Title:
NEOPEPTIDES AND METHODS USEFUL FOR DETECTION AND TREATMENT OF CANCER
Document Type and Number:
WIPO Patent Application WO2003087162
Kind Code:
A3
Abstract:
The present invention relates to neopeptides and methods useful for the detection and treatment of disorders associated with frameshift mutations in coding microsatellite regions. The neopeptides and methods are applicable in cancers, especially of DNA mismatch repair deficient (MMR) sporadic tumours and HNPCC associated tumours. The neopeptides disclosed in the invention are useful for detection of disorders and in therapy such as e.g. immuno-therapy. The diagnostic methods relate to diagnosis and prognostic assessment of disorders associated with frameshift polypeptides originating from frameshift mutations in coding microsatellite regions of genes based on the detection of immunological entities directed against said frameshift polypeptides in body fluids. With respect to the treatment of cancer, especially of DNA mismatch repair deficient (MMR) sporadic tumours and HNPCC associated tumours, the invention pertains to methods which use immuno therapy with combinatorial mixtures of tumour specific frameshift peptides to elicit a cytotoxic T-cell response specifically directed against tumour cells for use in prevention as well as in curative treatment of cancers and precancers.
Inventors:
VON KNEBEL-DOEBERITZ MAGNUS (DE)
GEBERT JOHANNES (DE)
LINNEBACHER MICHAEL (DE)
WOERNER STEFAN (DE)
RIDDER RUEDIGER (DE)
BORK PEER (DE)
YUAN YAN PING (DE)
GEBERT JOHANNES (DE)
LINNEBACHER MICHAEL (DE)
WOERNER STEFAN (DE)
RIDDER RUEDIGER (DE)
BORK PEER (DE)
YUAN YAN PING (DE)
Application Number:
PCT/EP2003/004083
Publication Date:
February 05, 2004
Filing Date:
April 17, 2003
Export Citation:
Assignee:
MTM LAB AG (DE)
VON KNEBEL-DOEBERITZ MAGNUS (DE)
GEBERT JOHANNES (DE)
LINNEBACHER MICHAEL (DE)
WOERNER STEFAN (DE)
RIDDER RUEDIGER (DE)
BORK PEER (DE)
YUAN YAN PING (DE)
VON KNEBEL-DOEBERITZ MAGNUS (DE)
GEBERT JOHANNES (DE)
LINNEBACHER MICHAEL (DE)
WOERNER STEFAN (DE)
RIDDER RUEDIGER (DE)
BORK PEER (DE)
YUAN YAN PING (DE)
International Classes:
C07K14/47; (IPC1-7): C07K14/82; G01N33/48; A61K48/00; A61K38/00; C12Q1/68
Domestic Patent References:
| WO2002004664A2 | 2002-01-17 |
Other References:
DATABASE EMBL [online] 10 September 2001 (2001-09-10), NATIONAL INSTITUTES OF HEALTH: "60233245139F1 NIH_MGC_96 Homo sapiens cDNA clone IMAGE:5287496 5', mRNA sequence", XP002226919, Database accession no. BI603282
DATABASE EMBL [online] 15 March 2002 (2002-03-15), NATIONAL INSTITUTES OF HEALTH: "AGENCOURT _6621833 NIH_MGC_125 Homo sapiens cDNA clone IMAGE:5724573 5', mRNA sequence", XP002226916, Database accession no. BM906641
DATABASE EMBL [online] 8 March 2002 (2002-03-08), KIM N.S.: "K-EST0027113 S9SNU601 Homo sapiens cDNA clone S9SNU601-25-D02 5', mRNA sequence", XP002226917, Database accession no. BM751114
DATABASE EMBL [online] 11 February 2001 (2001-02-11), GENOSCOPE: "5 prime end of clone CS0DI023YL23 of library LTI_NFL006_PL2 from placenta of male Homo sapiens (human)", XP002226918, Database accession no. AL545813
DATABASE EMBL [online] 30 September 2000 (2000-09-30), NATIONAL INSTITUTES OF HEALTH: "601510256F1 NIH_MGC_71 Homo sapiens cDNA clone IMAGE:3912036 5', mRNA sequence", XP002226920, Database accession no. BE883852
LINNEBACHER M ET AL: "FRAMESHIFT PEPTIDE-DERIVED T-CELL EPITOPES: A SOURCE OF NOVEL TUMOR-SPECIFIC ANTIGENS", INTERNATIONAL JOURNAL OF CANCER, NEW YORK, NY, US, vol. 93, 6 April 2001 (2001-04-06), pages 6 - 11, XP001061478, ISSN: 0020-7136
WOERNER S M ET AL: "SYSTEMATIC IDENTIFICATION OF GENES WITH CODING MICROSATELLITES MUTATED IN DNA MISMATCH REPAIR-DEFICIENT CANCER CELLS", INTERNATIONAL JOURNAL OF CANCER, NEW YORK, NY, US, vol. 93, no. 1, 1 July 2001 (2001-07-01), pages 12 - 19, XP001083712, ISSN: 0020-7136
DI PIETRO C ET AL: "Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAFI48, TAFI63 and TAFI110 subunits of class I general transcription initiation factor SL1.", CYTOGENETICS AND CELL GENETICS, vol. 89, no. 1-2, 2000, pages 133 - 136, XP009003813, ISSN: 0301-0171
DATABASE EMBL [online] 15 March 2002 (2002-03-15), NATIONAL INSTITUTES OF HEALTH: "AGENCOURT _6621833 NIH_MGC_125 Homo sapiens cDNA clone IMAGE:5724573 5', mRNA sequence", XP002226916, Database accession no. BM906641
DATABASE EMBL [online] 8 March 2002 (2002-03-08), KIM N.S.: "K-EST0027113 S9SNU601 Homo sapiens cDNA clone S9SNU601-25-D02 5', mRNA sequence", XP002226917, Database accession no. BM751114
DATABASE EMBL [online] 11 February 2001 (2001-02-11), GENOSCOPE: "5 prime end of clone CS0DI023YL23 of library LTI_NFL006_PL2 from placenta of male Homo sapiens (human)", XP002226918, Database accession no. AL545813
DATABASE EMBL [online] 30 September 2000 (2000-09-30), NATIONAL INSTITUTES OF HEALTH: "601510256F1 NIH_MGC_71 Homo sapiens cDNA clone IMAGE:3912036 5', mRNA sequence", XP002226920, Database accession no. BE883852
LINNEBACHER M ET AL: "FRAMESHIFT PEPTIDE-DERIVED T-CELL EPITOPES: A SOURCE OF NOVEL TUMOR-SPECIFIC ANTIGENS", INTERNATIONAL JOURNAL OF CANCER, NEW YORK, NY, US, vol. 93, 6 April 2001 (2001-04-06), pages 6 - 11, XP001061478, ISSN: 0020-7136
WOERNER S M ET AL: "SYSTEMATIC IDENTIFICATION OF GENES WITH CODING MICROSATELLITES MUTATED IN DNA MISMATCH REPAIR-DEFICIENT CANCER CELLS", INTERNATIONAL JOURNAL OF CANCER, NEW YORK, NY, US, vol. 93, no. 1, 1 July 2001 (2001-07-01), pages 12 - 19, XP001083712, ISSN: 0020-7136
DI PIETRO C ET AL: "Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAFI48, TAFI63 and TAFI110 subunits of class I general transcription initiation factor SL1.", CYTOGENETICS AND CELL GENETICS, vol. 89, no. 1-2, 2000, pages 133 - 136, XP009003813, ISSN: 0301-0171
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