Title:
MAGNETIC NANOPARTICLES FOR IMAGE DIAGNOSIS AND CONTRAST MEDIUM FOR IMAGE DIAGNOSIS
Document Type and Number:
WIPO Patent Application WO/2022/244680
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a contrast medium using a paramagnetic metal that accumulates at an abnormal protein deposition or aggregation site in the brain. Magnetic nanoparticles for image diagnosis which comprise magnetic iron oxide particles, gold fine particles supported on the surface of the magnetic iron oxide particles, a polymer chain attached to the gold fine particles and a molecule directing for a neurodegenerative disease-related protein and attached to at least a part of the polymer chain, and which are to be administered transnasally. These magnetic nanoparticles for image diagnosis are useful as an active ingredient of a contrast medium that accumulates at an abnormal protein deposition or aggregation site in the brain.
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Inventors:
SEINO SATOSHI (JP)
IKEHATA HIROTO (JP)
TOMIYAMA TAKAMI (JP)
UMEDA TOMOHIRO (JP)
IZAWA AKIHIRO (JP)
IKEHATA HIROTO (JP)
TOMIYAMA TAKAMI (JP)
UMEDA TOMOHIRO (JP)
IZAWA AKIHIRO (JP)
Application Number:
PCT/JP2022/020104
Publication Date:
November 24, 2022
Filing Date:
May 12, 2022
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
A61K49/18; A61K47/02; A61K47/10; A61K47/22; A61K49/08; A61K49/12
Domestic Patent References:
| WO2012176587A1 | 2012-12-27 |
Foreign References:
| JP2008266214A | 2008-11-06 |
Other References:
ZHANG SONG; GONG MINGFU; ZHANG DONG; YANG HUA; GAO FABAO; ZOU LIGUANG: "Thiol-PEG-carboxyl-stabilized Fe2O3/Au nanoparticles targeted to CD105: Synthesis, characterization and application in MR imaging of tumor angiogenesis", EUROPEAN JOURNAL OF RADIOLOGY, vol. 83, no. 7, 13 April 2014 (2014-04-13), NL , pages 1190 - 1198, XP028850102, ISSN: 0720-048X, DOI: 10.1016/j.ejrad.2014.03.034
ZENG JIAQI, WU JIAQI, LI MINGHUA, WANG PEIJUN: "A Novel Magnetic Nanoparticle for Early Detection of Amyloid Plaques in Alzheimer's Disease", ARCHIVES OF MEDICAL RESEARCH, vol. 49, no. 4, 1 May 2018 (2018-05-01), MX , pages 282 - 285, XP093007159, ISSN: 0188-4409, DOI: 10.1016/j.arcmed.2018.09.005
OKUMURA YUKI, MAYA YOSHIFUMI, ONISHI TAKAKO, SHOYAMA YOSHINARI, IZAWA AKIHIRO, NAKAMURA DAISAKU, TANIFUJI SHIGEYUKI, TANAKA AKIHIR: "Design, Synthesis, and Preliminary Evaluation of SPECT Probes for Imaging β-Amyloid in Alzheimer’s Disease Affected Brain", ACS CHEMICAL NEUROSCIENCE, vol. 9, no. 6, 20 June 2018 (2018-06-20), US , pages 1503 - 1514, XP093007161, ISSN: 1948-7193, DOI: 10.1021/acschemneuro.8b00064
ISHII, KENJI: "Clinical application of amyloid PET", PHARMA MEDICA, vol. 32, no. 1, 1 January 2014 (2014-01-01), JP , pages 243 - 252, XP009541240, ISSN: 0289-5803
LUO SHEN, MA CHI, ZHU MING-QIN, JU WEI-NA, YANG YU, WANG XU: "Application of Iron Oxide Nanoparticles in the Diagnosis and Treatment of Neurodegenerative Diseases With Emphasis on Alzheimer’s Disease", FRONTIERS IN CELLULAR NEUROSCIENCE, vol. 14, 1 January 2020 (2020-01-01), pages 1 - 11, XP093007174, DOI: 10.3389/fncel.2020.00021
SEINO, SATOSHI; IKEHATA, H.; TANABE, M.; UMEDA, T.; TOMIYAMA, T.; TANAKA, A.; SAKANE, T.; YAMAUCHI, K.; NOMURA, K.; TONOOKA, S.; I: "01aA-5 Surface design of iron-oxide nanoparticles for intracerebral magnetic particle imaging", 45TH ANNUAL CONFERENCE ON MAGNETICS IN JAPAN; AUGUST 31 - SEPTEMBER 2, 2021, vol. 45, 17 August 2021 (2021-08-17) - 2 September 2021 (2021-09-02), JP, pages 80, XP009541379, ISSN: 1882-2959
SEINO, SATOSHI: "Synthesis and evaluation of gold/iron oxide composite nanoparticles suitable for nanobio applications", THE 2014 ANNUAL MEETING RECORD I.E.E. JAPAN (IEEJ); MARCH 18-20, 2014, vol. 5, 5 March 2014 (2014-03-05), Japan, pages S12(1) - S12(4), XP009541386
KOJIMA HIROKI, MUKAI YOHEI, YOSHIKAWA MAI, KAMEI KAZUMASA, YOSHIKAWA TOMOAKI, MORITA MASAHITO, INUBUSHI TOSHIRO, YAMAMOTO TAKAO A,: "Simple PEG Conjugation of SPIO via an Au−S Bond Improves Its Tumor Targeting Potency as a Novel MR Tumor Imaging Agent", BIOCONJUGATE CHEMISTRY, vol. 21, no. 6, 16 June 2010 (2010-06-16), US , pages 1026 - 1031, XP093007181, ISSN: 1043-1802, DOI: 10.1021/bc900487p
ZENG JIAQI, WU JIAQI, LI MINGHUA, WANG PEIJUN: "A Novel Magnetic Nanoparticle for Early Detection of Amyloid Plaques in Alzheimer's Disease", ARCHIVES OF MEDICAL RESEARCH, vol. 49, no. 4, 1 May 2018 (2018-05-01), MX , pages 282 - 285, XP093007159, ISSN: 0188-4409, DOI: 10.1016/j.arcmed.2018.09.005
OKUMURA YUKI, MAYA YOSHIFUMI, ONISHI TAKAKO, SHOYAMA YOSHINARI, IZAWA AKIHIRO, NAKAMURA DAISAKU, TANIFUJI SHIGEYUKI, TANAKA AKIHIR: "Design, Synthesis, and Preliminary Evaluation of SPECT Probes for Imaging β-Amyloid in Alzheimer’s Disease Affected Brain", ACS CHEMICAL NEUROSCIENCE, vol. 9, no. 6, 20 June 2018 (2018-06-20), US , pages 1503 - 1514, XP093007161, ISSN: 1948-7193, DOI: 10.1021/acschemneuro.8b00064
ISHII, KENJI: "Clinical application of amyloid PET", PHARMA MEDICA, vol. 32, no. 1, 1 January 2014 (2014-01-01), JP , pages 243 - 252, XP009541240, ISSN: 0289-5803
LUO SHEN, MA CHI, ZHU MING-QIN, JU WEI-NA, YANG YU, WANG XU: "Application of Iron Oxide Nanoparticles in the Diagnosis and Treatment of Neurodegenerative Diseases With Emphasis on Alzheimer’s Disease", FRONTIERS IN CELLULAR NEUROSCIENCE, vol. 14, 1 January 2020 (2020-01-01), pages 1 - 11, XP093007174, DOI: 10.3389/fncel.2020.00021
SEINO, SATOSHI; IKEHATA, H.; TANABE, M.; UMEDA, T.; TOMIYAMA, T.; TANAKA, A.; SAKANE, T.; YAMAUCHI, K.; NOMURA, K.; TONOOKA, S.; I: "01aA-5 Surface design of iron-oxide nanoparticles for intracerebral magnetic particle imaging", 45TH ANNUAL CONFERENCE ON MAGNETICS IN JAPAN; AUGUST 31 - SEPTEMBER 2, 2021, vol. 45, 17 August 2021 (2021-08-17) - 2 September 2021 (2021-09-02), JP, pages 80, XP009541379, ISSN: 1882-2959
SEINO, SATOSHI: "Synthesis and evaluation of gold/iron oxide composite nanoparticles suitable for nanobio applications", THE 2014 ANNUAL MEETING RECORD I.E.E. JAPAN (IEEJ); MARCH 18-20, 2014, vol. 5, 5 March 2014 (2014-03-05), Japan, pages S12(1) - S12(4), XP009541386
KOJIMA HIROKI, MUKAI YOHEI, YOSHIKAWA MAI, KAMEI KAZUMASA, YOSHIKAWA TOMOAKI, MORITA MASAHITO, INUBUSHI TOSHIRO, YAMAMOTO TAKAO A,: "Simple PEG Conjugation of SPIO via an Au−S Bond Improves Its Tumor Targeting Potency as a Novel MR Tumor Imaging Agent", BIOCONJUGATE CHEMISTRY, vol. 21, no. 6, 16 June 2010 (2010-06-16), US , pages 1026 - 1031, XP093007181, ISSN: 1043-1802, DOI: 10.1021/bc900487p
Attorney, Agent or Firm:
TANAKA, Junya et al. (JP)
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