Title:
LIPID DROPLET TARGETED FLUORESCENT DYE, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/199140
Kind Code:
A1
Abstract:
Disclosed are a lipid droplet targeted fluorescent dye, and a preparation method therefor and the use thereof, the method involving subjecting 1,3-bis(dicyanomethylidene)indan and 4-[bis(4-methylphenyl)amino]benzaldehyde to a simple reaction, followed by recrystallization and purification to obtain pure 2,2'-(2-(4-(di-p-tolylamino)benzylidene)-1H-indene-1,3(2H)-dialkylene)dimethyl nitrile. The preparation method is simple, allows the product to be obtained in one step with almost no by-products, is high in efficiency, is low in cost, and has potential in terms of large-scale preparation; and the prepared lipid droplet targeted fluorescent dye can be used for monitoring the dynamic change in lipid droplets in cells and can be used for distinguishing immune cells from tumor cells.
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Inventors:
ZHANG PENGFEI (CN)
XU XIULI (CN)
CAI LINTAO (CN)
GONG PING (CN)
LUO YUAN (CN)
XU XIULI (CN)
CAI LINTAO (CN)
GONG PING (CN)
LUO YUAN (CN)
Application Number:
PCT/CN2021/137756
Publication Date:
September 29, 2022
Filing Date:
December 14, 2021
Export Citation:
Assignee:
SHENZHEN INST ADV TECH (CN)
International Classes:
C09B23/04; C09B23/14; C09K11/06; G01N21/64
Domestic Patent References:
| WO2011118578A1 | 2011-09-29 |
Foreign References:
| CN113045908A | 2021-06-29 | |||
| CN110283586A | 2019-09-27 |
Other References:
ZHANG ZHIJUN, XU WENHAN, KANG MIAOMIAO, WEN HAIFEI, GUO HENG, ZHANG PENGFEI, XI LEI, LI KAI, WANG LEI, WANG DONG, TANG BEN ZHONG: "An All‐Round Athlete on the Track of Phototheranostics: Subtly Regulating the Balance between Radiative and Nonradiative Decays for Multimodal Imaging‐Guided Synergistic Therapy", ADVANCED MATERIALS, VCH PUBLISHERS, DE, DE , pages 2003210, XP055969775, ISSN: 0935-9648, DOI: 10.1002/adma.202003210
LI, X. ; KIM, S.H. ; SON, Y.A.: "Optical properties of donor-@p-(acceptor)"n merocyanine dyes with dicyanovinylindane as acceptor group and triphenylamine as donor unit", DYES AND PIGMENTS, ELSEVIER APPLIED SCIENCE PUBLISHERS BARKING, GB, vol. 82, no. 3, 1 September 2009 (2009-09-01), GB , pages 293 - 298, XP026021565, ISSN: 0143-7208, DOI: 10.1016/j.dyepig.2008.12.014
LI, X. ; KIM, S.H. ; SON, Y.A.: "Optical properties of donor-@p-(acceptor)"n merocyanine dyes with dicyanovinylindane as acceptor group and triphenylamine as donor unit", DYES AND PIGMENTS, ELSEVIER APPLIED SCIENCE PUBLISHERS BARKING, GB, vol. 82, no. 3, 1 September 2009 (2009-09-01), GB , pages 293 - 298, XP026021565, ISSN: 0143-7208, DOI: 10.1016/j.dyepig.2008.12.014
Attorney, Agent or Firm:
BEIJING ZHONG XUN TONG DA INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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