Title:
LIQUID COMPOSITION AND COMPOSITION FOR ACTIVATING SIRTUIN
Document Type and Number:
WIPO Patent Application WO/2023/119368
Kind Code:
A1
Abstract:
Provided is a novel composition that contains nicotinamide mononucleotide and has excellent biofunctional activity. The present invention pertains to a liquid composition that contains nicotinamide mononucleotide and an aronia extract.
Inventors:
IKOMA YUUKI (JP)
YAMANE TAKUYA (JP)
YAMANE TAKUYA (JP)
Application Number:
PCT/JP2021/047040
Publication Date:
June 29, 2023
Filing Date:
December 20, 2021
Export Citation:
Assignee:
DREAM POWER INCORPORATED (JP)
International Classes:
A61K36/73; A61K31/706
Foreign References:
| CN111728211A | 2020-10-02 | |||
| CN112155186A | 2021-01-01 |
Other References:
JUN YOSHINO; KATHRYNF. MILLS; MYEONGJIN YOON; SHIN-ICHIRO IMAI;: "Nicotinamide Mononucleotide, a Key NADIntermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice", CELL METABOLISM, vol. 14, no. 4, 31 August 2011 (2011-08-31), United States , pages 528 - 536, XP028308487, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2011.08.014
NAKAGAWA, YOSHIKO; MASAKI IGARASHI, MASAOMI MIURA; YUICHIRO FUKAMI; TOSHIYA SATO; TAKANOBU SAKURAI; TAKASHI NAKAGAWA; TOSHIMASA YA: "026-5 Investigation of the effect of nicotinamide mononucleotide (NMN) oral intake on human aging", PROGRAM AND ABSTRACTS OF THE 21ST ANNUAL MEETING OF THE JAPANESE SOCIETY OF ANTI-AGING MEDICINE; JUNE 25-27, 2021, vol. 21st, 2 June 2021 (2021-06-02) - 27 June 2021 (2021-06-27), JP, pages 231, XP009547592
TSUBOTA, KAZUO : "Possibility of anti-aging by NAD-related intermediate metabolites", FOOD STYLE 21, vol. 25, no. 1, 1 January 2021 (2021-01-01), JP , pages 26 - 29, XP009547368, ISSN: 1343-9502
KIM BOHKYUNG, PARK YOUNGKI, WEGNER CASEY J., BOLLING BRADLEY W., LEE JIYOUNG: "Polyphenol-rich black chokeberry (Aronia melanocarpa) extract regulates the expression of genes critical for intestinal cholesterol flux in Caco-2 cells", THE JOURNAL OF NUTRITIONAL BIOCHEMISTRY, vol. 24, no. 9, 1 September 2013 (2013-09-01), AMSTERDAM, NL , pages 1564 - 1570, XP093075166, ISSN: 0955-2863, DOI: 10.1016/j.jnutbio.2013.01.005
PLATONOVA ELENA Y.; SHAPOSHNIKOV MIKHAIL V.; LEE HYE-YEON; LEE JI-HYEON; MIN KYUNG-JIN; MOSKALEV ALEXEY: "Black chokeberry (Aronia melanocarpa) extracts in terms of geroprotector criteria", TRENDS IN FOOD SCIENCE & TECHNOLOGY, vol. 114, 13 June 2021 (2021-06-13), GB , pages 570 - 584, XP086685758, ISSN: 0924-2244, DOI: 10.1016/j.tifs.2021.06.020
WEI JIE, ZHANG GUOKUN, ZHANG XIAO, XU DEXIN, GAO JUN, FAN JUNGANG, ZHOU ZHIQUAN: "Anthocyanins from Black Chokeberry ( Aroniamelanocarpa Elliot) Delayed Aging-Related Degenerative Changes of Brain", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 65, no. 29, 26 July 2017 (2017-07-26), US , pages 5973 - 5984, XP093075169, ISSN: 0021-8561, DOI: 10.1021/acs.jafc.7b02136
ZHAO YINGCHUN, LIU XINGLONG, ZHENG YINAN, LIU WENCONG, DING CHUANBO: "Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota", SCIENTIFIC REPORTS, vol. 11, no. 1, 1 January 2021 (2021-01-01), pages 1 - 15, XP093075172, DOI: 10.1038/s41598-021-00071-6
NAKAGAWA, YOSHIKO; MASAKI IGARASHI, MASAOMI MIURA; YUICHIRO FUKAMI; TOSHIYA SATO; TAKANOBU SAKURAI; TAKASHI NAKAGAWA; TOSHIMASA YA: "026-5 Investigation of the effect of nicotinamide mononucleotide (NMN) oral intake on human aging", PROGRAM AND ABSTRACTS OF THE 21ST ANNUAL MEETING OF THE JAPANESE SOCIETY OF ANTI-AGING MEDICINE; JUNE 25-27, 2021, vol. 21st, 2 June 2021 (2021-06-02) - 27 June 2021 (2021-06-27), JP, pages 231, XP009547592
TSUBOTA, KAZUO : "Possibility of anti-aging by NAD-related intermediate metabolites", FOOD STYLE 21, vol. 25, no. 1, 1 January 2021 (2021-01-01), JP , pages 26 - 29, XP009547368, ISSN: 1343-9502
KIM BOHKYUNG, PARK YOUNGKI, WEGNER CASEY J., BOLLING BRADLEY W., LEE JIYOUNG: "Polyphenol-rich black chokeberry (Aronia melanocarpa) extract regulates the expression of genes critical for intestinal cholesterol flux in Caco-2 cells", THE JOURNAL OF NUTRITIONAL BIOCHEMISTRY, vol. 24, no. 9, 1 September 2013 (2013-09-01), AMSTERDAM, NL , pages 1564 - 1570, XP093075166, ISSN: 0955-2863, DOI: 10.1016/j.jnutbio.2013.01.005
PLATONOVA ELENA Y.; SHAPOSHNIKOV MIKHAIL V.; LEE HYE-YEON; LEE JI-HYEON; MIN KYUNG-JIN; MOSKALEV ALEXEY: "Black chokeberry (Aronia melanocarpa) extracts in terms of geroprotector criteria", TRENDS IN FOOD SCIENCE & TECHNOLOGY, vol. 114, 13 June 2021 (2021-06-13), GB , pages 570 - 584, XP086685758, ISSN: 0924-2244, DOI: 10.1016/j.tifs.2021.06.020
WEI JIE, ZHANG GUOKUN, ZHANG XIAO, XU DEXIN, GAO JUN, FAN JUNGANG, ZHOU ZHIQUAN: "Anthocyanins from Black Chokeberry ( Aroniamelanocarpa Elliot) Delayed Aging-Related Degenerative Changes of Brain", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 65, no. 29, 26 July 2017 (2017-07-26), US , pages 5973 - 5984, XP093075169, ISSN: 0021-8561, DOI: 10.1021/acs.jafc.7b02136
ZHAO YINGCHUN, LIU XINGLONG, ZHENG YINAN, LIU WENCONG, DING CHUANBO: "Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota", SCIENTIFIC REPORTS, vol. 11, no. 1, 1 January 2021 (2021-01-01), pages 1 - 15, XP093075172, DOI: 10.1038/s41598-021-00071-6
Attorney, Agent or Firm:
FUKAMI PATENT OFFICE, P.C. (JP)
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