Title:
MAMMALIAN HEPARANASE
Document Type and Number:
WIPO Patent Application WO2001077341
Kind Code:
A3
Abstract:
The present invention provides isolated mammalian heparanase polypeptides, and the isolated polynucleotide molecules that encode them, as well as vectors and host cells comprising such polynucleotide molecules. The invention also provides a method for identification of an agent that alters heparanase activity.
Inventors:
SMETS GERDA MARTHA CORNELIA (BE)
SPRENGEL JOERG JUERGEN (BE)
SPRENGEL JOERG JUERGEN (BE)
Application Number:
PCT/EP2001/003878
Publication Date:
March 21, 2002
Filing Date:
April 05, 2001
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NV (BE)
SMETS GERDA MARTHA CORNELIA (BE)
SPRENGEL JOERG JUERGEN (BE)
SMETS GERDA MARTHA CORNELIA (BE)
SPRENGEL JOERG JUERGEN (BE)
International Classes:
C07K16/40; C12N9/24; C12N15/56; A61K38/00; (IPC1-7): C12N15/56; A01K67/027; A61K31/7088; A61K38/47; A61K39/395; C07K16/40; C12N5/10; C12N9/24; C12N15/11; C12Q1/34; G01N33/573; G01N33/577
Domestic Patent References:
| WO2001048161A2 | 2001-07-05 | |||
| WO2001046392A2 | 2001-06-28 | |||
| WO2001021814A1 | 2001-03-29 | |||
| WO1999021975A1 | 1999-05-06 | |||
| WO1999043830A2 | 1999-09-02 |
Foreign References:
| US5206223A | 1993-04-27 |
Other References:
MCKENZIE E ET AL: "Cloning and expression profiling of hpa2, a novel mammalian heparanase family member", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 276, no. 3, 5 October 2000 (2000-10-05), pages 1170 - 1177, XP002155087, ISSN: 0006-291X
DATABASE EM_EST EMBL; 6 January 2000 (2000-01-06), NCI-CGAP, XP002181947
DATABASE EM_RO EMBL; 2 November 1999 (1999-11-02), PODYMA K A ET AL: "Heparanase from parathyroid cell line", XP002181948
KOSIR M A ET AL: "Degradation of basement membrane by prostate tumor heparanase", JOURNAL OF SURGICAL RESEARCH, ACADEMIC PRESS INC., SAN DIEGO, CA, US, vol. 81, no. 1, January 1999 (1999-01-01), pages 42 - 47, XP002155606, ISSN: 0022-4804
NAKAJIMA M ET AL: "HEPARANASES AND TUMOR METASTASIS", JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 36, no. 2, 1988, pages 157 - 168, XP001030761, ISSN: 0730-2312
KISILEVSKY R ET AL: "ARRESTING AMYLOIDOSIS IN VIVO USING SMALL-MOLECULE ANIONIC SULPHONATES OR SULPHATES: IMPLICATIONS FOR ALZHEIMER'S DISEASE", NATURE MEDICINE, NATURE PUBLISHING, CO, US, vol. 1, no. 2, 1 February 1995 (1995-02-01), pages 143 - 148, XP000611547, ISSN: 1078-8956
DATABASE EM_EST EMBL; 6 January 2000 (2000-01-06), NCI-CGAP, XP002181947
DATABASE EM_RO EMBL; 2 November 1999 (1999-11-02), PODYMA K A ET AL: "Heparanase from parathyroid cell line", XP002181948
KOSIR M A ET AL: "Degradation of basement membrane by prostate tumor heparanase", JOURNAL OF SURGICAL RESEARCH, ACADEMIC PRESS INC., SAN DIEGO, CA, US, vol. 81, no. 1, January 1999 (1999-01-01), pages 42 - 47, XP002155606, ISSN: 0022-4804
NAKAJIMA M ET AL: "HEPARANASES AND TUMOR METASTASIS", JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 36, no. 2, 1988, pages 157 - 168, XP001030761, ISSN: 0730-2312
KISILEVSKY R ET AL: "ARRESTING AMYLOIDOSIS IN VIVO USING SMALL-MOLECULE ANIONIC SULPHONATES OR SULPHATES: IMPLICATIONS FOR ALZHEIMER'S DISEASE", NATURE MEDICINE, NATURE PUBLISHING, CO, US, vol. 1, no. 2, 1 February 1995 (1995-02-01), pages 143 - 148, XP000611547, ISSN: 1078-8956
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