homolog 7 (Drosophila) ) , GeneBank accession No: NM_015097 (CLASP2 , Cytoplasmic linker associated protein 2), GeneBank accession No: NM_016343 (CENPF, Centromere protein F, 350/400ka(mitosin) ) , GeneBank accession No: NM_016426 (GTSEl , G-2 and S-phase expressed 1), GeneBank accession No: NM_018492 (PBK, PDZ binding kinase), GeneBank accession No: NM_018685 (ANLN, Anillin, actin binding protein ( scraps homolog, Drosophila)), GeneBank accession No: NM_020242 (KNSL7 , Kinesin family member 15), GeneBank accession No: NM_031966 (CCNBl , Cyclin Bl), GeneBank accession No: NM_138555 (KIF23 , Kinesin family member 23), GeneBank accession No: U65410 (MAD2L1 , MAD2 mitotic arrest deficient-like l(yeast)), GeneBank accession No: AB020656 (CYLD, Cylindromatosis ( turban tumor syndrome)), GeneBank accession No: AF033122 ( SESNl , Sestrin 1), GeneBank accession No: AK074377 (UHRFl , Chromosome 19 open reading frame 31), GeneBank accession No: AK091170 (CDKN2C, Cyclin- dependent kinase inhibitor 2C(pl8, inhibits CDK4 ) ) , GeneBank accession No: AK094323 (NFYC, Nuclear transcription factor Y, gamma), GeneBank accession No: AY366508 (LOH11CR2A, Loss of heterozygosity, 11, chromosomal region 2, gene A), GeneBank accession No: BCO33O86(TCF19, Transcription factor 19(SCl)), GeneBank accession No: BC040303 (PTP4A1 , Protein tyrosine phosphatase type IVA, member 1), GeneBank accession No: BC040991 (TFDP2 , Transcription factor Dp-2(E2F dimerization partner 2)), GeneBank accession No: BC092412(SGOL2, Shugoshin-like 2(S. pombe ) ) , GeneBank accession No: BQ278454 (CKSlB, CDC28 protein kinase regulatory subunit IB), GeneBank accession No: BX649128(SESN3, Sestrin 3), GeneBank accession No: CD049340 (AURKB, Aurora kinase B), GeneBank accession No: M89914(NF1, Neurofibromin 1 (neurofibromatosis , von Recklinghausen disease, Watson disease)), GeneBank accession No: NM_001005414 ( ZWINT, ZWlO interactor antisense), GeneBank accession No: NM_001008491 ( Sep 2, Septin 2), GeneBank accession No: NM_001274 (CHEKl , CHKl checkpoint homolog(S. pombe ) ) , GeneBank accession No: NM_002105(H2AFX, H2A histone family, member X), GeneBank accession No: NM_002388 (MCM3 , MCM3 minichromosome maintenance deficient 3(S. cerevisiae) ) , GeneBank accession No: NM_002417(MKI67, Antigen identified by monoclonal antibody Ki-67), GeneBank accession No: NM_002875 (RAD51 , RAD51 homolog(RecA homolog, E. CoIi)(S. cerevisiae)), GeneBank accession No: NM_003884 (PCAF, P300/CBP-associated factor), GeneBank accession No: NM_004526(MCM2, MCM2 minichromosome maintenance deficient 2, mitotin(S. cerevisiae)), GeneBank accession No: NM_004847 (AIFl , Allograft inflammatory factor 1), GeneBank accession No: NM_005915 (MCM6 , MCM6 minichromosome maintenance deficient 6(MIS5 homolog, S. pombe ) ( S . cerevisiae)), GeneBank accession No: NM_012090 (MACFl , Microtubule-actin crosslinking factor 1), GeneBank accession No: NM_012415(RAD54B, RAD54 homolog B(S. cerevisiae)), GeneBank accession No: NM__014264 (PLK4 , Polo-like kinase 4(Drosophila) ) , GeneBank accession No: NM_015714 (G0S2 , GO/Glswitch 2), GeneBank accession No: NM_024680 (FLJ23311 , E2F transcription factor 8), GeneBank accession No: XM_034274 (MYBLl , V-myb myeloblastosis viral oncogene homolog ( avian) -like 1), GeneBank accession No: AKOO172O(FLJ1O858, Nei endonuclease Vlll-like 3(E. coli)), GeneBank accession No: AY032677 (POLQ, Polymerase (DNA directed), theta), GeneBank accession No: BC034480 (BLM, Bloom syndrome), GeneBank accession No: BC073161 (RAD51C, RAD51 homolog C(S. cerevisiae ) ) , GeneBank accession No: CR600021(HMGB2, High-mobility group box 2), GeneBank accession No: CR625391 (RAD51AP1 , RAD51 associated protein 1), GeneBank accession No: CR936783 (FLJ40869 , Hypothetical protein LOC284952), GeneBank accession No: DQ140356 (KIAA1596 , Fanconi anemia, complementation group M), GeneBank accession No: NM_001067 (TOP2A, Topoisomerase (DNA) II alpha 17OkDa), GeneBank accession No: NM_001618 (PARPl , Poly(ADP-ribose) polymerase family, member 1), GeneBank accession No: NM_003362 (UNG, Uracil-DNA glycosylase ) , GeneBank accession No: NM_006904 (PRKDC, Protein kinase, DNA-activated, catalytic polypeptide), GeneBank accession No: NM_130398 (EXOl, Exonuclease 1), GeneBank accession No: AB020807(TLR6, Toll-like receptor 6), GeneBank accession No: AB032980(DCDC2, Doublecortin domain containing 2), GeneBank accession No: AB209866 (TFPI , Tissue factor pathway inhibitor ( lipoprotein-associated coagulation inhibitor)), GeneBank accession No: AK057015 (HSPA4 , Heat shock 7OkDa protein 4), GeneBank accession No: AK095515 ( IFITl , Interferon-induced protein with tetratricopeptide repeats 1), GeneBank accession No: AK122686(IF, I factor (complement )), GeneBank accession No: AK123010 (RRM2 , Ribonucleotide reductase M2 polypeptide), GeneBank accession No: BC035582 (TRIM22 , Tripartite motif-containing 22), GeneBank accession No: BX537894 (LOC493869 , Similar to RIKEN cDNA 2310016C16), GeneBank accession No: M14338 (PROSl , Protein S(alpha)), GeneBank accession No: NM_000821 (GGCX, Gamma-glutamyl carboxylase), GeneBank accession No: NM_000963 (PTGS2, Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase ) ) , GeneBank accession No: NM_001001547 (CD36 , CD36 antigen(collagen type I receptor, thrombospondin receptor)), GeneBank accession No: NM_001512 (GSTA4, Glutathione S-transferase A4 ) , GeneBank accession No: NM_001629 ( AL0X5AP, Arachidonate 5- lipoxygenase-activating protein), GeneBank accession No: NM_001752(CAT, Catalase), GeneBank accession No: NM_001837(CCR3, Chemokine (C-C motif) receptor 3), GeneBank accession No: NM_001979 (EPHX2 , Epoxide hydrolase 2, cytoplasmic), GeneBank accession No: NM_001994 (F13B, Coagulation factor XIII, B polypeptide), GeneBank accession No: NM_002182( ILlRAP, Interleukin 1 receptor accessory protein), GeneBank accession No: NM_006120(HLA-DMA, Major histocompatibility complex, class II, DM alpha), GeneBank accession No: NM_173216 ( SIATl , ST6 beta-galactosamide alpha-2 , 6-sialyltranferase 1), GeneBank accession No: NM_202002 (FOXMl, Forkhead box Ml), GeneBank accession No: AB163917 (LRAP, Leukocyte-derived arginine aminopeptidase) , GeneBank accession No: BC027881 (AFP, Alpha-fetoprotein) , GeneBank accession No: NM_015915 ( SPG3A, Spastic paraplegia 3A( autosomal dominant)), GeneBank accession No: NM_000671(ADH5, Alcohol dehydrogenase 5(class III), chi polypeptide), GeneBank accession No: J05428 (UGT2B7 , UDP glucuronosyltransferase 2 family, polypeptide B7 ) , GeneBank accession No: NM_000672 ( ADH6 , Alcohol dehydrogenase 6 (class V)), GeneBank accession No: M15943(ADH4, Alcohol dehydrogenase 4(class II), pi polypeptide), GeneBank accession No: AK223395 (FBPl , Fructose-1 , 6-bisphosphatase 1), GeneBank accession No: NM_000151 (G6PC, Glucose-6- phosphatase, catalytic (glycogen storage disease type I, von Gierke disease)), GeneBank accession No: XM_113962 (KIAA0650 , Structural maintenance of chromosomes flexible hinge domain containing 1), GeneBank accession No: AB020644 (ACSL6 , Acyl- CoA synthetase long-chain family member 6), GeneBank accession No: AB209907 (PLDl , Phospholipase Dl, phophatidylcholine-specific ) , GeneBank accession No: AF285167 (ABCAl, ATP-binding cassette, sub-family A(ABCl), member 1), GeneBank accession No: AF297872 (TRERFl , Transcriptional regulating factor 1), GeneBank accession No: AF3O3134(ALDH8A1, Aldehyde dehydrogenase 8 family, member Al), GeneBank accession No: AF339053 (PLA2G12B, Phospholipase A2 , group XIIB), GeneBank accession No: AK096018 (HADHSC, L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain), GeneBank accession No: AK124635 (PCSK9, Proprotein convertase subtilisin/kexin type 9), GeneBank accession No: AK127346 (SIAT9 , ST3 beta-galactoside alpha- 2 , 3-sialyltransferase 5), GeneBank accession No: AL359559 (AGPS, Alkylglycerone phosphate synthase), GeneBank accession No: AY691170 (PLCL3 , Phospholipase C-like 3), GeneBank accession No: BG567934 (APOM, Apolipoprotein M), GeneBank accession No: BX538214 (C6orf167 , Chromosome 6 open reading frame 167), GeneBank accession No: BX640945 (FADS2 , Fatty acid desaturase 2), GeneBank accession No: BX648473(PIGK, Phosphatidylinositol glycan, class K), GeneBank accession No: BX648557 (HSD17B2 , Hydroxysteroid ( 17- beta) dehydrogenase 2), GeneBank accession No: CR749601 (ETNKl, Death-associated protein kinase 3), GeneBank accession No: NM_000859 (HMGCR, 3-hydroxy-3- methylglutaryl-Coenzyme A reductase), GeneBank accession No: NM_001443 (FABPl, Fatty acid binding protein 1, liver), GeneBank accession No: NM_002130 (HMGCSl , 3-hydroxy-3- methylglutaryl-Coenzyme A synthase l(soluble)), GeneBank accession No: NM_003725 (RODH, Hydroxysteroid( 17-beta) dehydrogenase 6), GeneBank accession No: NM_004845 (PCYTlB, Phosphate cytidylyltransferase 1, choline, beta), GeneBank accession No: NM_014762 (DHCR24 , 24-dehydrocholesterol reductase), GeneBank accession No: NM_020139 (DHRS6 , Dehydrogenase/reductase (SDR family) member 6), GeneBank accession No: NM_020918 (GPAM, Glycerol-3-phosphate acyltransferase , mitochondrial), GeneBank accession No: NM_032523(OSBPL6, Oxysterol binding protein-like 6), GeneBank accession No: NM_033505 ( SELI , Selenoprotein I), GeneBank accession No: Z28339 (AKRlDl , Aldo-keto reductase family 1, member Dl (delta 4-3-ketosteroid-5-beta- reductase)), GeneBank accession No: AK024899 (ENPP3 , Ectonucleotide pyrophosphatase/ phosphodiesterase 3), GeneBank accession No: AK025546 (PTPN4 , Protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte )), GeneBank accession No: AK124910 (ENPP2 , Ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin) ) , GeneBank accession No: BC035116 (FLJ35059 fis, CDNA FLJ30761 fis, clone FEBRA2000538) , GeneBank accession No: BC050565 (PASK, PAS domain containing serine/threonine kinase), GeneBank accession No: L13436 (NPR2 , Natriuretic peptide receptor B/guanylate cyclase B( atrionatriuretic peptide receptor B)), GeneBank accession No: NM_001005862 (ERBB2 , V-erb-b2 erythroblastic leukemia viral oncogene homolog 2 , neuro/glioblastoma derived oncogene homolog ( avian) ), GeneBank accession No: NM_005012 (RORl , Receptor tyrosine kinase-like orphan receptor 1), GeneBank accession No: NM_006035(CDC42BPB, CDC42 binding protein kinase beta(DMPK- like)), GeneBank accession No: NM_014791 (MELK, Maternal embryonic leucine zipper kinase), GeneBank accession No: NM_023028(FGFR2, Fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer yndrome, Jackson-Weiss syndrome)), GeneBank accession No: NM_080836 ( STK35 , Serine/threonine kinase 35), GeneBank accession No: AF419331 (FUSIPl , FUS interacting protein ( serine/arginine-rich) 1), GeneBank accession No: AK091927 (SFRS3, Splicing factor, arginine/serine-rich 3), GeneBank accession No: BC010266 (HNRNPAl , Heterogeneous nuclear ribonucleoprotein Al), GeneBank accession No: BC012360(CTAGE5, CTAGE family, member 5), GeneBank accession No: BC036046 (PLRGl, Pleiotropic regulator 1(PRLl homolog, Arabidopsis ) ) , GeneBank accession No: BC065384 (PCFIl, PCFIl, cleavage and polyadenylation factor subunit, homolog(S. cerevisiae) ) , GeneBank accession No: BX537360 (CPSF5 , Nudix( nucleoside diphosphate linked moiety X) -type motif 21), GeneBank accession No: BX537494 (HNRPA2B1 , Heterogeneous nuclear ribonucleoprotein A2/B1), GeneBank accession No: BX647784 (HNRPR, Heterogeneous nuclear ribonucleoprotein R), GeneBank accession No: CA455267 (PPIH, Peptidyl prolyl isomerase H(cyclophilin H)), GeneBank accession No: CR596214 (HNRPAO, Heterogeneous nuclear ribonucleoprotein AO), GeneBank accession No: NM_001326(CSTF3, Hypothetical protein LOC283267), GeneBank accession No: NM_004640 (BATl , HLA-B associated transcript 1), GeneBank accession No: NM_005463 (HNRPDL, Heterogeneous nuclear ribonucleoprotein D-like), GeneBank accession No: NM_006924 (SFRSl, Splicing factor, arginine/serine-rich 1( splicing factor 2, alternate splicing factor)), GeneBank accession No: NM_012426 ( SF3B3 , Splicing factor 3b, subunit 3, 13OkDa), GeneBank accession No: NM_018048 (FLJ10292 , Mago-nashi homolog), GeneBank accession No: NM_030919(C20orf 129, Chromosome 20 open reading frame 129), GeneBank accession No: NM_031370 (HNRPD, Heterogeneous nuclear ribonucleoprotein D(AU-rich element RNA binding protein 1, 37kDa) ) , GeneBank accession No: NM_138933 ( ACF, Apobec-1 complementation factor), GeneBank accession No: AB193259 (ACE2 , Angiotensin I converting enzyme (peptidyl- dipeptidase A) 2), GeneBank accession No: BX648769 (EWSRl , Ewing sarcoma breakpoint region 1), GeneBank accession No: AB023154(DTX4, Deltex 4 homolog (Drosophila) ) , GeneBank accession No: AL543755 ( VAV3 , Vav 3 oncogene), GeneBank accession No: M75106(CPB2, Carboxypeptidase B2 (plasma, carboxypeptidase U)), GeneBank accession No: NM_021045(ZNF248, Zinc finger protein 248), GeneBank accession No: AB209194 (B4GALT6 , UDP-GaI :betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6), GeneBank accession No: AF279145 (ANTXRl , Anthrax toxin receptor 1), GeneBank accession No: NM_025074 (FRASl, Fraser syndrome 1), GeneBank accession No: AK025790 (KIF20A, Kinesin family member 20A), GeneBank accession No: NM_006152 (LRMP, Lymphoid-restricted membrane protein), GeneBank accession No: NM_000340(SLC2A2, Solute carrier family 2 ( facilitated glucose transporter), member 2), GeneBank accession No: AF071592(KIF4A, Kinesin family member 4A), GeneBank accession No: NM_013277 (RACGAPl , Rac GTPase activating protein 1), GeneBank accession No: AY043484 ( SCNlA, Sodium channel, voltage-gated, type I, alpha), GeneBank accession No: AY791349(KIF18A, Kinesin family member 18A), GeneBank accession No: NM_018018 ( SLC38A4 , Solute carrier family 38, member 4), GeneBank accession No: AK094603 (FLJ37284 fis, unnamed protein product; Homo sapiens cDNA FLJ37284 fis, clone BRAMY2013590. ) , GeneBank accession No: NM_021069(ARGBP2, Sorbin and SH3 domain containing 2), GeneBank accession No: NM_001005747 (CACNB4 , Calcium channel, voltage-dependent, beta 4 subunit), GeneBank accession No: AJ496568(SLC25A12, Solute carrier family 25 (mitochondrial carrier, Aralar), member 12), GeneBank accession No: NM_030641 (APOL6, Apolipoprotein L, 6), GeneBank accession No: NM_173512 (FLJ39822, Hypothetical protein FLJ39822), GeneBank accession No: NM_000037 (ANKl , Ankyrin 1, erythrocytic), GeneBank accession No: NM_001011554 (SLC13A3, Solute carrier family 13 ( sodium-dependent dicarboxylate transporter), member 3), GeneBank accession No: AB091343(C10orf3, Centrosomal protein 55kDa), GeneBank accession No: AK000643 ( ASB9 , Ankyrin repeat and SOCS box- containing 9), GeneBank accession No: AK055221 (FBXO5 , F-box protein 5), GeneBank accession No: AK075271 ( SPTLC2L, Serine palmitoyltransferase, long chain base subunit 2- like( aminotransferase 2)), GeneBank accession No: AK122685 (GLUDl, Glutamate dehydrogenase 1), GeneBank accession No: AK127098 (FLJ10706 , Chromosome 1 open reading frame 112), GeneBank accession No: AL133031 (MLRl , Transcription factor MLRl), GeneBank accession No: AY007723(MAL2, MaI, T-cell differentiation protein 2), GeneBank accession No: BC022255 (Spc25 , Spindle pole body component 25 homolog(S. cerevisiae ) ) , GeneBank accession No: BC041882(ATF7IP2, Activating transcription factor 7 interacting protein 2), GeneBank accession No: BC052951 (LMNBl, Lamin Bl), GeneBank accession No: BC098313(FLJ20641, Hypothetical protein FLJ20641), GeneBank accession No: NM_001809 (CENPA, Centromere protein A, 17kDa), GeneBank accession No: NM_145061 (C13orf3 , Chromosome 13 open reading frame 3), GeneBank accession No: XM_372695(LOC390859, PREDICTED: Homo sapiens similar to Chain A, Crystal Structure Of The R463a Mutant Of Human Glutamate Dehydrogenase(LOC390859 ) , mRNA) .
The above genes are up-regulated or down-regulated at least double the average by phenanthrene, which are composed of those genes involved in MAPKinase signaling pathway, MAPKKK cascade, apoptosis, mitotic cell cycle, cell cycle, cell differentiation, cell motility, cytoskeleton, morphogenesis, response to DNA damage stimulus, response to chemical stimulus, response to external stimulus, response to stress, immune response, metabolism of xenobiotics by cytochrome p450, alcohol metabolism, lipid metabolism, phosphate metabolism, DNA metabolism, and metal binding or transport.
The present inventors treated phenanthrene to human liver cancer cell line (HepG2), followed by examination of cytotoxicity to identify the said genes. As a result, phenanthrene was confirmed to have cytotoxicity in human liver cancer cell line (see Figure 1), based on which concentration of phenanthrene was determined. Human liver cancer cell line was treated with phenanthrene by the concentration determined above, from which mRNA was extracted. During the synthesis of cDNA from the mRNA, the cDNA was labeled with Cy5. cDNA of the control group which was not treated with phenanthrene was labeled with Cy3. The labeled cDNA was hybridized with 44 k oligo-microarray chip (human whole genome microarray (Agilent, USA)) and then fluorescent image was scanned to analyze gene expression patterns (see Figure 2). When the ratio of Cy5 to Cy3 was at least 2.0, the gene was classified as up- regulated. When the ratio of Cy5 to Cy3 was up to 0.5, the gene was classified as down-regulated. As a result, up- regulated genes took 0.69% (302 out of 44,000 genes) and down-regulated genes took 0.55% (244 out of 44,000 genes). Genes which were down-regulated or up-regulated by phenanthrene were classified according to their functions, as genes respectively involved in MAPKinase signaling pathway, MAPKKK cascade, apoptosis, mitotic cell cycle, cell cycle, cell differentiation, cell motility, cytoskeleton, morphogenesis, response to DNA damage stimulus, response to chemical stimulus, response to external stimulus, response to stress, immune response, metabolism of xenobiotics by cytochrome p450, alcohol metabolism, lipid metabolism, phosphate metabolism, DNA metabolism, metal binding or transport, etc. (see Table 2 and Table 3 ) . There has been no report saying that the genes are related with cytotoxicity in human liver cancer cells treated with phenanthrene.
The present inventors separated 19 up-regulated genes and 9 down-regulated genes, with which real-time RT-PCR (reverse transcript polymerase chain reaction) was performed to examine gene expression patterns. As a result, gene expression patterns of those 19 up-regulated genes and 9 down-regulated genes were similar to those observed on oligo-microarray chip (see Table 5). These genes were GeneBank accession No: BM913048 (TIMP metallopeptidase inhibitor 1), GeneBank accession No: BX649164 ( serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), GeneBank accession No: NM_004864(Growth differentiation factor 15), GeneBank accession No: NM_000499 (Cytochrome P450, family 1, subfamily A, polypeptide 1), GeneBank accession No: AK095363(Aquaporin 3), GeneBank accession No: NM_001013632 (Similar to hypothetical protein 4833401D15), GeneBank accession No: BC042390 (Vesicle transport through interaction with t-SNAREs homolog lB(yeast)), GeneBank accession No: BQ683841 ( SlOO calcium binding protein All (calgizzarin) ) , GeneBank accession No: NM_003897 ( Immediate early response 3), GeneBank accession No: BM926478 (Retinol binding protein 1, cellular), GeneBank accession No: BU945318 (metallothionein 2A), GeneBank accession No: AK094474(Ras homolog gene family, member C), GeneBank accession No: Y11307 (Cysteine-rich, angiogenic inducer, 61), GeneBank accession No: AY247738 (Tribbles homolog 3 (Drosophila) ) , GeneBank accession No: Z25424(MAP kinase interacting serine/threonine kinase 2), GeneBank accession No: NM_001769 (CD9 antigen(p24 ) ) , GeneBank accession No: Y12692 (Wingless-type MMTV integration site family, member 11) , GeneBank accession No: X02812 (Transforming growth factor, beta l(Camurati- Engelmann disease)), GeneBank accession No: NM_000596 ( Insulin-like growth factor binding protein 1), GeneBank accession No: NM__006101 (Kinetochore associated 2), GeneBank accession No: NM_003318 (TTK protein kinase), GeneBank accession No: NM_001067 (Topoisomerase ( DNA) II alpha 17OkDa), GeneBank accession No: NM_018492 (PDZ binding kinase), GeneBank accession No: U65410(MAD2 mitotic arrest deficient-like l(yeast)), GeneBank accession No: AK074377 (Chromosome 19 open reading frame 31), GeneBank accession No: CR600021 (High-mobility group box 2), GeneBank accession No: BC022255 ( Spindle pole body component 25 homolog(S. cerevisiae) ) , GeneBank accession No: AB091343(Centrosomal protein 55kDa) .
In the kit of the present invention, the oligonucleotide containing total length or a part of the gene or its complementary oligonucleotide contains 18-30 nucleic acids and more preferably 20-25 nucleic acids, but not always limited thereto. In the kit of the present invention, the oligonucleotide containing total length or a part of the gene or its complementary oligonucleotide can be included on a DNA microarray chip.
The DNA microarray chip can be prepared by the conventional method well known to those in the art. The conventional method for preparing DNA microarray chip is as follows: micropipetting method using piezoelectric process to fix the screened biomarker as a probe DNA molecule on a DNA chip board; or a method using a pin type spotter, but not always limited thereto. In a preferred embodiment of the present invention, the pin type spotter microarray was used. The board of DNA microarray chip is coated with one of active groups selected from the group consisting of amino-silane, poly-L-lysine and aldehyde, but not always limited thereto. The said board can be selected from the group consisting of slide glass, plastic, metal, silicon, nylon membrane and nitrocellulose membrane, but not always limited thereto. In a preferred embodiment of the present invention, the slide glass coated with amino-silane was used.
The present invention provides a kit for identification of exposure to phenanthrene which contains human liver cells additionally. The human liver cell herein is preferably HepG2 , but not always limited thereto and any cells and tissues originated from human liver or liver cancer can be used.
The kit of the present invention can additionally include a fluorescent material, and the fluorescent material herein is selected from the group consisting of strepavidin-like phosphatase conjugate, chemiflurorensce and chemiluminescent , but not always limited thereto. In a preferred embodiment of the present invention, Cy3 and Cy5 were used.
The kit of the present invention can additionally include a reaction reagent. The reaction reagent herein is selected from the group consisting of hybridization buffer, reverse transcriptase for the synthesis of cDNA from mRNA, cNTPs and rNTP (pre-mixed or separated), marker reagent such as chemical inducer of fluorescent staining, and washing buffer, but not always limited thereto and any reaction reagent necessary for hybridization on DNA microarray known to those in the art can be included.
The present invention also provides a kit for identification of exposure to phenanthrene containing a primer set capable of amplifying the said gene.
The primer of the kit contains preferably at least two sets of forward primers and reverse primers selected from the group consisting of sequences represented by SEQ. ID. NO: 1 - NO: 56, but not always limited thereto, and any primer set containing a forward primer and a reverse primer which is complementary to the said gene and capable of amplifying a biomarker gene and designed to produce 100 - 300 bp product can be used. The present invention further provides a method for detecting the said gene for the identification of exposure to phenanthrene comprising the following steps:
1) comparing expressions of genes up- or down- regulated by phenanthrene in the experimental group somatic cells and the control group somatic cells; and
2) determining exposure to phenanthrene if the expression of the said gene of step 1) is significantly different from that of the control. In this method, the somatic cell of step 1) is preferably human liver cancer cell line (HepG2), but not always limited thereto and any cells originated from human liver or liver cancer cells and tissues can be used.
In this method, the expression of the gene of step 1) can be measured at the level of mRNA or protein. The expression at mRNA level is measured preferably by oligonucleotide or polynucleotide microarray or RT-PCR. The expression at protein level is preferably measured by protein microarray or ELISA, but not always limited thereto.
The present invention also provides a method for detecting the said gene for the identification of exposure to phenanthrene, comprising the following steps:
1 ) extracting RNAs from the experimental group human somatic cells and the control group human somatic cells; 2) synthesizing cDNAs from the RNAs of the experimental group and the control group of step 1), and labeling the cDNAs with different fluorescent materials;
3) hybridizing the cDNAs labeled with different fluorescent materials in step 2) with DNA microarray containing oligonucleotide comprising total length or a part of the gene up- or down-regulated by the exposure to phenanthrene or its complementary oligonucleotide;
4) analyzing the DNA microarray reacted in step 3); and
5 ) determining exposure to phenanthrene by comparing the expression of the gene between the experimental group and the control group, precisely if the gene expression of the experimental group is significantly changed by phenanthrene, compared with that of the control group, it is judged that the gene is exposed to phenanthrene.
In this method, the somatic cell of step 1) is preferably human liver cancer cell line (HepG2), but not always limited thereto and any cells originated from human liver or liver cancer cells and tissues can be used.
In this method, the florescent material of step 3) is preferably selected from the group consisting of Cy3 , Cy5 , FITC (poly L-lysine-fluorescein isothiocyanate) , RITC (rhodamine-B-isothiocyanate ) and rhodamine, but not always limited thereto and any fluorescent material well-known to those in the art can be used.
In this method, the DNA microarray of step 5) is preferably whole human genome oligo microarray (Agilent,
USA) , but not always limited thereto and any microarray chip loaded with genes up- or down-regulated (see Table 2 and Table 3) can be used. It is more preferred to use the
DNA microarray chip developed by the present inventors.
The analysis method of step 5) preferably uses GenePix 4.1 software (Axon Instruments, USA), but not always limited thereto and any software known to those in the art can be used.
The present invention also provides a method for detecting the said gene for the identification of exposure to phenanthrene, comprising the following steps:
1 ) extracting RNAs from the experimental group human somatic cells and the control group human somatic cells;
2) performing real-time RT-PCR (reverse transcript polymerase chain reaction) with the RNAs of step 1) using a primer set capable of amplifying the gene up- or down- regulated by phenanthrene; and
3 ) determining exposure to phenanthrene by comparing gene expressions, precisely if the gene expression in the experimental group exposed to phenanthrene is significantly changed, compared with that of the control group, it is judged that the gene is exposed to phenanthrene.
In this method, the somatic cell of step 1) is preferably human liver cancer cell line (HepG2), but not always limited thereto and any cells originated from human liver or liver cancer cells and tissues can be used.
In this method, the primer of step 3) can be any primer that is capable of amplifying a biomarker and is complementary to the screened biomarker gene. In this invention, 28 sets of forward primers and reverse primers represented by SEQ. ID. NO: 1 -NO: 56 are presented, but not always limited thereto.
[Advantageous Effect]
The kit for identification of exposure to phenanthrene and a method for identification of exposure to phenanthrene of the present invention are useful for determining risk of phenanthrene and monitoring thereof using a gene specifically up- or down-regulated by phenanthrene as a biomarker, and also useful as a tool to investigate toxicity caused by phenanthrene.
[Description of Drawings]
The application of the preferred embodiments of the present invention is best understood with reference to the accompanying drawings, wherein: Figure 1 is a diagram illustrating the cytotoxicity of phenanthrene in human liver cancer cell line.
Figure 2 is a diagram illustrating the gene expression pattern in human liver cancer cell line treated with phenanthrene which is analyzed by using microarray chip.
[Mode for Invention] Practical and presently preferred embodiments of the present invention are illustrative as shown in the following Examples.
However, it will be appreciated that those skilled in the art, on consideration of this disclosure, may make modifications and improvements within the spirit and scope of the present invention.
Example 1; Cell culture and chemical treatment <!-!> Cell culture Human liver cancer cell line HepG2 (Korean Cell Line Bank) was cultured in 100 mm dish containing DMEM (Gibco- BRL, USA) supplemented with 10% FBS until it grew 80%. The present inventors selected phenanthrene, one of polycyclic aromatic hydrocarbons having carcinogenicity, and dissolved thereof in DMSO. The concentration of a vehicle was up to 0.1% in every experiment.
<l-2> Cytotoxicity test (MTT assay) and chemical treatment MTT assay was performed with HepG2 according to the method of Mossman et al (J. Immunol. Methods, 65, 55-63, 1983). Cells were inoculated in 24-well plate at the concentration of 4xlO 5 cells/well and treated with phenanthrene dissolved in DMSO in DMEM (Gibco-BRL, USA) . 48 hours later, the cells were treated with MTT (3-4,5- dimethylthiazol-2 , 5-diphenyltetra zolium bromide) at the concentration of 5 mg/iwl, followed by culture in a tube at 37 ° C for 3 hours. The medium was discarded and formed formazan crystal was dissolved in 500 βi of DMSO. The solution was aliquoted in a 96-well plate and OD 5 4 0 was measured.
Cytotoxicity of phenanthrene in HepG2 was investigated. As a result, the test sample was educted at the concentration of 500 uM or up but cytotoxicity was not observed. So, 500 uM, which was the highest concentration at which the test sample was not educted, was determined as the concentration for microarray (Figure 1).
Example 2 : Microarray <2-l> Extraction of target RNA and labeling with fluorescent material
HepG2 cells were distributed in 100 mm dish at the concentration of 6 x 10 6 cells/m£, to which phenanthrene was treated at the concentration determined in Example <1- 2> for 48 hours. Then, total RNA was extracted from the treated cells using trizol reagent (Invitrogen life technologies, USA) according to the manufacturer's instruction. The RNA was purified with RNeasy mini kit (Qiagen, USA). Genome DNA was eliminated by using RNase- free DNase set (Qiagen, USA) during the purification of RNA. Total RNA was quantified with spectrophotometer and the concentration was confirmed by Agilent 2100 Bioanalyzer (Agilent Technologies, USA) and agarose gel electrophoresis,
<2-2> Preparation of labeled cDNA
For oligo-microarray analysis, cDNA was synthesized with the total RNA of the phenanthrene treated group obtained in Example <2-l>. 30 βg of total RNA was mixed with 2 βg (1 βg/βϋ) of primer at 65 ° C for 10 minutes, followed by annealing in ice. Reagents were mixed as shown in Table 1 for reverse transcription of the annealed RNA.
Table 1
The total RNA extracted from the control group HepG2 cell line was labeled with Cy3-dUTP (green) and the RNA extracted from the phenanthrene treated HepG2 cell line was labeled with Cy5-dUTP (red). Two samples were mixed and purified by Microcon YM-30 column (Millipore, USA).
<2-3> Hybridization
Hybridization and washing were performed according to GenoCheck' s instruction. Hybridization was performed in a 62 ° C oven for 12 hours. 44 k Whole Human Genome Oligo Microarray (Agilent, USA) was used as a DNA microarray chip. After washing (washing with 2 χ SSC/0.1% SDS for 2 minutes, Ix SSC for 3 minutes and 0.2* SSC for 2 minutes), slide was dried by centrifugation at 800 rpm for 3 minutes .
<2-4> Obtainment of fluorescent image
Hybridization image on the slide was scanned by Genepix 4000B (Axon Instruments, USA). Non-hybridized gene was washed off the chip and fluorescent image was obtained by using laser fluorescence scanner. Green fluorescent image indicates the activity of the gene expressed in the control group, while red fluorescent image indicates the activity of the gene expressed specifically in the experimental group. Yellow fluorescent image indicates there is no big difference in gene expression between the two groups (green + red). Those scanned images were analyzed by GenePix 4.1 software (Axon Instruments, USA) to investigate changes of gene expression. From the data obtained thereby, marker genes for phenanthrene were selected (Figure 2).
As a result, among 44,000 genes on the chip, those genes up-regulated by phenanthrene, making the ratio of Cy5 to Cy3 to be at least 2.0, took 0.69% (302 out of 44,000 genes) and those genes down-regulated took 0.55% (244 out of 44,000 genes) .
Those genes up-regulated or down-regulated at least 2 fold by phenanthrene were classified according to functions. As a result, the genes were grouped into those involved in MAPKinase signal pathway, those involved in MAPKKK cascade, those involved in apoptosis, those involved in mitotic cell cycle, those involved in cell cycle, those involved in cell differentiation, those involved in cell motility, those involved in cytoskeleton, those involved in morphogenesis, those involved in response to DNA damage stimulus, those involved in response to chemical stimulus, those involved in response to external stimulus, those involved in response to stress, those involved in immune response, those involved in metabolism of xenobiotics by cytochrome p450, those involved in alcohol metabolism, those involved in lipid metabolism, those involved in phosphate metabolism, those involved in DNA metabolism, and those involved in metal binding or transport (Table 2 and Table 3 ) . There has been no report saying that phenanthrene causes cytotoxicity in human liver cancer cells.
Table 2
Genes up-regulated by phenanthrene
Table 3
Genes down-regulated by phenanthrene
Example 3: Quantification by real-time RT-PCR (reverse transcriptase polymerase chain reaction)
Among those genes up-regulated or down-regulated at least double the normal level by phenanthrene, 19 up- regulated genes and 9 down regulated genes were selected. These genes are as follows: GeneBank accession No: BM913048 (TIMP metallopeptidase inhibitor 1), GeneBank accession No: BX649164 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1 ) , member 1 ) , GeneBank accession No: NM_004864 (Growth differentiation factor 15), GeneBank accession No: NM_000499 (Cytochrome P450, family 1, subfamily A, polypeptide 1), GeneBank accession No: AK095363 (Aquaporin 3), GeneBank accession No: NM_001013632 (Similar to hypothetical protein 4833401D15), GeneBank accession No: BC042390 (Vesicle transport through interaction with t-SNAREs homolog IB (yeast)), GeneBank accession No: BQ683841 (SlOO calcium binding protein All (calgizzarin) ) , GeneBank accession No: NM_003897 (Immediate early response 3), GeneBank accession No: BM926478 (Retinol binding protein 1, cellular), GeneBank accession No: BU945318 (metallothionein 2A) , GeneBank accession No: AK094474 (Ras homolog gene family, member C), GeneBank accession No: Y11307 (Cysteine-rich, angiogenic inducer, 61), GeneBank accession No: AY247738 (Tribbles homolog 3 (Drosophila) ) , GeneBank accession No: Z25424 (MAP kinase interacting serine/threonine kinase 2), GeneBank accession No: NM_001769 (CD9 antigen (p24)), GeneBank accession No: Y12692 (Wingless-type MMTV integration site family, member 11), GeneBank accession No: X02812 (Transforming growth factor, beta 1 (Camurati- Engelmann disease)), GeneBank accession No: NM_000596 (Insulin-like growth factor binding protein 1), GeneBank accession No: NM_006101 (Kinetochore associated 2), GeneBank accession No: NM_003318 (TTK protein kinase), GeneBank accession No: NM_001067 (Topoisomerase (DNA) II alpha 17OkDa), GeneBank accession No: NM_018492 (PDZ binding kinase), GeneBank accession No: U65410 (MAD2 mitotic arrest deficient-like 1 (yeast)), GeneBank accession No: AK074377 (Chromosome 19 open reading frame 31), GeneBank accession No: CR600021 (High-mobility group box 2), GeneBank accession No: BC022255 (Spindle pole body component 25 homolog (S. cerevisiae) ) , GeneBank accession No: AB091343 (Centrosomal protein 55kDa).
To investigate expression patterns of those genes and quantify their expressions, quantitative real-time RT-PCR was performed using My IQ Real-time PCR (Bio-rad, USA) . Particularly, cDNA was synthesized by reverse transcription using oligo dT primer and Superscript kit
(Omniscipt™ kit, Qiagen, Co., USA) . To quantify the PCR product, SYBR Green I staining (Bio-rad, USA) was performed. SYBR Green I staining is a double stranded DNA conjugation based staining method. During PCR, as double stranded DNA generates, fluorescence intensity increases. First, target gene used for PCR and endogenous control (GAPDH) primer were added to SYBR Green master mix, followed by PCR. Then, primer optimization was performed to determine the proper concentration. The synthesized cDNA and each primer were mixed (Table 4), to which SYBR Green master mix was added, followed by PCR. The PCR product was analyzed by using quantification software (Table 5) .
Table 4
Primer sequences
Table 5
Results of real-time quantitative PCR
As a result, the expression patterns of those 19 up- regulated genes and 9 down-regulated genes by phenanthrene were similar to those confirmed by oligo-microarray examining the gene expressions by phenanthrene.
Those skilled in the art will appreciate that the conceptions and specific embodiments disclosed in the foregoing description may be readily utilized as a basis for modifying or designing other embodiments for carrying out the same purposes of the present invention. Those skilled in the art will also appreciate that such equivalent embodiments do not depart from the spirit and scope of the invention as set forth in the appended claims.