Title:
LIPID NANOPARTICLE
Document Type and Number:
WIPO Patent Application WO/2020/262150
Kind Code:
A1
Abstract:
This lipid nanoparticle serving as a gene delivery carrier capable of performing selective delivery to spleen contains DODAP (1,2-dioleoyl-3-dimethylaminopropane) and DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine). The ratio of DODAP content to the total content of DODAP and DOPE is 10-75 mol%, and the ratio of the total content of DODAP and DOPE to the total amount of lipid constituting the lipid nanoparticle is 60-88 mol%.
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Inventors:
HARASHIMA HIDEYOSHI (JP)
IBRAHEEM IKRAMY ABDELRAHEEM KHALIL (JP)
KIMURA SEIGO (JP)
IBRAHEEM IKRAMY ABDELRAHEEM KHALIL (JP)
KIMURA SEIGO (JP)
Application Number:
PCT/JP2020/023773
Publication Date:
December 30, 2020
Filing Date:
June 17, 2020
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
A61K9/107; A61K48/00; A61K9/127; A61K31/7088; A61K47/18; A61K47/24; A61K47/28; A61K47/34
Foreign References:
| JP2014523411A | 2014-09-11 | |||
| JP2013245190A | 2013-12-09 | |||
| US5660855A | 1997-08-26 |
Other References:
OBERLI, MA ET AL.: "Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy", NANO LETTERS, vol. 17, no. 3, 2017, pages 1326 - 1335, XP055614115, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.6b03329
Attorney, Agent or Firm:
NISHIZAWA Kazuyoshi et al. (JP)
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