Title:
KRAB-CONTAINING ZINC FINGER PROTEIN AND CANCER
Document Type and Number:
WIPO Patent Application WO/2022/238542
Kind Code:
A3
Abstract:
The present invention provides methods for detecting cancer as well as agents and compositions for treating cancer by modulating the expression and/or activity of one or more i) KRAB-containing zinc finger protein (KZFP), ii) mRNA encoding a KZFP, and/or iii) KZFP gene.
Inventors:
TRONO DIDIER (CH)
MARTINS FELIPE (CH)
TURELLI PRISCILLA (CH)
MARTINS FELIPE (CH)
TURELLI PRISCILLA (CH)
Application Number:
PCT/EP2022/062972
Publication Date:
December 15, 2022
Filing Date:
May 12, 2022
Export Citation:
Assignee:
ECOLE POLYTECHNIQUE FED LAUSANNE EPFL (CH)
International Classes:
C12N15/113; A61K31/7088
Domestic Patent References:
| WO2010123982A2 | 2010-10-28 | |||
| WO2020248018A1 | 2020-12-17 | |||
| WO2020061391A1 | 2020-03-26 |
Foreign References:
| CN110452984A | 2019-11-15 | |||
| US20200216911A1 | 2020-07-09 |
Other References:
JOSEPH B. ADDISON ET AL: "KAP1 Promotes Proliferation and Metastatic Progression of Breast Cancer Cells", CANCER RESEARCH, vol. 75, no. 2, 24 November 2014 (2014-11-24), US, pages 344 - 355, XP055566880, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-14-1561
ZHAN WEI ET AL: "ZNF671 Inhibits the Proliferation and Metastasis of NSCLC via the Wnt/[beta]-Catenin Pathway", CANCER MANAGEMENT AND RESEARCH, vol. Volume 12, 1 January 2020 (2020-01-01), GB, pages 599 - 610, XP055957267, ISSN: 1179-1322, DOI: 10.2147/CMAR.S235933
ZHANG JIAN ET AL: "The Tumor Suppressor Role of Zinc Finger Protein 671 (ZNF671) in Multiple Tumors Based on Cancer Single-Cell Sequencing", FRONTIERS IN ONCOLOGY, vol. 9, 1 January 2019 (2019-01-01), pages 1214, XP055958120, Retrieved from the Internet DOI: 10.3389/fonc.2019.01214
JIAN ZHANG ET AL: "Epigenetic-Mediated Downregulation of Zinc Finger Protein 671 (ZNF671) Predicts Poor Prognosis in Multiple Solid Tumors", FRONTIERS IN ONCOLOGY, vol. 9, 7 May 2019 (2019-05-07), XP055766242, DOI: 10.3389/fonc.2019.00342
ZHAN WEI ET AL: "ZNF671 Inhibits the Proliferation and Metastasis of NSCLC via the Wnt/[beta]-Catenin Pathway", CANCER MANAGEMENT AND RESEARCH, vol. Volume 12, 1 January 2020 (2020-01-01), GB, pages 599 - 610, XP055957267, ISSN: 1179-1322, DOI: 10.2147/CMAR.S235933
ZHANG JIAN ET AL: "The Tumor Suppressor Role of Zinc Finger Protein 671 (ZNF671) in Multiple Tumors Based on Cancer Single-Cell Sequencing", FRONTIERS IN ONCOLOGY, vol. 9, 1 January 2019 (2019-01-01), pages 1214, XP055958120, Retrieved from the Internet
JIAN ZHANG ET AL: "Epigenetic-Mediated Downregulation of Zinc Finger Protein 671 (ZNF671) Predicts Poor Prognosis in Multiple Solid Tumors", FRONTIERS IN ONCOLOGY, vol. 9, 7 May 2019 (2019-05-07), XP055766242, DOI: 10.3389/fonc.2019.00342
Attorney, Agent or Firm:
KATZAROV S.A. (CH)
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