Title:
METHOD FOR CONSTRUCTING IMMUNE TOLERANCE INDUCTION SCHEME FOR ORTHOTOPIC LIVER TRANSPLANTATION
Document Type and Number:
WIPO Patent Application WO/2023/236132
Kind Code:
A1
Abstract:
Provided are an immune tolerance scheme for orthotopic liver transplantation and a method for constructing an animal model thereof. The animal model features proper and reasonable design and good reproducibility, which meets the requirements of orthotopic liver transplantation in rats. The present invention also possesses similarities to liver transplantation in humans, a high postoperative survival rate, good reproducibility, and a tolerance rate of up to 100%. The postoperative liver function assay and pathological analysis demonstrate that the present invention can solve the problems of inefficiency, high mortality rate, and high requirements on personnel and microscopic devices, and can be applied to the basic research of tolerance induction in donor-recipient combinations.
Inventors:
ZHOU SHAOTANG (CN)
Application Number:
PCT/CN2022/097775
Publication Date:
December 14, 2023
Filing Date:
June 09, 2022
Export Citation:
Assignee:
ZHOU SHAOTANG (CN)
International Classes:
A61D3/00; A61D1/00; A61D7/00; A61D7/04
Foreign References:
| CN113576703A | 2021-11-02 | |||
| CN111543384A | 2020-08-18 | |||
| CN105941329A | 2016-09-21 | |||
| CN104739541A | 2015-07-01 | |||
| CN114224549A | 2022-03-25 | |||
| US20150289499A1 | 2015-10-15 |
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