Title:
LIPID MEMBRANE STRUCTURE WITH NUCLEAR TRANSFERABILITY
Document Type and Number:
WIPO Patent Application WO/2011/132713
Kind Code:
A1
Abstract:
Disclosed is a lipid membrane structure that can effectively deliver nucleic acid into a nucleus of immune cells such as dendritic cells. Specifically disclosed is a lipid membrane structure for delivering matter into a cell nucleus that has been modified with a polypeptide with an activity of promoting the transfer of lipid membrane structures into the cell nucleus, wherein the lipid membrane is a polypeptide from an amino acid sequence represented by (a) SEQ ID No. 1 and/or a polypeptide from an amino acid sequence represented by (b) SEQ ID No. 1 wherein one or several amino acids have been deleted and/or substituted and/or inserted.
Inventors:
HARASHIMA HIDEYOSHI
AKITA HIDETAKA
SHARIF MOHAMMAD SHAHEEN
NAKAMURA TAKASHI
ISHII SOICHIRO
FUTAKI SHIROH
AKITA HIDETAKA
SHARIF MOHAMMAD SHAHEEN
NAKAMURA TAKASHI
ISHII SOICHIRO
FUTAKI SHIROH
Application Number:
PCT/JP2011/059738
Publication Date:
October 27, 2011
Filing Date:
April 20, 2011
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
UNIV KYOTO (JP)
HARASHIMA HIDEYOSHI
AKITA HIDETAKA
SHARIF MOHAMMAD SHAHEEN
NAKAMURA TAKASHI
ISHII SOICHIRO
FUTAKI SHIROH
UNIV KYOTO (JP)
HARASHIMA HIDEYOSHI
AKITA HIDETAKA
SHARIF MOHAMMAD SHAHEEN
NAKAMURA TAKASHI
ISHII SOICHIRO
FUTAKI SHIROH
International Classes:
A61K9/127; A61K31/711; A61K38/00; A61K47/24; A61K47/34; A61K47/42; A61K48/00; A61P35/00; C07K14/00; C12N15/00
Domestic Patent References:
| WO2005032593A1 | 2005-04-14 | |||
| WO2008105178A1 | 2008-09-04 | |||
| WO2005032593A1 | 2005-04-14 | |||
| WO2006101201A1 | 2006-09-28 | |||
| WO2007102481A1 | 2007-09-13 |
Foreign References:
| JP2007508846A | 2007-04-12 | |||
| JP2002316997A | 2002-10-31 | |||
| JP2006028030A | 2006-02-02 | |||
| JP2006028030A | 2006-02-02 | |||
| JPH01249717A | 1989-10-05 | |||
| JPH02149512A | 1990-06-08 | |||
| JPH04346918A | 1992-12-02 | |||
| JP2004010481A | 2004-01-15 | |||
| JP2890316B2 | 1999-05-10 | |||
| JP2007314526A | 2007-12-06 | |||
| JP2003343857A | 2003-12-03 |
Other References:
MIN, S.H. ET AL.: "A composite gene delivery system consisting of polyethylenimine and an amphipathic peptide KALA", J GENE MED, vol. 8, no. 12, 2006, pages 1425 - 1434, XP055098238
TOMOYUKI KAKUDO ET AL.: "Controlled Intracellular Trafficking Using Plasma and Endosomal Membrane Interactive Peptides", MEMBRANE, vol. 28, no. 2, 2003, pages 46 - 54
SHOKO KOBAYASHI ET AL.: "Tanpakushitsu no Kakusotatsu o Mezashita Cation-sei Shishitsu/ pH Kanjusei Peptide-kei no Riyo", ABSTRACTS OF ANNUAL MEETING OF PHARMACEUTICAL SOCIETY OF JAPAN, vol. 128TH, no. 3, 2008, pages 22
HIDETAKA AKITA ET AL.: "Dai 4 Sho Idenshi Donyu no Tameno Saibo Seibutsu Igaku to sono Kanren Gijutsu, 8. Saibo-nai Traffic", GENE & MEDICINE MOOK, 2006, pages 228 - 234
SHAHEEN SHARIF MOHAMMAD ET AL.: "MHC Class-I mediated antigen presentation by a KALA modified T-MEND vector expressing a high luciferase activity in murine derived dendritic cells (JAWS-II)", DRUG DELIVERLY SYSTEM, vol. 25, no. 3, May 2010 (2010-05-01), pages 310
DRUG DELIVERY SYSTEM, vol. 22-2, 2007, pages 115 - 122
BIOCHEMISTRY, vol. 26, 1987, pages 2964 - 2972
BIOCHEMISTRY, vol. 43, 2004, pages 5618 - 5623
JOURNAL OF CONTROLLED RELEASE, vol. 98, 2004, pages 317 - 323
BIOCHEMISTRY, vol. 36, 1997, pages 3008 - 3017
BIOOR. MED. CHEM., vol. 5, 1997, pages 1883 - 1891
POLYMER JOURNAL, vol. 22, 1990, pages 355 - 360
"STEALTH LIPOSOME", CRC PRESS, INC., pages: 233 - 244
BIOCHEMISTRY, vol. 46, 2007, pages 13490 - 13504
THE JOURNAL OF GENE MEDICINE, vol. 10, 2008, pages 1134 - 1149
FUTAKI, S. ET AL., BIOCONJUG. CHEM., vol. 12, no. 6, 2001, pages 1005 - 1011
BIOCHEMISTRY, vol. 43, 2004, pages 5618 - 5628
J. CONTROL. RELEASE, vol. 131, 2008, pages 137 - 144
NAKAMURA, T. ET AL., MOL. THER., vol. 16, 2008, pages 1507 - 1514
See also references of EP 2572706A4
TOMOYUKI KAKUDO ET AL.: "Controlled Intracellular Trafficking Using Plasma and Endosomal Membrane Interactive Peptides", MEMBRANE, vol. 28, no. 2, 2003, pages 46 - 54
SHOKO KOBAYASHI ET AL.: "Tanpakushitsu no Kakusotatsu o Mezashita Cation-sei Shishitsu/ pH Kanjusei Peptide-kei no Riyo", ABSTRACTS OF ANNUAL MEETING OF PHARMACEUTICAL SOCIETY OF JAPAN, vol. 128TH, no. 3, 2008, pages 22
HIDETAKA AKITA ET AL.: "Dai 4 Sho Idenshi Donyu no Tameno Saibo Seibutsu Igaku to sono Kanren Gijutsu, 8. Saibo-nai Traffic", GENE & MEDICINE MOOK, 2006, pages 228 - 234
SHAHEEN SHARIF MOHAMMAD ET AL.: "MHC Class-I mediated antigen presentation by a KALA modified T-MEND vector expressing a high luciferase activity in murine derived dendritic cells (JAWS-II)", DRUG DELIVERLY SYSTEM, vol. 25, no. 3, May 2010 (2010-05-01), pages 310
DRUG DELIVERY SYSTEM, vol. 22-2, 2007, pages 115 - 122
BIOCHEMISTRY, vol. 26, 1987, pages 2964 - 2972
BIOCHEMISTRY, vol. 43, 2004, pages 5618 - 5623
JOURNAL OF CONTROLLED RELEASE, vol. 98, 2004, pages 317 - 323
BIOCHEMISTRY, vol. 36, 1997, pages 3008 - 3017
BIOOR. MED. CHEM., vol. 5, 1997, pages 1883 - 1891
POLYMER JOURNAL, vol. 22, 1990, pages 355 - 360
"STEALTH LIPOSOME", CRC PRESS, INC., pages: 233 - 244
BIOCHEMISTRY, vol. 46, 2007, pages 13490 - 13504
THE JOURNAL OF GENE MEDICINE, vol. 10, 2008, pages 1134 - 1149
FUTAKI, S. ET AL., BIOCONJUG. CHEM., vol. 12, no. 6, 2001, pages 1005 - 1011
BIOCHEMISTRY, vol. 43, 2004, pages 5618 - 5628
J. CONTROL. RELEASE, vol. 131, 2008, pages 137 - 144
NAKAMURA, T. ET AL., MOL. THER., vol. 16, 2008, pages 1507 - 1514
See also references of EP 2572706A4
Attorney, Agent or Firm:
SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)
Patent business corporation patent firm Sykes (JP)
Download PDF:
Claims:
Previous Patent: NOVEL HYDROXAMIC ACID DERIVATIVE
Next Patent: EJECTION TOOL AND FILLING METHOD FOR FILLING MATERIAL FOR EJECTION TOOL
Next Patent: EJECTION TOOL AND FILLING METHOD FOR FILLING MATERIAL FOR EJECTION TOOL