Title:
MEDICINE RESPONSE ASSAY IN RESPIRATORY DISEASE
Document Type and Number:
WIPO Patent Application WO2001079560
Kind Code:
A3
Abstract:
Correlations between polymorphisms in the 5-lipoxygenase gene, or polymorphisms in the leukotriene C4 synthase gene, and a subject's phenotypic response to treatment with a leukotriene receptor antagonist for respiratory disease are described. Methods of screening subjects to aid in treatment, and methods of screening therapeutic compounds, are presented.
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Inventors:
ANDERSON WAYNE H (US)
EDWARDS LISA D (US)
EMMETT AMANDA H (US)
PILLAI SREEKUMAR (US)
SPRANKEL CATHERINE S (US)
EDWARDS LISA D (US)
EMMETT AMANDA H (US)
PILLAI SREEKUMAR (US)
SPRANKEL CATHERINE S (US)
Application Number:
PCT/US2001/012534
Publication Date:
October 17, 2002
Filing Date:
April 17, 2001
Export Citation:
Assignee:
GLAXO GROUP LTD (GB)
ANDERSON WAYNE H (US)
EDWARDS LISA D (US)
EMMETT AMANDA H (US)
PILLAI SREEKUMAR (US)
SPRANKEL CATHERINE S (US)
ANDERSON WAYNE H (US)
EDWARDS LISA D (US)
EMMETT AMANDA H (US)
PILLAI SREEKUMAR (US)
SPRANKEL CATHERINE S (US)
International Classes:
C12N15/09; C12Q1/68; (IPC1-7): C12Q1/68
Domestic Patent References:
| WO1997042347A2 | 1997-11-13 | |||
| WO1999010529A1 | 1999-03-04 |
Other References:
DRAZEN JEFFREY M ET AL: "Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment.", NATURE GENETICS, vol. 22, no. 2, June 1999 (1999-06-01), pages 168 - 170, XP002206737, ISSN: 1061-4036
SANAK MAREK ET AL: "Leukotriene C4 synthase promoter polymorphism and risk of aspirin-induced asthma.", LANCET (NORTH AMERICAN EDITION), vol. 350, no. 9091, 29 November 1997 (1997-11-29), pages 1599 - 1600, XP002206738, ISSN: 0099-5355
SILVERMAN E ET AL: "Pharmacogenetics of the 5-lipoxygenase pathway in asthma.", CLINICAL AND EXPERIMENTAL ALLERGY, vol. 28, no. SUPPL. 5, November 1998 (1998-11-01), pages 164 - 170, XP002206739, ISSN: 0954-7894
IN ET AL: "NATURALLY OCCURRING MUTATIONS IN THE HUMAN 5-LIPOXYGENASE GENE PROMOTER THAT MODIFY TRANSCRIPTION FACTOR BINDING AND REPORTER GENE TRANSCRIPTION", JOURNAL OF CLINICAL INVESTIGATION, NEW YORK, NY, US, vol. 99, no. 5, 1997, pages 1130 - 1137, XP002145101, ISSN: 0021-9738
CALHOUN W J: "Anti-leukotrienes for asthma.", CURRENT OPINION IN PHARMACOLOGY. ENGLAND JUN 2001, vol. 1, no. 3, June 2001 (2001-06-01), pages 230 - 234, XP002206741, ISSN: 1471-4892
SANAK MAREK ET AL: "Leukotriene C4 synthase promoter polymorphism and risk of aspirin-induced asthma.", LANCET (NORTH AMERICAN EDITION), vol. 350, no. 9091, 29 November 1997 (1997-11-29), pages 1599 - 1600, XP002206738, ISSN: 0099-5355
SILVERMAN E ET AL: "Pharmacogenetics of the 5-lipoxygenase pathway in asthma.", CLINICAL AND EXPERIMENTAL ALLERGY, vol. 28, no. SUPPL. 5, November 1998 (1998-11-01), pages 164 - 170, XP002206739, ISSN: 0954-7894
IN ET AL: "NATURALLY OCCURRING MUTATIONS IN THE HUMAN 5-LIPOXYGENASE GENE PROMOTER THAT MODIFY TRANSCRIPTION FACTOR BINDING AND REPORTER GENE TRANSCRIPTION", JOURNAL OF CLINICAL INVESTIGATION, NEW YORK, NY, US, vol. 99, no. 5, 1997, pages 1130 - 1137, XP002145101, ISSN: 0021-9738
CALHOUN W J: "Anti-leukotrienes for asthma.", CURRENT OPINION IN PHARMACOLOGY. ENGLAND JUN 2001, vol. 1, no. 3, June 2001 (2001-06-01), pages 230 - 234, XP002206741, ISSN: 1471-4892
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