Title:
METHOD OF CONSTRUCTING scDb LIBRARY
Document Type and Number:
WIPO Patent Application WO/2003/087163
Kind Code:
A1
Abstract:
By disposing restriction enzyme sites appropriately for antigen-encoding regions, a bispecific Db library can be efficiently and collectively constructed from an scFv library without resort to any troublesome procedures.
Inventors:
KOJIMA TETSUO (JP)
Application Number:
PCT/JP2003/004773
Publication Date:
October 23, 2003
Filing Date:
April 15, 2003
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
KOJIMA TETSUO (JP)
KOJIMA TETSUO (JP)
International Classes:
C07K16/00; C07K16/46; C12N15/10; (IPC1-7): C07K16/46; C12N15/09
Domestic Patent References:
| WO1993017706A1 | 1993-09-16 |
Foreign References:
| US5223409A | 1993-06-29 | |||
| US3773919A | 1973-11-20 | |||
| EP0058481A1 | 1982-08-25 | |||
| EP0133988A2 | 1985-03-13 | |||
| US4945050A | 1990-07-31 |
Other References:
MCGUINNESS B.T. ET AL.: "Phage diabody repertoires for selection of large number of bispecific antibody fragments", NATURE BIOTECHNOLOGY, vol. 14, no. 9, 1996, pages 1149 - 1154, XP002100039
DENARDO D.G. ET AL.: "Anti-HLA-DR/anti-DOTA diabody construction in modular gene design platform: bispecific antibodies for pretargeted radioimmunotherapy", CANCER BIOTHERAPY & RADIOPHARMACEUTICALS, vol. 16, no. 6, 2001, pages 525 - 535, XP008022084
ANDRIS-WIDHOPF J. ET AL.: "Methods for the generation of chicken monoclonal antibody fragments by phage display", JOURNAL OF IMMUNOLOGICAL METHODS, vol. 242, 2000, pages 159 - 181, XP004210719
TURNER D.J. ET AL.: "Importance of the linker in expression of single-chain Fv antibody fragments: optimization of peptide sequence using pohage display technology", JOURNAL OF IMMUNOLOGICAL METHODS, vol. 205, 1997, pages 43 - 54, XP004082109
TANG Y. ET AL.: "Selection of linkers for a catalytic single-chain antibody using phage display technology", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 26, 1996, pages 15682 - 15686, XP002962142
HOLLIGER P. ET AL.: "Diabodies, small bivalent and bispecific antibody fragments", PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448, XP002008022
HAMMERLING ET AL., J. EXP. MED., vol. 128, 1968, pages 1461 - 1473
SONGSIVILAI ET AL., CLIN. EXP. IMMUNOL., vol. 79, 1990, pages 315 - 321
LE DOUSSAL ET AL., INT. J. CANCER SUPPL., vol. 7, 1992, pages 58 - 62
LE DOUSSAL ET AL., J. NUCL. MED., vol. 34, 1993, pages 1662 - 1671
STICKNEY ET AL., CANCER RES., vol. 51, 1991, pages 6650 - 6655
SEGAL; SNIDER, CHEM. IMMUNOL., vol. 47, 1989, pages 179 - 213
SEGAL ET AL.: "Biologic Therapy of Cancer", vol. 2
VOLKEL ET AL., PROT. ENGINEERING, vol. 14, no. 10, 2001, pages 815 - 823
MCGUINNESS ET AL., NATURE BIOTECHNOLOGY, vol. 14, 1996, pages 1149 - 1154
NATURE, vol. 195, 1962, pages 788
THE JOURNAL OF AMERICAN MEDICAL ASSOCIATION, vol. 199, 1967, pages 519
SCIENCE, vol. 122, 1952, pages 501
VIROLOGY, vol. 8, 1959, pages 396
PROCEEDING OF THE SOCIETY FOR THE BIOLOGICAL MEDICINE, vol. 73, 1950, pages 1
DANIEL R. MARSHAK ET AL.: "Strategies for Protein Purification and Characterization: A Laboratory Course Manual", 1996, COLD SPRING HARBOR LABORATORY PRESS
HARLOW AND DAVID LANE: "Antibodies: A Laboratory Course Manual", 1988, COLD SPRING HARBOR LABORATORY PRESS
SMITH, SCIENCE, vol. 228, 1985, pages 1315
SCOTT; SMITH, SCIENCE, vol. 249, 1990, pages 386
CWIRLA ET AL., PROC. NATL. ACAD. SCI. USA, vol. 8, 1990, pages 309
DEVLIN ET AL., SCIENCE, vol. 249, 1990, pages 404
WELLS; LOWMAN, CURR. OPIN. STRUCT. BIOL., vol. 2, 1992, pages 597
OSLO: "Remington's Pharmaceutical Science 16th edition", 1980
LANGER ET AL., J. BIOMED. MATER. RES., vol. 15, 1981, pages 167 - 277
LANGER, CHEM. TECH., vol. 12, 1982, pages 98 - 105
SIDMAN ET AL., BIOPOLYMERS, vol. 22, 1983, pages 547 - 556
ADOLPH: "Virus Genome Methods", 1996, CRC PRESS
HUNTER ET AL., NATURE, vol. 144, 1962, pages 945
DAVID ET AL., BIOCHEMISTRY, vol. 13, 1974, pages 1014
PAIN ET AL., J. IMMUNOL. METH., vol. 40, 1981, pages 219
NYGEN, J. HISTOCHEM. CYTOCHEM., vol. 30, 1982, pages 407
ZOLA: "Monoclonal Antibodies: A Manual of Techniques", 1987, CRC PRESS INC., pages: 147 - 158
DENARDO D.G. ET AL.: "Anti-HLA-DR/anti-DOTA diabody construction in modular gene design platform: bispecific antibodies for pretargeted radioimmunotherapy", CANCER BIOTHERAPY & RADIOPHARMACEUTICALS, vol. 16, no. 6, 2001, pages 525 - 535, XP008022084
ANDRIS-WIDHOPF J. ET AL.: "Methods for the generation of chicken monoclonal antibody fragments by phage display", JOURNAL OF IMMUNOLOGICAL METHODS, vol. 242, 2000, pages 159 - 181, XP004210719
TURNER D.J. ET AL.: "Importance of the linker in expression of single-chain Fv antibody fragments: optimization of peptide sequence using pohage display technology", JOURNAL OF IMMUNOLOGICAL METHODS, vol. 205, 1997, pages 43 - 54, XP004082109
TANG Y. ET AL.: "Selection of linkers for a catalytic single-chain antibody using phage display technology", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 26, 1996, pages 15682 - 15686, XP002962142
HOLLIGER P. ET AL.: "Diabodies, small bivalent and bispecific antibody fragments", PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448, XP002008022
HAMMERLING ET AL., J. EXP. MED., vol. 128, 1968, pages 1461 - 1473
SONGSIVILAI ET AL., CLIN. EXP. IMMUNOL., vol. 79, 1990, pages 315 - 321
LE DOUSSAL ET AL., INT. J. CANCER SUPPL., vol. 7, 1992, pages 58 - 62
LE DOUSSAL ET AL., J. NUCL. MED., vol. 34, 1993, pages 1662 - 1671
STICKNEY ET AL., CANCER RES., vol. 51, 1991, pages 6650 - 6655
SEGAL; SNIDER, CHEM. IMMUNOL., vol. 47, 1989, pages 179 - 213
SEGAL ET AL.: "Biologic Therapy of Cancer", vol. 2
VOLKEL ET AL., PROT. ENGINEERING, vol. 14, no. 10, 2001, pages 815 - 823
MCGUINNESS ET AL., NATURE BIOTECHNOLOGY, vol. 14, 1996, pages 1149 - 1154
NATURE, vol. 195, 1962, pages 788
THE JOURNAL OF AMERICAN MEDICAL ASSOCIATION, vol. 199, 1967, pages 519
SCIENCE, vol. 122, 1952, pages 501
VIROLOGY, vol. 8, 1959, pages 396
PROCEEDING OF THE SOCIETY FOR THE BIOLOGICAL MEDICINE, vol. 73, 1950, pages 1
DANIEL R. MARSHAK ET AL.: "Strategies for Protein Purification and Characterization: A Laboratory Course Manual", 1996, COLD SPRING HARBOR LABORATORY PRESS
HARLOW AND DAVID LANE: "Antibodies: A Laboratory Course Manual", 1988, COLD SPRING HARBOR LABORATORY PRESS
SMITH, SCIENCE, vol. 228, 1985, pages 1315
SCOTT; SMITH, SCIENCE, vol. 249, 1990, pages 386
CWIRLA ET AL., PROC. NATL. ACAD. SCI. USA, vol. 8, 1990, pages 309
DEVLIN ET AL., SCIENCE, vol. 249, 1990, pages 404
WELLS; LOWMAN, CURR. OPIN. STRUCT. BIOL., vol. 2, 1992, pages 597
OSLO: "Remington's Pharmaceutical Science 16th edition", 1980
LANGER ET AL., J. BIOMED. MATER. RES., vol. 15, 1981, pages 167 - 277
LANGER, CHEM. TECH., vol. 12, 1982, pages 98 - 105
SIDMAN ET AL., BIOPOLYMERS, vol. 22, 1983, pages 547 - 556
ADOLPH: "Virus Genome Methods", 1996, CRC PRESS
HUNTER ET AL., NATURE, vol. 144, 1962, pages 945
DAVID ET AL., BIOCHEMISTRY, vol. 13, 1974, pages 1014
PAIN ET AL., J. IMMUNOL. METH., vol. 40, 1981, pages 219
NYGEN, J. HISTOCHEM. CYTOCHEM., vol. 30, 1982, pages 407
ZOLA: "Monoclonal Antibodies: A Manual of Techniques", 1987, CRC PRESS INC., pages: 147 - 158
Attorney, Agent or Firm:
Shimizu, Hatsushi (1-1-1 Oroshi-mach, Tsuchiura-shi Ibaraki, JP)
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