Title:
METHOD FOR CONDUCTING PHYLOGENETIC ANALYSIS OF CELLS
Document Type and Number:
WIPO Patent Application WO/2023/157933
Kind Code:
A1
Abstract:
The present invention relates to a method for conducting phylogenetic analysis of cells. This method involves: (1) comparing, with respect to a plurality of single cells originating from the same individual, RNA sequence data on a transcriptome of each single cell with corresponding genome sequence data and screening sites at which the RNA sequence is different from the genome sequence; (2) screening, among the sites specified by the screening in step (1), a site at which three or more single nucleotide polymorphisms are detected, as a somatic mutation site; and (3) creating a phylogenetic tree of the cells on the basis of base sequence information on the somatic mutation site obtained in step (2).
Inventors:
OOTA SATOSHI (JP)
Application Number:
PCT/JP2023/005534
Publication Date:
August 24, 2023
Filing Date:
February 16, 2023
Export Citation:
Assignee:
RIKEN (JP)
International Classes:
G16B10/00
Foreign References:
| US20140206006A1 | 2014-07-24 | |||
| JP2012505666A | 2012-03-08 | |||
| JP2021179867A | 2021-11-18 |
Other References:
"Panoramic View Report: Life Science and Clinical Research Field (2021). Center for Research and Development Strategy", 1 March 2021, JAPAN SCIENCE AND TECHNOLOGY AGENCY, JP, ISBN: 978-4-88890-711-8, article "Passages", pages: 230 - 520-538, XP009548948
Attorney, Agent or Firm:
YAMAMOTO, Osamu et al. (JP)
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