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Title:
MACROCYCLE COMPOUNDS AS INHIBITORS OF RAS
Document Type and Number:
WIPO Patent Application WO/2023/015559
Kind Code:
A1
Abstract:
The present disclosure discloses a compound, or a pharmaceutically acceptable salt thereof having the structure of Formula (I), and pharmaceutical compositions including the same, that are inhibitors of one or more RAS proteins and are useful in the treatment of RAS-associated diseases such as cancer.

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Inventors:
ZHANG JIAN (CN)
LI YONG (CN)
ZHANG SHAOMIN (CN)
XI CAIMING (CN)
SHAO HEYAN (CN)
HE KANG (CN)
WANG LONG (CN)
Application Number:
PCT/CN2021/112499
Publication Date:
February 16, 2023
Filing Date:
August 13, 2021
Export Citation:
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Assignee:
NUTSHELL BIOTECH SHANGHAI CO LTD (CN)
International Classes:
C07D513/22; A61K31/429; A61K31/5025; A61P35/00; C07D487/12; C07D487/20; C07D491/12; C07D498/12; C07D513/12; C07D515/12; C07D519/00
Domestic Patent References:
WO2022060583A12022-03-24
WO2022060836A12022-03-24
WO2020132597A12020-06-25
WO2021091967A12021-05-14
WO2021091956A12021-05-14
WO2021091982A12021-05-14
WO2000001382A12000-01-13
Foreign References:
US6329376B12001-12-11
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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