Title:
MEDICINAL COMPOSITIONS WITH [2.2.1] AND [3.1.1] BICYCLOSKELETON ANTAGONISTIC TO BOTH OF PGD¿2?/TXA¿2? RECEPTORS
Document Type and Number:
WIPO Patent Application WO/2000/053573
Kind Code:
A1
Abstract:
Novel compounds antagonistic to both of thromboxane A¿2? and prostaglandin D¿2? receptors and medicinal compositions containing the same. As the above compounds, compounds represented by general formula (I) are found out; wherein R?1¿ represents -CH¿2?-CH=CH-CH¿2?-CH¿2?-CH¿2?-COOR?2¿ or CH=CH-CH¿2?-CH¿2?-CH¿2?-COOR?2¿ (wherein R?2¿ represents hydrogen or alkyl); m is 0 or 1; p is 0 or 1; X?1¿ and X?3¿ independently represent each optionally substituted aryl or optionally substituted heteroaryl; X?2¿ represents a single bond, -CH¿2?-, -S-, -SO¿2?-, -CH¿2?-O-, -O-CH¿2?-, -CH¿2?-S-, -S-CH¿2?-, etc.; and X?4¿ represents -CH¿2?-, -CH¿2?-CH¿2?-, -C(=O)-, etc.
Inventors:
HONMA TSUNETOSHI (JP)
HIRAMATSU YOSHIHARU (JP)
ARIMURA AKINORI (JP)
HIRAMATSU YOSHIHARU (JP)
ARIMURA AKINORI (JP)
Application Number:
PCT/JP2000/001223
Publication Date:
September 14, 2000
Filing Date:
March 02, 2000
Export Citation:
Assignee:
SHIONOGI & CO (JP)
HONMA TSUNETOSHI (JP)
HIRAMATSU YOSHIHARU (JP)
ARIMURA AKINORI (JP)
HONMA TSUNETOSHI (JP)
HIRAMATSU YOSHIHARU (JP)
ARIMURA AKINORI (JP)
International Classes:
A61K31/00; A61K31/201; A61K31/381; A61K31/40; A61K31/402; A61K31/4025; A61K31/404; A61K31/4155; A61K31/4178; A61K31/4188; A61K31/422; A61K31/423; A61K31/426; A61K31/427; A61K31/428; A61K31/4402; A61K31/4725; C07C311/21; C07C317/44; C07C323/62; C07D207/323; C07D207/48; C07D209/08; C07D213/75; C07D277/46; C07D277/52; C07D307/68; C07D307/84; C07D333/34; C07D333/38; C07D333/54; C07D333/68; C07D333/76; C07D333/78; C07D409/06; C07D409/12; C07D413/06; C07D417/06; C07D495/04; C07D207/32; (IPC1-7): C07C233/85; C07C323/62; C07C311/21; C07C317/44; C07D409/12; C07D333/38; C07D295/02; C07D333/36; C07D417/00; C07D513/00; A61K31/196; A61K31/381; A61K31/40; A61K31/404; A61K31/426; A61K31/4025; A61K31/435; A61K31/4155; A61K31/4164; A61K31/4188
Domestic Patent References:
| WO1997000853A1 | 1997-01-09 | |||
| WO1999015502A1 | 1999-04-01 |
Other References:
T. TSURI ET. AL.: "Bicyclo(2.2.1)heptane and 6,6-Dimethylbicyclo(3,1.1)heptane Derivatives: Orally Active, Potent, and Selective Prostagrandin D2 Receptor Antagonists", J. MED. CHEM., vol. 40, no. 22, 1997, pages 3504 - 3507, XP002928844
See also references of EP 1176139A4
See also references of EP 1176139A4
Attorney, Agent or Firm:
Yamauchi, Hideaki (Ltd. Patent Dept. 12-4 Sagisu 5-chom, Fukushima-ku Osaka-shi Osaka, JP)
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