Title:
MEDICINAL COMPOSITION FOR TREATING AND PREVENTING CHRONIC DISEASE
Document Type and Number:
WIPO Patent Application WO/2018/105708
Kind Code:
A1
Abstract:
The present invention addresses the problem of developing a novel therapy for a chronic disease, against which conventional therapies show no or little efficacy, and provides a medicinal composition for treating and/or preventing an inflammatory chronic disease, said medicinal composition being to be used together with a biological preparation etc. capable of inhibiting tissue invasion by leukocytes. The medicinal composition according to the present invention comprises, as an active ingredient, siRNA suppressing the expression of CHST15 gene, etc., said siRNA containing a structure formed by the hybridization of RNA containing the base sequence represented by SEQ ID NO: 1 with RNA complementary to the aforesaid RNA.
Inventors:
YONEYAMA HIROYUKI (JP)
Application Number:
PCT/JP2017/044090
Publication Date:
June 14, 2018
Filing Date:
December 07, 2017
Export Citation:
Assignee:
STELIC INST & CO INC (JP)
International Classes:
A61K48/00; A61K31/7105; A61K31/711; A61K31/713; A61P1/00; A61P1/18; A61P11/06; A61P29/00
Domestic Patent References:
| WO2014013535A1 | 2014-01-23 | |||
| WO2016086147A1 | 2016-06-02 | |||
| WO2016057424A1 | 2016-04-14 | |||
| WO2009004995A1 | 2009-01-08 | |||
| WO2009084232A1 | 2009-07-09 | |||
| WO2014013535A1 | 2014-01-23 | |||
| WO2017078054A1 | 2017-05-11 |
Foreign References:
| JP2014515018A | 2014-06-26 | |||
| JP2014523906A | 2014-09-18 | |||
| JP2012519708A | 2012-08-30 |
Other References:
WATANABE, K. ET AL.: "Small interfering RNA therapy against carbohydrate sulfotransferase 15 inhibits cardiac remodeling in rats with dilated cardiomyopathy.", CELL , SIGNAL., vol. 27, no. 7, July 2015 (2015-07-01), pages 1517 - 1524, XP055509853, ISSN: 0898-6568
SUZUKI, K. ET AL.: "Pivotal role of carbohydrate sulfotransferase 15 in fibrosis and mucosal healing in mouse colitis.", PLOS ONE, vol. 11, no. 7, 13 July 2016 (2016-07-13), pages e0158967, XP055470858, ISSN: 1932-6203
PATNODE, M. L. ET AL., GLYCOBIOLOGY, vol. 23, 2013, pages 381 - 394
KIRYU, H. ET AL., BIOINFORMATICS, vol. 27, 2011, pages 1788 - 1797
SUZUKI, K. ET AL., SUL078 GASTROENTEROLOGY, vol. 204
FIRE, A. ET AL., NATURE, vol. 391, 1998, pages 806 - 811
GREEN, M.R.SAMBROOK, J.: "Molecular Cloning: A Laboratory Manual", 2012, COLD SPRING HARBOR LABORATORY PRESS
SUZAWA, K. ET AL., AM. J. GASTROENTEROL., vol. 102, 2007, pages 1499 - 1509
YEH, J.-C. ET AL., CELL, vol. 105, 2001, pages 957 - 969
KOBAYASHI, M. ET AL., BIOL. PHARM. BULL., vol. 32, 2009, pages 774 - 779
A. VAN ZANTES.D. ROSEN, BIOCHEMICAL SOCIETY TRANSACTIONS, vol. 31, 2003, pages 313 - 317
COLOMBEL, J.F. ET AL., GASTROENTEROLOGY, vol. 141, 2011, pages 1194 - 1201
See also references of EP 3552632A4
SUZUKI, K. ET AL.: "Pivotal role of carbohydrate sulfotransferase 15 in fibrosis and mucosal healing in mouse colitis.", PLOS ONE, vol. 11, no. 7, 13 July 2016 (2016-07-13), pages e0158967, XP055470858, ISSN: 1932-6203
PATNODE, M. L. ET AL., GLYCOBIOLOGY, vol. 23, 2013, pages 381 - 394
KIRYU, H. ET AL., BIOINFORMATICS, vol. 27, 2011, pages 1788 - 1797
SUZUKI, K. ET AL., SUL078 GASTROENTEROLOGY, vol. 204
FIRE, A. ET AL., NATURE, vol. 391, 1998, pages 806 - 811
GREEN, M.R.SAMBROOK, J.: "Molecular Cloning: A Laboratory Manual", 2012, COLD SPRING HARBOR LABORATORY PRESS
SUZAWA, K. ET AL., AM. J. GASTROENTEROL., vol. 102, 2007, pages 1499 - 1509
YEH, J.-C. ET AL., CELL, vol. 105, 2001, pages 957 - 969
KOBAYASHI, M. ET AL., BIOL. PHARM. BULL., vol. 32, 2009, pages 774 - 779
A. VAN ZANTES.D. ROSEN, BIOCHEMICAL SOCIETY TRANSACTIONS, vol. 31, 2003, pages 313 - 317
COLOMBEL, J.F. ET AL., GASTROENTEROLOGY, vol. 141, 2011, pages 1194 - 1201
See also references of EP 3552632A4
Attorney, Agent or Firm:
TSUKUNI & ASSOCIATES et al. (JP)
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