Title:
METHOD, COMPUTER SYSTEM AND SOFTWARE FOR SELECTING Tag SNP, AND DNA MICROARRAY EQUIPPED WITH NUCLEIC ACID PROBE CORRESPONDING TO Tag SNP SELECTED BY SAID SELECTION METHOD
Document Type and Number:
WIPO Patent Application WO/2015/194655
Kind Code:
A1
Abstract:
The present invention addresses the problem of discovering a means for achieving the more proper selection of a Tag SNP to be contained in a nucleic acid probe, which is a probe contained in a DNA microarray or the like and used as a means for carrying out imputation, in the imputation of SNPs. Specifically, it is found that the problem can be solved by a method for selecting a Tag SNP that is used as a means for imputing information on SNPs of human genome using human genome information that includes information on a group of SNPs, in which genotypes of multiple individuals are specified, for the purpose of constituting a group of nucleic acid probes corresponding to the Tag SNP, wherein the sum total of mutual information amounts between Tag SNP candidates and Target SNPs for the candidates is employed as a measure for the selection of the Tag SNP. Thus, provided are: a computer system and a computer program which are developed on the basis of the above-mentioned principle; a DNA microarray which is equipped with a group of nucleic acid probes corresponding to a Tag SNP selected by the aforementioned means; and a method for producing the DNA microarray.
Inventors:
NAGASAKI MASAO (JP)
KOJIMA KANAME (JP)
NARIAI NAOKI (JP)
MIMORI TAKAHIRO (JP)
KAWAI YOSUKE (JP)
KOJIMA KANAME (JP)
NARIAI NAOKI (JP)
MIMORI TAKAHIRO (JP)
KAWAI YOSUKE (JP)
Application Number:
PCT/JP2015/067686
Publication Date:
December 23, 2015
Filing Date:
June 19, 2015
Export Citation:
Assignee:
UNIV TOHOKU NAT UNIV CORP (JP)
International Classes:
C12M1/00; C12N15/09; C12Q1/68; G01N33/53; G01N37/00; G16B25/20
Foreign References:
| JP2008250971A | 2008-10-16 | |||
| US20030033290A1 | 2003-02-13 | |||
| US20090004652A1 | 2009-01-01 |
Other References:
THE INTERNATIONAL HAPMAP 3 CONSORTIUM: "Integrating common and rare genetic variation in diverse human populations", NATURE, 2 September 2010 (2010-09-02), XP055247268, Retrieved from the Internet [retrieved on 20150703]
"Nipponjin ni Saitekika sareta SNP Array 'Japonica Array R' o Sekkei", 24 June 2015 (2015-06-24), Retrieved from the Internet [retrieved on 20150703]
"Nipponjin ni Saitekika sareta SNP Array 'Japonica Array R' o Sekkei", 24 June 2015 (2015-06-24), Retrieved from the Internet
Attorney, Agent or Firm:
SHIMURA MITSUHARU (JP)
Mitsuharu Shimura (JP)
Mitsuharu Shimura (JP)
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