Title:
MALARIAL VACCINATION METHODS AND REGIMENS
Document Type and Number:
WIPO Patent Application WO/2019/140136
Kind Code:
A1
Abstract:
Compositions, methods, and regimens for vaccinating subjects against malaria parasites are provided herein. The compositions include first and second compositions having priming and/or trapping components. The priming components include, but are not limited to, DNA or RNA polynucleotides, and the trapping components include, but are not limited to, DNA or RNA polynucleotides, one or more attenuated sporozoites and/or other liver-specific antigens as viral or other formulations. Following administration of one or more of the compositions provided herein using one or more of the vaccination regimens and/or methods, high levels of liver resident memory CD8+ T cells are induced in the subjects leading to protection against sporozoite challenge.
Inventors:
MURPHY SEAN C (US)
STONE BRADLEY CHRISTOPHER (US)
STONE BRADLEY CHRISTOPHER (US)
Application Number:
PCT/US2019/013114
Publication Date:
July 18, 2019
Filing Date:
January 10, 2019
Export Citation:
Assignee:
UNIV WASHINGTON (US)
International Classes:
A61K39/015; A61K45/06
Domestic Patent References:
| WO2005002512A2 | 2005-01-13 |
Foreign References:
| US20170274061A1 | 2017-09-28 |
Other References:
FERNANDEZ-RUIZ ET AL.: "Liver-Resident Memory CD 8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection", IMMUNITY, vol. 45, no. 4, 18 October 2016 (2016-10-18), pages 889 - 902, XP029771332, doi:10.1016/j.immuni.2016.08.011
Attorney, Agent or Firm:
DUEPPEN, Lara J. et al. (US)
Download PDF:
Previous Patent: MEDICAL APPARATUS WITH HYPOPHARYNGEAL SUCTIONING CAPABILITY
Next Patent: COMPOSITIONS AND METHODS OF EXPANSION OF T CELL POPULATIONS
Next Patent: COMPOSITIONS AND METHODS OF EXPANSION OF T CELL POPULATIONS