LIPID PARTICLE AND NUCLEIC ACID DELIVERY CARRIER

WIPO Patent Application WO/2016/010110

A1

The present invention addresses the problem of providing a lipid particle, said lipid particle having a low cytotoxicity, being capable of stably holding a nucleic acid molecule outside a cell and being capable of escaping from an endosome and quickly releasing the nucleic acid in cytoplasm, and a nucleic acid delivery carrier. Provided are: a lipid particle that comprises a compound represented by general formula (1), at least one kind of lipid selected from the group consisting of a sterol, a neutral lipid and a lipid having a polyethylene glycol chain and a nucleic acid; and a nucleic acid delivery carrier. In general formula (1), R1 and R2 are either the same or different and represent a C10-22 alkyl group.

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NISHIKAWA NAOYUKI (JP)
OHNO MAKOTO (JP)
SUGIYAMA SUSUMU (JP)
IWAKI YOSHIHIDE (JP)

PCT/JP2015/070397

January 21, 2016

July 16, 2015

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FUJIFILM CORP (JP)

A61K31/7088; A61K9/10; A61K31/713; A61K47/22; A61K47/24; A61K47/28; A61K47/34; A61K48/00

WO1997049723A1

1997-12-31

JPH10504021A	1998-04-14
JP2013537518A	2013-10-03

TEISUKE OKANO, INTRODUCTION TO MODERN PHARMECEUTICS, 10 April 1987 (1987-04-10), pages 285 - 286, XP008183716
See also references of EP 3170503A4

SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)

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