Title:
LIVE ATTENUATED CHIMERIC PORCINE CIRCOVIRUS VACCINE
Document Type and Number:
WIPO Patent Application WO/2011/116094
Kind Code:
A3
Abstract:
The present invention provides a novel chimeric porcine circovirus infectious DNA clone and live attenuated chimeric virus with the PCV2, preferably of subtype PCV2b, capsid gene integrated into a non-pathogenic PCV1 virus genome. In a particular embodiment, the PCV2 capids gene is of subtype PCV2b, the predominant subtype circulating in pigs worldwide. The attenuated chimeric virus, designated PCVl-2b, effectively protects pigs from PCV2b challenges, and can be used as a live vaccine, as well as an inactivated (killed) vaccine, that provides protection and cross protection against PCV2b and PCV2a subtypes infection. The live attenuated vaccine of the present invention is also effective protecting pigs from porcine circovirus-associated disease (PCVAD).
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Inventors:
MENG XIANG-JIN (US)
BEACH NATHAN (US)
RAMAMOORTHY SHEELA (US)
BEACH NATHAN (US)
RAMAMOORTHY SHEELA (US)
Application Number:
PCT/US2011/028665
Publication Date:
April 19, 2012
Filing Date:
March 16, 2011
Export Citation:
Assignee:
VIRGINIA TECH INTELL PROP (US)
MENG XIANG-JIN (US)
BEACH NATHAN (US)
RAMAMOORTHY SHEELA (US)
MENG XIANG-JIN (US)
BEACH NATHAN (US)
RAMAMOORTHY SHEELA (US)
International Classes:
C12N15/34; A61K39/12; A61P31/20; C07K14/01; C12N7/04; C12N15/62
Foreign References:
| US20090017064A1 | 2009-01-15 | |||
| US20100055122A1 | 2010-03-04 | |||
| US20090221018A1 | 2009-09-03 | |||
| US20090162398A1 | 2009-06-25 |
Other References:
KYLE P. HORLEN ET AL.: "A cluster of farms experiencing severe porcine circovirus associated disease: Clinical features and association with the PCV2b genotype.", JOURNAL OF SWINE HEALTH AND PRODUCTION., vol. 15, no. 5, 2007, pages 270 - 278, XP008162432
M. FENAUX ET AL.: "A Chimeric Porcine Circovirus (PCV) with the Immunogenic Capsid Gene of the Pathogenic PCV Type 2 (PCV2) Cloned into the Genomic Backbone of the Nonpathogenic PCV1 Induces Protective Immunity against PCV2 Infection in Pigs.", JOURNAL OF VIROLOGY., vol. 78, no. 12, 2004, pages 6297 - 6303, XP008039321
M. FENAUX ET AL.: "Immunogenicity and Pathogenicity of Chimeric Infectious DNA Clones of Pathogenic Porcine Circovirus Type 2 (PCV2) and Nonpathogenic PCV1 in Weanling Pigs.", JOURNAL OF VIROLOGY., vol. 77, no. 20, 2003, pages 11232 - 11243, XP002359218
M. FENAUX ET AL.: "A Chimeric Porcine Circovirus (PCV) with the Immunogenic Capsid Gene of the Pathogenic PCV Type 2 (PCV2) Cloned into the Genomic Backbone of the Nonpathogenic PCV1 Induces Protective Immunity against PCV2 Infection in Pigs.", JOURNAL OF VIROLOGY., vol. 78, no. 12, 2004, pages 6297 - 6303, XP008039321
M. FENAUX ET AL.: "Immunogenicity and Pathogenicity of Chimeric Infectious DNA Clones of Pathogenic Porcine Circovirus Type 2 (PCV2) and Nonpathogenic PCV1 in Weanling Pigs.", JOURNAL OF VIROLOGY., vol. 77, no. 20, 2003, pages 11232 - 11243, XP002359218
Attorney, Agent or Firm:
GREENBAUM, Michael, C. (600 New Hampshire Ave. N, Washington DC, US)
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