Title:
METHOD FOR ASSESSING OR SELECTING SEBACEOUS-GLAND- OR HAIR-FOLLICLE-SELECTIVE ANDROGEN RECEPTOR ACTIVITY CONTROLLING AGENT
Document Type and Number:
WIPO Patent Application WO/2017/163391
Kind Code:
A1
Abstract:
Provided is a method for searching for a substance capable of controlling the activity of an androgen receptor rapidly, with high accuracy and in a sebaceous-gland- and hair-follicle-selective manner. A method for assessing or selecting a sebaceous-gland- or hair-follicle-selective androgen receptor activity controlling agent, said method comprising: (A) applying a substance of interest to a sebaceous gland-originated cell or a hair follicle-originated cell under low-oxygen conditions; (B) measuring the activity of HIF1α in the cell; (C) comparing the activity measured in step (B) with the activity of HIF1α in a control group; and (D) assessing the HIF1α activity-controlling effect of the substance on the basis of the result obtained in step (C).
Inventors:
INOUE TAKAYOSHI (JP)
HACHIYA AKIRA (JP)
KATO ARISA (JP)
HACHIYA AKIRA (JP)
KATO ARISA (JP)
Application Number:
PCT/JP2016/059553
Publication Date:
September 28, 2017
Filing Date:
March 25, 2016
Export Citation:
Assignee:
KAO CORP (JP)
International Classes:
C12Q1/02; A61K31/713; A61K48/00; A61P17/08; A61P17/10; A61P17/14; C12N15/09
Foreign References:
| JP2002535984A | 2002-10-29 |
Other References:
RANDALL. VALERIE ANNE: "Androgens and hair growth", DERMATOLOGY THERAPY, vol. 21, 2008, pages 314 - 328, XP055426699
GILTAY. E.J ET AL.: "Effects of sex steroid deprivation/administration on hair growth and skin sebum production in transsexual males and females", JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, vol. 85, 2000, pages 2913 - 2921, XP055426700
ROGENBERGER CHRISTIAN ET AL.: "Upregulation of hypoxia-inducible factors in normal and psoriatic skin", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 127, 2007, pages 2445 - 2452, XP055426701
TAKAKAZU MITANI ET AL.: "Teisanso Signal ni yoru Androgen Juyotai Signal no Chosetsu", JOURNAL OF JAPANESE BIOCHEMICAL SOCIETY, vol. 146, 25 September 2009 (2009-09-25), pages 4P-247, XP009516477, ISSN: 0021-924X
MATURITAS, vol. 59, 2008, pages 174 - 181
DERMATOL THER, vol. 21, 2008, pages 314 - 328
J CLIN ENDOCRINOL METAB, vol. 85, 2000, pages 2913 - 2921
BR J DERMATOL, vol. 152, 2005, pages 466 - 473
J EXP MED, vol. 201, 2005, pages 105 - 115
J INVEST DERMATOL, vol. 131, 2011, pages 1793 - 1805
MOL CELL, vol. 40, 2010, pages 294 - 309
J INVEST DERMATOL, vol. 126, 2006, pages 2596 - 2606
J INVEST DERMATOL, vol. 127, 2007, pages 2445 - 2452
DATABASE Genbank [O] Database accession no. NG_012077.1
SCIENCE, vol. 227, 1985, pages 1435 - 1441
J INVEST DERMATOL, vol. 113, 1999, pages 1011 - 1120
J INVEST DERMATOL, vol. 120, 2003, pages 905 - 914
J STEROID BIOCHEM MOL BIOL, vol. 123, 2011, pages 58 - 64
J STEROID BIOCHEM & MOL BIOL, vol. 123, 2011, pages 58 - 64
J CLIN ENDOCRINOL METAB, vol. 79, 1994, pages 703 - 706
J CLIN ENDOCRINOL METAB, vol. 83, 1998, pages 2266 - 2274
BR J DERMATOL, vol. 107, 1982, pages 583 - 590
GILTAY. E.J ET AL.: "Effects of sex steroid deprivation/administration on hair growth and skin sebum production in transsexual males and females", JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, vol. 85, 2000, pages 2913 - 2921, XP055426700
ROGENBERGER CHRISTIAN ET AL.: "Upregulation of hypoxia-inducible factors in normal and psoriatic skin", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 127, 2007, pages 2445 - 2452, XP055426701
TAKAKAZU MITANI ET AL.: "Teisanso Signal ni yoru Androgen Juyotai Signal no Chosetsu", JOURNAL OF JAPANESE BIOCHEMICAL SOCIETY, vol. 146, 25 September 2009 (2009-09-25), pages 4P-247, XP009516477, ISSN: 0021-924X
MATURITAS, vol. 59, 2008, pages 174 - 181
DERMATOL THER, vol. 21, 2008, pages 314 - 328
J CLIN ENDOCRINOL METAB, vol. 85, 2000, pages 2913 - 2921
BR J DERMATOL, vol. 152, 2005, pages 466 - 473
J EXP MED, vol. 201, 2005, pages 105 - 115
J INVEST DERMATOL, vol. 131, 2011, pages 1793 - 1805
MOL CELL, vol. 40, 2010, pages 294 - 309
J INVEST DERMATOL, vol. 126, 2006, pages 2596 - 2606
J INVEST DERMATOL, vol. 127, 2007, pages 2445 - 2452
DATABASE Genbank [O] Database accession no. NG_012077.1
SCIENCE, vol. 227, 1985, pages 1435 - 1441
J INVEST DERMATOL, vol. 113, 1999, pages 1011 - 1120
J INVEST DERMATOL, vol. 120, 2003, pages 905 - 914
J STEROID BIOCHEM MOL BIOL, vol. 123, 2011, pages 58 - 64
J STEROID BIOCHEM & MOL BIOL, vol. 123, 2011, pages 58 - 64
J CLIN ENDOCRINOL METAB, vol. 79, 1994, pages 703 - 706
J CLIN ENDOCRINOL METAB, vol. 83, 1998, pages 2266 - 2274
BR J DERMATOL, vol. 107, 1982, pages 583 - 590
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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