Title:
MACHINE PERFUSION WITH COMPLEMENT INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2012/078968
Kind Code:
A3
Abstract:
Methods for perfusing one or more organs, tissues or the like (hereinafter "organs") with a composition comprising at least one complement inhibitor to sustain, maintain or improve the viability of the organs before and/or during transplantation.
Inventors:
KRAVITZ DAVID (US)
Application Number:
PCT/US2011/064122
Publication Date:
August 02, 2012
Filing Date:
December 09, 2011
Export Citation:
Assignee:
LIFELINE SCIENT INC (US)
KRAVITZ DAVID (US)
KRAVITZ DAVID (US)
International Classes:
A01N1/02
Domestic Patent References:
| WO2000053007A1 | 2000-09-14 | |||
| WO1999015011A1 | 1999-04-01 | |||
| WO1996018293A1 | 1996-06-20 | |||
| WO2004105484A1 | 2004-12-09 |
Foreign References:
| EP0647398A1 | 1995-04-12 | |||
| US5599659A | 1997-02-04 |
Other References:
H. PATEL ET AL.: "Therapeutic strategy with a membrane-localizing complement regulator to increase the number of usable donor organs after prolonged cold storage", J. AM. SOCIETY OF NEPHROLOGY, vol. 17, April 2006 (2006-04-01), pages 1102 - 1111, XP007920688, ISSN: 1046-6673, DOI: 10.1681/ASN.2005101116
L. BERGAMASCHINI, G. GOBBO, S. GATTI, L. CACCAMO, P. PRATO, M. MAGGIONI, P. BRAIDOTTI, R. DI STEFANO AND L. R. FASSATI: "Endothelial targeting with C1-inhibitor reduces complement activation in vitro and during ex vivo reperfusion of pig liver", CLINICAL & EXPERIMENTAL IMMUNOLOGY, vol. 126, no. 3, December 2001 (2001-12-01), pages 412 - 420, XP007920689, DOI: 10.1046/j.1365-2249.2001.01695.x
KROSHUS T J ET AL: "COMPLEMENT INHIBITION WITH AN ANTI-C5 MONOCLONAL ANTIBODY PREVENTS ACUTE CARDIAC TISSUE INJURY IN AN EX VIVO MODEL OF PIG-TO-HUAMN XENOTRANSPLANTATION", TRANSPLANTATION, WILLIAMS AND WILKINS, BALTIMORE US, vol. 60, no. 11, 15 November 1995 (1995-11-15), pages 1194 - 1202, XP009057930, ISSN: 0041-1337
C. SCHRÖDER ET AL.: "Hyperacute rejection of mouse lung by human blood: characterization of the model and the role of complement", TRANSPLANTATION, vol. 76, no. 5, 15 September 2003 (2003-09-15), pages 755 - 760, XP007920690, DOI: 10.1097/01.TP.0000069836.91593.09
L. BERGAMASCHINI, G. GOBBO, S. GATTI, L. CACCAMO, P. PRATO, M. MAGGIONI, P. BRAIDOTTI, R. DI STEFANO AND L. R. FASSATI: "Endothelial targeting with C1-inhibitor reduces complement activation in vitro and during ex vivo reperfusion of pig liver", CLINICAL & EXPERIMENTAL IMMUNOLOGY, vol. 126, no. 3, December 2001 (2001-12-01), pages 412 - 420, XP007920689, DOI: 10.1046/j.1365-2249.2001.01695.x
KROSHUS T J ET AL: "COMPLEMENT INHIBITION WITH AN ANTI-C5 MONOCLONAL ANTIBODY PREVENTS ACUTE CARDIAC TISSUE INJURY IN AN EX VIVO MODEL OF PIG-TO-HUAMN XENOTRANSPLANTATION", TRANSPLANTATION, WILLIAMS AND WILKINS, BALTIMORE US, vol. 60, no. 11, 15 November 1995 (1995-11-15), pages 1194 - 1202, XP009057930, ISSN: 0041-1337
C. SCHRÖDER ET AL.: "Hyperacute rejection of mouse lung by human blood: characterization of the model and the role of complement", TRANSPLANTATION, vol. 76, no. 5, 15 September 2003 (2003-09-15), pages 755 - 760, XP007920690, DOI: 10.1097/01.TP.0000069836.91593.09
Attorney, Agent or Firm:
ARMSTRONG, Joel S. (277 South Washington StreetSuite 50, Alexandria VA, US)
Download PDF:
Previous Patent: COMPOSITIONS AND METHODS FOR INCREASING ERYTHROPOIETIN (EPO) PRODUCTION
Next Patent: METHODS AND COMPOSITIONS FOR LENS BLOCKING
Next Patent: METHODS AND COMPOSITIONS FOR LENS BLOCKING