Title:
METHOD FOR CO-PRODUCING VALPROAMIDE AND SODIUM VALPROATE
Document Type and Number:
WIPO Patent Application WO/2023/221851
Kind Code:
A1
Abstract:
Provided is a method for preparing valproamide represented by chemical structural formula I and sodium valproate represented by formula II. The method is characterized in that cyanoacetate and 1-chloropropane are subjected to composite catalytic dipropylation under the action of alkali to obtain 2-cyano-2-valproate represented by formula III; the 2-cyano-2-valproate is hydrolyzed and deacidified to obtain propylvaleronitrile represented by formula V; the propylvaleronitrile is subjected to alcoholysis under acid catalysis to obtain the valproamide represented by formula I and valproate represented by formula VI; and the valproate is hydrolyzed in a sodium hydroxide solution to obtain the sodium valproate represented by formula II.
Inventors:
HU AIXI (CN)
LI MINGFANG (CN)
YE JIAO (CN)
LIU YUYANG (CN)
LI MINGFANG (CN)
YE JIAO (CN)
LIU YUYANG (CN)
Application Number:
PCT/CN2023/093479
Publication Date:
November 23, 2023
Filing Date:
May 11, 2023
Export Citation:
Assignee:
HUNAN XIANGZHONG PHARMACEUTICAL CO LTD (CN)
UNIV HUNAN (CN)
UNIV HUNAN (CN)
International Classes:
C07C253/30; B01J31/02; C07C51/09; C07C51/41; C07C53/128; C07C67/22; C07C69/22; C07C231/06; C07C233/05; C07C255/03; C07C255/18
Foreign References:
| CN113200844A | 2021-08-03 | |||
| CN113173845A | 2021-07-27 | |||
| CN114763319A | 2022-07-19 | |||
| CN114763328A | 2022-07-19 | |||
| CN114790151A | 2022-07-26 | |||
| US4127604A | 1978-11-28 | |||
| CN111349003A | 2020-06-30 | |||
| CN103073424A | 2013-05-01 |
Other References:
NOROOZI PESYAN NADER; EBRAHIMI MARZIYEH: "Synthesis of newN-glycosides based on Valproic acid analogs tetrazole derivatives", IRANIAN CHEMICAL SOCIETY. JOURNAL, IRANIAN CHEMICAL SOCIETY, IR, vol. 14, no. 5, 24 January 2017 (2017-01-24), IR , pages 1059 - 1067, XP036172609, ISSN: 1735-207X, DOI: 10.1007/s13738-017-1055-7
LI XINYUAN, TAN CHANGSHENG, XU ZONGXIANG, HE JIANGBO, YU DIHUA : "SYNTHESIS OF ANTIEPILEPTIC VALPROIC ACID SALTS AND AMIDE BY PHASE TRANSFER CATALYSIS", PHARMACEUTICAL INDUSTRY, no. 5, 1 January 1984 (1984-01-01), pages 4 - 6, XP093109016, DOI: 10.16522/j.cnki.cjph.1984.05.002
ZHANG, LIJUAN, EDITOR-IN-CHIEF: " 4. Replacement Reactions of Halogens", CHINESE JOURNAL OF ORGANIC CHEMISTRY, SCIENCE PRESS, BEIJING., CN, vol. 2008, 31 October 2008 (2008-10-31), CN , pages 80 - 86, XP009550435, ISSN: 0253-2786
LI XINYUAN, TAN CHANGSHENG, XU ZONGXIANG, HE JIANGBO, YU DIHUA : "SYNTHESIS OF ANTIEPILEPTIC VALPROIC ACID SALTS AND AMIDE BY PHASE TRANSFER CATALYSIS", PHARMACEUTICAL INDUSTRY, no. 5, 1 January 1984 (1984-01-01), pages 4 - 6, XP093109016, DOI: 10.16522/j.cnki.cjph.1984.05.002
ZHANG, LIJUAN, EDITOR-IN-CHIEF: " 4. Replacement Reactions of Halogens", CHINESE JOURNAL OF ORGANIC CHEMISTRY, SCIENCE PRESS, BEIJING., CN, vol. 2008, 31 October 2008 (2008-10-31), CN , pages 80 - 86, XP009550435, ISSN: 0253-2786
Attorney, Agent or Firm:
BEIJING FORESTSONG PATENT AGENCY CO., LTD. (CN)
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