Title:
COMPOUND PHARMACEUTICAL COMPOSITION FOR TREATING GLAUCOMA AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/221852
Kind Code:
A1
Abstract:
The present invention provides ophthalmic double and triple compound pharmaceutical compositions for treating glaucoma and ocular hypertension. The stability of the pharmaceutical compositions is obviously improved by means of a salt modification technology. The double compound pharmaceutical composition is prepared from a netarsudil free alkali or a pharmaceutically acceptable salt thereof, and an adrenergic β receptor blocker. The triple compound pharmaceutical composition is prepared from a netarsudil free alkali or a pharmaceutically acceptable salt thereof, an adrenergic β receptor blocker, and a prostaglandin analog. The double and triple compound pharmaceutical compositions have excellent stability at pH 4.5-5.4. An effective amount of the pharmaceutical compositions of the present invention are administered once a day to the eyes of patients in need thereof at or near bedtime, such that the intraocular pressure can be efficiently and quickly reduced and is maintained in a physiological range more persistently, showing small side effects and high patient compliance.
Inventors:
JIANG QIKUN (CN)
WANG TAO (CN)
CHI MEILING (CN)
ZHAO CHEN (CN)
WANG TAO (CN)
CHI MEILING (CN)
ZHAO CHEN (CN)
Application Number:
PCT/CN2023/093497
Publication Date:
November 23, 2023
Filing Date:
May 11, 2023
Export Citation:
Assignee:
UNIV SHENYANG PHARMACEUTICAL (CN)
International Classes:
A61K31/472; A61K9/08; A61K31/5377; A61K45/06; A61P27/02
Foreign References:
| CN114796219A | 2022-07-29 | |||
| US20210346350A1 | 2021-11-11 | |||
| CN115038449A | 2022-09-09 | |||
| US20200108064A1 | 2020-04-09 |
Other References:
YEE SUSAN: "Glaucoma Therapy: Finding the Right Combination", REVIEW OF OPTOMETRY, 15 April 2017 (2017-04-15), XP093109951, Retrieved from the Internet
Attorney, Agent or Firm:
BEIJING WITAL PATENT AGENCY CO., LTD (CN)
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