Title:
MANUFACTURING PROCESS FOR MEMANTINE
Document Type and Number:
WIPO Patent Application WO/2014/115638
Kind Code:
A1
Abstract:
This method for manufacturing 3,5-dimethyl-1-adamantanamine includes the following steps (i) through (iii). (i) A step for reacting 3,5-dimethyl-1-adamantanol with oxygen and nitrile in an organic solvent to obtain a reaction solution. (ii) A step for adding water to the reaction solution obtained in step (i) to obtain 1-amido-3,5-dimethyladamantane. (iii) A step for hydrolyzing the 1-amido-3,5-dimethyladamantane obtained in step (ii) in the presence of an alcohol-containing solvent and an inorganic base.
Inventors:
SHIMO TETSUYA (JP)
Application Number:
PCT/JP2014/050716
Publication Date:
July 31, 2014
Filing Date:
January 16, 2014
Export Citation:
Assignee:
MITSUBISHI GAS CHEMICAL CO (JP)
International Classes:
C07C209/62; C07C211/38; C07C231/06; C07C233/06
Domestic Patent References:
| WO2007096124A1 | 2007-08-30 | |||
| WO2006076562A1 | 2006-07-20 | |||
| WO2008040560A1 | 2008-04-10 | |||
| WO2005062724A2 | 2005-07-14 | |||
| WO2011078101A1 | 2011-06-30 | |||
| WO2005062724A2 | 2005-07-14 | |||
| WO2009057140A2 | 2009-05-07 | |||
| WO2006076562A1 | 2006-07-20 | |||
| WO2008062472A2 | 2008-05-29 |
Foreign References:
| JP4118555B2 | 2008-07-16 | |||
| CN102432473A | 2012-05-02 |
Other References:
See also references of EP 2949643A4
PLAKHOTNIK, V. M.; KOVTUN, V. YU.; YASHUNSKII, V. G., ZHURNAL ORGANICHESKOI KHIMII, vol. 18, no. 5, 1982, pages 1001 - 5
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 122, no. 30, 2000, pages 7390 - 7391
PLAKHOTNIK, V. M.; KOVTUN, V. YU.; YASHUNSKII, V. G., ZHURNAL ORGANICHESKOI KHIMII, vol. 18, no. 5, 1982, pages 1001 - 5
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 122, no. 30, 2000, pages 7390 - 7391
Attorney, Agent or Firm:
INABA, Yoshiyuki et al. (JP)
Yoshiyuki Inaba (JP)
Yoshiyuki Inaba (JP)
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