Title:
SYNTHESIS OF $g(a)-AMINO-$g(a)',$g(a)'-DIHALOKETONES AND PROCESS FOR THE PREPARATION OF $g(b)-AMINO ACID DERIVATIVES BY THE USE OF THE SAME
Document Type and Number:
WIPO Patent Application WO/2000/053575
Kind Code:
A1
Abstract:
An optically active $g(b)-amino acid ester derivative can be efficiently prepared on an industrial scale by reacting a $g(a)-amino acid ester derivative with a base and a dihalomethane to prepare a $g(a)-amino-$g(a)',$g(a)'-dihaloketone derivative, reacting this derivative with lithium amide and an alkyllithium successively, and then treating the obtained product with an acid in an alcohol.
Inventors:
NISHIYAMA AKIRA (JP)
INOUE KENJI (JP)
INOUE KENJI (JP)
Application Number:
PCT/JP2000/001424
Publication Date:
September 14, 2000
Filing Date:
March 09, 2000
Export Citation:
Assignee:
KANEKA CORP (JP)
NISHIYAMA AKIRA (JP)
INOUE KENJI (JP)
NISHIYAMA AKIRA (JP)
INOUE KENJI (JP)
International Classes:
C07C269/06; C07C271/18; C07C271/22; (IPC1-7): C07C269/06; C07C271/18; C07C271/22
Foreign References:
| JPH1059909A | 1998-03-03 |
Other References:
"JIKKEN KAGAKU KOUZA 21, YUKIGOUSEI III-ALDEHYDE, KETONE, QUINONE", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, CHEMICAL SOCIETY OF JAPAN, TOKYO., JP, no. 04, 5 February 1991 (1991-02-05), JP, pages 290/291, XP002946284, ISSN: 0009-2673
"JIKKEN KAGAKU KOUZA 21, YUKIGOUSEI III - ACID, AMINO ACID PEPTIDE", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, CHEMICAL SOCIETY OF JAPAN, TOKYO., JP, 30 November 1992 (1992-11-30), JP, pages 31, XP002946285, ISSN: 0009-2673
"JIKKEN KAGAKU KOUZA 21, YUKIGOUSEI III - ACID, AMINO ACID PEPTIDE", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, CHEMICAL SOCIETY OF JAPAN, TOKYO., JP, 30 November 1992 (1992-11-30), JP, pages 31, XP002946285, ISSN: 0009-2673
Attorney, Agent or Firm:
Yasutomi, Yasuo (Nishinakajima 5-chome Yodogawa-ku Osaka-shi, Osaka, JP)
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