Title:
LSD1-SELECTIVE INHIBITOR HAVING LYSINE STRUCTURE
Document Type and Number:
WIPO Patent Application WO/2014/084298
Kind Code:
A1
Abstract:
The present invention mainly addresses the problem of providing a novel compound having a LSD1-selective inhibitory activity and also having an anti—tumor/anti-cancer activity, an anti-virus activity and the like.
As a means for solving the problem, a compound represented by formula (I) or a pharmaceutically acceptable salt thereof is provided.
[In the formula, R1 to R5, A, and *1 to *3 are as defined in the description.]
Inventors:
SUZUKI TAKAYOSHI (JP)
ITOH YUKIHIRO (JP)
OGASAWARA DAISUKE (JP)
MIYATA NAOKI (JP)
MIZUKAMI TAMIO (JP)
SASAKI RYUZO (JP)
TAKAORI AKIFUMI (JP)
KAWAHARA MASAHIRO (JP)
ITOH YUKIHIRO (JP)
OGASAWARA DAISUKE (JP)
MIYATA NAOKI (JP)
MIZUKAMI TAMIO (JP)
SASAKI RYUZO (JP)
TAKAORI AKIFUMI (JP)
KAWAHARA MASAHIRO (JP)
Application Number:
PCT/JP2013/082011
Publication Date:
June 05, 2014
Filing Date:
November 28, 2013
Export Citation:
Assignee:
KYOTO PREFECTURAL PUBLIC UNIV CORP (JP)
PUBLIC UNIV CORP NAGOYA CITY UNIV (JP)
EDUCATIONAL CORP KANSAI BUNRI SOUGOUGAKUEN (JP)
FRONTIER PHARMA INC (JP)
UNIV KYOTO (JP)
PUBLIC UNIV CORP NAGOYA CITY UNIV (JP)
EDUCATIONAL CORP KANSAI BUNRI SOUGOUGAKUEN (JP)
FRONTIER PHARMA INC (JP)
UNIV KYOTO (JP)
International Classes:
C07C237/06; A61K31/165; A61K31/166; A61K31/27; A61K31/495; A61P35/00; A61P35/02; A61P43/00; C07D295/18
Domestic Patent References:
| WO2010143582A1 | 2010-12-16 | |||
| WO2010043721A1 | 2010-04-22 | |||
| WO2010143582A1 | 2010-12-16 |
Other References:
SCHMIDT, D. M. Z. ET AL.: "TRANS-2-PHENYLCYCLOPROPYLAMINE IS A MECHANISM-BASED INACTIVATOR OF THE HISTONE DEMETHYLASE LSD1", BIOCHEMISTRY, vol. 46, 2007, pages 4408 - 4416, XP002690093
OGASAWARA,D. ET AL.: "LYSINE-SPECIFIC DEMETHYLASE 1-SELECTIVE INACTIVATORS: PROTEIN-TARGETED DRUG DELIVERY MECHANISM", ANGEWANDTE CHEMIE , INTERNATIONAL EDITION, vol. 52, no. 33, pages 8620 - 8624, XP055255288
BIOCHEMISTRY, vol. 46, 2007, pages 4408 - 4416
NATURE, vol. 437, 2005, pages 436 - 439
J. AM. CHEM. SOC, vol. 131, 2009, pages 17536 - 17537
SCHENK T ET AL., NATURE MEDICINE, vol. 18, 2012, pages 605 - 11
LIANG Y ET AL., NATURE MEDICINE, vol. 15, 2009, pages 1312 - 1317
SHI L ET AL., NAT MEDICINE, vol. 19, 2013, pages 291 - 294
See also references of EP 2927212A4
OGASAWARA,D. ET AL.: "LYSINE-SPECIFIC DEMETHYLASE 1-SELECTIVE INACTIVATORS: PROTEIN-TARGETED DRUG DELIVERY MECHANISM", ANGEWANDTE CHEMIE , INTERNATIONAL EDITION, vol. 52, no. 33, pages 8620 - 8624, XP055255288
BIOCHEMISTRY, vol. 46, 2007, pages 4408 - 4416
NATURE, vol. 437, 2005, pages 436 - 439
J. AM. CHEM. SOC, vol. 131, 2009, pages 17536 - 17537
SCHENK T ET AL., NATURE MEDICINE, vol. 18, 2012, pages 605 - 11
LIANG Y ET AL., NATURE MEDICINE, vol. 15, 2009, pages 1312 - 1317
SHI L ET AL., NAT MEDICINE, vol. 19, 2013, pages 291 - 294
See also references of EP 2927212A4
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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