Title:
METAL-OXIME CHELATES FOR USE AS RADIOPHARMACEUTICAL AGENTS
Document Type and Number:
WIPO Patent Application WO1994008949
Kind Code:
A3
Abstract:
PCT No. PCT/GB93/02088 Sec. 371 Date May 9, 1995 Sec. 102(e) Date May 9, 1995 PCT Filed Oct. 8, 1993 PCT Pub. No. WO94/08949 PCT Pub. Date Apr. 28, 1994Novel metal chelating compounds, and radiometal, e.g., technetium-99m complexes thereof. The compounds can be used to radiolabel small biologically active species with minimal effect on their biodistribution and activity. The compounds have formula (a) or (b): where Z is (CR2)n or (CR)n, n is 2 or 3, X is a ligand comprising S, N or O, each R is H or C1-C20 substituted or unsubstituted hydrocarbon group, provided that 1-3 CR2 groups represent a CO (amide) moiety, and provided that 1-3 R may each comprise a targeting group and/or a protein reactive functionality.
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Inventors:
ARCHER COLIN MILL (GB)
CANNING LEWIS REUBEN (GB)
GILL HARJIT KAUR (GB)
RILEY ANTHONY LEONARD MARK (GB)
CANNING LEWIS REUBEN (GB)
GILL HARJIT KAUR (GB)
RILEY ANTHONY LEONARD MARK (GB)
Application Number:
PCT/GB1993/002088
Publication Date:
June 09, 1994
Filing Date:
October 08, 1993
Export Citation:
Assignee:
AMERSHAM INT PLC (GB)
International Classes:
A61K31/28; A61K31/415; A61K51/00; A61K51/04; A61P35/00; A61P43/00; C07B59/00; C07C251/36; C07C251/38; C07C251/70; C07C271/20; C07C271/22; C07C323/52; C07C323/60; C07C325/02; C07C327/02; C07C327/22; C07D233/91; C07F1/08; C07F1/10; C07F13/00; (IPC1-7): C07C251/38; C07D233/91; A61K49/02; C07C271/20; C07C271/22; C07C323/52
Domestic Patent References:
| WO1992007860A2 | 1992-05-14 |
Foreign References:
| EP0179608A2 | 1986-04-30 | |||
| EP0123504A2 | 1984-10-31 | |||
| EP0417870A2 | 1991-03-20 | |||
| EP0502595A2 | 1992-09-09 |
Other References:
C.D.GUTSCHE ET. AL.: "Association Phenomena. 3. Polyfunctional Catalysis of Acetyl Phosphate Decomposition.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 100, no. 6, 15 March 1978 (1978-03-15), GASTON, PA US, pages 1857 - 65, XP002660885
C. D. GUTSCHE ET. AL.: "Association phenomena. 7. Mixed Chelate and Comicellar Catalysis of Acetyl Phosphate "Olysis" Reactions", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 107, no. 26, 25 December 1985 (1985-12-25), GASTON, PA US, pages 7964 - 7
C. D. GUTSCHE ET. AL.: "Association Phenomena. 3. Polyfunctional Catalysis of Acetyl Phosphate Decomposition", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 100, no. 6, 15 March 1978 (1978-03-15), GASTON, PA US, pages 1857 - 65, XP002660885
C. D. GUTSCHE ET. AL.: "Association phenomena. 7. Mixed Chelate and Comicellar Catalysis of Acetyl Phosphate "Olysis" Reactions", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 107, no. 26, 25 December 1985 (1985-12-25), GASTON, PA US, pages 7964 - 7
C. D. GUTSCHE ET. AL.: "Association Phenomena. 3. Polyfunctional Catalysis of Acetyl Phosphate Decomposition", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 100, no. 6, 15 March 1978 (1978-03-15), GASTON, PA US, pages 1857 - 65, XP002660885
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