Title:
THE M30 GENE FAMILY AND THE UTILIZATION THEREOF
Document Type and Number:
WIPO Patent Application WO2002021138
Kind Code:
A3
Abstract:
The invention relates to, among other things, a method for diagnosing neurodegenerative diseases. According to the invention, the concentration of a protein, which shares similarities with the protein Pellino, or of a mammal homologue of this protein or of a mutein of this protein, which, over a domain of 50 amino acids of the amino sequence thereof, shares a sequence identity of over 60 % with one of the sequences, is determined in a body sample. The invention also relates to the utilization of ligands, which bind to M30 and to the homologues thereof, and to the utilization of functional inhibitors for producing a medicament for treating neurodegenerative diseases. The invention additionally relates to a screening method for identifying and/or characterizing functional inhibitors and/or ligands of M30 or of a homologue of M30.
Inventors:
SCHNEIDER ARMIN (DE)
HIEMISCH HOLGER (DE)
ROSSNER MORITZ (DE)
KLUGMANN MATTHIAS (DE)
NAIM JOMANA (DE)
EISENHARDT GISELA (DE)
KUNER ROHINI (DE)
LANAHAN ANTHONY (US)
WORLEY PAUL (US)
SPIELVOGEL DANIELA (DE)
SCHEEK SIGRID (DE)
HIEMISCH HOLGER (DE)
ROSSNER MORITZ (DE)
KLUGMANN MATTHIAS (DE)
NAIM JOMANA (DE)
EISENHARDT GISELA (DE)
KUNER ROHINI (DE)
LANAHAN ANTHONY (US)
WORLEY PAUL (US)
SPIELVOGEL DANIELA (DE)
SCHEEK SIGRID (DE)
Application Number:
PCT/EP2001/010366
Publication Date:
March 20, 2003
Filing Date:
September 07, 2001
Export Citation:
Assignee:
AXARON BIOSCIENCE AG (DE)
SCHNEIDER ARMIN (DE)
HIEMISCH HOLGER (DE)
ROSSNER MORITZ (DE)
KLUGMANN MATTHIAS (DE)
NAIM JOMANA (DE)
EISENHARDT GISELA (DE)
KUNER ROHINI (DE)
LANAHAN ANTHONY (US)
WORLEY PAUL (US)
SPIELVOGEL DANIELA (DE)
SCHEEK SIGRID (DE)
SCHNEIDER ARMIN (DE)
HIEMISCH HOLGER (DE)
ROSSNER MORITZ (DE)
KLUGMANN MATTHIAS (DE)
NAIM JOMANA (DE)
EISENHARDT GISELA (DE)
KUNER ROHINI (DE)
LANAHAN ANTHONY (US)
WORLEY PAUL (US)
SPIELVOGEL DANIELA (DE)
SCHEEK SIGRID (DE)
International Classes:
A61P25/28; A61P35/00; G01N33/68; (IPC1-7): G01N33/68; A01K67/027; A61K48/00; A61P25/28; A61P35/00; C07K14/00; C07K16/00; C12N5/00; G01N33/574
Other References:
KRAMER GERO ET AL: "Determination of apoptotic activity in the sera of patients with hormone refractory prostate cancer by a novel M30 apoptosis assay.", EUROPEAN UROLOGY, vol. 39, no. Suppl. 5, March 2001 (2001-03-01), XVIth Congress of the European Association of Urology;Geneva, Switzerland; April 07-10, 2001, pages 80, XP009000127, ISSN: 0302-2838
LINDER S ET AL: "The M30 antibody can be used to quantitate apoptosis in breast cancer cell extracts and culture supernatants.", TUMOR BIOLOGY, vol. 21, no. Supplement 1, September 2000 (2000-09-01), 28th Meeting of the International Society for Oncodevelopmental Biology and Medicine;Munich, Germany; September 08-13, 2000, pages 30, XP001105832, ISSN: 1010-4283
DATABASE SWALL [online] XP002217749, retrieved from EBI Database accession no. O77237
DATABASE EMBL [online] XP002217750, retrieved from EBI Database accession no. AP002748
LINDER S ET AL: "The M30 antibody can be used to quantitate apoptosis in breast cancer cell extracts and culture supernatants.", TUMOR BIOLOGY, vol. 21, no. Supplement 1, September 2000 (2000-09-01), 28th Meeting of the International Society for Oncodevelopmental Biology and Medicine;Munich, Germany; September 08-13, 2000, pages 30, XP001105832, ISSN: 1010-4283
DATABASE SWALL [online] XP002217749, retrieved from EBI Database accession no. O77237
DATABASE EMBL [online] XP002217750, retrieved from EBI Database accession no. AP002748
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