Title:
LACTATE DEHYDROGENASE INHIBITOR AND ANTIEPILEPTIC DRUG CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2016/129583
Kind Code:
A1
Abstract:
The invention provides a lactate dehydrogenase inhibitor that makes it possible to suppress refractory epilepsy in which conventional antiepileptic drugs are ineffective, and an antiepileptic drug containing said inhibitor. The lactate dehydrogenase inhibitor of the invention contains a compound represented by formula (III); i.e., isosafrole or a compound having isosafrole as a scaffold, and the antiepileptic drug of the invention has these compounds as an active ingredient.
Inventors:
INOUE TSUYOSHI (JP)
SADA NAGISA (JP)
SADA NAGISA (JP)
Application Number:
PCT/JP2016/053764
Publication Date:
August 18, 2016
Filing Date:
February 09, 2016
Export Citation:
Assignee:
NAT UNIV CORP OKAYAMA UNIV (JP)
International Classes:
A61K31/36; A61P25/08; A61P43/00
Domestic Patent References:
| WO2014115764A1 | 2014-07-31 |
Foreign References:
| JP2013510106A | 2013-03-21 | |||
| US4209517A | 1980-06-24 | |||
| US20130079336A1 | 2013-03-28 |
Other References:
LIU, XI ET AL.: "Inhibition of endothelin A receptor protects brain microvascular endothelial cells against hypoxia-induced injury", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 34, no. 1, 2014, pages 313 - 320, XP055473006
BAXENDALE, S. ET AL.: "Identification of compounds with anti-convulsant properties in a zebrafish model of epileptic seizures", DISEASE MODELS & MECHANISMS, vol. 5, no. 6, 2012, pages 773 - 784, XP055473006
AUKUNURU, J. ET AL.: "Synthesis of novel piperonal derivatives and evaluation of their anticonvulsant activity using a nanoparticular formulation", INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND NANOTECHNOLOGY, vol. 2, no. 1, 2009, pages 435 - 442, XP055473057
WANG, S. ET AL.: "Chemical structure- physiological activity relationship in cinnamamides and their analogs. III. Relationship between chemical structure and anticonvulsant action", BEIJING YIXUEYUAN XUEBAO, vol. 14, no. 1, 1982, pages 65 - 70, XP008172426
ZHANG, XIAO-HUI ET AL.: "Relation between chemical structure and physiological activity in cinnamamides and their analogs. I. Study on anticonvulsant activity", BEIJING YIXUEYUAN XUEBAO, vol. 12, no. 2, 1980, pages 83 - 91, XP009505328
SADA, N. ET AL.: "Targeting LDH enzymes with a stiripentol analog to treat epilepsy", SCIENCE, vol. 437, March 2015 (2015-03-01), pages 1362 - 1367, XP055473066
BAXENDALE, S. ET AL.: "Identification of compounds with anti-convulsant properties in a zebrafish model of epileptic seizures", DISEASE MODELS & MECHANISMS, vol. 5, no. 6, 2012, pages 773 - 784, XP055473006
AUKUNURU, J. ET AL.: "Synthesis of novel piperonal derivatives and evaluation of their anticonvulsant activity using a nanoparticular formulation", INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND NANOTECHNOLOGY, vol. 2, no. 1, 2009, pages 435 - 442, XP055473057
WANG, S. ET AL.: "Chemical structure- physiological activity relationship in cinnamamides and their analogs. III. Relationship between chemical structure and anticonvulsant action", BEIJING YIXUEYUAN XUEBAO, vol. 14, no. 1, 1982, pages 65 - 70, XP008172426
ZHANG, XIAO-HUI ET AL.: "Relation between chemical structure and physiological activity in cinnamamides and their analogs. I. Study on anticonvulsant activity", BEIJING YIXUEYUAN XUEBAO, vol. 12, no. 2, 1980, pages 83 - 91, XP009505328
SADA, N. ET AL.: "Targeting LDH enzymes with a stiripentol analog to treat epilepsy", SCIENCE, vol. 437, March 2015 (2015-03-01), pages 1362 - 1367, XP055473066
Attorney, Agent or Firm:
SSINPAT PATENT FIRM (JP)
Patent business corporation SSINPAT (JP)
Patent business corporation SSINPAT (JP)
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