Title:
LIGANDS TO ENHANCE CELLULAR UPTAKE OF BIOMOLECULES
Document Type and Number:
WIPO Patent Application WO2003067209
Kind Code:
A3
Abstract:
The present invention relates to the design and synthesis of homogeneous A-L-P constructs, which contain a hepatic ligand to direct an oligomer or "payload" to a heptatocyte intracellularly via a receptor-mediated, ligand-directed pathway.
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Inventors:
TS O PAUL O P (US)
DUFF ROBERT (US)
ZHOU YUANZHONG (US)
DEAMOND SCOTT (US)
ROBY CLINTON (US)
DUFF ROBERT (US)
ZHOU YUANZHONG (US)
DEAMOND SCOTT (US)
ROBY CLINTON (US)
Application Number:
PCT/US2002/019908
Publication Date:
November 27, 2003
Filing Date:
June 21, 2002
Export Citation:
Assignee:
CELL WORKS INC (US)
UNIV JOHNS HOPKINS (US)
TS O PAUL O P (US)
DUFF ROBERT (US)
ZHOU YUANZHONG (US)
DEAMOND SCOTT (US)
ROBY CLINTON (US)
UNIV JOHNS HOPKINS (US)
TS O PAUL O P (US)
DUFF ROBERT (US)
ZHOU YUANZHONG (US)
DEAMOND SCOTT (US)
ROBY CLINTON (US)
International Classes:
A61K31/7088; C12N15/09; A61K47/48; A61P1/16; A61P31/12; C07H15/18; C07H21/00; C12N15/11; (IPC1-7): C07K16/00
Foreign References:
| US5994517A | 1999-11-30 |
Other References:
HANGELAND ET AL.: "Cell-type specific and ligand specific enhancement of cellular uptake of oligodeoxynucleoside methylphosphonates covalently linked with a neoglycopeptide YEE (ah-GalNAc)3", BIOCONJUGATE CHEMISTRY, vol. 6, 1995, pages 695 - 701, XP002231915
ALT ET AL.: "Specific inhibition of hepatitis C viral gene expression by antisense phosphorothioate oligodeoxynucleotides", HEPATOLOGY, vol. 22, 1995, pages 707 - 717, XP000603288
KORBA ET AL.: "Antisense oligonucleotides are effective inhibitors of hepatitis B virus replication in vitro", ANTIVIRAL RESEARCH, vol. 28, 1995, pages 225 - 242, XP000603334
CHEN ET AL.: "Specific inhibition of delta antigen by in vitro system by antisense oligodeoxynucleotide: implication for translation mechanism and treatment", JOURNAL OF VIROLOGICAL METHODS, vol. 65, 1997, pages 183 - 189, XP002969197
ALT ET AL.: "Specific inhibition of hepatitis C viral gene expression by antisense phosphorothioate oligodeoxynucleotides", HEPATOLOGY, vol. 22, 1995, pages 707 - 717, XP000603288
KORBA ET AL.: "Antisense oligonucleotides are effective inhibitors of hepatitis B virus replication in vitro", ANTIVIRAL RESEARCH, vol. 28, 1995, pages 225 - 242, XP000603334
CHEN ET AL.: "Specific inhibition of delta antigen by in vitro system by antisense oligodeoxynucleotide: implication for translation mechanism and treatment", JOURNAL OF VIROLOGICAL METHODS, vol. 65, 1997, pages 183 - 189, XP002969197
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