Title:
MARKER FOR IDIOPATHIC SCOLIOSIS
Document Type and Number:
WIPO Patent Application WO/2019/164007
Kind Code:
A1
Abstract:
Provided is an idiopathic scoliosis marker that, in a test for biological fluid such as blood, urine, and saliva, and spinal fluid, enables accurate, early detection of an onset of idiopathic scoliosis and prompt, reliable prediction of the condition, and that is capable of serving as a diagnostic or therapeutic marker. This idiopathic scoliosis marker comprises one or more proteins selected from among actin, fibronectin, vitamin-D-binding protein, coagulation factor XIII-A, fibrinogen, complement factor H-associated protein, complement 3, adiponectin, and prothrombin, and can serve as a diagnostic and/or therapeutic marker for idiopathic scoliosis on the basis of the levels of concentration and/or activation of such proteins.
Inventors:
KIMURA TOMOATSU (JP)
SEKI SHOJI (JP)
MAKINO HIROTO (JP)
SEKI SHOJI (JP)
MAKINO HIROTO (JP)
Application Number:
PCT/JP2019/007195
Publication Date:
August 29, 2019
Filing Date:
February 26, 2019
Export Citation:
Assignee:
NATIONAL UNIV CORPORATION UNIV OF TOYAMA (JP)
International Classes:
G01N33/68; G01N33/53
Other References:
ZHUANG, Q. ET AL.: "Differential Proteome Analysis of Bone Marrow Mesenchymal Stem Cells from Adolescent Idiopathic Scoliosis Patients", PLOS ONE, vol. 6, no. 4, April 2011 (2011-04-01), pages 1 - 14, XP055632860
WALLER, T. ET AL.: "Familial or Sporadic Idiopathic Scoliosis - classification based on artificial neural network and GAPDH and ACTB transcription profile", BIOMEDICAL ENGINEERING ONLINE, vol. 12, no. 1, 2013, pages 1 - 14, XP021141843, doi:10.1186/1475-925X-12-1
CLARK, E. M. ET AL.: "Association Between Components of Body Composition and Scoliosis: A Prospective Cohort Study Reporting Differences Identifiable Before the Onset of Scoliosis", JOURNAL OF BONE AND MINERAL RESEARCH, vol. 29, no. 8, August 2014 (2014-08-01), pages 1729 - 1736, XP055632866
LIU, Z. ET AL.: "A critical role of abnormal leptin bioavailability in the etiology of adolescent idiopathic scoliosis", SCOLIOSIS AND SPINAL DISORDERS, vol. 12, no. 1, May 2017 (2017-05-01), pages 39 - 40
MAKINO, H. ET AL.: "Vitamin D Binding Protein (DBP) Is Increased In Adolescent Idiopathic Scoliosis Patients With Thoracolumbar/Lumbar Curvatures", ORS 2017 ANNUAL MEETING POSTER, 2017
WALLER, T. ET AL.: "Familial or Sporadic Idiopathic Scoliosis - classification based on artificial neural network and GAPDH and ACTB transcription profile", BIOMEDICAL ENGINEERING ONLINE, vol. 12, no. 1, 2013, pages 1 - 14, XP021141843, doi:10.1186/1475-925X-12-1
CLARK, E. M. ET AL.: "Association Between Components of Body Composition and Scoliosis: A Prospective Cohort Study Reporting Differences Identifiable Before the Onset of Scoliosis", JOURNAL OF BONE AND MINERAL RESEARCH, vol. 29, no. 8, August 2014 (2014-08-01), pages 1729 - 1736, XP055632866
LIU, Z. ET AL.: "A critical role of abnormal leptin bioavailability in the etiology of adolescent idiopathic scoliosis", SCOLIOSIS AND SPINAL DISORDERS, vol. 12, no. 1, May 2017 (2017-05-01), pages 39 - 40
MAKINO, H. ET AL.: "Vitamin D Binding Protein (DBP) Is Increased In Adolescent Idiopathic Scoliosis Patients With Thoracolumbar/Lumbar Curvatures", ORS 2017 ANNUAL MEETING POSTER, 2017
Attorney, Agent or Firm:
SHINKYU PARTNERS P.C. (JP)
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