Title:
METHOD FOR COVALENT BOND MODIFYING MAMMALIAN ATG8 HOMOLOGUE
Document Type and Number:
WIPO Patent Application WO/2018/214813
Kind Code:
A1
Abstract:
Provided is a method for covalently modifying a mammalian ATG8 homologue, comprising providing a compound SM-LG, wherein the compound SM-LG comprises a part SM- capable of regulating the mammalian ATG8 homologue and a leaving part -LG. The compound SM-LG reacts with the mammalian ATG8 homologue to produce a mammalian ATG8 homologue covalent complex. Also provided are a mammalian ATG8 homologue covalent complex obtained by the method and a use thereof.
Inventors:
LUO CHENG (CN)
YAO ZHIYI (CN)
XIE YULI (CN)
WAN WEI (CN)
YUE LIYAN (CN)
ZHANG YUANYUAN (CN)
JIANG HUALIANG (CN)
CHEN KAIXIAN (CN)
YAO ZHIYI (CN)
XIE YULI (CN)
WAN WEI (CN)
YUE LIYAN (CN)
ZHANG YUANYUAN (CN)
JIANG HUALIANG (CN)
CHEN KAIXIAN (CN)
Application Number:
PCT/CN2018/087449
Publication Date:
November 29, 2018
Filing Date:
May 18, 2018
Export Citation:
Assignee:
SUZHOU AUTOPHARM BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/122; A61P25/00; A61P25/28; A61P35/00; C07K14/47
Domestic Patent References:
| WO2011019636A2 | 2011-02-17 | |||
| WO2015164850A1 | 2015-10-29 | |||
| WO2011033389A2 | 2011-03-24 |
Foreign References:
| CN102574816A | 2012-07-11 | |||
| US20110117588A1 | 2011-05-19 | |||
| US20090163545A1 | 2009-06-25 | |||
| CN104042612A | 2014-09-17 | |||
| CN105143263A | 2015-12-09 |
Other References:
CANELA, M.D. ET AL.: "Targeting the Colchicine Site in Tubulin through Cyclohexanedione Derivatives", RSC ADVANCES, 9 February 2016 (2016-02-09), XP055550396
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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