Title:
MEDICINAL COMPOSITION FOR IMPROVING AND/OR STABILIZING CIRCULATORY DYNAMICS AFTER ONSET OF HEMORRHAGIC SHOCK
Document Type and Number:
WIPO Patent Application WO/2018/021175
Kind Code:
A1
Abstract:
[Problem] To provide a medicinal composition which is capable of improving the survival time and survival rate of patients after the onset of hemorrhagic shock.
[Solution] A gaseous medicinal composition for improving and/or stabilizing the circulatory dynamics after the onset of hemorrhagic shock, said medicinal composition containing hydrogen gas. The medicinal composition according to the present invention can be administered in a case where a transfusion treatment cannot be performed. The medicinal composition according to the present invention can increase the survival rate or prolong the survival time after the onset of hemorrhagic shock, compared with a case where the medicinal composition is not administered.
Inventors:
SUZUKI MASARU (JP)
MATSUOKA TADASHI (JP)
TAMURA TOMOYOSHI (JP)
HAYASHIDA KEI (JP)
SANO MOTOAKI (JP)
MATSUOKA TADASHI (JP)
TAMURA TOMOYOSHI (JP)
HAYASHIDA KEI (JP)
SANO MOTOAKI (JP)
Application Number:
PCT/JP2017/026431
Publication Date:
February 01, 2018
Filing Date:
July 21, 2017
Export Citation:
Assignee:
UNIV KEIO (JP)
TAIYO NIPPON SANSO CORP (JP)
TAIYO NIPPON SANSO CORP (JP)
International Classes:
A61K33/00; A61K9/72; A61K47/02; A61P9/00
Domestic Patent References:
| WO2014024984A1 | 2014-02-13 |
Other References:
KOHAMA KEISUKE ET AL.: "Hydrogen inhalation protects against acute lung injury induced by hemorrhagic shock and resuscitation", SURGERY, vol. 158, no. 2, August 2015 (2015-08-01), pages 399 - 407, XP055569864
SHEN MEIHUA ET AL.: "A review of experimental studies of hydrogen as a new therapeutic agent in emergency and critical care medicine", MEDICAL GAS RESEARCH, vol. 4, no. 17, 8 November 2014 (2014-11-08), pages 1 - 8, XP021203691, ISSN: 2045-9912
YOTARO SHINOZAWA ET AL.: "6. PATHOPHYSIOLOGIES OF ISCHEMIC/REPERFUSION INJURIES ASSOCIATING WITH HEMORRHAGIC SHOCK AND UP-TO-DATA TREATMENT", JOURNAL OF JAPAN SURGICAL SOCIETY, vol. 104, no. 12, 1 December 2003 (2003-12-01), pages 835 - 839, XP9513347
TADASHI MATSUOKA ET AL.: "Rat Shukketsusei Shock Model ni Okeru Suiso Gas Kyunyu no Seizonritsu Kaizen Koka ni Tsuite", JOURNAL OF ABDOMINAL EMERGENCY MEDICINE, vol. 37, no. 2, 2 February 2017 (2017-02-02), pages 222, XP9513319
MATSUOKA TADASHI ET AL.: "Hydrogen gas inhalation inhibits progression to the ''irreversible", JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 10 August 2017 (2017-08-10), XP9513321, [retrieved on 20170620]
KOHAMA K ET AL.: "Hydrogen inhalation protects against acute lung injury induced by hemorrhaig shock and resuscitation", SURGERY, vol. 158, 2015, pages 399
ZUNMIN DU: "Three hydrogen-rich solutions protect against intestinal injury in uncontrolled hemorrhagic shock", INT J CLIN EXP MED, vol. 8, no. 5, 2015, pages 7620 - 7626
ZUNMIN DU, MB ET AL.: "Effects of three hydrogen-rich liquids on hemorrhagic shock in rats", JOURNAL OF SURGICAL RESERACH, vol. 193, 2015, pages 377 - 382
See also references of EP 3492088A4
SHEN MEIHUA ET AL.: "A review of experimental studies of hydrogen as a new therapeutic agent in emergency and critical care medicine", MEDICAL GAS RESEARCH, vol. 4, no. 17, 8 November 2014 (2014-11-08), pages 1 - 8, XP021203691, ISSN: 2045-9912
YOTARO SHINOZAWA ET AL.: "6. PATHOPHYSIOLOGIES OF ISCHEMIC/REPERFUSION INJURIES ASSOCIATING WITH HEMORRHAGIC SHOCK AND UP-TO-DATA TREATMENT", JOURNAL OF JAPAN SURGICAL SOCIETY, vol. 104, no. 12, 1 December 2003 (2003-12-01), pages 835 - 839, XP9513347
TADASHI MATSUOKA ET AL.: "Rat Shukketsusei Shock Model ni Okeru Suiso Gas Kyunyu no Seizonritsu Kaizen Koka ni Tsuite", JOURNAL OF ABDOMINAL EMERGENCY MEDICINE, vol. 37, no. 2, 2 February 2017 (2017-02-02), pages 222, XP9513319
MATSUOKA TADASHI ET AL.: "Hydrogen gas inhalation inhibits progression to the ''irreversible", JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 10 August 2017 (2017-08-10), XP9513321, [retrieved on 20170620]
KOHAMA K ET AL.: "Hydrogen inhalation protects against acute lung injury induced by hemorrhaig shock and resuscitation", SURGERY, vol. 158, 2015, pages 399
ZUNMIN DU: "Three hydrogen-rich solutions protect against intestinal injury in uncontrolled hemorrhagic shock", INT J CLIN EXP MED, vol. 8, no. 5, 2015, pages 7620 - 7626
ZUNMIN DU, MB ET AL.: "Effects of three hydrogen-rich liquids on hemorrhagic shock in rats", JOURNAL OF SURGICAL RESERACH, vol. 193, 2015, pages 377 - 382
See also references of EP 3492088A4
Attorney, Agent or Firm:
NANJO, Masahiro et al. (JP)
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