Title:
LIPID NANOPARTICLE COMPLEX CAPTURING APTIDE FUSED WITH CELL-PENETRATING MATERIAL AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/241925
Kind Code:
A1
Abstract:
The present invention relates to a lipid nanoparticle complex capturing an aptide fused with cell-penetrating materials, and a use thereof. Specifically, the lipid nanoparticle complex according to the present invention comprises long and short chain phospholipids and captures an aptide fused with cell-penetrating materials. Particularly, when the long and short chain phospholipids are included at a specific molar ratio, the lipid nanoparticle complex exhibits a discoid structure. Further, compared with treatment with aptide alone, the lipid nanoparticle complex in which aptide for STAT protein is captured as aptide is excellent in cell or skin cell permeability and can deliver the aptide to the dermal layer to exhibit a therapeutic effect on psoriasis without side effects, and suppresses the expression of fibrosis-related genes upregulated by TGF-β. Therefore, the lipid nanoparticle complex according to the present invention can be useful as a transporter of various aptides.
Inventors:
JON SANGYONG (KR)
KIM JIN YONG (KR)
KEUM HYEONGSEOP (KR)
KIM JINJOO (KR)
KIM JIN YONG (KR)
KEUM HYEONGSEOP (KR)
KIM JINJOO (KR)
Application Number:
PCT/KR2019/006474
Publication Date:
December 03, 2020
Filing Date:
May 30, 2019
Export Citation:
Assignee:
KOREA ADVANCED INST SCI & TECH (KR)
International Classes:
A61K9/51; A61K8/02; A61K8/55; A61K8/64; A61K47/24; A61K47/62; A61P17/06; A61Q19/00
Domestic Patent References:
| WO2009059425A1 | 2009-05-14 |
Foreign References:
| KR20190099827A | 2019-08-28 |
Other References:
KIM, J. Y. ET AL.: "Nanoparticle-assisted transcutaneous delivery of a signal transducer and activator of transcription 3-inhibiting peptide ameliorates psoriasis-like skin inflammation", ACS NANO, vol. 12, 27 June 2018 (2018-06-27), pages 6904 - 6916, XP055770158
KIM, D. ET AL.: "A specific STAT3-binding peptide exerts antiproliferative effects and antitumor activity by inhibiting STAT3 phosphorylation and signaling", CANCER RESEARCH, vol. 74, no. 8, 27 February 2014 (2014-02-27), pages 2144 - 2151, XP055770159
BADENHORST, T. ET AL.: "Pharmaceutical Strategies for the Topical Dermal Delivery of Peptides/Proteins for Cosmetic and Therapeutic Applications", AUSTIN JOURNAL OF PHARMACOLOGY THERAPEUTICS, vol. 2, no. 6, 2014, pages 1 - 10, XP055381624
SANO, S. ET AL.: "Stat 3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model", NATURE MEDICINE, vol. 11, no. 1, 12 December 2004 (2004-12-12), pages 43 - 49, XP002560119, DOI: 10.1038/nm1162
KIM, D. ET AL.: "A specific STAT3-binding peptide exerts antiproliferative effects and antitumor activity by inhibiting STAT3 phosphorylation and signaling", CANCER RESEARCH, vol. 74, no. 8, 27 February 2014 (2014-02-27), pages 2144 - 2151, XP055770159
BADENHORST, T. ET AL.: "Pharmaceutical Strategies for the Topical Dermal Delivery of Peptides/Proteins for Cosmetic and Therapeutic Applications", AUSTIN JOURNAL OF PHARMACOLOGY THERAPEUTICS, vol. 2, no. 6, 2014, pages 1 - 10, XP055381624
SANO, S. ET AL.: "Stat 3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model", NATURE MEDICINE, vol. 11, no. 1, 12 December 2004 (2004-12-12), pages 43 - 49, XP002560119, DOI: 10.1038/nm1162
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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